Revista Espanola De Quimioterapia最新文献_第9页

Demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in Madrid (Spain), during the May-June 2022 international outbreak. 2022 年 5 月至 6 月国际猴痘疫情爆发期间，在马德里（西班牙）一家三甲医院就诊的首批 30 例人类猴痘确诊病例的人口统计学、临床和微生物学特征。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-04-01 Epub Date: 2023-01-18 DOI: 10.37201/req/112.2022

A Cobos, M Valerio, M Palomo, I Adán, P Catalán, C Veintimilla, F López-Andújar, C Rincón, A Galar, R Alonso, M Machado, P Gijón, T Aldámiz-Echevarría Lois, L Pérez Latorre, C Diez, C Fanciulli, E Bouza Santiago, P Muñoz

{"title":"Demographic, clinical and microbiological characteristics of the first 30 human monkeypox confirmed cases attended in a tertiary hospital in Madrid (Spain), during the May-June 2022 international outbreak.","authors":"A Cobos, M Valerio, M Palomo, I Adán, P Catalán, C Veintimilla, F López-Andújar, C Rincón, A Galar, R Alonso, M Machado, P Gijón, T Aldámiz-Echevarría Lois, L Pérez Latorre, C Diez, C Fanciulli, E Bouza Santiago, P Muñoz","doi":"10.37201/req/112.2022","DOIUrl":"10.37201/req/112.2022","url":null,"abstract":"The present outbreak of Human Monkeypox (HMPX) that has begun in May 2022 and has spread across all continents in less than two months has qualitative and quantitative characteristics that make it different from the pattern of human disease previously caused by this virus. It has spread with enormous ease, affects almost exclusively adults, behaves as a sexually transmitted disease and focuses on very specific groups and transmission conditions. The high incidence in the city of Madrid in males that have sex with males (MSM) has allowed us to observe and report the experience with the first 30 cases diagnosed in our institution. Patients presented with febrile symptoms, genital and paragenital skin lesions reminiscent of smallpox, but less extensive and severe. The disease may also cause proctitis, pharyngitis and perioral lesions. The PCR test for diagnostic confirmation has been shown to be very sensitive and effective, not only in skin lesions but also in blood and other fluids such as pharyngeal, rectal exudates and blood. A very high proportion of patients with HMPX also have other sexually transmitted diseases that must be actively detected in this context. The spontaneous evolution of our patients has been good and hospitalization has been practically unnecessary. Transmission to non-sexual cohabitants and health personnel has been nonexistent and the lesions have disappeared in less than 30 days without leaving sequelae and no need for specific antiviral treatment.","PeriodicalId":21232,"journal":{"name":"Revista Espanola De Quimioterapia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/26/revespquimioter-36-194.PMC10066919.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9237583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

[Eikenella corrodens brain abscess after frontal sinusitis in immunocompetent patient]. [免疫正常患者额窦炎后艾肯氏菌对脑脓肿的腐蚀]。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-04-01 DOI: 10.37201/req/094.2022

D Salas Olortegui, O Moreno Felici, J Calvó Gómez, J Colomina Rodríguez

引用次数: 0

Fatal septic shock and Waterhouse-Friderichsen syndrome caused by serovar B Capnocytophaga canimorsus in an immunocompetent patient. Case report and review. 免疫功能正常患者血清B型巨细胞吞噬致致致命性感染性休克和Waterhouse-Friderichsen综合征。病例报告和复查。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-02-01 Epub Date: 2022-11-25 DOI: 10.37201/req/060.2022

D Fernández Vecilla, I Angulo López, F E Calvo Muro, C Aspichueta Vivanco, F Renzi, M E Pereda Martínez, J Rosselló Soria, J L Díaz de Tuesta Del Arco

{"title":"Fatal septic shock and Waterhouse-Friderichsen syndrome caused by serovar B Capnocytophaga canimorsus in an immunocompetent patient. Case report and review.","authors":"D Fernández Vecilla, I Angulo López, F E Calvo Muro, C Aspichueta Vivanco, F Renzi, M E Pereda Martínez, J Rosselló Soria, J L Díaz de Tuesta Del Arco","doi":"10.37201/req/060.2022","DOIUrl":"10.37201/req/060.2022","url":null,"abstract":"Rev Esp Quimioter 2023;36(1): 92-96 92 Two sets of blood cultures were obtained before starting empiric broad-spectrum antibiotic therapy with intravenous piperacillin-tazobactam, meropenem and clindamycin (4/0,5g single dose, 2 g/8 h and 900 mg/8 h, respectively). Despite high-dose intravenous fluid replacement, noradrenaline and bicarbonate infusions, the patient didn ́t improve and was transferred to intensive care unit after orotracheal intubation. A body CT scan was conducted, which described signs of hypovolemic shock with thickening of both adrenal glands with crosslinking of the peri-renal fluid, as well as liver with periportal edema and no highlight of the spleen (Figure 2A). Her condition deteriorated rapidly overnight and, in spite of cardiopulmonary resuscitation measures, patient expired 16 hours after admission. Because of multi-organ failure and septic shock of unknown origin, an autopsy was requested.","PeriodicalId":21232,"journal":{"name":"Revista Espanola De Quimioterapia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/ea/revespquimioter-36-092.PMC9910678.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10790924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Propionimicrobium lymphophilum a new urinary tract infection cause? 嗜淋巴丙酸菌是一种新的尿路感染原因吗?

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-02-01 DOI: 10.37201/req/086.2022

D Fernández Vecilla, I Angulo López, M L Gurruchaga Yanes, M C Nieto Toboso, J L Díaz de Tuesta Del Arco

引用次数: 0

Impact and control of the COVID pandemic in an elite sports club: Real Madrid. COVID 流行病在精英体育俱乐部中的影响和控制：皇家马德里。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-02-01 Epub Date: 2022-11-07 DOI: 10.37201/req/072.2022

N Mihic, J Abascal, J López Chicharro, F Segura, S Huurman, B Núñez de Aysa, E Bouza

{"title":"Impact and control of the COVID pandemic in an elite sports club: Real Madrid.","authors":"N Mihic, J Abascal, J López Chicharro, F Segura, S Huurman, B Núñez de Aysa, E Bouza","doi":"10.37201/req/072.2022","DOIUrl":"10.37201/req/072.2022","url":null,"abstract":"The incidence and risk factors for poor outcome in patients with COVID are well known, as are the protective measures in high-risk populations. In contrast, the epidemiological and clinical behavior of this disease in the population of elite athletes who are the paradigm of good health is poorly understood. Data on COVID in athletes are scarce and have focused preferentially on the consequences on sports performance of confinement measures and on the pathophysiological risks of infected athletes. Real Madrid is a large elite sports institution with facilities in the City of Madrid where 600 athletes train daily. The incidence of COVID during a study period of 671 days of observation in athletes, professional or amateur, working in the institution has been 0,74 per 1,000 days of exposure. The disease has been asymptomatic or oligosymptomatic in all athletes and did not require any hospital admissions. The different teams did not have to suspend any of its sportive commitments for COVID during the study period and there was no evidence of outbreaks of internal transmission between members of the different teams.","PeriodicalId":21232,"journal":{"name":"Revista Espanola De Quimioterapia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/87/revespquimioter-36-059.PMC9910681.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9300279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytomegalovirus reactivation in patients diagnosed with severe COVID-19: A point prevalence study in a general hospital. 重症COVID-19患者巨细胞病毒再激活:某综合医院点流行病学研究

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-02-01 DOI: 10.37201/req/068.2022

M J Pérez-Granda, P Catalán, P Muñoz, T Aldámiz, J C Barrios, C Ramírez, R García-Martínez, M V Villalba, L Puente, E Bouza

{"title":"Cytomegalovirus reactivation in patients diagnosed with severe COVID-19: A point prevalence study in a general hospital.","authors":"M J Pérez-Granda, P Catalán, P Muñoz, T Aldámiz, J C Barrios, C Ramírez, R García-Martínez, M V Villalba, L Puente, E Bouza","doi":"10.37201/req/068.2022","DOIUrl":"https://doi.org/10.37201/req/068.2022","url":null,"abstract":"Objective: To determine the prevalence of CMV reactivation in a population admitted for severe COVID-19 to a general hospital.Methods: Point prevalence study in all hospitalized patients with severe COVID-19 (admitted either to general wards or ICU). Determination of the presence of CMV DNA in circulating blood. COVID-19 was confirmed in patients with compatible clinical manifestations, usually with pneumonia and a positive nasopharyngeal PCR test.Results: We included 140 hospitalized patients with COVID-19 who consented to participate. A total of 16 patients (11.42%), had circulating CMV-DNA in peripheral blood at the time of the study. Patients with positive CMV viral load were mainly ICU patients (11/37 -29,7%) and only 5/103 cases (4,85%) were hospitalized into general wards. The accumulated doses of corticosteroids (prednisone equivalents) in the study day were (median and IQR) 987.50 mg (396.87-2,454.68) and 187.50 mg (75.00-818.12) respectively in CMV positive and negative patients (p < 0.001). A significant proportion of CMV positive patients were discovered because of the study and were clinically unsuspected by their physicians. The coinfected COVID-CMV positive population had a higher risk of accumulated secondary nosocomially-acquired infections and a worse prognosis.Conclusions: CMV reactivation should be systematically searched in patients in COVID-19 cases admitted to the ICU.","PeriodicalId":21232,"journal":{"name":"Revista Espanola De Quimioterapia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/46/revespquimioter-36-045.PMC9910675.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10790915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antimicrobial resistance in Gram-negative bacilli in Spain: an experts' view. 西班牙革兰氏阴性杆菌的耐药性:专家观点。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-02-01 DOI: 10.37201/req/119.2022

P Retamar-Gentil, R Cantón, V Abril López de Medrano, J Barberán, A Canut Blasco, C Dueñas Gutiérrez, C García-Vidal, N Larrosa Escartín, J Lora-Tamayo, F J Martínez Marcos, C Martín Ruíz, J Pasquau Liaño, P Rascado, O Sanz Peláez, G Yagüe Girao, J P Horcajada

{"title":"Antimicrobial resistance in Gram-negative bacilli in Spain: an experts' view.","authors":"P Retamar-Gentil, R Cantón, V Abril López de Medrano, J Barberán, A Canut Blasco, C Dueñas Gutiérrez, C García-Vidal, N Larrosa Escartín, J Lora-Tamayo, F J Martínez Marcos, C Martín Ruíz, J Pasquau Liaño, P Rascado, O Sanz Peláez, G Yagüe Girao, J P Horcajada","doi":"10.37201/req/119.2022","DOIUrl":"https://doi.org/10.37201/req/119.2022","url":null,"abstract":"Background: Antibiotic resistance in Gram-negative bacilli poses a serious problem for public health. In hospitals, in addition to high mortality rates, the emergence and spread of resistance to practically all antibiotics restricts therapeutic options against serious and frequent infections.Objective: The aim of this work is to present the views of a group of experts on the following aspects regarding resistance to antimicrobial agents in Gram-negative bacilli: 1) the current epidemiology in Spain, 2) how it is related to local clinical practice and 3) new therapies in this area, based on currently available evidence.Methods: After reviewing the most noteworthy evidence, the most relevant data on these three aspects were presented at a national meeting to 99 experts in infectious diseases, clinical microbiology, internal medicine, intensive care medicine, anaesthesiology and hospital pharmacy.Results and conclusions: Subsequent local debates among these experts led to conclusions in this matter, including the opinion that the approval of new antibiotics makes it necessary to train the specialists involved in order to optimise how they use them and improve health outcomes; microbiology laboratories in hospitals must be available throughout a continuous timetable; all antibiotics must be available when needed and it is necessary to learn to use them correctly; and the Antimicrobial Stewardship Programs (ASP) play a key role in quickly allocating the new antibiotics within the guidelines and ensure appropriate use of them.","PeriodicalId":21232,"journal":{"name":"Revista Espanola De Quimioterapia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/eb/revespquimioter-36-065.PMC9910669.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9300805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of hospital emergency departments in identifying patients with unknown HIV infection: an opportunity for diagnosis. 医院急诊科在识别未知HIV感染患者中的作用:一个诊断的机会。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-02-01 DOI: 10.37201/req/079.2022

A García-Martínez, M I Carbó

引用次数: 0

[EDP-938, a new antiviral with inhibitory activity against the nucleoprotein of the respiratory syncytial virus]. [EDP-938，一种对呼吸道合胞病毒核蛋白具有抑制活性的新型抗病毒药物]。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-02-01 DOI: 10.37201/req/096.2022

J Reina, C Iglesias

引用次数: 1

Potentially inappropriate medications according to Marc, STOPP and PRISCUS criteria in a cohort of elderly HIV+ patients. The COMMPI project. 根据Marc, STOPP和PRISCUS标准，老年HIV+患者队列中可能不适当的药物。compi项目。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-02-01 DOI: 10.37201/req/070.2022

P García-Lloret, Y Borrego-Izquierdo, M Manzano-García, M G Cantillana-Suárez, A Gutiérrez-Pizarraya, R Morillo-Verdugo

{"title":"Potentially inappropriate medications according to Marc, STOPP and PRISCUS criteria in a cohort of elderly HIV+ patients. The COMMPI project.","authors":"P García-Lloret, Y Borrego-Izquierdo, M Manzano-García, M G Cantillana-Suárez, A Gutiérrez-Pizarraya, R Morillo-Verdugo","doi":"10.37201/req/070.2022","DOIUrl":"https://doi.org/10.37201/req/070.2022","url":null,"abstract":"Objective: The objective is to determine the prevalence of potentially inappropriate drugs according to the Marc, STOPP, and PRISCUS lists in elderly HIV patients.Methods: It was an observational, retrospective, and multicenter study. People living with HIV 65 years or older who underwent chronic concomitant treatment were included. Descriptive and multivariate analyzes were performed to study the association between polypharmacy and potentially inappropriate medication compliance.Results: A total of 55 patients were included, 81.8% men and a median age of 69 years (IQR: 67-73). The median number of comorbidities was 3 (IQR: 2-5) and the most frequent pattern of multimorbidity was cardiometabolic (62.9%). The predominant antiretroviral treatment was triple therapy (65.5%). Polypharmacy was present in 70.9% of the patients and 25.5% had major polypharmacy. The most frequent polypharmacy pattern was cardiovascular (69.2%). The percentage of potentially inappropriate medications according to the Marc, STOPP and PRISCUS lists was 65.5%, 30.9% and 14.5%, respectively (p<0.001). Adjusted for age and sex, polypharmacy was not independently associated with potentially inappropriate medication compliance in any of the lists.Conclusions: Polypharmacy and potentially inappropriate medications have a high prevalence. There is great variability in the percentage according to the list applied. Age, sex, and presence of polypharmacy are not predisposing factors to the presence of potentially inappropriate medications.","PeriodicalId":21232,"journal":{"name":"Revista Espanola De Quimioterapia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/be/revespquimioter-36-052.PMC9910679.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10723841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0