Potentially inappropriate medications according to Marc, STOPP and PRISCUS criteria in a cohort of elderly HIV+ patients. The COMMPI project.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-02-01 DOI:10.37201/req/070.2022

P García-Lloret, Y Borrego-Izquierdo, M Manzano-García, M G Cantillana-Suárez, A Gutiérrez-Pizarraya, R Morillo-Verdugo

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Abstract

Objective: The objective is to determine the prevalence of potentially inappropriate drugs according to the Marc, STOPP, and PRISCUS lists in elderly HIV patients.

Methods: It was an observational, retrospective, and multicenter study. People living with HIV 65 years or older who underwent chronic concomitant treatment were included. Descriptive and multivariate analyzes were performed to study the association between polypharmacy and potentially inappropriate medication compliance.

Results: A total of 55 patients were included, 81.8% men and a median age of 69 years (IQR: 67-73). The median number of comorbidities was 3 (IQR: 2-5) and the most frequent pattern of multimorbidity was cardiometabolic (62.9%). The predominant antiretroviral treatment was triple therapy (65.5%). Polypharmacy was present in 70.9% of the patients and 25.5% had major polypharmacy. The most frequent polypharmacy pattern was cardiovascular (69.2%). The percentage of potentially inappropriate medications according to the Marc, STOPP and PRISCUS lists was 65.5%, 30.9% and 14.5%, respectively (p<0.001). Adjusted for age and sex, polypharmacy was not independently associated with potentially inappropriate medication compliance in any of the lists.

Conclusions: Polypharmacy and potentially inappropriate medications have a high prevalence. There is great variability in the percentage according to the list applied. Age, sex, and presence of polypharmacy are not predisposing factors to the presence of potentially inappropriate medications.

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根据Marc, STOPP和PRISCUS标准，老年HIV+患者队列中可能不适当的药物。compi项目。

目的:目的是根据Marc, STOPP和PRISCUS清单确定老年HIV患者中潜在不适当药物的流行情况。方法:采用观察性、回顾性、多中心研究。65岁或以上接受慢性伴随治疗的艾滋病毒感染者也包括在内。采用描述性和多变量分析来研究多种用药与潜在不适当用药依从性之间的关系。结果:共纳入55例患者，男性81.8%，中位年龄69岁(IQR: 67-73)。合并症的中位数为3 (IQR: 2-5)，多病最常见的模式是心脏代谢(62.9%)。主要的抗逆转录病毒治疗是三联疗法(65.5%)。70.9%的患者存在多药，25.5%的患者为重度多药。最常见的是心血管(69.2%)。Marc、STOPP和PRISCUS清单中存在潜在不适宜用药的比例分别为65.5%、30.9%和14.5%(结论:多药及潜在不适宜用药的发生率较高)。根据所应用的列表，百分比有很大的差异。年龄、性别和是否使用多种药物不是潜在不适当药物的易感因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.