ResuscitationPub Date : 2025-08-25DOI: 10.1016/j.resuscitation.2025.110790
Tomas Drabek , Garrett A. Cavaliere
{"title":"How to plan for prehospital ECPR, and move mountains","authors":"Tomas Drabek , Garrett A. Cavaliere","doi":"10.1016/j.resuscitation.2025.110790","DOIUrl":"10.1016/j.resuscitation.2025.110790","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"215 ","pages":"Article 110790"},"PeriodicalIF":4.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ResuscitationPub Date : 2025-08-25DOI: 10.1016/j.resuscitation.2025.110789
Dennis W. Simon , Patrick M. Kochanek
{"title":"Mesenchymal stem cell therapy for cardiac arrest: promise, challenges, and the path forward","authors":"Dennis W. Simon , Patrick M. Kochanek","doi":"10.1016/j.resuscitation.2025.110789","DOIUrl":"10.1016/j.resuscitation.2025.110789","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"215 ","pages":"Article 110789"},"PeriodicalIF":4.6,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ResuscitationPub Date : 2025-08-23DOI: 10.1016/j.resuscitation.2025.110788
Remy Stieglis , Vera G.M. van Eeden , Rudolph W. Koster
{"title":"Reply to: Distance between OHCA and AED location within a community first responder system to achieve early AED connection","authors":"Remy Stieglis , Vera G.M. van Eeden , Rudolph W. Koster","doi":"10.1016/j.resuscitation.2025.110788","DOIUrl":"10.1016/j.resuscitation.2025.110788","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"215 ","pages":"Article 110788"},"PeriodicalIF":4.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ResuscitationPub Date : 2025-08-22DOI: 10.1016/j.resuscitation.2025.110787
Bing Gong , Guobing Chen
{"title":"Rethinking distance metrics for early AED connection in community responder systems","authors":"Bing Gong , Guobing Chen","doi":"10.1016/j.resuscitation.2025.110787","DOIUrl":"10.1016/j.resuscitation.2025.110787","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"215 ","pages":"Article 110787"},"PeriodicalIF":4.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ResuscitationPub Date : 2025-08-21DOI: 10.1016/j.resuscitation.2025.110782
Peter C. Lind, Benjamin H. Risager, Henrik Gammelager, John Bro-Jeppesen, Mads Svart, Lene W.T. Boel, Jørgen B. Hasselstrøm, Charlotte Uggerhøj Andersen, Rozh Al-Mashhadi, Tomas Frahm Nielsen, Lars W. Andersen, Asger Granfeldt
{"title":"Why do patients develop in-hospital cardiac arrest? A prospective clinical observational study (WHY-IHCA)","authors":"Peter C. Lind, Benjamin H. Risager, Henrik Gammelager, John Bro-Jeppesen, Mads Svart, Lene W.T. Boel, Jørgen B. Hasselstrøm, Charlotte Uggerhøj Andersen, Rozh Al-Mashhadi, Tomas Frahm Nielsen, Lars W. Andersen, Asger Granfeldt","doi":"10.1016/j.resuscitation.2025.110782","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110782","url":null,"abstract":"No previous study has described in-hospital cardiac arrest (IHCA) aetiologies prospectively","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"23 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144901860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ResuscitationPub Date : 2025-08-20DOI: 10.1016/j.resuscitation.2025.110785
Shaun Theodor Florentz Sødergren , Jonas Buchvald Pedersen
{"title":"Playing for time – UEFA EURO 2024 – How mega sport events can change the game in cardiac arrest","authors":"Shaun Theodor Florentz Sødergren , Jonas Buchvald Pedersen","doi":"10.1016/j.resuscitation.2025.110785","DOIUrl":"10.1016/j.resuscitation.2025.110785","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"215 ","pages":"Article 110785"},"PeriodicalIF":4.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ResuscitationPub Date : 2025-08-20DOI: 10.1016/j.resuscitation.2025.110784
Morgane Laverdure , Derek So , Aun Yeong Chong , Alexander Dick , Michael Froeschl , Christopher Glover , Marino Labinaz , George Wells , Jordan Bernick , Michel Le May
{"title":"Inferior vena cava thrombosis associated with endovascular cooling catheters: impact on clinical outcomes","authors":"Morgane Laverdure , Derek So , Aun Yeong Chong , Alexander Dick , Michael Froeschl , Christopher Glover , Marino Labinaz , George Wells , Jordan Bernick , Michel Le May","doi":"10.1016/j.resuscitation.2025.110784","DOIUrl":"10.1016/j.resuscitation.2025.110784","url":null,"abstract":"<div><h3>Background</h3><div>Endovascular cooling catheters are used to induce and maintain therapeutic hypothermia. While generally considered safe, complications have been reported, notably catheter-related inferior vena cava (IVC) thrombosis. We sought to determine the frequency and clinical impact of this complication in patients managed with therapeutic hypothermia following out-of-hospital cardiac arrest (OHCA).</div></div><div><h3>Methods</h3><div>We performed a post hoc analysis of the Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest (CAPITAL-CHILL) trial, which randomized 367 comatose OHCA survivors to mild (34 °C) vs moderate (31 °C) hypothermia using endovascular cooling catheters. Patients were routinely screened for IVC thrombosis using abdominal ultrasonography. Patients with IVC thrombosis were compared with patients without. The primary outcome was death or poor neurological outcome at 180 days.</div></div><div><h3>Results</h3><div>We excluded 48 patients who died before ultrasonography. Amongst the remaining 319, 21 (6.6 %) developed IVC thrombosis. In patients who developed an IVC thrombosis versus those who did not, there was no difference in the primary outcome (47.6 % vs 38.3 %, P = 0.39). In-hospital bleeding was higher in the IVC thrombosis group, but not statistically significant (33.3 % vs 22.8 %, P = 0.24). Patients with IVC thrombosis were more likely to be discharged from hospital on an anticoagulant (76.9 % vs 22.5 %, P < 0.0001).</div></div><div><h3>Conclusion</h3><div>Despite intravenous anticoagulation, IVC thrombosis remains a relevant complication of endovascular cooling. Though not associated with death or poor neurological outcomes, it was associated with high in-hospital bleeding rates and anticoagulant use at discharge.</div></div>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"215 ","pages":"Article 110784"},"PeriodicalIF":4.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ResuscitationPub Date : 2025-08-20DOI: 10.1016/j.resuscitation.2025.110783
Carlos Rubio-Chacón , Alonso Mateos-Rodríguez , Fernando Neria , Juan Ignacio Torres-González , Mario Fernández-Ruiz , Amado Andrés
{"title":"Capnometry predicts the viability of procured kidneys from uncontrolled donation after circulatory death donors","authors":"Carlos Rubio-Chacón , Alonso Mateos-Rodríguez , Fernando Neria , Juan Ignacio Torres-González , Mario Fernández-Ruiz , Amado Andrés","doi":"10.1016/j.resuscitation.2025.110783","DOIUrl":"10.1016/j.resuscitation.2025.110783","url":null,"abstract":"<div><h3>Introduction</h3><div>Although uncontrolled donation after circulatory death (uDCD) donors provide kidney transplants with excellent long-term survival rates, a significant percentage of grafts are eventually found not to be viable for transplantation. Capnometry during cardiopulmonary resuscitation (CPR) is a marker of tissue metabolism and organ perfusion. We analyzed whether capnometry values in potential uDCD donors could help to differentiate between valid (who provided at least one transplantable kidney) and futile uDCD donors (those not yielding suitable grafts for transplantation).</div></div><div><h3>Material and methods</h3><div>This study was performed at two transplant centers between January 2018 and December 2023. Patients who had unsuccessful out-of-hospital CPR attempt after cardiopulmonary arrest (CPA) and met the criteria for uDCD were selected. Capnometry values were analyzed at the start of CPR, at the midpoint and at arrival at the hospital (transfer), along with other prehospital variables that could influence the selection of a viable donor.</div></div><div><h3>Results</h3><div>Overall, 69 potential uDCD donors were included, of which 26 (37.7 %) were valid and 43 (62.3 %) were futile. The capnometry values in valid donors compared to futile donors were 24.5 mmHg versus 16 mmHg at the initial reading <em>(P</em>-value <0.078) and 26 mmHg versus 15 mmHg at transfer, respectively <em>(P</em>-value <0.004). The optimal cut-off value for transfer capnometry levels to discriminate viable from futile donors was 17 mmHg. In the multivariable model, mechanical chest compression (odds ratio [OR]: 14.29; <em>P</em>-value = 0.009), transient return of pulse (OR: 19.0; <em>P</em>-value = 0.013), donor age (OR [per one-year increase]: 0.91; <em>P</em>-value = 0.026) and capnometry values at arrival at hospital (OR [per one-mmHg increase]: 1.08, <em>P</em>-value = 0.012) were independent predictors of donor viability.</div></div><div><h3>Conclusions</h3><div>Capnometry obtained at hospital arrival is useful for identifying valid uDCD donors. In addition, younger donor age, use of mechanical chest compression devices, and transient return of pulse are prehospital variables that also increase the odds of viability in this type of donors.</div></div>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"215 ","pages":"Article 110783"},"PeriodicalIF":4.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ResuscitationPub Date : 2025-08-17DOI: 10.1016/j.resuscitation.2025.110781
Alonso A Mateos Rodriguez, Carlos Rubio Chacon, Eduardo Miñambres Garcia
{"title":"[Comments on 'Does cardiopulmonary resuscitation before donor death affect solid organ transplant function? A systematic review and meta-analysis'].","authors":"Alonso A Mateos Rodriguez, Carlos Rubio Chacon, Eduardo Miñambres Garcia","doi":"10.1016/j.resuscitation.2025.110781","DOIUrl":"10.1016/j.resuscitation.2025.110781","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110781"},"PeriodicalIF":4.6,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}