Radiotherapy and Oncology最新文献_第5页

Prospective Evaluation of Adaptive Radiotherapy in Locally Advanced Head and Neck Cancer: Dosimetric Gains and Early Clinical Outcomes 局部晚期头颈癌适应性放疗的前瞻性评价：剂量学增益和早期临床结果

IF 5.3 1区医学

Radiotherapy and Oncology Pub Date : 2026-03-01 Epub Date: 2026-04-09 DOI: 10.1016/S0167-8140(26)00215-X

Soorej Balan Kaliyath , A Kesava Ramagopal , Punyasha Priyambada Mohanty , Ajay Kumar Kondeti

引用次数: 0

NKT-Cell Gene Signatures Correlate with Favourable Survival and Show Distinct DNA Methylation Patterns in Oropharyngeal Cancer nkt细胞基因特征与口咽癌的有利生存相关，并显示出不同的DNA甲基化模式

IF 5.3 1区医学

Radiotherapy and Oncology Pub Date : 2026-03-01 Epub Date: 2026-04-09 DOI: 10.1016/S0167-8140(26)00166-0

Luka Minarik , Rita Khoueiry , Mirela Leskur , Vincent Cahais , Zdenko Herceg , Merica Glavina Durdov , Benjamin Benzon

引用次数: 0

Medial retropharyngeal lymph node involvement and recurrence rate in patients with nasopharyngeal carcinoma – a German multicenter analysis 鼻咽癌患者内侧咽后淋巴结受累和复发率-德国多中心分析

IF 5.3 1区医学

Radiotherapy and Oncology Pub Date : 2026-03-01 Epub Date: 2026-04-09 DOI: 10.1016/S0167-8140(26)00188-X

Justus Kaufmann , Eirini Nikolaidou , Isabel Krabbes , Nwabata Oji , Simone Ferdinandus , Julian Hlouschek , Georg Wurschi , Jan-Niklas Becker , Jana Schaule , Jörg Andreas Müller , Laura Oebel , Sebastian Altmann , Felix Ehret , Alexander Rühle , Christian Grad

引用次数: 0

Open-Faced Immobilisation Masks: Enhancing Comfort without Compromising Accuracy in HNC Radiotherapy, an Institutional experience 开放式固定化口罩：在不影响HNC放射治疗准确性的情况下提高舒适度，一个机构经验

IF 5.3 1区医学

Radiotherapy and Oncology Pub Date : 2026-03-01 Epub Date: 2026-04-09 DOI: 10.1016/S0167-8140(26)00252-5

Laura Kennedy , Jennifer Trousdell , Abdullah Al-Khunaizi , Leanne McNamara , Antonia Smyth , John Gaffney

引用次数: 0

From Guidelines to real-world Practice: Patterns of Care in Elderly Head and Neck Cancer Patients from a Tertiary Care Centre 从指南到现实世界的实践：三级护理中心老年头颈癌患者的护理模式

IF 5.3 1区医学

Radiotherapy and Oncology Pub Date : 2026-03-01 Epub Date: 2026-04-09 DOI: 10.1016/S0167-8140(26)00229-X

Suman Bhasker , Anjali V.R. , Nehla Haroon K.M. , Aswin M Ravi

引用次数: 0

Efficacy of Extreme Radiotherapy De-escalation to Elective Nodal Beds in Head and Neck Cancer Treated with Curative Intent at a Community-Based Center 在一个社区为基础的中心，极端放疗降压至选择性淋巴结床治疗头颈癌的疗效

IF 5.3 1区医学

Radiotherapy and Oncology Pub Date : 2026-03-01 Epub Date: 2026-04-09 DOI: 10.1016/S0167-8140(26)00219-7

Adam Katzenberg , Leia Hockstein , Sujung Park , Lydia Clements , Lana Desouza-Lawrence , Julian Amin , Adam Raben

引用次数: 0

Aims+Scope/Editorial Board/ Publication information 目标+范围/编辑委员会/出版信息

IF 5.3 1区医学

Radiotherapy and Oncology Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/S0167-8140(26)00058-7

引用次数: 0

Machine learning model for predicting interfraction motion of the seminal vesicles in prostate cancer radiotherapy 预测前列腺癌放疗中精囊干涉运动的机器学习模型

IF 5.3 1区医学

Radiotherapy and Oncology Pub Date : 2026-03-01 Epub Date: 2026-01-06 DOI: 10.1016/j.radonc.2026.111368

Mitsuaki Terabe , Takeshi Kamomae , Yuki Taniguchi , Takayuki Miyachi , Hajime Ichikawa , Risei Miyauchi , Junji Ito , Mariko Kawamura , Shunichi Ishihara , Shinji Naganawa

{"title":"Machine learning model for predicting interfraction motion of the seminal vesicles in prostate cancer radiotherapy","authors":"Mitsuaki Terabe , Takeshi Kamomae , Yuki Taniguchi , Takayuki Miyachi , Hajime Ichikawa , Risei Miyauchi , Junji Ito , Mariko Kawamura , Shunichi Ishihara , Shinji Naganawa","doi":"10.1016/j.radonc.2026.111368","DOIUrl":"10.1016/j.radonc.2026.111368","url":null,"abstract":"<div><h3>Background and purpose</h3><div>In external beam radiotherapy for prostate cancer, inclusion of the seminal vesicles (SV) in the clinical target volume (CTV) is often complicated by considerable SV motion and deformation. This study aimed to investigate the feasibility of predicting patient-specific SV motion using anatomical features surrounding the prostate on planning CT (pCT) images.</div></div><div><h3>Materials and methods</h3><div>Interfractional SV motion was quantified using five pretreatment cone-beam CT (CBCT) scans per patient from a cohort of 191 prostate cancer patients. Patients whose SV was not fully covered by a 3-mm margin were assigned to the High SV Motion Group, which served as the target for prediction. A total of 42 anatomical features were extracted from the contours of the prostate, SV, bladder, and rectum on the pCT. Feature selection was performed using Random-Forest Recursive Feature Elimination, and a machine learning model was developed and evaluated using both internal and external patient cohorts.</div></div><div><h3>Results</h3><div>Four anatomical features were selected, including those based on the anatomical relationship between the prostate and the SV. Using these features, the best-performing light gradient boosting machine model achieved an area under the receiver operating characteristic curve of 0.724 in the internal test and 0.632 in the external test for identifying patients in the High SV Motion Group.</div></div><div><h3>Conclusion</h3><div>This study suggests an association between anatomical features derived from pCT and patient-specific SV motion. Although the current predictive performance is moderate, this approach may help support radiotherapy strategies when the SV is included in the CTV.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Article 111368"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photon FLASH spares radiation-induced changes in cardiac function, remodelling and arrythmia in a preclinical model 在临床前模型中，光子闪光避免了辐射引起的心功能、重构和心律失常的变化。

IF 5.3 1区医学

Radiotherapy and Oncology Pub Date : 2026-03-01 Epub Date: 2026-01-05 DOI: 10.1016/j.radonc.2026.111369

Mihaela Ghita-Pettigrew , Kathryn H. Brown , Brianna N. Kerr , Gerard M. Walls , Ioannis I. Verginadis , Gabriel Adrian , Kristoffer Petersson , Stephen J. McMahon , Karl T. Butterworth

{"title":"Photon FLASH spares radiation-induced changes in cardiac function, remodelling and arrythmia in a preclinical model","authors":"Mihaela Ghita-Pettigrew , Kathryn H. Brown , Brianna N. Kerr , Gerard M. Walls , Ioannis I. Verginadis , Gabriel Adrian , Kristoffer Petersson , Stephen J. McMahon , Karl T. Butterworth","doi":"10.1016/j.radonc.2026.111369","DOIUrl":"10.1016/j.radonc.2026.111369","url":null,"abstract":"<div><h3>Introduction</h3><div>Preclinical studies have demonstrated the ability of FLASH irradiation to expand the therapeutic window by sparing normal tissues. The heart is a critical organ at risk in patients receiving radiotherapy for thoracic cancers. This study aimed to quantify the cardiac sparing effects of photon FLASH delivered as single (FLASH) or FLASH split dose (FSD) exposures.</div></div><div><h3>Methods</h3><div>Female C57BL/6 mice were irradiated with 18.5 ± 0.6 Gy delivered to the whole heart using a FLASH-SARRP (Xstrahl Life Sciences, UK) at a dose rate of 85.6 ± 1.6 Gy/s (isocentre dose rate 75.9 ± 1.5 Gy/s). Comparative studies were undertaken using 18.6 ± 0.4 Gy delivered using two consecutive pulses (FSD) at an average dose rate of 2.8 ± 0.9 Gy/s, and with 20.1 ± 0.5 Gy using a conventional SARRP at a dose rate of 3.4 ± 0.2 Gy/min (CONV). Transthoracic echocardiography was performed at 10 and 30 weeks with supporting histology and analysis of serum biomarkers 30 weeks post irradiation.</div></div><div><h3>Results</h3><div>In comparison to CONV and FSD exposures, FLASH significantly reduced radiation-induced loss of cardiac function, cardiac remodelling and arrythmia 30 weeks after irradiation. These observations were supported by reduced myocardial fibrosis, cardiac injury biomarkers and inflammatory cytokines.</div></div><div><h3>Conclusions</h3><div>This study highlights the ability of photon FLASH to preserve cardiac function and structure from radiation damage with the level of sparing dependent on average dose rate and beam structure.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"216 ","pages":"Article 111369"},"PeriodicalIF":5.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Older Patients With Locally Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Seen in a Dedicated Geriatric Oncology Clinic 专门的老年肿瘤诊所对局部复发或转移性头颈部鳞状细胞癌的老年患者的评估

IF 5.3 1区医学

Radiotherapy and Oncology Pub Date : 2026-03-01 Epub Date: 2026-04-09 DOI: 10.1016/S0167-8140(26)00233-1

Eltayeb Elhassan , Michelle Hannan , Anne Horgan , Caitriona Goggin

引用次数: 0