{"title":"ESTIMATING DIFFEOMORPHIC MAPPINGS BETWEEN TEMPLATES AND NOISY DATA: VARIANCE BOUNDS ON THE ESTIMATED CANONICAL VOLUME FORM.","authors":"Daniel J Tward, Partha P Mitra, Michael I Miller","doi":"10.1090/qam/1527","DOIUrl":"10.1090/qam/1527","url":null,"abstract":"<p><p>Anatomy is undergoing a renaissance driven by the availability of large digital data sets generated by light microscopy. A central computational task is to map individual data volumes to standardized templates. This is accomplished by regularized estimation of a diffeomorphic transformation between the coordinate systems of the individual data and the template, building the transformation incrementally by integrating a smooth flow field. The canonical volume form of this transformation is used to quantify local growth, atrophy, or cell density. While multiple implementations exist for this estimation, less attention has been paid to the variance of the estimated diffeomorphism for noisy data. Notably, there is an infinite dimensional unobservable space defined by those diffeomorphisms which leave the template invariant. These form the stabilizer subgroup of the diffeomorphic group acting on the template. The corresponding flat directions in the energy landscape are expected to lead to increased estimation variance. Here we show that a least-action principle used to generate geodesics in the space of diffeomor-phisms connecting the subject brain to the template removes the stabilizer. This provides reduced-variance estimates of the volume form. Using simulations we demonstrate that the asymmetric large deformation diffeomorphic mapping methods (LDDMM), which explicitly incorporate the asymmetry between idealized template images and noisy empirical images, provide lower variance estimators than their symmetrized counterparts (cf. ANTs). We derive Cramer-Rao bounds for the variances in the limit of small deformations. Analytical results are shown for the Jacobian in terms of perturbations of the vector fields and divergence of the vector field.</p>","PeriodicalId":20964,"journal":{"name":"Quarterly of Applied Mathematics","volume":"77 ","pages":"467-488"},"PeriodicalIF":0.8,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1090/qam/1527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37482947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ronak Mehta, Hyunwoo J Kim, Shulei Wang, Sterling C Johnson, Ming Yuan, Vikas Singh
{"title":"LOCALIZING DIFFERENTIALLY EVOLVING COVARIANCE STRUCTURES VIA SCAN STATISTICS.","authors":"Ronak Mehta, Hyunwoo J Kim, Shulei Wang, Sterling C Johnson, Ming Yuan, Vikas Singh","doi":"10.1090/qam/1522","DOIUrl":"10.1090/qam/1522","url":null,"abstract":"<p><p>Recent results in coupled or temporal graphical models offer schemes for estimating the relationship structure between features when the data come from related (but distinct) longitudinal sources. A novel application of these ideas is for analyzing group-level differences, i.e., in identifying if <i>trends</i> of estimated objects (e.g., covariance or precision matrices) are different across disparate conditions (e.g., gender or disease). Often, poor effect sizes make detecting the <i>differential</i> signal over the <i>full</i> set of features difficult: for example, dependencies between only a <i>subset of features</i> may manifest differently across groups. In this work, we first give a parametric model for estimating trends in the space of SPD matrices as a function of one or more covariates. We then generalize scan statistics to graph structures, to search over distinct subsets of features (graph partitions) whose temporal dependency structure may show statistically significant group-wise differences. We theoretically analyze the Family Wise Error Rate (FWER) and bounds on Type 1 and Type 2 error. Evaluating on US census data, we identify groups of states with cultural and legal overlap related to baby name trends and drug usage. On a cohort of individuals with risk factors for Alzheimer's disease (but otherwise cognitively healthy), we find scientifically interesting group differences where the default analysis, i.e., models estimated on the <i>full graph</i>, do not survive reasonable significance thresholds.</p>","PeriodicalId":20964,"journal":{"name":"Quarterly of Applied Mathematics","volume":"77 2","pages":"357-398"},"PeriodicalIF":0.9,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813049/pdf/nihms-1052984.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39893257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolution partial differential equations with discontinuous data","authors":"T. Trogdon, G. Biondini","doi":"10.1090/QAM/1526","DOIUrl":"https://doi.org/10.1090/QAM/1526","url":null,"abstract":"","PeriodicalId":20964,"journal":{"name":"Quarterly of Applied Mathematics","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1090/QAM/1526","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42093021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantitative estimates of the field excited by an emitter in a narrow region between two circular inclusions","authors":"Hyeonbae Kang, KiHyun Yun","doi":"10.1090/QAM/1551","DOIUrl":"https://doi.org/10.1090/QAM/1551","url":null,"abstract":"A field excited by an emitter can be enhanced due to presence of closely located inclusions. In this paper we consider such field enhancement when inclusions are disks of the same radii, and the emitter is of dipole type and located in the narrow region between two inclusions. We derive quantitatively precise estimates of the field enhancement in the narrow region. The estimates reveal that the field is enhanced by a factor of $epsilon^{-1/2}$ in most area, where $epsilon$ is the distance between two inclusions. This factor is the same as that of gradient blow-up when there is a smooth back-ground field, not a field excited by an emitter. The method of deriving estimates shows clearly that enhancement is due to potential gap between two inclusions.","PeriodicalId":20964,"journal":{"name":"Quarterly of Applied Mathematics","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1090/QAM/1551","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48761759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On generalized diffusion and heat systems on an evolving surface with a boundary","authors":"Hajime Koba","doi":"10.1090/qam/1564","DOIUrl":"https://doi.org/10.1090/qam/1564","url":null,"abstract":"We consider a diffusion process on an evolving surface with a piecewise Lipschitz-continuous boundary from an energetic point of view. We employ an energetic variational approach with both surface divergence and transport theorems to derive the generalized diffusion and heat systems on the evolving surface. Moreover, we investigate the boundary conditions for the two systems to study their conservation and energy laws. As an application, we make a mathematical model for a diffusion process on an evolving double bubble. Specifically, this paper is devoted to deriving the representation formula for the unit outer co-normal vector to the boundary of a surface.","PeriodicalId":20964,"journal":{"name":"Quarterly of Applied Mathematics","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2018-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1090/qam/1564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48953941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On generalized compressible fluid systems on an evolving surface with a boundary","authors":"Hajime Koba","doi":"10.1090/qam/1648","DOIUrl":"https://doi.org/10.1090/qam/1648","url":null,"abstract":"We consider compressible fluid flow on an evolving surface with a smooth boundary from an energetic point of view. We employ both an energetic variational approach and the first law of thermodynamics to make mathematical models for compressible fluid flow on the evolving surface. Moreover, we investigate the boundary conditions in co-normal direction for our fluid systems to study the conservation and energy laws of the systems.","PeriodicalId":20964,"journal":{"name":"Quarterly of Applied Mathematics","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2018-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45627019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Steady Prandtl layer expansions with external forcing","authors":"Yan Guo, Sameer Iyer","doi":"10.1090/qam/1655","DOIUrl":"https://doi.org/10.1090/qam/1655","url":null,"abstract":"In this article we apply the machinery developed by Guo and Iyer [Validity of Steady Prandtl Layer Expansions, Comm. Pure Appl. Math. (to appear) (2022)] together with a new compactness estimate and a new quantity, the “degree”, in order to prove validity of steady Prandtl layer expansions with external forcing. The compactness techniques introduced in this article allow us to treat more general background Prandtl layers than Guo and Iyer [Validity of Steady Prandtl Layer Expansions, Comm. Pure Appl. Math. (to appear) (2022)].","PeriodicalId":20964,"journal":{"name":"Quarterly of Applied Mathematics","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2018-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47194685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nonexistence of small, smooth, time-periodic, spatially periodic solutions for nonlinear Schrödinger equations","authors":"D. Ambrose, J. D. Wright","doi":"10.1090/QAM/1519","DOIUrl":"https://doi.org/10.1090/QAM/1519","url":null,"abstract":"We study the question of nonexistence of small spatially periodic, time-periodic solutions for cubic nonlinear Schrödinger equations. We prove that in certain regions of the period-amplitude plane, time-periodic solutions do not exist. To be more precise, we prove that for almost any value in a bounded set of possible temporal periods, there is an amplitude threshold, below which any initial value is not the initial value for a time-periodic solution. The proof requires a certain level of Sobolev regularity on solutions. The methods used are not based on any special structure of the nonlinear Schrödinger equation, and can be applied more generally.","PeriodicalId":20964,"journal":{"name":"Quarterly of Applied Mathematics","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2018-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1090/QAM/1519","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42345547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seung‐Yeal Ha, Jeongho Kim, Chanho Min, T. Ruggeri, Xiongtao Zhang
{"title":"Uniform stability and mean-field limit of a thermodynamic Cucker-Smale model","authors":"Seung‐Yeal Ha, Jeongho Kim, Chanho Min, T. Ruggeri, Xiongtao Zhang","doi":"10.1090/QAM/1517","DOIUrl":"https://doi.org/10.1090/QAM/1517","url":null,"abstract":"","PeriodicalId":20964,"journal":{"name":"Quarterly of Applied Mathematics","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2018-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1090/QAM/1517","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46877984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}