Purinergic Signalling最新文献_第4页

Microglial purinergic signaling in Alzheimer's disease. 阿尔茨海默病中的小胶质细胞嘌呤能信号传导

IF 2.4 4区医学

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2024-06-24 DOI: 10.1007/s11302-024-10029-8

Shu-Ya Mei, Ning Zhang, Meng-Jing Wang, Pei-Ran Lv, Qi Liu

{"title":"Microglial purinergic signaling in Alzheimer's disease.","authors":"Shu-Ya Mei, Ning Zhang, Meng-Jing Wang, Pei-Ran Lv, Qi Liu","doi":"10.1007/s11302-024-10029-8","DOIUrl":"10.1007/s11302-024-10029-8","url":null,"abstract":"Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease. The prevalent features of AD pathogenesis are the appearance of β-amyloid (Aβ) plaques and neurofibrillary tangles, which cause microglial activation, synaptic deficiency, and neuronal loss. Microglia accompanies AD pathological processes and is also linked to cognitive deficits. Purinergic signaling has been shown to play a complex and tight interplay with the chemotaxis, phagocytosis, and production of pro-inflammatory factors in microglia, which is an important mechanism for regulating microglia activation. Here, we review recent evidence for interactions between AD, microglia, and purinergic signaling and find that the purinergic P2 receptors pertinently expressed on microglia are the ionotropic receptors P2X4 and P2X7, and the subtypes of P2YRs expressed by microglia are metabotropic receptors P2Y2, P2Y6, P2Y12, and P2Y13. The adenosine P1 receptors expressed in microglia include A1R, A2AR, and A2BR. Among them, the activation of P2X4, P2X7, and adenosine A1, A2A receptors expressed in microglia can aggravate the pathological process of AD, whereas P2Y2, P2Y6, P2Y12, and P2Y13 receptors expressed by microglia can induce neuroprotective effects. However, A1R activation also has a strong neuroprotective effect and has a significant anti-inflammatory effect in chronic neuroinflammation. These receptors regulate a variety of pathophysiological processes in AD, including APP processing, Aβ production, tau phosphorylation, neuroinflammation, synaptic dysfunction, and mitochondrial dysfunction. This review also provides key pharmacological advances in purinergic signaling receptors.","PeriodicalId":20952,"journal":{"name":"Purinergic Signalling","volume":" ","pages":"815-827"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role and recent progress of P2Y12 receptor in cancer development. P2Y12 受体在癌症发展中的作用和最新进展。

IF 2.4 4区医学

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2024-06-14 DOI: 10.1007/s11302-024-10027-w

Yanni Xi, Zhenya Min, Mianxue Liu, Xueqin Lin, Zhao-Hua Yuan

引用次数: 0

Role of the P2X7 receptor in breast cancer progression. P2X7 受体在乳腺癌进展中的作用。

IF 2.4 4区医学

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2024-07-23 DOI: 10.1007/s11302-024-10039-6

Yanan Du, Yahui Cao, Wei Song, Xin Wang, Qingqing Yu, Xiaoxiang Peng, Ronglan Zhao

{"title":"Role of the P2X7 receptor in breast cancer progression.","authors":"Yanan Du, Yahui Cao, Wei Song, Xin Wang, Qingqing Yu, Xiaoxiang Peng, Ronglan Zhao","doi":"10.1007/s11302-024-10039-6","DOIUrl":"10.1007/s11302-024-10039-6","url":null,"abstract":"Breast cancer is a common malignant tumor, whose incidence is increasing year by year, and it has become the malignant tumor with the highest incidence rate in women. Purine ligand-gated ion channel 7 receptor (P2X7R) is a cation channel receptor with Adenosine triphosphate ( ATP) as a ligand, which is widely distributed in cells and tissues, and is closely related to tumorigenesis and progression. P2X7R plays an important role in cancer by interacting with ATP. Studies have shown that P2X7R is up-regulated in breast cancer and can promote tumor invasion and metastasis by activating the protein kinase B (AKT) signaling pathway, promoting epithelial-mesenchymal transition (EMT), controlling the generation of extracellular vesicle (EV), and regulating the expression of the inflammatory protein cyclooxygenase 2 (COX-2). Furthermore, P2X7R was proven to play an essential role in the proliferation and apoptosis of breast cancer cells. Recently, inhibitors targeting P2X7R have been found to inhibit the progression of breast cancer. Natural P2X7R antagonists, such as rhodopsin, and the isoquinoline alkaloid berberine, have also been shown to be effective in inhibiting breast cancer progression. In this article, we review the research progress of P2X7R and breast cancer intending to provide new targets and directions for breast cancer treatment.","PeriodicalId":20952,"journal":{"name":"Purinergic Signalling","volume":" ","pages":"791-799"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation. 星形胶质细胞 P2X7 受体调节小鼠在急性应激刺激下的抑郁样行为反应

IF 2.4 4区医学

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2024-09-26 DOI: 10.1007/s11302-024-10047-6

Xin-Yi Cheng, Wen-Jing Ren, Xuan Li, Jan M Deussing, Peter Illes, Yong Tang, Patrizia Rubini

{"title":"Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation.","authors":"Xin-Yi Cheng, Wen-Jing Ren, Xuan Li, Jan M Deussing, Peter Illes, Yong Tang, Patrizia Rubini","doi":"10.1007/s11302-024-10047-6","DOIUrl":"10.1007/s11302-024-10047-6","url":null,"abstract":"Acute stress causes depressive-like reactions in the tail suspension (TST) and forced swim tests (FST) of mice. Similarly, inescapable foot shock is able to promote the development of anhedonia as indicated by decreased sucrose consumption of treated mice in the sucrose preference test (SPT). The astrocyte-specific deletion of the P2X7R by a conditional knockout strategy or its knockdown by the intracerebroventricular (i.c.v.) delivery of an adeno-associated virus (AAV) expressing P2X7R-specific shRNA in astrocytes significantly prolonged the immobility time in TST and FST. In contrast, the shRNA-induced downregulation of the P2X7R in neurons, oligodendrocytes, or microglia had no detectable effect on the behavior of treated mice in these tests. Moreover, sucrose consumption in the SPT was not altered following inescapable foot shock treatment in any of these cell type-specific approaches. Immunohistochemistry indicated that the administered astrocyte-specific AAV efficiently conveyed expression of shRNA by hippocampal CA1 astrocytes, but not by neurons. In conclusion, P2X7R in astrocytes of this area of the brain appears to be involved in depressive-like reactions to acute stressors.","PeriodicalId":20952,"journal":{"name":"Purinergic Signalling","volume":" ","pages":"687-694"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats. 治疗穴位中的 CD39 活性有助于针灸对关节炎大鼠的镇痛机制。

IF 2.4 4区医学

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2024-11-15 DOI: 10.1007/s11302-024-10065-4

Yu-Jia Li, Jie Lin, Si-Qi Tang, Wei-Min Zuo, Guang-Hong Ding, Xue-Yong Shen, Li-Na Wang

{"title":"CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats.","authors":"Yu-Jia Li, Jie Lin, Si-Qi Tang, Wei-Min Zuo, Guang-Hong Ding, Xue-Yong Shen, Li-Na Wang","doi":"10.1007/s11302-024-10065-4","DOIUrl":"10.1007/s11302-024-10065-4","url":null,"abstract":"Our previous work had identified that at the acupuncture point (acupoint), acupuncture-induced ATP release was a pivotal event in the initiation of analgesia. We aimed to further elucidate the degradation of ATP by CD39. Acupuncture was administered at Zusanli acupoint on arthritis rats, and pain thresholds of the hindpaws were determined. Pharmacological tools or adeno-associated viruses were administered at the acupoints to interfere with targeting signals. Protein expression was determined with qRT-PCR, WB, or immunofluorescent labeling. Cultured keratinocytes, HaCaT line, were subjected to hypotonic shock to simulate needling stimulation. Extracellular ATP and adenosine levels were quantified using luciferase-luciferin assay and ELISA, respectively. Acupuncture-induced prompt analgesia was impaired by inhibiting CD39 activities to prevent the degradation of ATP to AMP but was mimicked by using CD39 agonists. Acupuncture-induced ATP accumulation exhibited synchronous changes. Similarly, acupuncture analgesia was hindered by suppressing CD73 to prevent the conversion of AMP to adenosine. Furthermore, the acupuncture effect was replicated by agonism at P2Y2Rs but inhibited by antagonism at them. Acupuncture upregulated CD73 and P2Y2Rs but not CD39. Immunofluorescent labeling demonstrated that keratinocytes were a primary site for these proteins. Shallow acupuncture also demonstrated antinociception. In vitro tests showed that hypotonic shock induced HaCaT cells to release ATP and adenosine, which was impaired by suppressing CD39 and CD73, respectively. Finally, agonism at P2Y2Rs promoted ATP release and [Ca2+]i rise. CD39 at the acupoints contributes to the analgesic mechanism of acupuncture. It may facilitate adenosine signaling in conjunction with CD73 or provide an appropriate ATP milieu for P2Y2Rs. Skin tissue may be one of the scenes for these signalings.","PeriodicalId":20952,"journal":{"name":"Purinergic Signalling","volume":" ","pages":"577-592"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of P2X7 receptor in retinal diseases. P2X7受体在视网膜疾病中的治疗潜力。

IF 2.4 4区医学

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2025-07-04 DOI: 10.1007/s11302-025-10104-8

Min Wen, Qin Xu, Jinfeng Xie, Rong Wu, Xiaomei Chen, Nianlian Wen, Sheng Huang

{"title":"Therapeutic potential of P2X7 receptor in retinal diseases.","authors":"Min Wen, Qin Xu, Jinfeng Xie, Rong Wu, Xiaomei Chen, Nianlian Wen, Sheng Huang","doi":"10.1007/s11302-025-10104-8","DOIUrl":"10.1007/s11302-025-10104-8","url":null,"abstract":"Retinal diseases affect the health of millions of people worldwide and activated P2X7 receptors (P2X7Rs) are associated with the pathophysiology of a variety of retina-related diseases, including diabetic retinopathy, age-related macular degeneration, and glaucoma. Increasing evidence indicated that P2X7R is over-activated in retinopathy and is involved in the occurrence and development of diabetic retinopathy. Purine vasotoxicity caused by over-activation of P2X7R can lead to decreased retinal blood flow and vascular dysfunction and activation of P2X7R can lead to the production of a large number of inflammatory factors, causing local inflammatory cells to infiltrate and form a vascular microenvironment, thus constituting the pathophysiological basis for the occurrence and development of retinopathy. A variety of P2X7R antagonists have been studied in clinical trials as potential treatments for retinal diseases. However, currently no P2X7R antagonists has been approved for retina diseases. In this review, we mainly focus on recent progress on the involvement of P2X7R in retinal diseases and its therapeutic potential in the future.","PeriodicalId":20952,"journal":{"name":"Purinergic Signalling","volume":" ","pages":"863-871"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

P2Y₁₄ receptors: a new target for treating ulcerative colitis. P2Y14 受体：治疗溃疡性结肠炎的新靶点。

IF 2.4 4区医学

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2024-05-09 DOI: 10.1007/s11302-024-10017-y

Yan-Qin Zuo, Yong Tang

引用次数: 0

Electroacupuncture alleviates capsaicin-induced rectal visceral pain in rats via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway. 电针通过阻断p2x4r激活的p38通路，抑制TRPV1的表达，减轻辣椒素诱导的大鼠直肠内脏疼痛。

IF 2.4 4区医学

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2025-06-25 DOI: 10.1007/s11302-025-10100-y

Yahong Xue, Qinbing Zhu, Jing Zhang, Xiaofeng Wang

{"title":"Electroacupuncture alleviates capsaicin-induced rectal visceral pain in rats via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway.","authors":"Yahong Xue, Qinbing Zhu, Jing Zhang, Xiaofeng Wang","doi":"10.1007/s11302-025-10100-y","DOIUrl":"10.1007/s11302-025-10100-y","url":null,"abstract":"Electroacupuncture (EA), as a combination of traditional acupuncture and modern electrotherapy, and has analgesic effects on various acute and chronic pain. It has been proved to ameliorate chronic visceral pain, but its specific role in rectal visceral pain remains underexplored. A capsaicin (CAP)-induced visceral pain rat model was established, and behavioral pain responses were observed and recorded. Measurement of mechanical pain threshold was performed using electronic Von Frey system. Rectal tissues, and the activity of microglia cells were detected by Hematoxylin/eosin staining and immunofluorescence, respectively. Contents of interleukin (IL)-6, IL-1β and tumor necrosis factor-α (TNF-α) were determined by enzyme-linked immunosorbent assay. Western blot was performed to determine the expressions of P2X4 receptor (P2X4R), p38 mitogen-activated protein kinase (p38), phosphorylated p38 (p-p38), transient receptor potential vanilloid-1 (TRPV1) and ionized calcium binding adapter molecule 1 (Iba-1). Transfection efficiency of TRPV1 overexpression plasmids was examined by quantitative real-time polymerase chain reaction. EA abrogated CAP-induced upregulation of behavioral pain responses and mechanical threshold, damage on rectal tissue, activation of microglia, stimulation of inflammatory response and promotion of P2X4R-p38-TRPV1 pathway expressions in rats, while P2X4R activation reversed the effect of EA. P2X4R antagonist weakened CAP-induced upregulation of P2X4R-p38-TRPV1 pathway expressions, microglia activation as well as increase of IL-1β in HMO6 cells, which was reversed by TRPV1 overexpression. Collectively, EA improves CAP-induced rectal visceral pain via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway in microglia. However, the specificity role of P2X4R needs to be confirmed by more experiment.","PeriodicalId":20952,"journal":{"name":"Purinergic Signalling","volume":" ","pages":"565-576"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine. 嘌呤能 P2X7 受体参与小檗碱的抗视网膜光损伤作用

IF 2.4 4区医学

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2024-03-15 DOI: 10.1007/s11302-024-09999-6

Shan-Shan Ye, Jia-Ning Wang, Ya-Fei Zhao, Le-Shu Dai, Ji-Zhou Zhang, Yan-Qin Zuo, Jian-Tao Song

{"title":"Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine.","authors":"Shan-Shan Ye, Jia-Ning Wang, Ya-Fei Zhao, Le-Shu Dai, Ji-Zhou Zhang, Yan-Qin Zuo, Jian-Tao Song","doi":"10.1007/s11302-024-09999-6","DOIUrl":"10.1007/s11302-024-09999-6","url":null,"abstract":"Berberine (BBR) is a Chinese herb with antioxidant and anti-inflammatory properties. In a previous study, we found that BBR had a protective effect against light-induced retinal degeneration in BALB/c mice. The purinergic P2X7 receptor (P2X7R) plays a key role in retinal degeneration via inducing oxidative stress, inflammatory changes, and cell death. The aim of this study was to investigate whether BBR can induce protective effects in light damage experiments and whether P2X7R can get involved in these effects. C57BL/6 J mice and P2X7 knockout (KO) mice on the C57BL/6 J background were used. We found that BBR preserved the outer nuclear layer (ONL) thickness and retinal ganglion cells following light stimulation. Furthermore, BBR significantly suppressed photoreceptor apoptosis, pro-apoptotic c-fos expression, pro-inflammatory responses of Mϋller cells, and inflammatory factors (TNF-α, IL-1β). In addition, protein levels of P2X7R were downregulated in BBR-treated mice. Double immunofluorescence showed that BBR reduced overexpression of P2X7R in retinal ganglion cells and Mϋller cells. Furthermore, BBR combined with the P2X7R agonist BzATP blocked the effects of BBR on retinal morphology and photoreceptor apoptosis. However, in P2X7 KO mice, BBR had an additive effect resulting in thicker ONL and more photoreceptors. The data suggest that the P2X7 receptor is involved in retinal light damage, and BBR inhibits this process by reducing histological impairment, cell death, and inflammatory responses.","PeriodicalId":20952,"journal":{"name":"Purinergic Signalling","volume":" ","pages":"675-685"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140137145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional role of P2X7 purinergic receptor in cancer and cancer-related pain. P2X7 嘌呤能受体在癌症和癌症相关疼痛中的功能作用

IF 2.4 4区医学

Purinergic Signalling Pub Date : 2025-08-01 Epub Date: 2024-05-21 DOI: 10.1007/s11302-024-10019-w

Yong-Sheng Xu, Jun Xiang, Si-Jian Lin

{"title":"Functional role of P2X7 purinergic receptor in cancer and cancer-related pain.","authors":"Yong-Sheng Xu, Jun Xiang, Si-Jian Lin","doi":"10.1007/s11302-024-10019-w","DOIUrl":"10.1007/s11302-024-10019-w","url":null,"abstract":"Numerous studies have revealed that the ATP-gated ion channel purinergic 2X7 receptor (P2X7R) plays an important role in tumor progression and the pathogenesis of cancer pain. P2X7R requires activation by extracellular ATP to perform its regulatory role functions. During tumor development or cancer-induced pain, ATP is released from tumor cells or other cells in the tumor microenvironment (such as tumor-associated immune cells), which activates P2X7R, opens ion channels on the cell membrane, affects intracellular molecular metabolism, and regulates the activity of tumor cells. Furthermore, peripheral organs and receptors can be damaged during tumor progression, and P2X7R expression in nerve cells (such as microglia) is significantly upregulated, enhancing sensory afferent information, sensitizing the central nervous system, and inducing or exacerbating pain. These findings reveal that the ATP-P2X7R signaling axis plays a key regulatory role in the pathogenesis of tumors and cancer pain and also has a therapeutic role. Accordingly, in this study, we explored the role of P2X7R in tumors and cancer pain, discussed the pharmacological properties of inhibiting P2X7R activity (such as the use of antagonists) or blocking its expression in the treatment of tumor and cancer pain, and provided an important evidence for the treatment of both in the future.","PeriodicalId":20952,"journal":{"name":"Purinergic Signalling","volume":" ","pages":"801-813"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0