Research Journal of Pharmaceutical Dosage Forms and Technology最新文献_第6页

Emulgel: A Novel Topical Drug Delivery 乳凝胶:一种新的局部给药方式

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-05-18 DOI: 10.52711/0975-4377.2023.00021

Likitha B, F. Sheeba, Yeshavantha Kumar, Shivanand K Mutta, H. S. Keerthy

{"title":"Emulgel: A Novel Topical Drug Delivery","authors":"Likitha B, F. Sheeba, Yeshavantha Kumar, Shivanand K Mutta, H. S. Keerthy","doi":"10.52711/0975-4377.2023.00021","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00021","url":null,"abstract":"Emulgel is a fresher class of dosage forms that are prepared by entrapment of large amounts of hydroalcoholic liquid into a network of colloidal solid particles. Emulgel formulations lead to faster drug release compared to ointments and creams. Even supposing gels have many uses but the major difficulty is to delivery of hydrophobic drugs. So, too weak these limitations, emulgels are unit ready. The mixture of gels and emulsions leads to emulgels. Emulsions it's an exact degree of elegance and is of course washed off whenever chosen, they take a high ability to penetrate the skin. Another necessary issue is to increase the drug release of even hydrophilicmedicine by creating w/o emulgel. Among the cluster of solid preparations, the utilization of emulgels has expandedin cosmetics and pharmaceutical preparations. Polymers act as emulsifiers and thickeners as a result of the gelling capability of those compounds permits the formulation of unchanging emulsions and creams by decreasing surface and surface tension and at a similar time increasing the viscosity of the aqueous part. Emulgels area unit is principally used for the delivery of analgesics, medication, anti-fungal, anti-acne medicine, and numerous cosmetic formulations. By applying an appropriate applied mathematics style dissimilar grades of emulgel area unit ready. There area unit numerous favorable properties like being thixotropic, emollient, greaseless, simply spreadable, simply removable, soluble, a longer period, non-staining, bio-friendly, clear and pleasing look. Many penetration enhancers will raise the result.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78019372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ethnobotanical Study of Antifungal Medicinal plant in the region of El Bayadh (Algeria) 阿尔及利亚El Bayadh地区抗真菌药用植物的民族植物学研究

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-05-18 DOI: 10.52711/0975-4377.2023.00014

Mustapha Mahmoud Dif, Omar Alami, Amel Haderia Benchohra, Naima Allali

引用次数: 0

Traditional Ayurvedic Formulation in the Management of COVID-19 传统阿育吠陀配方在COVID-19治疗中的应用

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-05-18 DOI: 10.52711/0975-4377.2023.00020

Mayur S. Mahajan, K. Bobe, B. Chavan

{"title":"Traditional Ayurvedic Formulation in the Management of COVID-19","authors":"Mayur S. Mahajan, K. Bobe, B. Chavan","doi":"10.52711/0975-4377.2023.00020","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00020","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that belongs to the coronavirus family. The first case was reported in December 2019, and the disease has become a pandemic. Impaired immune regulation is one of the factors that play a role in its pathogenesis and results in poor outcomes of COVID-19 patients. There have been many studies with drug candidates used as antivirals or immunomodulators. However, the results of these investigations showed that the drug candidates were not significantly effective against the disease. Meanwhile, people believe that consuming herbal immunomodulators can prevent or even cure COVID-19. Unfortunately, specific preclinical and clinical trials to evaluate the effects of herbal immunoregulators have not been conducted. Certain natural compounds might be effective for the treatment of COVID-19 based on general concepts from previous experiments. This review discusses some herbal agents extracted from various plants, including Curcuma longa, Cinchona, Ashwagandh aand Lianhuaqingwen, which are considered for the treatment of COVID-19. In addition, we discuss the pros and cons of utilising herbal medicine during the COVID-19 pandemic, draw some conclusions, and make recommendations at the end of the session.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83056901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Characterization of a multiple Emulsion containing Vitamin - C 含维生素C复合乳剂的配方与表征

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-03-17 DOI: 10.52711/0975-4377.2023.00001

M. Swamy, Samyuktha Metta, A. A. Kumar, C. J. Mohan Reddy, G. Dharani, K. Ramya

{"title":"Formulation and Characterization of a multiple Emulsion containing Vitamin - C","authors":"M. Swamy, Samyuktha Metta, A. A. Kumar, C. J. Mohan Reddy, G. Dharani, K. Ramya","doi":"10.52711/0975-4377.2023.00001","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00001","url":null,"abstract":"Multiple Mixes have been proposed to have multitudinous uses including their use for improvement of bioavailability or as a dragged medicine delivery system. But the essential insecurity of this system needs to be overcome before they find implicit operation in medicinals. Multiple mixes are frequently stabilized using a combination of hydrophilic and hydrophobic surfactants. The rate of these surfactants is important in achieving stable multiple mixes. The purpose of the study was to prepare a stable multiple conflation containing a skin anti-aging agent and using paraffin oil emulsion. Vitamin C, was incorporated into the inner waterless phase of water- in- oil emulsion- in- water (w/ o/ w) multiple conflation at a attention of 1. Multiple conflation was prepared by two step system. Stability studies were performed at different accelerated conditions, i.e. 8°C (in refrigerator), 25°C (in roaster), 40°C(in roaster), and 40°C at 75 RH (in stability cabin) for 28 days to prognosticate the stability of phrasings. The ideal of this study was to prepare multiple conflation of Ascorbic acid by two step emulsification using different non-ionic surfactants, Tweens and Agar, and estimate for stability, chance medicine ruse. The study concluded that stable multiple conflation with high ruse effectiveness can be prepared by two step emulsification system using agar- agar primary emulsifier and Tween 80 as secondary emulsifier. F2 formulation is the best formulation than the F1 and F3 formulations based on phase separation and other tests.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74193087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation Development and In vitro Characterisation of Stavudine Extended Release Matrix Tablets 司他夫定缓释基质片的处方研制及体外表征

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-03-17 DOI: 10.52711/0975-4377.2023.00006

Y. Sirisha, Kurni Sai Kumar, R. Sri. S

引用次数: 0

Formulation and Evaluation of Nanogel used for the Treatment of Psorasis 纳米凝胶治疗银屑病的配方及评价

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-03-17 DOI: 10.52711/0975-4377.2023.00004

Dethliya Madhuri, Jain Neetesh Kumar

{"title":"Formulation and Evaluation of Nanogel used for the Treatment of Psorasis","authors":"Dethliya Madhuri, Jain Neetesh Kumar","doi":"10.52711/0975-4377.2023.00004","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00004","url":null,"abstract":"Context: Although several formulation strategies have been developed for the treatment of psoriasis, there is an unmet need for optimization of its therapy. Objective: The objective was to develop a nanogel composed of Acitretin (ACT) loaded nanostructured lipid carrier (ACT-NLC) and to evaluate its potential in imiquimod-induced psoriasis model to ameliorate symptoms of psoriasis. Materials and methods: The developed control (CNGs) nanogels, acitretin loaded nanogels (ActCNGs) were characterized by UV and FTIR. Results and discussion: The systems were found to be spherical in shape with a size range of 98±10, and 138±8 nm having zeta potential values of +28±3 and +27±3 mV for CNGs and ActCNGs respectively. The in vitro haemolysis assay revealed that all the nanogel systems are blood compatible. The systems exhibited higher swelling and release at acidic pH. The ex vivo skin permeation studies using porcine skin confirmed the higher deposition of the systems at epidermal and dermal layers, which was confirmed further by fluorescent imaging. The in vivo anti-psoriatic activity study using Perry's mouse tail model and skin safety studies confirmed the potential benefit of the system for topical delivery of acitretin in psoriasis.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78610941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Bosentan Pulsatile Drug Delivery System by using Press Coated Technique 波生坦脉冲给药系统的研制与评价

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-03-17 DOI: 10.52711/0975-4377.2023.00005

Shiva Srikrishna, Kasula Sadhana, R. Sri. S

引用次数: 0

A Recent Advance on Transdermal Drug Delivery System 经皮给药系统研究进展

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-03-17 DOI: 10.52711/0975-4377.2023.00010

D. Singh, Manoj Kumar Mishra

引用次数: 0

HPLC Analytical Method Development and Validation for Estimation of Cytarabine and Daunorubicin in API and Pharmaceutical Formulation 原料药和制剂中阿糖胞苷和柔红霉素含量测定的高效液相色谱分析方法的建立与验证

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-03-17 DOI: 10.52711/0975-4377.2023.00002

T. Vijayalaxmi, Vunjali Laxman Sai, R. Sri. S

引用次数: 0

A Recent Advantage on Gastroretentive Drug Delivery System: An Overview 胃保留性给药系统的最新优势:综述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-03-17 DOI: 10.52711/0975-4377.2023.00007

K. Patel, Rajendra Chouksey

{"title":"A Recent Advantage on Gastroretentive Drug Delivery System: An Overview","authors":"K. Patel, Rajendra Chouksey","doi":"10.52711/0975-4377.2023.00007","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00007","url":null,"abstract":"In recent years, gastro-retentive drug delivery system (GRDDS) has gained researcher’s interest in the field of oral drug delivery. Various GRDDS approaches can be utilized to retain the dosage forms in the stomach and to release the drug slowly for an extended period of time. GRDDS can be used to prolong the residence time of delivery system in the stomach. This results in targeting of drug release at a specific site for the systemic or local effects. GRDDS can be used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. The challenges include fast gastric emptying of the dosage form which results in the poor bioavailability of the drug. Prolongation of the retention of drugs in stomach those having low solubility at high intestinal pH improves the solubility of drugs. GRDDS has proved to be effective in systemic actions as well as in local actions to treat gastric or duodenal ulcers. Local activity in the upper part of the small intestine can be obtained by improving the residence time of delivery system in the stomach. The system is useful for drugs which are unstable in the intestine or having a low solubility/permeability in the small intestine. Various GRDDS approaches include high density (sinking) systems, low-density (floating systems), muco-adhesive, expandable, unfold able, super porous hydrogel systems, and magnetic systems.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80813760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0