Reviews on Clinical Pharmacology and Drug Therapy最新文献

{"title":"DYNAMICS OF THE STIMULATING EFFECTS OF GONADOTROPIN AND THIENOPYRIMIDINE DERIVATIVE TP03 ON OVULATION AND OVARIAN STEROIDOGENESIS IN FOLLIMAG-STIMULATED IMMATURE FEMALE RATS","authors":"K. Derkach, A. Bakhtyukov, V. Sorokoumov, E. A. Didenko, Irina V. Romanova, I. Morina, I. Lebedev, L. V. Bayunova, A. Shpakov","doi":"10.17816/rcf622883","DOIUrl":"https://doi.org/10.17816/rcf622883","url":null,"abstract":"Gonadotropin preparations, primarily human chorionic gonadotropin (hCG), are widely used to induce ovulation and correct reproductive disorders in women, but they are characterized by a number of side effects. A possible alternative is low-molecular-weight allosteric agonists of the luteinizing hormone receptor (LHR), including the thieno[2,3-d]-pyrimidine derivatives we developed. The purpose of the work was a comparative study of the effect of thieno[2,3-d]-pyrimidine TP03 and hCG on ovarian weight, corpus luteum formation, plasma levels of estradiol, progesterone and LH in immature female rats pre-treated with Follimag, as well as their effect on expression of ovarian genes encoding LHR and key components of steroidogenesis. TP03 was administered at a dose of 20 mg/kg (i.p.), hCG at a dose of 15 IU/rat (s.c.), both 48 hours after the Follimag injection. The estimated parameters were studied 1, 2, 4, 8, 16 and 24 hours after administration of TP03 or hCG. Plasma levels of hormones were determined using ELISA, and gene expression in the ovaries was determined using real-time PCR. The allosteric LHR agonist TP03 increased ovarian weight, progesterone production in the blood and the expression of steroidogenic genes encoding the cholesterol-transporting protein StAR and the cytochromes CYP11A1 and CYP17A1, and also stimulated the formation of the corpus luteum (1624 hours after treatment). The temporal dynamics of its stimulating effects were similar to those of hCG, although their magnitude was slightly inferior to those of gonadotropin. The TP03-induced decrease in blood estradiol levels and aromatase gene expression in the ovaries was also more moderate. Unlike hCG, which suppressed the expression of the gene encoding LHR 8 hours after treatment, TP03 maintained a high level of expression of this gene, preventing a decrease in the sensitivity of the ovaries to endogenous LH. Thus, TP03 is a good candidate for the role of an ovulation inducer, acting more mildly than hCG in terms of stimulating ovarian steroidogenesis, which reduces the risks of developing ovarian hyperstimulation syndrome and resistance of ovarian cells to gonadotropins.","PeriodicalId":21186,"journal":{"name":"Reviews on Clinical Pharmacology and Drug Therapy","volume":"73 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Яркий изобретатель-новатор фармаколог Александр Ливиевич Ураков (к 70-летию со дня рождения)","authors":"Petr D. Shabanov","doi":"10.17816/rcf627547","DOIUrl":"https://doi.org/10.17816/rcf627547","url":null,"abstract":"Яркий изобретатель-новатор фармаколог Александр Ливиевич Ураков (к 70-летию со дня рождения)","PeriodicalId":21186,"journal":{"name":"Reviews on Clinical Pharmacology and Drug Therapy","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the pharmacological efficacy and potential of nitazoxanide, a broad–spectrum thiazolide drug","authors":"V. V. Rusanovsky, A. A. Savelyeva, Z. G. Tadtaeva, Egor S. Astudin, Alexandr E. Krivoshein, Alexandr A. Akimov, N. A. Kuritcyna","doi":"10.17816/rcf624703","DOIUrl":"https://doi.org/10.17816/rcf624703","url":null,"abstract":"The article is devoted to the possibility and prospects of using nitazoxanide in a wide range of diseases. Based on literature data, the authors evaluate the pharmacological effectiveness and substantiate the potential of using nitazoxanide in bacterial, helminthic, protean, viral and oncological diseases. This information is of interest and can be used to decide on the need to conduct clinical trials of nitazoxanide in Russia. \u0000The goal is to evaluate the pharmacological activity and potential of nitazoxanide in bacterial, helminthic, protean, viral and oncological diseases. \u0000Materials and methods: A systematic search for current information was conducted in four databases until December 1, 2023: PubMed, EMBASE, Web of Science and Cochrane Library. Work included preclinical studies in vitro and in vivo, as well as randomized clinical trials comparing the pharmacological effectiveness of nitazoxanide and placebo. \u0000Conclusions: the broad-spectrum thiazolide drug nitazoxanide has antibacterial, antiprotozoal, anthelmintic, antiviral and antitumor activity. This is achieved through its pharmacological properties, namely: regulation of the cell cycle, apoptosis, cell proliferation and migration; activation of innate immunity; influence on the synthesis and activation of cell proteins, some of which are links in cellular signaling pathways; binding to proteins of viruses, bacteria, protozoa and helminths with disruption of their vital functions; immunomodulating effect by regulating the activity of pro- and anti-inflammatory cytokines. The article systematizes and summarizes current information on the pharmacodynamics of NTZ, as well as the results of preclinical and clinical studies of the drug, and discusses further prospects.","PeriodicalId":21186,"journal":{"name":"Reviews on Clinical Pharmacology and Drug Therapy","volume":"26 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHARMACOLOGICAL CORRECTION OF EXPERIMENTALLY INDUCED OSTEOPOROSIS COMPLICATED BY DIABETES MELLITUS TYPE 2","authors":"Petr D. Shabanov","doi":"10.17816/rcf623110","DOIUrl":"https://doi.org/10.17816/rcf623110","url":null,"abstract":"BACKGROUND: Osteoporosis is a significant problem in the world with important medical and economic consequences. An important contribution to solving the problem of osteoporosis can be the creation of drugs based on unique biologically active compounds. aim: Evaluate of the processes of osteogenesis, according to the evaluation of markers of bone remodeling in blood serum at the stages of therapy of experimental osteoporosis complicated by diabetes type 2. Materials and methods: The study was performed on an experimental model of osteoporosis, followed by induction of diabetes type 2, using biochemical methods for analyzing markers of osteoporosis in blood serum. Results: According to the results of the study of the content of markers of bone remodeling, the dependence of the anti-osteoporotic activity of a composite preparation based on succinic acid salts on glucose metabolism disorders in DM is shown. High efficacy of the new drug in monotherapy, and in combination with vitamin D3 in the activation of osteogenesis processes in experimental osteoporosis. it was leveled by a violation of metabolic processes, induction of diabetes type 2. Conclusion: The dependence of the pharmacological effectiveness of the anti-osteoporosis agent on the model of osteoporosis in female rats on metabolic disorders in the form of diabetes type 2 is shown. \u0000 Keywords: osteoporosis, experimental model, markers of osteogenesis, anti-osteoporosis agent, type 2 diabetes.","PeriodicalId":21186,"journal":{"name":"Reviews on Clinical Pharmacology and Drug Therapy","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics. Review of the current state of the problem from the standpoint of clinical pharmacology and evidence-based medicine","authors":"D. Kachanov, Andrei V. Pavlysh, Tatiana Yurievna Galunova, Galina Ya. Lapkina","doi":"10.17816/rcf321186","DOIUrl":"https://doi.org/10.17816/rcf321186","url":null,"abstract":"When using antibiotics in the treatment of various diseases, the quantitative and qualitative composition of the microbiota, both pathogenic and symbiotic, changes dramatically. Both oral and parenteral use of antibacterial drugs has an impact and changes the quantitative and qualitative composition of the intestinal microbiota, which subsequently entails changes in the pathways of cell development and long-term violations of physiology at all levels of functioning of the macroorganism. In this article, the analysis of available data on modern probiotic drugs drugs that contribute to improving the normal microbiota of the human body was carried out. The undoubted effectiveness of various probiotics in acute and antibiotic-associated diarrhea, eradication of Helicobacter pylori was noted.","PeriodicalId":21186,"journal":{"name":"Reviews on Clinical Pharmacology and Drug Therapy","volume":"103 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the key endocannabinoids and their receptros in breast cancer","authors":"Mikhail Akimov, P. Dudina, Tatiana Vyunova, A. Kalueff, Natalia Gretskaya, Vladimir V. Bezuglov","doi":"10.17816/rcf623144","DOIUrl":"https://doi.org/10.17816/rcf623144","url":null,"abstract":"Breast cancer is the main cause of death of women from cancer. Endocannabinoids and their exogenous analogues, for example, tetrahydrocannabinol, exhibit antitumor effect on a wide range of animal models of cancer. However, several studies have shown that under certain conditions, treatment with cannabinoids can stimulate the proliferation of cancer cells in vitro and disrupt the immune system's involvement in suppressing tumors. There are also conflicting reports about the antitumor role of the endocannabinoid system itself in cancer. The purpose of this review is to consider the main options for the action of key ligands and receptors of the endocannabinoid system in the context of breast cancer.","PeriodicalId":21186,"journal":{"name":"Reviews on Clinical Pharmacology and Drug Therapy","volume":"221 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NATURAL DEEP EUTECTIC SOLVENTS ARE PROMISING AGENTS FOR THE EXTRACTION OF SUBSTANCES FROM PLANT MATERIALS","authors":"E. Andrusenko, R. I. Glushakov, Gregory Aleksandrovich Redkin","doi":"10.17816/rcf611034","DOIUrl":"https://doi.org/10.17816/rcf611034","url":null,"abstract":"There is currently an increasing trend to reduce the amount of synthetic products or additives and replace them with natural ones. Historical experience and developments in human health science demonstrate the adverse effects of xenobiotics on natural metabolism and human health. The trend towards natural products is essential for vitality, social activity, a decent quality of life, and the prevention of adverse events and diseases. The pharmaceutical, cosmetic and food industries place special emphasis on natural and biologically active chemicals isolated from plants or microorganisms. The main task in this direction is the development of effective and environmental methods for their isolation. Deep eutectic solvents (DES) are a mixture of two or more components and are among the solvents with unique properties such as low volatility, low melting points, ease of preparation, inexpensive starting materials and, most importantly, they are practically non-toxic to humans. Deep eutectic solvents are used as an environmentally friendly method for the extraction of biologically active substances (BAS) from medicinal plants, as well as a safe alternative for food, pharmaceutical and various industries. Traditional organic solvent extraction methods have several disadvantages, such as long extraction times, safety of use, environmental damage, high cost, and the need to use large volumes of solvents. This review provides a summary of the research progress regarding the benefits of using deep eutectic solvents for the extraction of bioactive compounds such as phenolic acid, flavonoids, isoflavones, catechins, polysaccharides, curcuminoids, proanthocyanidin, phycocyanin, gingerols, ginsenosides, anthocyanins, rutin, chlorogenic acids and other. The study of the biological activity of extracts is considered: antioxidant, antibacterial and antitumor activity.","PeriodicalId":21186,"journal":{"name":"Reviews on Clinical Pharmacology and Drug Therapy","volume":"34 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140457141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MECHANISMS OF STRUCTURAL MYOCARDIAL REMODELING UNDER THE INFLUENCE OF VIBRATION","authors":"O. Levchenkova, V. V. Vorobieva","doi":"10.17816/rcf624185","DOIUrl":"https://doi.org/10.17816/rcf624185","url":null,"abstract":"The review presents literature data analysis devoted to the study of structural changes in the heart in patients with vibration disease, identified by echocardiographic methods in the form of concentric remodeling of the left ventricle chambers and disturbance of its diastolic function, a decrease in the intensity of the heart structure work compared to healthy ones in 1.2 times (p0.05). The changes in morphometric and bioenergetic parameters of cardiomyocytes against the background of various experimental vibration modes (7 and 56 sessions with a frequency of 8 Hz) confirms the violation of the ideal relationship between the spatial configuration of the heart cavities, the ability to contract and the energy supply potential. The loss of cardiac myofibrils symbolizes the convertion of myocardial hypertrophy to the decompensation stage and the increase in degenerative (dystrophic) signs, in particular the loss of sarcomeres of cardiomyocytes. \u0000To realize the processes of pathological structural (morphological) and energy restructuring of tissue under the influence of vibration-mediated hemodynamic and ischemic factors, it is necessary to involve in the process numerous mediators that regulate metabolism, proliferation, growth and survival of cells, such as STIM (stromal interaction molecule), SERCA (calcium ATPase of the endo(sarco)plasmic reticulum), IP3R (inositol-1,4,5-triphosphate receptor), Orai (protein that forms CRAC channels), TRPC (transient receptor potential canonical), etc. As one of the most important link of structural cardiac remodeling is performed by the degradation system of the extracellular matrix, including matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), which regulate the rate of mRNA synthesis on the DNA matrix by binding to specific DNA regions that control cardiac nutrition and plasticity. A lot of analyzed facts make it possible to explain some patterns of the development of cardiac remodeling in patients with vibration disease and to determine the direction of pathogenetically based approaches to therapy, taking into account not only the vibration-protective effect of drugs, but also their ability to inhibit and regress myocardial remodeling.","PeriodicalId":21186,"journal":{"name":"Reviews on Clinical Pharmacology and Drug Therapy","volume":"23 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140457705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of the original anticonvulsant Galodif® — a GABAA receptor modulator for alcohol withdrawal syndrome","authors":"T. V. Shushpanova, Anna I. Mandel, N. A. Bokhan, E. D. Schastnyy","doi":"10.17816/rcf607434","DOIUrl":"https://doi.org/10.17816/rcf607434","url":null,"abstract":"BACKGROUND: The development of new drugs to improve the effectiveness of treatment and rehabilitation programs for patients suffering from addiction diseases, which are non-addictive and have a stimulating effect on detoxification processes in the body, can increase the effectiveness of therapy and reduce the cost of treatment. A deficiency of GABAergic inhibition in brain structures plays a leading role in the occurrence of paroxysmalness. The innovative anticonvulsant Galodif® (1-[(3-chlorophenyl)(phenyl)methyl]urea), a GABAA receptor modulator, has low toxicity and hepatoprotective properties, which allows it to be recommended for use in the treatment of patients with alcohol dependence. \u0000AIM: The aim of this study is to evaluation of the effectiveness of the use of the anticonvulsant drug galodif1 in complex therapy in patients with alcohol dependence with compulsive and paroxysmal disorders with pathological craving for alcohol when withdrawing of alcohol. \u0000MATERIALS AND METHODS: A limited open-type clinical study of the therapeutic effectiveness of the innovative anticonvulsant galodif1 included 128 male patients (average age 38.3 ± 8.9 years) with a diagnosis of “Mental and behavioral disorders as a result of alcohol consumption, dependence syndrome” (F10.232) and “Mental and behavioral disorders as a result of alcohol consumption, withdrawal states” (F10.302). 68 patients received Galodif® 300 mg per day as an anticonvulsant for 21 days. 60 patients made up the comparison group, receiving carbamazepine at a dose of 400 mg per day. \u0000RESULTS: The use of the anticonvulsant Galodif® in complex therapy of patients revealed: normothymoleptic activity of the drug; when assessing depression on the Hamilton Depression Rating Scale (HDRS), the average total score decreased from 28.3 ± 1.3 to 5.7 ± 1.9, and a reduction in unmotivated fear and anxiety was noted; vegetative stabilizing effect with a sympathicolytic component with normalization of heart rate; reduction of headaches; weakening or disappearance of pathological desire during withdrawal syndrome in 88% of cases, in the post-withdrawal state — in 57% of cases; taking the drug did not cause any unwanted side effects. \u0000CONCLUSIONS: The use of the anticonvulsant Galodif®, which modulates GABAA receptors, has low toxicity and detoxification properties and does not cause side effects, has been proposed as one of the modern pharmacotherapeutic approaches in the treatment of patients with alcohol dependence.","PeriodicalId":21186,"journal":{"name":"Reviews on Clinical Pharmacology and Drug Therapy","volume":"48 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139683631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriophages: Clinical significance and application prospects","authors":"Andrey I. Danilov, A. V. Evseev","doi":"10.17816/rcf624214","DOIUrl":"https://doi.org/10.17816/rcf624214","url":null,"abstract":"A review of the literature data covering topical issues of the use of bacteriophages in clinical practice is presented. Traditionally, phage therapy is based on the use of natural phages for the lysis of bacteria at the infection site. Despite some limitations, it has significant advantages over antibiotic therapy. The use of biotechnological methods currently makes it possible to eliminate the disadvantages of phage therapy by creating recombinant drugs and, in the future, expand its capabilities through the use of lytic phage proteins and their modified derivatives. Currently, bacteriophages are used not only for the treatment of infections but also for prevention and diagnosis (phagotyping to identify the source of infection). Bacteriophages are also used in genetic engineering as vectors for transferring DNA sections. Few side effects have been described about bacteriophages. Particularly, they do not negatively affect the intestinal microbiota, and compared with antibiotics, they are much less likely to be associated with allergic reactions. Moreover, existing randomized clinical trials, which are the gold standard of clinical trials, in phage therapy are extremely insufficient, which dictates the need to concentrate the efforts of all stakeholders in this direction.","PeriodicalId":21186,"journal":{"name":"Reviews on Clinical Pharmacology and Drug Therapy","volume":"6 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139683407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}