{"title":"Posttranslational modifications in diabetes: Mechanisms and functions.","authors":"Ang Hu, Haohong Zou, Bin Chen, Jianing Zhong","doi":"10.1007/s11154-022-09740-x","DOIUrl":"10.1007/s11154-022-09740-x","url":null,"abstract":"<p><p>As one of the most widespread chronic diseases, diabetes and its accompanying complications affect approximately one tenth of individuals worldwide and represent a growing cause of morbidity and mortality. Accumulating evidence has proven that the process of diabetes is complex and interactive, involving various cellular responses and signaling cascades by posttranslational modifications (PTMs). Therefore, understanding the mechanisms and functions of PTMs in regulatory networks has fundamental importance for understanding the prediction, onset, diagnosis, progression, and treatment of diabetes. In this review, we offer a holistic summary and illustration of the crosstalk between PTMs and diabetes, including both types 1 and 2. Meanwhile, we discuss the potential use of PTMs in diabetes treatment and provide a prospective direction for deeply understanding the metabolic diseases.</p>","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"94 21 1","pages":"1011-1033"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81278540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Efstratios Kardalas, E. Sakkas, M. Ruchała, D. Macut, G. Mastorakos
{"title":"Correction to: The role of transforming growth factor beta in thyroid autoimmunity: current knowledge and future perspectives","authors":"Efstratios Kardalas, E. Sakkas, M. Ruchała, D. Macut, G. Mastorakos","doi":"10.1007/s11154-022-09722-z","DOIUrl":"https://doi.org/10.1007/s11154-022-09722-z","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"33 1","pages":"1101 - 1101"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86913161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rosaria M Ruggeri, Barbara Altieri, Erika Grossrubatcher, Roberto Minotta, Maria Grazia Tarsitano, Virginia Zamponi, Andrea MIsidori, Antongiulio Faggiano, Anna Maria Colao
{"title":"Sex differences in carcinoid syndrome: A gap to be closed.","authors":"Rosaria M Ruggeri, Barbara Altieri, Erika Grossrubatcher, Roberto Minotta, Maria Grazia Tarsitano, Virginia Zamponi, Andrea MIsidori, Antongiulio Faggiano, Anna Maria Colao","doi":"10.1007/s11154-022-09719-8","DOIUrl":"10.1007/s11154-022-09719-8","url":null,"abstract":"<p><p>The incidence of neuroendocrine neoplasms and related carcinoid syndrome (CS) has markedly increased over the last decades and women seem to be more at risk than men for developing CS. Nevertheless, very few studies have investigated sex differences in clinical presentation and outcomes of CS. However, as per other tumours, sex might be relevant in influencing tumour localization, delay in diagnosis, clinical outcomes, prognosis and overall survival in CS. The present review was aimed at evaluating sex differences in CS, as they emerge from an extensive search of the recent literature. It emerged that CS occurs more frequently in female than in male patients with NENs and women seem to have a better prognosis and a slight advantage in overall survival and response to therapy. Moreover, the disease likely impacts differently the quality of life of men and women, with different psychological and social consequences. Nevertheless, sex differences, even if partially known, are deeply underestimated in clinical practice and data from clinical trials are lacking. There is urgent need to increase our understanding of the sex-related differences of CS, in order to define tailored strategies of management of the disease, improving both the quality of life and the prognosis of affected patients.</p>","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"128 1","pages":"659-669"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88186258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Definition and diagnosis of aggressive pituitary tumors.","authors":"Leandro Kasuki, Gérald Raverot","doi":"10.1007/s11154-019-09531-x","DOIUrl":"10.1007/s11154-019-09531-x","url":null,"abstract":"<p><p>Pituitary adenomas are considered benign tumors, but approximately 10% of them can have an aggressive behavior and more rarely (0.2%) can present metastasis, being classified as pituitary carcinomas. Aggressive adenomas are generally large and invasive tumors that present unusually rapid growth and/or that grow irrespective of conventional treatment with surgery, medical therapy and radiotherapy. Nevertheless, large tumors, as well as invasive tumors are not always aggressive, with this definition being possible only after clinical follow-up of these tumors, with growth rate and response to therapies being key points to its diagnosis. The correct identification and diagnosis of aggressive adenomas is of great importance as they are associated with great morbidity and increased mortality.</p>","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"108 1","pages":"203-208"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87623852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ebtesam Abdullah Al-Suhaimi, Meneerah Abdulrahman Al-Jafary
{"title":"Endocrine roles of vitamin K-dependent- osteocalcin in the relation between bone metabolism and metabolic disorders.","authors":"Ebtesam Abdullah Al-Suhaimi, Meneerah Abdulrahman Al-Jafary","doi":"10.1007/s11154-019-09517-9","DOIUrl":"10.1007/s11154-019-09517-9","url":null,"abstract":"<p><p>Obesity and diabetes are important metabolic diseases and a major public health problem among the world, they have serious health and economic complications. Overweight and obesity are increased risk for deficiency of vitamin particularly shortage of fat soluble-vitamins. Studies reported that vitamin K supplementation reduces oxidative stress and metabolic risk biomarkers for diabetes, as well as reduces progression of insulin resistance. Vitamin K-dependent-protein osteocalcin (bone derived hormone) plays crucial roles in energy metabolism. There is a clear association between circulating vitamin k and dependent-osteocalcin concentrations with obesity and risk of Type 2 diabetes. Osteocalcin through molecular mechanisms improves insulin resistance, lipid and glucose profile, and mediate vitamin K positive effects. Insulin also signals osteocalcin to regulate bone mineralization. Normal carboxylation of vitamin K-dependent proteins/ hormones is a key step in preventing apoptosis and calcification of vascular endothelial cells. A missing relationship between bone, glucose and fat metabolism could clarify and manage many metabolic mechanisms. This review focuses on the physiological relationship between vitamin K-dependent-osteocalcin, metabolic and cardiovascular diseases through some molecular proteins and hormones including adipokines. A better understanding of the mechanism of action of osteocalcin modulated by vitamin K could help in implementing therapeutic drugs to cure metabolic diseases.</p>","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"65 1","pages":"117-125"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81618607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Pellegrini, I. Cioffi, A. Evangelista, V. Ponzo, I. Goitre, G. Ciccone, E. Ghigo, S. Bo
{"title":"Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis","authors":"M. Pellegrini, I. Cioffi, A. Evangelista, V. Ponzo, I. Goitre, G. Ciccone, E. Ghigo, S. Bo","doi":"10.1007/s11154-019-09524-w","DOIUrl":"https://doi.org/10.1007/s11154-019-09524-w","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"9 1","pages":"17-33"},"PeriodicalIF":0.0,"publicationDate":"2019-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79301832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention","authors":"B. Yılmaz, H. Terekeci, S. Sandal, F. Keleştimur","doi":"10.1007/s11154-019-09521-z","DOIUrl":"https://doi.org/10.1007/s11154-019-09521-z","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"458 1","pages":"127-147"},"PeriodicalIF":0.0,"publicationDate":"2019-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83029722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The gut microbiota modulates both browning of white adipose tissue and the activity of brown adipose tissue","authors":"J. Moreno-Navarrete, J. Fernández-Real","doi":"10.1007/s11154-019-09523-x","DOIUrl":"https://doi.org/10.1007/s11154-019-09523-x","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"17 1","pages":"387 - 397"},"PeriodicalIF":0.0,"publicationDate":"2019-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85061152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ghrelin and liver disease","authors":"Mar Quiñones, Johan Fernø, O. Al-Massadi","doi":"10.1007/s11154-019-09528-6","DOIUrl":"https://doi.org/10.1007/s11154-019-09528-6","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"49 1","pages":"45-56"},"PeriodicalIF":0.0,"publicationDate":"2019-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90838923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Minty, Thibault Canceil, M. Serino, R. Burcelin, F. Tercé, V. Blasco-Baque
{"title":"Oral microbiota-induced periodontitis: a new risk factor of metabolic diseases","authors":"M. Minty, Thibault Canceil, M. Serino, R. Burcelin, F. Tercé, V. Blasco-Baque","doi":"10.1007/s11154-019-09526-8","DOIUrl":"https://doi.org/10.1007/s11154-019-09526-8","url":null,"abstract":"","PeriodicalId":21105,"journal":{"name":"Reviews in Endocrine and Metabolic Disorders","volume":"239 1","pages":"449 - 459"},"PeriodicalIF":0.0,"publicationDate":"2019-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73712714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}