Research in Cardiovascular Medicine最新文献

{"title":"Focal right ventricular apical hypertrophy or apical muscular ventricular septal defect","authors":"Z. Sani, Taimoor Etemad, M. Behjati, Z. Khajali, R. Alizadehsani, A. Khosravi, S. Nahavandi, S. S. Shariful Islam","doi":"10.4103/rcm.rcm_35_20","DOIUrl":"https://doi.org/10.4103/rcm.rcm_35_20","url":null,"abstract":"A 28-year-old male patient was referred to our imaging center with the differential diagnosis of a right ventricular (RV) apical mass. He was a known case of the ventricular septal defect (VSD) with a history of spontaneous closure at the age of 2 years. His chief complaint was chest pain and palpitation. He was referred with a transthoracic echocardiography report of RV apical hypertrophy with almost apical obliteration or RV apical mass. Cardiovascular magnetic resonance imaging demonstrated few intramyocardial crypts of basal anteroseptal left ventricular (LV) segment. There was no evidence of concomitant LV apical hypertrophy. Indeed, there was a small conical- and tunnel-shaped serpiginous apical-infundibular muscular VSD (3.6 mm RV side's diameter and 7.6 mm LV side's diameter) resulted in a localized and severely hypertrophied RV apical segment and no significant shunt (QP/QS: 1.16). There was no evidence of other cardiac mass.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43235717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical profile and angiographic patterns of patients undergoing treatment for in-stent restenosis and outcomes associated with the treatment","authors":"S. Patil, M. Chatterjee, Natraj Setty, S. Jadhav","doi":"10.4103/rcm.rcm_21_20","DOIUrl":"https://doi.org/10.4103/rcm.rcm_21_20","url":null,"abstract":"Context: The optimal treatment strategy for in-stent restenosis (ISR) still remains under debate. Moreover, there have been scarce data on Indian patients relating to ISR treatment. Aim: The aim of this study was to determine the clinical profile and angiographic pattern of patients with ISR and to evaluate the outcome of these patients being treated for ISR. Settings and Design: This was a cross-sectional study which consisted of patients who had coronary angiographic characteristic of ISR. Materials and Methods: Patients were divided into subgroups as per presentation, acute coronary syndrome (ACS), and non-ACS. After the ISR event and treatment, the patients were followed up for a minimum period of 6 months for any adverse events. The primary outcome of the study was occurrence of a major adverse cardiac event. Statistical Analysis: Chi-square test, Fisher's exact test, Student's t-test, or Mann–Whitney test was applied according to type and distribution of variable (SPSS software). Results: One hundred patients with 109 culprit lesions of ISR were included in the study. The ACS was dominant clinical presentation mode, occurring in 62 patients. Fifty-four percent of the patients were treated with percutaneous coronary intervention, 26% were managed with coronary artery bypass grafting, and 19% were treated with optimized medical therapy. Majority of the adverse events (12 out of 15 patients) occurred in the ACS group, with a statistically significant difference at 6-month follow-up (P = 0.021). Conclusion: Patients with ISR have ACS as the most common mode of presentation. Patients with ISR presenting with ACS are at high risk and must be closely monitored. The treatment of ISR with drug-eluting stent or drug-coated balloon is most effective.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42055770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic modality of the long QT syndrome: Lesson from the past","authors":"E. Begić, E. Hodžić, Z. Begić, A. Iglica, N. Begić, Omer Jusic","doi":"10.4103/rcm.rcm_30_20","DOIUrl":"https://doi.org/10.4103/rcm.rcm_30_20","url":null,"abstract":"Long QT syndrome (LQTS) is a rare (1:2500–1:10,000) inherited disorder characterized by the onset of arrhythmogenic syncope, polymorphic ventricular tachycardia, and sudden cardiac death. The aim of this article was to describe an unexpected success with an unusual therapeutic modality of a patient diagnosed with LQTS syndrome (suspected Romano–Ward syndrome) during an 8-year period. A 59-year-old female patient was admitted to the hospital due to chest pain and nausea, and after diagnostic and therapeutical approach, a permanent dual-chamber rate-modulated (DDDR) pacemaker was implanted instead of the implantable cardioverter defibrillator (ICD). During the 8-year period, the patient remained stable, without rhythm disorder. Romano–Ward syndrome as a congenital LQTS carries a high risk of sudden cardiac death and presents an indication for ICD. In this patient, for objective reasons, this could not be performed. Implantation of a DDDR with an appropriate pharmacological therapy, including propranolol, in this case, proved to be a successful therapeutic modality.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44729959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of great cardiac vein signal in the differentiation of premature ventricular contraction origins in right and left ventricular outflow tracts","authors":"A. Fazelifar, Behzad Amanpour, M. Heidarali, A. Arani","doi":"10.4103/rcm.rcm_23_20","DOIUrl":"https://doi.org/10.4103/rcm.rcm_23_20","url":null,"abstract":"Background and Aim: “Idiopathic” ventricular arrhythmias most often arise from the right ventricular outflow tract (RVOT), although arrhythmias from the left ventricular outflow tract (LVOT) have also been observed. The aim of the study was to investigate the importance of signal of great cardiac vein (GCV) to distinguish premature ventricular contraction (PVC) originated from LVOT and PVC originated from RVOT. Materials and Methods: A coronary sinus catheter was placed in the GCV under fluoroscopy to measure the distance of GCV signal to the onset of QRS on surface electrocardiogram (ECG). Catheter ablation was performed utilizing radiofrequency energy in 31 patients. A 12-lead ECG was recorded during PVC. Successful ablation was defined as the complete disappearance of target PVC with no recurrence during the follow-up. Results: Thirty-one consecutive patients (16 male [51.6%]) were enrolled. Overall, 67.7% of the cases had PVC originated from the LVOT and 32.3% from the RVOT. Out of 48.4% of the females, 33.3% had PVC originated from the RVOT and 66.7% from the LVOT (P = 1). The mean ejection fraction regarding PVC originated from the LVOT and RVOT was 47.50 ± 8.95 and 45.50 ± 8.51, respectively (P = 0.7). The distance of GCV signal to the onset of QRS on surface ECG for LVOT- and RVOT-originated PVC was 15.38 ± 25.28 and −29.70 ± 25.66, respectively (P < 0.01). Conclusions: The differentiation between PVC originated from LVOT and RVOT is not entirely utilized through ECG criteria, thus the origin of PVC arising from RVOT/LVOT can be localized using the GCV signals.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44245652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of continuous holter of blood pressure in pediatric population: Single-center experience and review of literature","authors":"Z. Begić, N. Begić, E. Begić, D. Šečić, S. Begić","doi":"10.4103/rcm.rcm_31_20","DOIUrl":"https://doi.org/10.4103/rcm.rcm_31_20","url":null,"abstract":"Introduction: A Holter blood pressure monitoring is a basic method for the diagnosis and evaluation of hypertension therapy. Hypertension in children and adolescents is defined as an increase of systolic/diastolic pressure, which is equal, or above 95th percentile blood pressure for sex, age, and height. Aim: The aim of this study is to analyze the etiology of arterial hypertension (AH) in the pediatric population. Methods: Research had descriptive and retrospective character. During the period from March 2006 to April 2020, 1527 registered continuous Holters of blood pressure were analyzed. Data were taken from the medical documentation of patients that were hospitalized on Pediatric Clinic (register of continuous Holter of blood pressure). Results: Out of the total number of registered and analyzed patients 833 were male (54.5%) with dominant age 15–19 years of life 774 (50.6%), school-age children 660 (43.2%), preschool children 93 (6.1%). We had 902 (59%) first registrations and 626 (41%) control registrations. AH was verified in 52 patients (387 records of continuous Holter of blood pressure were performed to them). Primary AH was verified in 27 patients and secondary AH in 25 patients. Forty patients (76.9%) were treated with monotherapy while combined therapy was used in 12 (23.1%) of cases. Renal cause was in 28% patients, endocrine in 24%, cardiovascular in 24%, neurological in 16%, and rheumatic in 8% of patients with secondary AH. Conclusion: Continuous Holter of blood pressure represents useful diagnostic method and method of control of high blood pressure in children and adolescents. It should be routine method in everyday pediatric clinical practice especially in pediatric cardiology.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41380819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful pulmonary artery balloon angioplasty in a rare case of arterial tortuosity syndrome","authors":"Maryam Aliramezany, A. Firouzi, M. Parsaee, Z. Khajali","doi":"10.4103/rcm.rcm_16_20","DOIUrl":"https://doi.org/10.4103/rcm.rcm_16_20","url":null,"abstract":"Arterial tortuosity syndrome (ATS) is a very rare autosomal recessive disease which results from mutations of the SLC2A10 gene. In this article, we describe the results of vascular imaging of an adult patient with ATS who was presented with pulmonary hypertension and after a complete evaluation, he was a candidate for interventional balloon angioplasty. Our patient is one of the very limited numbers of list patients in the studies for whom percutaneous balloon angioplasty performed successfully.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46729985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rajaie cardiovascular medical and research center-percutaneous coronary intervention registry: A real-world registry on coronary interventions in a tertiary teaching cardiovascular center","authors":"H. Basiri, E. Khalilipur, A. Sarreshtedari, R. Zolfaghari, Parham Sadeghipour, M. Alemzadeh-Ansari, B. Mohebbi, A. Rashidinejad, Zahra Hosseini, Ali Zahedmedhr, A. Firouzi, F. Noohi, M. Kiavar, M. Peighambari, S. Abdi, Mohsen Maadani, Farshad Shakerian, R. Kiani, A. Mohebbi, M. Momtahen, M. Sadrameli, H. Sanati, O. Shafe, J. Moosavi, Yousef Moghadam, Reza Golpira, M. Maleki","doi":"10.4103/rcm.rcm_11_20","DOIUrl":"https://doi.org/10.4103/rcm.rcm_11_20","url":null,"abstract":"Introduction: Clinical registries are a targeted way of data collection aimed at finding a solution to a specific clinical inquiry. The present report introduces the Rajaie Cardiovascular, Medical and Research Center percutaneous coronary intervention (RHC-PCI) Registry. The primary objectives of the RHC-PCI Registry consist of monitoring different complex PCI procedures and their mutual impact on interventional cardiology programs. Methods: RHC is a large and well-known cardiovascular tertiary center in Iran. The RHC-PCI Registry was first launched in 2015, since which time it has collected >5000 parameters regarding the baseline, clinical, and procedural characteristics of various PCI procedures. Noncomplex coronary interventions, bifurcation stenting, left main interventions, chronic total occlusion (CTO) PCI, and bypass graft interventions comprise the major categories gathered by the RHC-PCI Registry. The main registry outcomes are comprised in-hospital mortality, major adverse cardiovascular events, vascular access site complications, and 6-month all-cause mortality. Results: In this primary report, we elaborate on the principal infrastructure of the RHC-PCI Registry and present a synopsis of the registry scope. During the first 40 months of the registry, 11,005 patients underwent PCI. The acute coronary syndrome was reported in 5043 (45.8%) patients. Bifurcation stenting, left main interventions, CTO PCI, and bypass graft interventions were performed in 1679 (15.2%), 236 (2.1%), 946 (8.5%), and 764 (6.9%) patients, respectively. The preferred access site was the femoral artery (n = 6614, 60%), and drug-eluting stents were deployed in 9230 (83.8%) patients. In-hospital mortality in the total registry data was reported in 104 (0.9%) patients. Conclusions: This report introduces the RHC-PCI Registry, its primary objectives, infrastructure, and preliminary results (the 3-year outcome).","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41555235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the reliability and validity of the Iranian caregiver burden questionnaire for heart failure","authors":"Marjohn Hamediseresht, Yasaman Khalili, Raana Asghari, S. Taghavi, A. Amin, N. Naderi","doi":"10.4103/rcm.rcm_13_20","DOIUrl":"https://doi.org/10.4103/rcm.rcm_13_20","url":null,"abstract":"Introduction: It is important to have a strong appropriate tool for measuring, evaluating, and understanding the nature and consequences of chronic stresses on caregivers of patients with heart failure (HF). The purpose of this study is the assessment of the validity and reliability of the questionnaire for evaluating the burden on caregivers of patients with HF. Methods: In order to assess the burden of caregivers of patients with HF, the Caregiver Burden Questionnaire for Heart Failure version 3 (CBQ-HF, version 3) was used. After translation and back translation, the questionnaire was provided to 20 caregivers, and after 2 weeks, the same caregivers refilled the questionnaire; so that, we could measure its reliability by calculating Cronbach's alpha. Face validity and content validity were also obtained at this stage. Finally, the questionnaire was provided to eighty caregivers; hence, the total number of one hundred caregivers completed the questionnaire. Results: From a total of 100 collected questionnaires, 68 of participants were male and 32 of participants were female. The mean ± standard deviation of emotional burden on the patient's caregivers was 46 ± 10 and the median of the physical, social, and living pattern burden was 14, 4, and 13, respectively. The test–retest reliability showed high internal consistency (Cronbach's alpha: 94%). Conclusion: This study approved the Persian version of CBQHF questionnaire as a standard and valid tool in Persian language, which can be used among caregivers of patients with HF in order to examine their problems and to plan for improving their quality of life.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48397010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Assessment and Monitoring in Rajaie Hospital (HAMRAH): A population-based cohort study","authors":"H. Bakhshandeh, M. Maleki, F. Noohi, S. Boudagh, Yasaman Khalili, A. Alizadehasl, N. Naderi, B. Mohebbi, Yousef Moghaddam, M. Haghjoo, M. Arabian, M. Alemzadeh-Ansari, M. Baay, H. Pouraliakbar, Zahra Ghaemmaghami, Shiva Khaleghparast, B. Ghadrdoost, H. Pasha, Zahra Hosseini, Reza Golpira, N. Mahdieh, Akbar Nikpajouh, Parham Sadeghipour","doi":"10.4103/rcm.rcm_17_20","DOIUrl":"https://doi.org/10.4103/rcm.rcm_17_20","url":null,"abstract":"Background and Objectives: Cardiovascular diseases (CVDs) impose great burden on the health systems worldwide. The prevention of CVDs depends on the correct information about the perveance/incidence of them and their determinants in the community and population-based studies are the most accurate ways for obtaining these data. The objective of this study is to determine the prevalence of the classic risk factors of CVDs among healthy adult residents of Tehran and their changes through a 10-year follow-up in Tehran, the capital of Iran. This article presents the study protocol. Methods: Heart Assessment and Monitoring in RAjaie Hospital, is a population-based study conducted in Rajaie Cardiovascular Medical and Research Center, the largest tertiary care hospital for CVDs in Tehran. It consists two phases: A survey and a prospective cohort. People between 30 and 75 years of age, without known CVDs, invite through a multistage random sampling process. They will assess for the CVD risk factors, laboratory indices, electrocardiography and echocardiography features, diet, physical activity levels, psychological aspects, and peripheral vascular diseases. All the participants will be followed for 10 years and the changes in the above-mentioned factors and incidence of CVDs assessed. Discussion: It is expected that through obtaining valid, population-specific data, the information for policy making and efficient management of CVDs in Iranian people be provided.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44376931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and angiographic profile of premature heart attack in patients with family history of premature coronary heart disease: A substudy of the PCAD registry (Registered under the Clinical Trials Registry of India [CTRI/2018/03/012544])","authors":"Rahul Krishnarao Patil, C. Satvic, L. Shetty, H. N. Natraj Setty, Spandana Komma, Anesh Jain, T. Raghu, C. Manjunath","doi":"10.4103/rcm.rcm_15_20","DOIUrl":"https://doi.org/10.4103/rcm.rcm_15_20","url":null,"abstract":"Aim: The aim is to study the clinical, social, biochemical, and angiographic profile of youth (under 35 years) with familial premature coronary artery disease (PCAD). Subjects and Methods: The PCAD registry is a prospective ongoing descriptive observational study of Indians aged below 40 years with coronary artery disease (CAD) which was started on April 1, 2017. Of 3450 patients registered in the PCAD registry till date, 1628 patients were aged 35 years or younger. Of these 1628 patients, 218 satisfied entry criteria. The entire clinical and angiographic profile of these patients was documented. The distribution of different lipid profile parameters was visualized by nonparametric density plot. The data were analyzed by statistical software R version 3.5.0. Results: Of 3450 patients registered in the PCAD registry till date, 1628 patients were aged ≤ 35 years. Two hundred and eighteen out of these 1628 patients (13.39%) belonged to the study group for this particular study. The mean age of all patients under the PCAD registry was 30.44 years, and 201 (92.2%) were males. 106 (48.62%) were smokers. Twenty-nine patients (13.33%) of them were diabetic. The most common index presentation of CAD in familial PCAD was with ST-elevation myocardial infarction (STEMI; 112 patients – 51.37%) and unstable angina/non-STEMI (58 patients – 26.6%). Forty-eight patients (22.01%) presented with evolved MI. Conclusions: Almost 14% of coronary events in younger age (under 35 years) were attributable to family history of CAD. Family history of CAD can be used as a criterion to select younger age population to perform targeted screening for cardiovascular diseases.","PeriodicalId":21031,"journal":{"name":"Research in Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44215574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}