Revista Espanola De Quimioterapia最新文献_第3页

Multidrug-resistant Acinetobacter baumannii: A therapeutic challenge. 多重耐药鲍曼不动杆菌：一项治疗挑战。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-10-01 Epub Date: 2023-07-21 DOI: 10.37201/req/012.2023

M Martínez Pérez, A Vázquez Blanquiño, R Morón, L Pérez Rodríguez, N Chueca Porcuna

引用次数: 0

The importance of prevalence and pre-test probability on the microbiological diagnosis of SARS-CoV-2: the case of Spain in 2020. 流行率和检测前概率对严重急性呼吸系统综合征冠状病毒2型微生物学诊断的重要性：2020年西班牙病例。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-10-01 Epub Date: 2023-07-21 DOI: 10.37201/req/033.2023

A Canut-Blasco, C Gómez-González, R Barbero-Herranz, I Barbero-Martínez, E Abasolo-Osinaga

{"title":"The importance of prevalence and pre-test probability on the microbiological diagnosis of SARS-CoV-2: the case of Spain in 2020.","authors":"A Canut-Blasco, C Gómez-González, R Barbero-Herranz, I Barbero-Martínez, E Abasolo-Osinaga","doi":"10.37201/req/033.2023","DOIUrl":"10.37201/req/033.2023","url":null,"abstract":"Objective: The aim of this work was to estimate the conditioned probability for the diagnosis of SARS-CoV-2 infection with reverse transcription polymerase chain reaction (RT-PCR), viral antigen rapid diagnostic tests (Ag-RDT), and antibody detection tests depending on the prevalence in the specific healthcare settings in Spain in 2020, and on the pre-test probability (PTP) according to the clinical situation, age and unknown or close contacts of the patient.Methods: Performance parameters of tests were obtained from literature. Prevalence data and PTP were obtained from Spanish sources and a survey, respectively. The post-test probability is the positive predictive value (PPV) when test is positive. For negative result, we also calculated the probability of having the infection (false negatives).Results: For both RT-PCR and viral Ag-RDT, the lowest PPV values were for the population screenings. This strategy proved to be useful in ruling out infection but generates a high number of false positives. At individual level, both tools provided high PPV (≥ 97%) when the PTP values are over 35%. In seroprevalence studies, though the specificity of IgG alone tests is high, under low seroprevalence, false positives cannot be avoided. Total antibodies tests are useful for diagnosis of COVID-19 in those doubtful cases with RT-PCR or Ag-RDT tests being repeatedly negative.Conclusions: The interpretating of results depends not only on the accuracy of the test, but also on the prevalence of the infection in different settings, and the PTP associated to the patient before performing the test.","PeriodicalId":21232,"journal":{"name":"Revista Espanola De Quimioterapia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/88/revespquimioter-36-498.PMC10586731.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9849480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pneumonia associated with parapneumonic effusion in an immunocompetent patient caused by Bordetella bronchiseptica]. [支气管败血博德特菌引起的免疫活性患者的肺炎伴肺炎旁积液]。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-10-01 Epub Date: 2023-06-01 DOI: 10.37201/req/006.2023

D Fernández Vecilla, M P Roche Matheus, G Iglesias Hidalgo, M J Unzaga Barañano, J L Díaz de Tuesta Del Arco

引用次数: 0

[Antimicrobial stewardship program in urinary tract infections due to multiresistant strains in the emergency department]. [急诊科多耐药菌株引起的尿路感染的抗菌管理计划]。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-10-01 Epub Date: 2023-07-17 DOI: 10.37201/req/009.2023

J Ruiz-Ramos, S Herrera-Mateo, M A Rivera-Martínez, A E Monje-López, H Hernández-Ontiveros, C S Pereia-Batista, Y M Martinez-Ysasis, M Puig-Campmany

{"title":"[Antimicrobial stewardship program in urinary tract infections due to multiresistant strains in the emergency department].","authors":"J Ruiz-Ramos, S Herrera-Mateo, M A Rivera-Martínez, A E Monje-López, H Hernández-Ontiveros, C S Pereia-Batista, Y M Martinez-Ysasis, M Puig-Campmany","doi":"10.37201/req/009.2023","DOIUrl":"10.37201/req/009.2023","url":null,"abstract":"Objective: Urinary tract infections (UTI) are a frequent reason for attendance at emergency department (ED). The present study evaluates the impact of a multidisciplinary program for the optimization of antibiotic therapy in patients with UTI caused by multi-drug resistant bacteria treated from the hospital ED.Methods: Descriptive study of the implementation of a program in which emergency, microbiology and pharmacy departments participated. Antibiotic treatment of the patients who consulted the ED with positive urine cultures caused by multidrug-resistant bacteria was reviewed upon discharge. In those patients with inappropriate treatment, doctors and/or pharmacists of the next level of healthcare or patients in the case of home discharge were contacted. The impact of the program was evaluated based on new visits to the ED at 30 days after discharge, compared with the results obtained from the usual practice three months prior the intervention.Results: During the first year, 2,474 urine cultures of patients with UTI were reviewed, 533 (21.7%) were caused by multidrug-resistant bacteria. Empirical treatment was inappropriate in 287 (53.4%), making treatment modifications in 243 of them. 73 (19.3%) patients returned to the ED 30 days after discharge, being lower than the results obtained in the three months prior intervention (27.9%; p=0.031), without significant differences in new visits associated with UTI.Conclusions: The implementation of a multidisciplinary program focused on multidrug resistant UTI at discharge form ED correct antibiotic therapy in a large number of patients, being a potentially tool to reduce the number of new ED visits.","PeriodicalId":21232,"journal":{"name":"Revista Espanola De Quimioterapia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/77/revespquimioter-36-486.PMC10586745.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Candida isolates from blood cultures and intra-abdominal samples: data derived from a multicentre prospective study conducted in Madrid. 血液培养和腹腔内样本中的非念珠菌分离株：数据来源于马德里进行的一项多中心前瞻性研究。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-10-01 Epub Date: 2023-06-26 DOI: 10.37201/req/025.2023

J Díaz-García, A Gómez, M Machado, L Alcalá, E Reigadas, C Sánchez-Carrillo, A Pérez-Ayala, E Gómez-García de la Pedrosa, F González-Romo, M S Cuétara, C García-Esteban, I Quiles-Melero, N D Zurita, M Muñoz-Algarra, M T Durán-Valle, A Sánchez-García, P Muñoz, P Escribano, J Guinea

{"title":"Non-Candida isolates from blood cultures and intra-abdominal samples: data derived from a multicentre prospective study conducted in Madrid.","authors":"J Díaz-García, A Gómez, M Machado, L Alcalá, E Reigadas, C Sánchez-Carrillo, A Pérez-Ayala, E Gómez-García de la Pedrosa, F González-Romo, M S Cuétara, C García-Esteban, I Quiles-Melero, N D Zurita, M Muñoz-Algarra, M T Durán-Valle, A Sánchez-García, P Muñoz, P Escribano, J Guinea","doi":"10.37201/req/025.2023","DOIUrl":"10.37201/req/025.2023","url":null,"abstract":"from blood cultures (n=12) or intra-abdominal samples (n=13; peritoneal samples [n=11], liver samples [n=2]) that represented 1.1% (n=12/1,101) and 1.3% (n=13/1,031) of isolates from blood cultures and intra-abdominal samples, respectively (Figure 1). Non-Candida yeasts were found in 1.3 % (n=25/1,912) of the patients (Candida spp were simultaneously found in 8/25 patients). Interestingly, higher species diversity was found in isolates from blood cultures; the species found in intra-abdominal samples were also found in blood culture isolates except for S. cerevisiae, which was exclusively found in intra-abdominal samples. Blood-cultured isolates were mainly sourced from patients in medical (42%) or ICU wards (33%), whereas intra-abdominal isolates were mainly sourced from patients in surgery wards (77%). The number of isolates detected per year were 12 in 2019, 8 in 2020, and 5 in 2021.","PeriodicalId":21232,"journal":{"name":"Revista Espanola De Quimioterapia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/eb/revespquimioter-36-541.PMC10586730.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9686165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Neisseria meningitidis, beyond the afectation of the central nervous system]. [脑膜炎奈瑟菌，中枢神经系统以外]。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-10-01 Epub Date: 2023-06-01 DOI: 10.37201/req/015.2023

H Fernández Manandu, E Molina Iturritza, I San José Muñiz, M Urrestarazu Larrañaga

引用次数: 0

Do face masks increase the rate of the Staphylococcus aureus nasal carriers? 口罩会增加金黄色葡萄球菌鼻腔携带者的发病率吗？

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-10-01 Epub Date: 2023-09-07 DOI: 10.37201/req/082.2023

S Urquía-Cutillas, M L Gómez-Lus, D Sevillano, N González, L Alou

引用次数: 0

In vitro assessment of the combined effect of letermovir and sirolimus on cytomegalovirus replication. 来特莫韦和西罗莫司对巨细胞病毒复制的联合作用的体外评估。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-10-01 Epub Date: 2023-06-28 DOI: 10.37201/req/016.2023

E Giménez, M Guerreiro, R Gozalbo-Rovira, C Aguilar, E Albert, J L Piñana, C Solano, D Navarro

{"title":"In vitro assessment of the combined effect of letermovir and sirolimus on cytomegalovirus replication.","authors":"E Giménez, M Guerreiro, R Gozalbo-Rovira, C Aguilar, E Albert, J L Piñana, C Solano, D Navarro","doi":"10.37201/req/016.2023","DOIUrl":"10.37201/req/016.2023","url":null,"abstract":"Objective: Letermovir (LMV) is used for prophylaxis of cytomegalovirus (CMV) reactivation and end-organ disease in adult CMV-seropositive allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). In turn, sirolimus (SLM) which displays in vitro anti-CMV activity, is frequently employed for prophylaxis of Graft vs. Host disease in allo-HSCT. Here, we aimed at assessing whether LMV and SLM used in combination may act synergistically in vitro on inhibiting CMV replication.Methods: The antiviral activity of LMV and SLM alone or in combination was evaluated by a checkerboard assay, using ARPE-19 cells infected with CMV strain BADrUL131-Y. LMV and SLM were used at concentrations ranging from 24 nM to 0.38 nM and 16 nM to 0.06 nM, respectively.Results: The mean EC50 for LMV and SLM was 2.44 nM (95% CI, 1.66-3.60) and 1.40 nM (95% CI, 0.41-4.74), respective. LMV and SLM interaction yielded mainly additive effects over the range of concentrations tested.Conclusions: The additive nature of the combination of LMV and SLM against CMV may have relevant clinical implications in management of CMV infection in allo-HSCT recipients undergoing prophylaxis with LMV.","PeriodicalId":21232,"journal":{"name":"Revista Espanola De Quimioterapia","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/d2/revespquimioter-36-526.PMC10586729.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nirmatrelvir/ritonavir as a possible treatment for Long-COVID. 尼马特雷韦/利托那韦作为长期新冠肺炎的可能治疗方法。

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-10-01 Epub Date: 2023-06-27 DOI: 10.37201/req/028.2023

I Pérez Catalán, A Gascón Buj, S García Muñoz, I Gómez Alfaro, C Roig Martí, M Torres García, R Reig Valero, R Ferrando Piqueres, L Mateu Campos, J M Ramos Rincón, J Usó Blasco

引用次数: 1

Role of Hologic® Panther AptimaTM SARS-CoV-2 assay in the detection of SARS-CoV-2: screening or diagnostic technique? Hologic®Panther AptimaTM严重急性呼吸系统综合征冠状病毒2型检测在检测严重急性呼吸综合征冠状病毒2中的作用：筛查还是诊断技术？

IF 1.9 4区医学

Revista Espanola De Quimioterapia Pub Date : 2023-10-01 Epub Date: 2023-06-02 DOI: 10.37201/req/135.2022

C García-Salguero, L Vallejo, M Martínez-Rodríguez, A Delgado-Iribarren, E Culebras

引用次数: 0