Research Journal of Pharmaceutical Dosage Forms and Technology最新文献_第2页

Immunotherapy in Cancer Treatment: Harnessing the Power of the Immune System 癌症治疗中的免疫疗法：利用免疫系统的力量

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2024-02-22 DOI: 10.52711/0975-4377.2024.00017

Alok Kumar, Kanchan Singh, Kartik Kumar, Sachin Kumar, Arjun Singh, Alpesh Tripath, Lakshya Tiwari

引用次数: 0

Formulation and Evaluation of Capsule-in-Capsule Technology for Biphasic delivery of Glipizide 用于双相给药格列吡嗪的胶囊中胶囊技术的制备与评估

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2024-02-22 DOI: 10.52711/0975-4377.2024.00005

Rupali Rathod, Manoj Bari, Shaikh Samir

{"title":"Formulation and Evaluation of Capsule-in-Capsule Technology for Biphasic delivery of Glipizide","authors":"Rupali Rathod, Manoj Bari, Shaikh Samir","doi":"10.52711/0975-4377.2024.00005","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00005","url":null,"abstract":"In the present research work, to formulation and evaluation of capsule-in-capsule technology for biphasic delivery of Glipizide. The advantages of fast releasing liquid-filled-capsules and slow release beads-filled-capsules were combined to meet the optimized requirements of our biphasic drug delivery system. Glipizide slow releasing beads were prepared by ionotrophic gelation method by using natural polymers like Sodium alginate, Pectin and were filled into a smaller capsule. Glipizide fast releasing liquid dispersion was prepared by using either Castor oil carriers and further prepared a glipizide emulsion. This fast releasing liquid and slow releasing beads-filled-capsule was further inserted into a bigger capsule body and Seal the capsule by hydro alcoholic solution. The various formulation batches were subjected to physicochemical studies, entrapment efficiency, drug content, in vitro drug release and stability studies. Interaction studies reveal that there was no interaction between drug and polymers employed in this study. The optimized capsule-in-a-capsule formulation released 22.65±0.74% of drug at the end of 30 min and 95.04±0.88% of drug at the end of 12h. The drug release profile of Glipizide capsule-in-a-capsule formulation fits well with Pepas model followed by zero order, first order and Korsemeyer-peppa’s model. Korsmeyer-Peppas model analysis indicated that the drug release followed non-Fickian transport mechanism. The stability results indicate that the various parameters of our optimized formulation are not affected on storage at 45°C/75%RH up to 4 months. Target of capsule-in-capsule drug delivery loading dose reaches therapeutic drug level in blood plasma for quicker onset of action and Maintenance dose which maintain an effective therapeutic level for prolong period. The prepared Glipizide biphasic cap-in-cap will be used for treatment of Diabetes.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Review on Floating Drug Delivery System 浮动给药系统综述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2024-02-22 DOI: 10.52711/0975-4377.2024.00007

Pradnya D. Lahamge, Yashpal M. More, Pallavi P. Ahire, Vinay R. Kothawade

{"title":"A Comprehensive Review on Floating Drug Delivery System","authors":"Pradnya D. Lahamge, Yashpal M. More, Pallavi P. Ahire, Vinay R. Kothawade","doi":"10.52711/0975-4377.2024.00007","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00007","url":null,"abstract":"The category of gastroretentive drug delivery systems (GRDDS) includes floating drug delivery systems (FDDS). These dose formulations are intended to extend the duration of the stomach's residence period by a sustained release technique. Drugs which are harder to dissolve in high pH environments have improved bioavailability and solubility when incorporated into GRDDS. Reduced intestinal absorption of solid dose forms can be accomplished by the flotation mechanism. The novel fusion of bilayer and floating mechanism is demonstrated by the bilayer floating drug delivery device. It demonstrates the effective creation of a controlled release formulation. Bilayer floating tablets offer a sustained release layer formulation in addition to an immediate release. A attempt was made to explain the mechanism of FDDS, or floating bilayer, in the review. In order to accomplish regulated administration of various medications with predetermined release profiles, bi-layer tablets were developed. The pharmaceutical industry has been more interested in creating bilayer tablets over the past ten years as a way to improve patient compliance and convenience by combining two or more API in a single dose form.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gastroretentive drug delivery system: An Overview 胃复安给药系统：概述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2024-02-22 DOI: 10.52711/0975-4377.2024.00015

Muskan Rathor, Anshika Garg

{"title":"Gastroretentive drug delivery system: An Overview","authors":"Muskan Rathor, Anshika Garg","doi":"10.52711/0975-4377.2024.00015","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00015","url":null,"abstract":"Gastric emptying is a complex and incredibly factor process. This causes the unusualness of the bioavailability of medication delivery system. GRDDSs can improve the controlled delivery of medications that have an ingestion window by continuously delivering the medication for a delayed time before it arrives at its assimilation site. Gastro retentive drug delivery system (GRDDS)s have gotten huge consideration in the previous many years, because of the way that they can overcome the limitations of regular oral controlled released drug delivery system identified with quick gastric emptying time. An ideal GRDDS can be characterized as a system which stays in the stomach for an adequate time and deliver the active ingredients in a controlled way so that sustained action can be created. This, altogether broadens the duration of medication release, prolongs dosing interval and expands bioavailability of medications and consequently improves compliance of the patients and viability of pharmacotherapy. This article gives an outline of the fundamental ideas used to design drug dosage form with delayed gastric residence time as well as the factors influencing gastric emptying, favourable circumstances, deficiencies, formulation consideration and, elements that influence gastro retentive system. The principal emphasis is on the whole grouping and various types of GRDDSs.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140439585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Concise Overview on Orodispersible Film along with their Formulation and Characterization Technique’s 关于可发散薄膜及其配方和表征技术的简要概述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2024-02-22 DOI: 10.52711/0975-4377.2024.00016

Navdeep Singh, S. Sweta, Shammy Jindal

{"title":"A Concise Overview on Orodispersible Film along with their Formulation and Characterization Technique’s","authors":"Navdeep Singh, S. Sweta, Shammy Jindal","doi":"10.52711/0975-4377.2024.00016","DOIUrl":"https://doi.org/10.52711/0975-4377.2024.00016","url":null,"abstract":"Orally fast-dissolving medicine delivery techniques are increasingly common at present. Due to the desire for these delivery systems, oro-dispersible film (ODF) was recently introduced for the delivery of medicines via the oral route. Most of drugs are delivering through oral route in the form of tablets, capsules and liquids, because they are simple to make and have a greater level of patient compliance. But these conventional dosage forms have many problems including big size of dosage form, and fear of chocking. Oral rapid disintegrating/oro-dispersible drug delivery systems were created to tackle such issues. Fast dissolving films were invented for the patients who have swallowing issues with conventional/traditional oral solid dosage forms. They also have a quick onset of effect, taking only a few seconds, because the drug is absorbed directly from the injection site to the systemic circulation, avoiding first-pass metabolism. In the preparation of films, polymers, surfactants, flavoring agents, coloring agents, sweetening agents, saliva stimulating agents, drug, and plasticizer are used. The drug incorporated in ODF should have pleasing taste, low molecular weight, high stability, and high aqueous solubility. Solvent and semisolid casting, hot melt extrusion, and rolling techniques are routinely used to prepare ODFs. Thickness, loss on drying, tensile strength, and elongation percentage are commonly assessed for evaluating ODFs, as well as their resistance to tearing, weight variation, folding endurance, pH, swelling property, transparency, disintegration, dissolution rate, and stability. The purpose of this review article is to provide a quick overview of ODF delivery systems.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140440943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Effective Treatment of Chronic Skin Allergy using Chlorpheniramine 使用氯苯那敏有效治疗慢性皮肤过敏综述

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2024-02-22 DOI: 10.52711/0975-4377.2024.00013

Nikhil Rathore, Abhishek Taiger, Suruchi Prasad

引用次数: 0

Formulation and Evaluation of Herbal Toothpaste 草药牙膏的配制与评估

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2024-02-22 DOI: 10.52711/0975-4377.2024.00004

D. Sunitha, M. Sudhakar, G. Abhigna, G. Deevena, J. Deekshitha, J. Swapna, J. Shreya

引用次数: 0

Recent Advances on Bilayer Tablet 双层片剂的最新进展

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2024-02-22 DOI: 10.52711/0975-4377.2024.00008

Vinay R. Kothawade, Yashpal M. More, Pradnya D. Lahamge, Pallavi P. Ahire

引用次数: 0

Preparation and Optimization of Ivabradine Hydrochloride Mouth-Dissolving Tablet 盐酸伊伐布雷定口腔溶解片的制备与优化

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-11-09 DOI: 10.52711/0975-4377.2023.00040

Heramb Shahane, Rani Ghosalkar, Kedar Bavaskar, Ashish Jain

{"title":"Preparation and Optimization of Ivabradine Hydrochloride Mouth-Dissolving Tablet","authors":"Heramb Shahane, Rani Ghosalkar, Kedar Bavaskar, Ashish Jain","doi":"10.52711/0975-4377.2023.00040","DOIUrl":"https://doi.org/10.52711/0975-4377.2023.00040","url":null,"abstract":"The aim of the present work was the preparation and optimization of mouth-dissolving tablets (MDTs) of Ivabradine hydrochloride by using natural super disintegrants. The tablets were prepared using microcrystalline cellulose as diluent and aspartame as a sweetening agent along with Natural super disintegrants. The natural super disintegrants used in this study were Guar Gum and Banana powder. By using natural superdisintegrants we had saved the environment and protected our bodies from the harmful effect of synthetic superdisintegrants. The tablet was prepared by the direct compression method. The 6mm of punch was used and the tablet weight is 110 mg. The tablets were evaluated for weight variation, hardness, friability, wetting time, disintegration time (DT), and dissolution study. Different concentration of superdisintegrants was used in this formulation as 6%, 8%, and 10%. The three batches of guar gum and 3 batches of banana powder were prepared i.e., a Total of six batches were prepared. From the results obtained, it can be concluded that the tablet formulation prepared with 10% banana powder i.e., 10 mg showed fast and higher drug release (98.66%) during in vitro dissolution study. Also, the hardness, friability, dissolution rate, and assay of prepared tablets (batch F6) were found to be acceptable according to standard limits. The result was the F6 batch was optimized batch from all the batches.","PeriodicalId":20963,"journal":{"name":"Research Journal of Pharmaceutical Dosage Forms and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139281871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nourishing Hair Oil 滋养发油

Research Journal of Pharmaceutical Dosage Forms and Technology Pub Date : 2023-11-09 DOI: 10.52711/0975-4377.2023.00046

Pratik B. Dandare, Puja. N. Gayke, Ankush B. Thorat, Aniket. R. Pawar, Sandip P. Narale, Prathamesh M. Bhadane, Priynka. M. Salve, B. M. Narwate

引用次数: 0