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210Pb dating and neutron activation analysis of the Sundarban mangrove sediments: sedimentation rate and metal contamination history 巽他班红树林沉积物的 210Pb 定年和中子活化分析：沉积速率和金属污染史
IF 1.8 3区 化学
Radiochimica Acta Pub Date : 2024-02-14 DOI: 10.1515/ract-2023-0245
Mohammad Amirul Islam, Shaiful Kabir, Ali Arman, Untung Sugiharto, M. Moinul Islam, Mohammad Belal Hossen
{"title":"210Pb dating and neutron activation analysis of the Sundarban mangrove sediments: sedimentation rate and metal contamination history","authors":"Mohammad Amirul Islam, Shaiful Kabir, Ali Arman, Untung Sugiharto, M. Moinul Islam, Mohammad Belal Hossen","doi":"10.1515/ract-2023-0245","DOIUrl":"https://doi.org/10.1515/ract-2023-0245","url":null,"abstract":"In this study, alpha spectrometry and neutron activation analysis were applied to assess the mass accumulation rate, contamination history, and ecological risk of the Sundarban mangrove sediments. The mass accumulation rates of sediments using <jats:sup>210</jats:sup>Pb dating determined for the first time in this area ranged from 0.068 to 3.20 kg m<jats:sup>−2</jats:sup> y<jats:sup>−1</jats:sup>, with an average of 0.61 kg m<jats:sup>−2</jats:sup> y<jats:sup>−1</jats:sup>. The contamination history of 11 metal(loid)s (Al, Ca, V, Cr, Fe, Ni, Cu, Zn, As, Hg, and Pb) was assessed. Different environmental contamination indices suggested that Sundarban mangrove sediments were contaminated by As. Considering different sediment quality guidelines, it was observed that Cr, Ni, and As posed occasional adverse biological effects on marine organisms. Multivariate statistical approaches were applied to elucidate the origin and transport behavior of the studied metal(loid)s in the mangrove ecosystem which suggested that sources of metal(loid) pollution were both anthropogenic and geogenic. The results from this study should improve the knowledge of metal contamination and ecological risk to biota to develop new strategies and enlarge management practices to save sensitive mangrove ecosystems.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron 在 30 MeV 回旋加速器中从辐照镓镍合金靶中生产 68Ge 并进行放射化学分离
IF 1.8 3区 化学
Radiochimica Acta Pub Date : 2024-02-14 DOI: 10.1515/ract-2023-0195
S. Chattopadhyay, Samarjit Singha, Shayantani Ash, Luna Barua, Devaraj G. Mahesh, Sujata SahaDas, Madhusmita, Md. Nayer Alam, Umesh Kumar, Suprakash Roy, Prosenjit Dhang, S. Dey
{"title":"Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron","authors":"S. Chattopadhyay, Samarjit Singha, Shayantani Ash, Luna Barua, Devaraj G. Mahesh, Sujata SahaDas, Madhusmita, Md. Nayer Alam, Umesh Kumar, Suprakash Roy, Prosenjit Dhang, S. Dey","doi":"10.1515/ract-2023-0195","DOIUrl":"https://doi.org/10.1515/ract-2023-0195","url":null,"abstract":"\u0000 Gallium-68 [t\u0000 1/2: 67.7 min, β+ (89 %)] has application in PET imaging mainly for prostate cancer and neuroendocrine tumours. Gallium-68 is generally obtained from a 68Ge/68Ga generator. It is therefore an important task to prepare 68Ge (t\u0000 1/2 = 271 days) radiochemical for the manufacture of 68Ge/68Ga generator to cater for the needs of various nuclear medicine centres. Germanium-68 has been produced successfully after irradiation of indigenously developed Ga–Ni targets in a 30 MeV cyclotron and chemical processing of the irradiated targets using an indigenous semi-automated module. The Ga–Ni targets were prepared by an electroplating method. The 68Ge has been radiochemically separated from irradiated Ga–Ni targets using Sephadex G-25 column chromatography. The chemical separation yield and radionuclidic purity of 68Ge were about 70 % (n = 3) and about 98.3 % (n = 3), respectively.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139777329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catalytic destruction of oxalate in the supernatant stream generated during plutonium reconversion process 对钚再转化过程中产生的上清液中的草酸盐进行催化销毁
IF 1.8 3区 化学
Radiochimica Acta Pub Date : 2024-02-14 DOI: 10.1515/ract-2023-0211
Arvind Prasad, Kadukkappilly S. Vijayan, Ravinuthala V. S. Rao, Desigan Narasimhan, Ananthasivan Krishnamoorty
{"title":"Catalytic destruction of oxalate in the supernatant stream generated during plutonium reconversion process","authors":"Arvind Prasad, Kadukkappilly S. Vijayan, Ravinuthala V. S. Rao, Desigan Narasimhan, Ananthasivan Krishnamoorty","doi":"10.1515/ract-2023-0211","DOIUrl":"https://doi.org/10.1515/ract-2023-0211","url":null,"abstract":"Plutonium oxalate supernatant requires a treatment step for further recovery of the residual Pu. As the oxalate ion present in the solution poses problems during the recovery of Pu, it needs to be destroyed. In the present work, Mn<jats:sup>2+</jats:sup> based catalytic destruction of oxalate ion was studied in detail, as it could minimize the generation of secondary radioactive waste compared to the conventional process. The effect of various parameters, namely concentrations of HNO<jats:sub>3</jats:sub>, catalyst, oxalic acid and effect of the metal ion has been studied. Moreover, the robustness of the catalytic destruction method along with the kinetics of oxalate destruction reaction has been investigated. The process was also demonstrated with Pu supernatant generated from CORAL at 1 L scale.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reverse phase liquid chromatographic method for the measurement of uranium in process stream solutions from uranium extraction facility 测量铀提取设施工艺流溶液中铀含量的反相液相色谱法
IF 1.8 3区 化学
Radiochimica Acta Pub Date : 2024-02-13 DOI: 10.1515/ract-2023-0187
Yarasi Balaji Rao, Shehanaz Bano, Putta V. Nagendra Kumar, Dinesh Srivastava
{"title":"Reverse phase liquid chromatographic method for the measurement of uranium in process stream solutions from uranium extraction facility","authors":"Yarasi Balaji Rao, Shehanaz Bano, Putta V. Nagendra Kumar, Dinesh Srivastava","doi":"10.1515/ract-2023-0187","DOIUrl":"https://doi.org/10.1515/ract-2023-0187","url":null,"abstract":"The present paper describes a simple method for the determination of uranium in uranium process stream solutions by reversed-phase liquid chromatographic method using C18 column, mixture of α-hydroxy isobutyric acid and methanol as eluent and flow-through spectrophotometer detector. This method has an advantage that interfering elements like rare-earth elements do not retain on the column and elute near the solvent peak thereby not interfering with uranium elution peak. Different eluents and parameters like pH, concentration of eluent are studied for the purpose. The spiking standard recovery was found to be more than 90 %. The developed method has been compared with other techniques and found to be in agreement.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zirconium sponge production: an integrated approach for chemical characterization of process intermediates using ICP-OES 海绵锆生产：利用 ICP-OES 对工艺中间产物进行化学特征描述的综合方法
IF 1.8 3区 化学
Radiochimica Acta Pub Date : 2024-02-13 DOI: 10.1515/ract-2023-0231
Yarasi Balaji Rao, Sirivella N. V. M. S. Gupta, Putta V. Nagendra Kumar, Dinesh Srivastava
{"title":"Zirconium sponge production: an integrated approach for chemical characterization of process intermediates using ICP-OES","authors":"Yarasi Balaji Rao, Sirivella N. V. M. S. Gupta, Putta V. Nagendra Kumar, Dinesh Srivastava","doi":"10.1515/ract-2023-0231","DOIUrl":"https://doi.org/10.1515/ract-2023-0231","url":null,"abstract":"The present paper discusses about the method developed for complete chemical characterization of Zirconium Washed and Dried Frit (WDF) and Reactor Grade ZrO<jats:sub>2</jats:sub> powder which includes nonmetallic element sulphur using Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES). Studies have been carried-out on several important aspects of method development such as effect of matrix on determination of analytes, removal of matrix using different solvents, selection of interference free &amp; sensitive wavelengths, calibration strategies like internal standard &amp; standard addition, optimization of several instrumental parameters which includes RF power, plasma gas flow, nebulizer gas flow, nitrogen purging etc., and are discussed. A % RSD of less than 1 % for Zr and up to 3 % for other elements has been achieved in this method. The developed method has been validated using standard recovery of spiked real time samples with known amount of reference materials. Integrated approach adopted in the development of this method has resulted in reduction of analytical waste generated and also enabled to give quick analytical feedback to production plant for downstream processing.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiochemical and chemical characterization of fuel, salt, and deposit from the electrorefining of irradiated U-6 wt% Zr in hot cells 热电池中辐照铀-6 wt% Zr 电提炼产生的燃料、盐和沉积物的放射化学和化学特性分析
IF 1.8 3区 化学
Radiochimica Acta Pub Date : 2024-02-13 DOI: 10.1515/ract-2023-0203
Dwarapudi Bola Sankar, Rajeswari Seshadri, Kalaiyarasu Thirunavukkarasu, Gurudas Pakhui, Jakkula Siva Brahmaji Rao, Suranjan Bera, Balija Sreenivasulu, Kumaresan Radhakrishnan, Periasamy Manoravi, Venkataraman Jayaraman
{"title":"Radiochemical and chemical characterization of fuel, salt, and deposit from the electrorefining of irradiated U-6 wt% Zr in hot cells","authors":"Dwarapudi Bola Sankar, Rajeswari Seshadri, Kalaiyarasu Thirunavukkarasu, Gurudas Pakhui, Jakkula Siva Brahmaji Rao, Suranjan Bera, Balija Sreenivasulu, Kumaresan Radhakrishnan, Periasamy Manoravi, Venkataraman Jayaraman","doi":"10.1515/ract-2023-0203","DOIUrl":"https://doi.org/10.1515/ract-2023-0203","url":null,"abstract":"Metal fuels are considered as the promising candidates for future fast breeder reactors. Pyro-chemical reprocessing is the ideal method for reprocessing spent metallic fuels due to the inherent process advantages. Electrorefining run was demonstrated in a hot cell facility with irradiated U-6 wt% Zr alloy at 500 °C using LiCl–KCl eutectic melt. In order to understand the behavior of the actinides and various fission products during high-temperature electrolysis, various process streams, viz., irradiated metal alloy fuel, the eutectic salt, and the cathode deposit were analyzed for the uranium, plutonium, and other fission product contents. Various methods employed for characterizing the process streams and the behaviors of some of the fission products during the electrolysis process are highlighted. The major gamma emitting radionuclides present in the irradiated fuel were <jats:sup>106</jats:sup>Ru, <jats:sup>125</jats:sup>Sb, <jats:sup>134</jats:sup>Cs, <jats:sup>137</jats:sup>Cs, <jats:sup>144</jats:sup>Ce, and <jats:sup>154</jats:sup>Eu. During electrorefining, cesium, cerium and europium were oxidized and dissolved in the molten media, whereas ruthenium and antimony remained in the anode basket. A minor contamination of zirconium was found in the cathode deposit.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139772984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total chemical synthesis of PSMA-617: an API for prostate cancer endotherapeutic applications PSMA-617 的全化学合成：用于前列腺癌内治疗的原料药
IF 1.8 3区 化学
Radiochimica Acta Pub Date : 2024-02-13 DOI: 10.1515/ract-2023-0205
Kalangattu Sundaran Ajish Kumar, Anupam Mathur
{"title":"Total chemical synthesis of PSMA-617: an API for prostate cancer endotherapeutic applications","authors":"Kalangattu Sundaran Ajish Kumar, Anupam Mathur","doi":"10.1515/ract-2023-0205","DOIUrl":"https://doi.org/10.1515/ract-2023-0205","url":null,"abstract":"Synthesis of PSMA-617, a peptide based ligand used in the preparation of nuclear medicine, <jats:sup>177</jats:sup>Lu-PSMA-617, for the treatment of prostate cancer, is demonstrated in 6 steps, starting from appropriately protected amino acid building blocks. A solution phase Boc-strategy was adopted for the synthesis of peptide, wherein deprotection of carbamate group using HCl (g), was employed as the key step. The synthesis furnished PSMA-617 in purity &gt;99.5 % as confirmed by HPLC analysis. ESI-MS and NMR analysis supported the structural integrity of the compound. The synthesized ligand was radiolabelled using <jats:sup>177</jats:sup>Lu to generate the desired radiopharmaceutical, <jats:sup>177</jats:sup>Lu-PSMA-617, in radiochemical purity &gt;98 %, as revealed by radio HPLC and TLC analysis. This establishes its potential as a nuclear medicine for therapeutic application.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theoretical analysis of light and heavy-ion induced reactions: production of medically relevant 97Ru 轻重离子诱导反应的理论分析：生产医学相关的 97Ru
IF 1.8 3区 化学
Radiochimica Acta Pub Date : 2024-02-13 DOI: 10.1515/ract-2023-0199
Malvika Sagwal, Moumita Maiti
{"title":"Theoretical analysis of light and heavy-ion induced reactions: production of medically relevant 97Ru","authors":"Malvika Sagwal, Moumita Maiti","doi":"10.1515/ract-2023-0199","DOIUrl":"https://doi.org/10.1515/ract-2023-0199","url":null,"abstract":"<jats:sup>97</jats:sup>Ru is a key radionuclide sought for diagnostic imaging due to its low-energy and intense γ-rays of 215.7 keV and 324.5 keV. New reaction routes to produce this radionuclide are constantly being investigated. A crucial step in carrying out such reactions is a reliable beforehand estimate of the production cross section of radionuclide and optimization conditions through robust theoretical frameworks. Existing literature on <jats:italic>α</jats:italic> + <jats:sup>95</jats:sup>Mo reaction has been freshly examined to understand the excitation function of <jats:sup>97</jats:sup>Ru. The data have been compared to other reactions of different projectiles on medium-mass targets. The reaction codes <jats:sc>pace</jats:sc>4, <jats:sc>empire</jats:sc>-3.2.2, and <jats:sc>talys</jats:sc>-1.96 have been employed to decipher the reaction mechanism and check the predictive ability of underlying theoretical models. The yield of <jats:sup>97</jats:sup>Ru at different projectile energies and thick target yield in the optimum energy range has also been determined from the theoretical modeling.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Excitation functions of alpha-particle induced nuclear reactions on nat Sn α粒子在锡上诱导核反应的激发函数
IF 1.8 3区 化学
Radiochimica Acta Pub Date : 2024-02-13 DOI: 10.1515/ract-2023-0202
Mahesh Choudhary, Namrata Singh, Aman Sharma, Aman Gandhi, Mahima Upadhyay, Rebecca Pachuau, Sandipan Dasgupta, Jagannath Datta, Ajay Kumar
{"title":"Excitation functions of alpha-particle induced nuclear reactions on nat Sn","authors":"Mahesh Choudhary, Namrata Singh, Aman Sharma, Aman Gandhi, Mahima Upadhyay, Rebecca Pachuau, Sandipan Dasgupta, Jagannath Datta, Ajay Kumar","doi":"10.1515/ract-2023-0202","DOIUrl":"https://doi.org/10.1515/ract-2023-0202","url":null,"abstract":"Excitation functions of alpha-particle induced nuclear reactions on <jats:sup> <jats:italic>nat</jats:italic> </jats:sup>Sn have been presented in the 11–40 MeV energy range. In the present study, the stacked-foil activation technique followed by offline gamma-ray spectrometry was used to measure the production of <jats:sup>119</jats:sup>Te, <jats:sup>121</jats:sup>Te, <jats:sup>122</jats:sup>Sb and <jats:sup>126</jats:sup>Sb from alpha-particle induced reactions on <jats:sup> <jats:italic>nat</jats:italic> </jats:sup>Sn. The TALYS nuclear code was used to calculate the theoretical predictions of the excitation functions of <jats:sup> <jats:italic>nat</jats:italic> </jats:sup>Sn(<jats:italic>α</jats:italic>,x) nuclear reactions. The measured data of the above-mentioned nuclear reactions were compared with the theoretical predictions and the experimental results available from EXFOR. In this study, covariance analysis was performed to calculate the uncertainty propagation in the measured cross sections.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation of [64Cu]Cu–NOTA complex as a potential renal PET imaging agent using 64Cu produced via the direct activation route 使用通过直接活化途径生产的 64Cu 制备[64Cu]Cu-NOTA 复合物，作为一种潜在的肾脏 PET 成像剂
IF 1.8 3区 化学
Radiochimica Acta Pub Date : 2024-02-13 DOI: 10.1515/ract-2023-0206
Sourav Patra, Sachin Jadhav, Priyalata Shetty, Khajan Singh, Ardhi Rajeswari, K. V. Vimalnath, Avik Chakraborty, Rubel Chakravarty, Sudipta Chakraborty
{"title":"Preparation of [64Cu]Cu–NOTA complex as a potential renal PET imaging agent using 64Cu produced via the direct activation route","authors":"Sourav Patra, Sachin Jadhav, Priyalata Shetty, Khajan Singh, Ardhi Rajeswari, K. V. Vimalnath, Avik Chakraborty, Rubel Chakravarty, Sudipta Chakraborty","doi":"10.1515/ract-2023-0206","DOIUrl":"https://doi.org/10.1515/ract-2023-0206","url":null,"abstract":"Glomerular filtration rate (GFR) could be determined more accurately using renal positron emission tomography (PET) than conventional gamma imaging. Copper-64 [<jats:italic>T</jats:italic> <jats:sub>½</jats:sub> = 12.7 h, <jats:italic>E</jats:italic> <jats:sub>β+</jats:sub> (max) = 653 keV, β<jats:sup>+</jats:sup> branching ratio = 17.8 %, 1346 keV γ-photon (0.54 %), EC (43.8 %), β<jats:sup>−</jats:sup> emission (38.4 %)] in the form of its hydrophilic complex with 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) is proposed as a potent formulation for renal PET imaging. A lyophilized kit was developed for formulation of ∼370 MBq dose of [<jats:sup>64</jats:sup>Cu]Cu–NOTA complex in a facile single step process using <jats:sup>64</jats:sup>Cu produced by thermal neutron activation in a research reactor. The complex could be synthesized with &gt;99 % yield and retained its integrity even when challenged by apoferritin. The rapid accumulation of [<jats:sup>64</jats:sup>Cu]Cu–NOTA in the kidney and clearance through urinary path was demonstrated using PET/CT imaging and <jats:italic>ex vivo</jats:italic> biodistribution study carried out in healthy Wistar rats to elucidate its effectiveness as a renal PET-imaging agent.","PeriodicalId":21167,"journal":{"name":"Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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