Reproductive and Developmental Medicine最新文献_第8页

Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study 巴西坦加拉达塞拉2015年至2016年寨卡疫情后的小头症流行率：一项基于人群的研究

IF 0.8 4区医学

Reproductive and Developmental Medicine Pub Date : 2022-06-01 DOI: 10.1097/RD9.0000000000000020

J. H. da Silva, A. C. P. Terças-Trettel, Juliano André Boquett, G. V. França, A. C. Cardoso-dos-Santos, M. Atanaka, Marcelo Zagonel de Oliveira, A. P. Terra, Viviane Karoline Vivi, Lucia Andreia Nunes de Oliveira, Lucia Schaedler, Ronaldo Fernandes Santos Alves, L. Schuler‐Faccini

{"title":"Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study","authors":"J. H. da Silva, A. C. P. Terças-Trettel, Juliano André Boquett, G. V. França, A. C. Cardoso-dos-Santos, M. Atanaka, Marcelo Zagonel de Oliveira, A. P. Terra, Viviane Karoline Vivi, Lucia Andreia Nunes de Oliveira, Lucia Schaedler, Ronaldo Fernandes Santos Alves, L. Schuler‐Faccini","doi":"10.1097/RD9.0000000000000020","DOIUrl":"https://doi.org/10.1097/RD9.0000000000000020","url":null,"abstract":"Abstract Objective: Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth characteristics. Methods: Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and December 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth characteristics. Results: Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before 2015. Conclusion: This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"6 1","pages":"98 - 103"},"PeriodicalIF":0.8,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46906030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Executive Editor-in-Chief's introduction for this Special Issue 执行总编辑为本期特刊所作的介绍

IF 0.8 4区医学

Reproductive and Developmental Medicine Pub Date : 2022-06-01 DOI: 10.1097/rd9.0000000000000022

R. Finnell

引用次数: 0

Mechanical stress-induced Hippo signaling in respect to primordial follicle development and polycystic ovary syndrome pathogenesis 机械应力诱导的河马信号在原始卵泡发育和多囊卵巢综合征发病机制中的作用

IF 0.8 4区医学

Reproductive and Developmental Medicine Pub Date : 2022-04-26 DOI: 10.1097/RD9.0000000000000009

Lang Xia, Jing Du

{"title":"Mechanical stress-induced Hippo signaling in respect to primordial follicle development and polycystic ovary syndrome pathogenesis","authors":"Lang Xia, Jing Du","doi":"10.1097/RD9.0000000000000009","DOIUrl":"https://doi.org/10.1097/RD9.0000000000000009","url":null,"abstract":"Abstract Polycystic ovary syndrome (PCOS) is a heterogeneous reproductive disease that can cause infertility. The Hippo signaling pathway, a network highly conserved throughout evolution, maintains the balance between follicle proliferation and dormancy. Dynamic changes in primordial follicles cannot occur without the participation of biological signals and mechanical force; however, little is known about the mechanism by which biomechanical signaling triggers PCOS, especially in the context of primordial follicle development. To investigate the contribution of mechanical stress and the Hippo signaling pathway to the onset of PCOS, we searched the literature via the PubMed database, and inclusion and exclusion criteria were established to ensure the rigor of this research. We eventually included 54 publications in which Hippo signaling and mechanical force were suggested to play a vital role in the development of primordial follicles as well as elucidate the pathogenesis of PCOS. The Hippo pathway modulating follicle growth can be perturbed via extracellular mechanical stress caused by the stiff ovarian cortical environment in PCOS. Clinical intervention targeting the Hippo pathway can alter the activity of core Hippo members, such as the Yes-associated protein/transcriptional co-activator PDZ-binding motif complex. In some patients with PCOS, follicle overactivation can be attributed to the dysfunction of Hippo signal transduction. PCOS, a condition with various patterns, cannot be accurately explained by a single, specific mechanism. The present review identifies potential targets and therapeutic strategies for PCOS.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"6 1","pages":"121 - 128"},"PeriodicalIF":0.8,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43441469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Year-end academic review of 2021: Advances in the field of birth defect prevention and control in China as of 2021 2021年末学术综述：截至2021年我国出生缺陷防治领域进展

IF 0.8 4区医学

Reproductive and Developmental Medicine Pub Date : 2022-03-01 DOI: 10.1097/rd9.0000000000000011

He-feng Huang

引用次数: 1

Source of human oocytes for infertility treatment and fertility preservation 用于不孕症治疗和保存生育能力的人卵母细胞来源

IF 0.8 4区医学

Reproductive and Developmental Medicine Pub Date : 2022-03-01 DOI: 10.1097/RD9.0000000000000007

R. Chian

引用次数: 4

Effect of vitrification on clinical outcomes of cleavage-stage embryos with poor quality in human embryo cryopreservation 玻璃化对低温保存质量差的卵裂期胚胎临床结果的影响

IF 0.8 4区医学

Reproductive and Developmental Medicine Pub Date : 2022-03-01 DOI: 10.1097/RD9.0000000000000004

Tao Liu, Y. Lian, Ping Liu, Rong Li, Jie Yan, J. Qiao

{"title":"Effect of vitrification on clinical outcomes of cleavage-stage embryos with poor quality in human embryo cryopreservation","authors":"Tao Liu, Y. Lian, Ping Liu, Rong Li, Jie Yan, J. Qiao","doi":"10.1097/RD9.0000000000000004","DOIUrl":"https://doi.org/10.1097/RD9.0000000000000004","url":null,"abstract":"Abstract Objective: To evaluate the effect of morphologic factors on survival rate (SR), pregnancy rate (PR), and implantation rate (IR) of human embryo vitrification following frozen embryo transfer (FET) on day 3 post-ovulation. Methods: Women undergoing FET (n = 921) with embryos cryopreserved by vitrification between 2012 and 2013 were enrolled in this retrospective cohort study. Results: Embryos with >9 blastomeres yielded the highest SR of 100%. Lower SR was observed in embryos with 5 to 6 (57.5%) and 4 blastomeres (41.4%). In terms of blastomere symmetry, the SR of embryos with equally sized blastomeres was significantly higher than that of embryos with unequally sized cells (82.5% vs. 64.6%, P < 0.05). As fragmentation increased, SR decreased from 92.1% to 20.6% (P < 0.05). Significant differences were observed among groups when analyzing PR and IR according to the 3 embryonic parameters before vitrification. Embryos with 13 to 16 blastomeres yielded the highest PR (39.5%) and IR (24.1%). The PR and IR of embryos with blastomeres of equal size were significantly higher than those with unequally sized blastomeres (36.5% vs. 21.7%, 23.7% vs. 12.4%, P < 0.05). After warming, embryos with 13 to 16 blastomeres yielded the highest PR and IR (40.9% and 24.2%, respectively). The PR and IR were observed to grow with an increase in the percentage of intact blastomeres (23.2%-38.2%, 14.2%-23.2%). Conclusions: These results show that vitrification methods do not effectively improve survival outcomes for embryos of poor quality and it is needed to develop a comprehensive vitrification protocol that considers all the practical aspects, including the current limitation regarding cleavage-stage embryos of poor quality.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"6 1","pages":"20 - 25"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44562421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of fatty acids and calcium in male reproduction 脂肪酸和钙在雄性生殖中的作用

IF 0.8 4区医学

Reproductive and Developmental Medicine Pub Date : 2022-03-01 DOI: 10.1097/RD9.0000000000000003

Taniya Naz, Srinjoy Chakraborty, S. Saha

{"title":"Role of fatty acids and calcium in male reproduction","authors":"Taniya Naz, Srinjoy Chakraborty, S. Saha","doi":"10.1097/RD9.0000000000000003","DOIUrl":"https://doi.org/10.1097/RD9.0000000000000003","url":null,"abstract":"Abstract Both fatty acids (FAs) and calcium ions play important roles in contraceptive cycles via several systems. Polyunsaturated FAs (PUFAs) act as precursors for prostaglandin production and can alter the expression of numerous crucial catalysts that are involved in prostaglandin and steroid digestion. Lipids are essential components of cell membranes. A diet rich in PUFAs enhances sperm motility and viability. It also improves testis development and spermatogenesis in several domesticated animal species. Increased PUFA content in spermatozoa increases plasma membrane fluidity, which is important for fertilization. However, the major drawback of high dietary PUFA intake is that it increases the levels of reactive oxygen species in the body. An increase in reactive oxygen species levels markedly affects fertility. Calcium is an important component that acts as an intra-cellular secondary messenger and plays an important role in some of the physiological processes that occur in male gametes. Some of these processes include spermatogenesis, sperm motility, capacitation, acrosome response, and fusion of gametes. These processes are associated with calcium influx through ion protein channels. Dietary fat intake is associated with increased intestinal calcium absorption. In this review, we discuss the impact of lipids, particularly PUFAs and monounsaturated FAs, and calcium ions on male reproduction, along with their effects on each other.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"6 1","pages":"57 - 64"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49259095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

How fertility preservation guidelines have progressed worldwide: Potential implications and inspiration 生育保护指南在世界范围内的进展：潜在影响和启示

IF 0.8 4区医学

Reproductive and Developmental Medicine Pub Date : 2022-03-01 DOI: 10.1097/RD9.0000000000000010

Minxin Chen, Ying Zhang, Qingqing Cai, Shuo Zhang, R. Xu, Hua Chen, Yuan-yuan Kang, Yue Wu, R. Chian, Cong-jian Xu

{"title":"How fertility preservation guidelines have progressed worldwide: Potential implications and inspiration","authors":"Minxin Chen, Ying Zhang, Qingqing Cai, Shuo Zhang, R. Xu, Hua Chen, Yuan-yuan Kang, Yue Wu, R. Chian, Cong-jian Xu","doi":"10.1097/RD9.0000000000000010","DOIUrl":"https://doi.org/10.1097/RD9.0000000000000010","url":null,"abstract":"Abstract To summarize fertility preservation (FP) guidelines and consensus provided by medical facilities worldwide. Five reference databases (PubMed/Embase, China BioMedical Literature Database, ClinicalKey, Wanfang Data, and China Knowledge Resource Integrated) and 7 guideline databases (Guideline International Network, National Collaborating Centre for Women's and Children's Health, National Guideline Clearinghouse, The National Institute for Health and Care Excellence, Scottish Intercollegiate Guidelines Network, New Zealand Guideline Group, and Canadian Medical Association infobase) were searched. Official websites of societies were searched to find relevant guidelines and consensus, and guidelines and published systematic reviews and consensus were reviewed from inception through May 2021. A literature search was performed regarding guidance offered in professional facilities, and 304 records (including 4 in Chinese) of existing guidelines for full-text review were found. Moreover, 55 guidelines were identified after a manual search. The literature review demonstrated that FP guidance and options were unevenly distributed worldwide for women who wanted to post-pone pregnancy or had impaired fertility after gonadal toxicity. With promising cancer survival rates and diversified family decisions, more attention should be paid to the improvement and update of accessible guidelines and regulatory infrastructure to inform patients about the available options and empower them to make informed choices. Restrictions to such services can be gradually eased due to the efficacy and safety of certain FP techniques for the right candidates to initiate pregnancy conception.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"6 1","pages":"34 - 41"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43777789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Character of cell-free genomic DNA in embryo culture medium and the prospect of its clinical application in preimplantation genetic testing 胚胎培养基中游离基因组DNA的特征及其在胚胎着床前基因检测中的临床应用前景

IF 0.8 4区医学

Reproductive and Developmental Medicine Pub Date : 2022-03-01 DOI: 10.1097/RD9.0000000000000002

Caixia Lei, Xiaoxing Sun

{"title":"Character of cell-free genomic DNA in embryo culture medium and the prospect of its clinical application in preimplantation genetic testing","authors":"Caixia Lei, Xiaoxing Sun","doi":"10.1097/RD9.0000000000000002","DOIUrl":"https://doi.org/10.1097/RD9.0000000000000002","url":null,"abstract":"Abstract There is increasing evidence that cell-free DNA (cfDNA) in spent culture media (SCM) can be amplified for genetic testing. Therefore, this paper reviews the characteristics of cfDNA, including its fragment size, amount, origin, as well as some factors affecting the success rate of its amplification, together to provide researchers with a more comprehensive perspective on embryonic cfDNA. The origin of cfDNA in SCM is complicated and poses challenges to the interpretation of genetic test results. Advanced molecular techniques should distinguish between embryonic and contaminated DNA to maximize the success rate of amplification and analysis. Recent data showed that the type of culture medium, assisted hatching or not, the type of amplification kit, and fresh or thawed embryos were not related to the success rate of amplification, but the length of culture time might affect the success rate. The longer culture time, the more cfDNA is available in the SCM. Then we focused on the concordance between trophectoderm (TE), inner cell mass, whole embryo, and embryonic cfDNA. Despite successful amplification, the concordance between TE and embryonic cfDNA was low. In summary, non-invasive genetic testing using SCM could represent a major advance in future single embryo selection, however, contamination and timing for media collection are key factors affecting the results, and current noninvasive cfDNA testing should not be directly applied to clinical practice. Further research is needed to improve the methods used for testing techniques and genetic analysis to achieve greater accuracy and trace its origins before it can be used in the clinics.","PeriodicalId":20959,"journal":{"name":"Reproductive and Developmental Medicine","volume":"130 1","pages":"51 - 56"},"PeriodicalIF":0.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61786221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Executive Editor-in-Chief's introduction for This Special Issue 本期特刊执行主编介绍

IF 0.8 4区医学

Reproductive and Developmental Medicine Pub Date : 2022-03-01 DOI: 10.1097/rd9.0000000000000008

R. Chian

引用次数: 0