Radiochimica Acta Radiochimica Acta最新文献_第2页

Radiosynthesis of a novel potential adenosine A3 receptor ligand, 5-ethyl 2,4-diethyl-3-((2-[18F]fluoroethyl)sulfanylcarbonyl)-6-phenylpyridine-5-carboxylate ([18F]FE@SUPPY:2) 新型潜在腺苷A3受体配体5-乙基2,4-二乙基-3-((2-[18F]氟乙基)磺酰基羰基)-6-苯基吡啶-5-羧酸盐([18F]FE@SUPPY:2)的放射性合成

Radiochimica Acta Radiochimica Acta Pub Date : 2009-12-01 DOI: 10.1524/RACT.2009.1663

D. Haeusler, M. Mitterhauser, L. Mien, K. Shanab, R. Lanzenberger, E. Schirmer, J. Ungersboeck, L. Nics, H. Spreitzer, H. Viernstein, R. Dudczak, et al.

{"title":"Radiosynthesis of a novel potential adenosine A3 receptor ligand, 5-ethyl 2,4-diethyl-3-((2-[18F]fluoroethyl)sulfanylcarbonyl)-6-phenylpyridine-5-carboxylate ([18F]FE@SUPPY:2)","authors":"D. Haeusler, M. Mitterhauser, L. Mien, K. Shanab, R. Lanzenberger, E. Schirmer, J. Ungersboeck, L. Nics, H. Spreitzer, H. Viernstein, R. Dudczak, et al.","doi":"10.1524/RACT.2009.1663","DOIUrl":"https://doi.org/10.1524/RACT.2009.1663","url":null,"abstract":"Abstract Since, to date very limited information on the distribution and function of the adenosine A3 receptor is available, the development of suitable radioligands is needed. Recently, we introduced [ 18F]FE@SUPPY (5-(2-[ 18F]fluoroethyl) 2,4-diethyl-3-(ethylsulfanylcarbonyl)-6-phenylpyridine-5-carboxylate) as the first PET-ligand for the A3R. Regarding the metabolic profile – this class of dialkylpyridines comprises two ester functions within one molecule, one carboxylic and one thiocarboxylic – one could expect carboxylesterases significantly contributing to cleavage and degradation. Therefore, our aim was the development of [ 18F]FE@SUPPY:2 (5-ethyl 2,4-diethyl-3-((2-[ 18F]fluoroethyl)sulfanylcarbonyl)-6-phenylpyridine-5-carboxylate), the functional isomer containing the label at the thiocarboxylic moiety. For satisfactory yields in high scale radiosyntheses, a reaction temperature of 75 °C has to be applied for at least 20 min using 20 mg/mL of precursor. So far, 6 complete high-scale radiosyntheses were performed. Starting from an average of 51.2±21.8 GBq (mean±SD) [ 18F]fluoride, 5.8±4.1 GBq of formulated [ 18F]FE@SUPPY:2 (12.0±5.4%, based on [ 18F]fluoride, not corrected for decay) were prepared in 75±8 min.","PeriodicalId":21029,"journal":{"name":"Radiochimica Acta Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86721684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Separation of 109Cd from silver targets by nanohematite 纳米赤铁矿从银靶中分离109Cd

Radiochimica Acta Radiochimica Acta Pub Date : 2009-12-01 DOI: 10.1524/RACT.2009.1664

M. Sadeghi, H. Karami, P. Sarabandi, M. Mirzaee

引用次数: 7

Charged particle induced reaction cross section data for production of the emerging medically important positron emitter 64Cu: A comprehensive evaluation 新型医学上重要的正电子发射器64Cu的带电粒子诱导反应截面数据的综合评价

Radiochimica Acta Radiochimica Acta Pub Date : 2009-12-01 DOI: 10.1524/RACT.2009.1670

M. Aslam, S. Sudár, M. Hussain, A. A. Malik, H. Shah, S. Qaim

{"title":"Charged particle induced reaction cross section data for production of the emerging medically important positron emitter 64Cu: A comprehensive evaluation","authors":"M. Aslam, S. Sudár, M. Hussain, A. A. Malik, H. Shah, S. Qaim","doi":"10.1524/RACT.2009.1670","DOIUrl":"https://doi.org/10.1524/RACT.2009.1670","url":null,"abstract":"Abstract The radionuclide 64Cu (T1/2=12.7 h) is an important non-standard positron emitter, suitable for combining PET imaging and targeted therapy. Its production in no-carrier-added form is done via charged particle induced reactions, and considerable amount of cross section data are available in the literature. We evaluated seven reactions, namely 64Ni(p, n) 64Cu, 64Ni(d, 2n) 64Cu, 68Zn(p, αn) 64Cu, 66Zn(p, 2n) 64Cu, 64Zn(d, 2p) 64Cu, 66Zn(p, α) 64Cu and natZn(d, x) 64Cu. Data analysis was generally limited up to about 25 MeV and the consistency check of experimental data was carried out using the nuclear model codes STAPRE, EMPIRE and TALYS. In a few cases experimental data were available up to 100 MeV; the consistency check in the high energy region was done only using the code TALYS. A statistical procedure (supported by nuclear model calculations) was then used to fit the data. The derived recommended sets of data, together with 95% confidence limits, are reported. The integral yields calculated from those data are also given. A critical comparison of the various production routes of 64Cu is presented. The 64Ni(p, n) 64Cu reaction, utilizing a highly enriched target, is the method of choice.","PeriodicalId":21029,"journal":{"name":"Radiochimica Acta Radiochimica Acta","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82397766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Investigation of K to L shell/subshell vacancy transitions of Zn and Fe in FexZn1-x thin film alloys FexZn1-x薄膜合金中Zn和Fe的K到L壳层/亚壳层空位跃迁研究

Radiochimica Acta Radiochimica Acta Pub Date : 2009-12-01 DOI: 10.1524/RACT.2009.1662

Ö. Söğüt

引用次数: 2