Research Journal of Pharmacology and Pharmacodynamics最新文献

{"title":"A Review on Antibacterial Activity of Curry Leaf","authors":"Pallavi B. Jire, Mayuri V. Khairnar, Mayuri V. Mali, Sulbha G. Patil","doi":"10.52711/2321-5836.2023.00024","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00024","url":null,"abstract":"A versatile plant is Murraya koenigii. It belongs to the family Rutaceae. The plant is also known as Meethi neem or Curry Leaf/Kari pataa. India is the plant’s native country. The world’s tropical and subtropical regions are where it is found and dispersed. The entire plant can be used to treat and cure a variety of illnesses. Beneficial for creating cosmetic and medicinal formulations. The plant has numerous Important phytochemicals, vitamins, and nutrients. Moreover, it has a wealth of nutrients and minerals. Due to the existence of these important chemical constituents (K, S, Ca, Zn, Fe, and Mg), the plant contains numerous minerals. Pharmaceutical effects such as anti-inflammatory, antipyretic, hypoglycaemic, ulcer-preventing, and wound-healing Insecticidal, anti-oxidant, hypocholesterolaemia, and helpful for improving memory are some more uses. Anti-fungal, anti-microbial, etc. This study's primary objective was to disseminate information about plants. Advantages/use for pharmaceutical and dietary purposes.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135999049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Stem Cell Therapy and its Various Aspects","authors":"Ganesh G. Dhakad, Bhagyashri O. Fate, Amruta R. Pandav, Abhijit V. Shrirao, N. Kochar, A. Chandewar","doi":"10.52711/2321-5836.2023.00016","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00016","url":null,"abstract":"Stem cells have the ability to differentiate into specific cell types. The two defining characteristics of a stem cell are perpetual self-renewal and the ability to differentiate into a specialized adult cell type. There are two major classes of stem cells: pluripotent that can become any cell in the adult body, and multipotent that are restricted to becoming a more limited population of cells. Cell sources, characteristics, differentiation and therapeutic applications are discussed. Stem cells have great potential in tissue regeneration and repair but much still needs to be learned about their biology, manipulation and safety before their full therapeutic potential can be achieved.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87341375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Anti-Inflammatory Property between Conventional drugs and Ayurvedic Preparations-an in vitro study","authors":"J. Lakshmi, A. Saritha","doi":"10.52711/2321-5836.2023.00011","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00011","url":null,"abstract":"Numerous medicinal products are used in the traditional medical systems in India. An alternative medicine for the treatment of various diseases is getting more popular now a days. Many medicinal plants provide relief of symptoms comparable to that of obtained from allopathic medicines. Therefore, agents of natural origin with very little side effects are required as substitute chemicals therapeutics. The Ayurvedic preparations include Rheumartho and Rheumatil (200µg/ml, 300µg/ml, and 450µg/ml) was investigated for anti- inflammatory effects in in vitro method. Inhibition of albumin denaturation was adopted for the in-vitro anti-inflammatory activity. The ayurvedic drugs were effective in inhibiting the heat induced haemolysis at different concentrations. The results revealed that ayurvedic preparations (Rheumatil and Rheumartho) at concentration 200 µg/ml, 300µg/ml reduces the inflammation significantly (P<0.01) compared to the control. From this study, it was concluded that ayurvedic preparations (Rheumartho and Rheumatil) possess anti- inflammatory with lesser side effects and more beneficial effects.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89744174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locomotor activity on zebra fish model using methanolic extract of Erigeron bonariensis L.","authors":"Sudipta Rani Bera, Suman Pattanayak, Lakshmi Kanta Kanthal, Ghalib Iqubal, Shyamal Manna, Sk Sayan Gazal, Souvik Hanra","doi":"10.52711/2321-5836.2023.00009","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00009","url":null,"abstract":"Erigeron bonariensis commonly known as Gulava has been used for thousands of year in the ayurveda for its various chemical constituent. This study was conducted to evaluate the locomotor activity of Erigeron bonariensis on zebrafish models as the locomotor behaviour of zebrafish has been widely used to study neuro-behaviour. The plant was collected and authenticated by botanical survey of India, Kolkata. The aerial parts of E. bonariensis were extracted using of methanol by maceration method and phytochemical tests were performed as per standard procedure. Then fishes were divided into 4 Groups of 6 animals each (n=6). Group 1 – served as control, Group 2 Group 3 and Group 4 – were treated with test substance at three dose (1 mg/ml, 2 mg/ml, 4 mg/ml) levels. Thenwe observed locomotor activity including total distance travelled, speed to evaluate the impact of E. bonariensis on the adult Zebra fish. The study showed the presence of glycosides, flavonoids, Amino acid, tannins and absence of Alkaloids, carbohydrates and saponin. The zebrafish was treated with methanolic extract of E. bonariensis which showed increase in locomotor activity. The extract did not show any kind of toxic effect during and after the observation period. Results in this study showed that CNS stimulating activity was found in E. bonariensis.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76992781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on pharmacological activities of Eleocarpus Serratus","authors":"Ananda N.V, Shekshavali T, Soundarya M","doi":"10.52711/2321-5836.2023.00013","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00013","url":null,"abstract":"E. serratus tropical flowering tree belong to the family elaeocarpaceae. The fruit of the tree is frequently consumed by people and is also used in folk medicine. It is also known as Ceylon olive. According to studies, E. serratus has anti-diarrheal, analgesic and anti-arthritic properties. Investigations on other effects such as antioxidants, Antimelanogenesis and antimicrobial studies have also been conducted. The present review is an effort to give detailed survey of the literature on photochemistry of E. serratus.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74777794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Butea monosperma Plant and Its Medicinal Use","authors":"Ganesh G. Dhakad, Sayali V. Ganjiwale, Shweta M. Nawghare, Abhijit V. Shrirao, N. Kochar, A. Chandewar","doi":"10.52711/2321-5836.2023.00014","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00014","url":null,"abstract":"Butea monosperma (Lam.) Kuntze (Syn. Butea frondosa; Family Fabaceae), This is a moderate sized deciduous tree which is widely distributed throughout India, Burma and Ceylon, popularly known as 'dhak' or 'palas', commonly known as ‘Flame of forest’. The family Fabaceae compromises of 630 genera and 18,000 species. The crude extracts of various parts and pure isolates of Butea monosperma was reported to possess antibacterial, antifungal, hypoglycemic, anti-inflammatory activities. Butea monosperma have been found to possess tonic, astringent, aphrodisiac and diuretics properties. The widespread uses of Butea monosperma in traditional systems of medicine have resulted in their extensive chemical analysis for their bio-active principles. This article briefly reviews the botany, chemistry and pharmacology of Butea monosperma (Lam) Kuntze. It is evident that without nature human being life is impossible. There are three basic necessity of humans is food, clothes and shelter and now the fourth one is good health, which provided by plant kingdom. Nature stands a golden mark and provided the storehouse of remedies to cure all ailments of mankind. Plant kingdom represents a rich house of organic compounds, many of which have been used for medicinal purposes and could serve as lead for the development of novel agents having good efficacy in various pathological disorders in the coming years. Herbs have always been the principal form of medicine in India and presently they are becoming popular throughout the world, as people strive to stay healthy in the face of chronic stress and pollution, and to treat illness with medicines that work in count with the body’s own defence.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85547320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Evaluation of Benincasa Hispida Cogn. Fruit on Chronic Foot Shock Induced Stress in Mice","authors":"Anjali M. Wankhade, Manish M. Wanjari, Rupali Dhuldhar, Umair Akhtar","doi":"10.52711/2321-5836.2023.00010","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00010","url":null,"abstract":"Stress can be defined as a brain-body reaction towards stimuli arising from the environment or from internal cues that are interpreted as a disruption of homeostasis. A number of reports indicated that treatment with herbal plant extracts could lead to a significant reduction in stress. The aim of this study was to evaluate the antistress activity through Inescapable electric chronic foot shock model in mice and to assess the effect of extract on stress induced behavioral changes in animals and to determine the efficiency of Benincasa hispida Cogn. Extract on Motor activity and Elevated plus maze to assess anxiety. In this study, mice were divided into five groups with five animals each. The first group received ip dose of the vehicle saline (2ml/kg). The second group received diazepam 1mg/kg ip along with foot shock. Third, fourth, and fifth groups received oral dose of 100, 200, and 400 mg /kg of fruit extract of Benincasa hispida along with foot shock. Inescapable electricFoot-shocks (intensity 0.8mA, interval: 10sec, duration:10sec) were delivered through a grid floor once daily for 21 days. The results showed that Benincasa hispida extract (200 and 400mg/kg) was found to have an antistress effect. The dose of Benincasa hispida extract (200 and 400mg/kg), increased entries into open arm and the time spend in open arm on the elevated plus maze test indicate that extract reduced the stress level and it significantly reduced the spontaneous motor activity and decreased the anxiety. The results suggest that the ethanolic extract of Benincasa hispida has potential antistress effect that can be explored for therapeutic advantage as an alternative treatment in medical conditions.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"135 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89145788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Introduction to Quality Assurance","authors":"Divyashree Kantilal Patil, Divyani Rajendra Patil, Sunila A. Pati","doi":"10.52711/2321-5836.2023.00015","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00015","url":null,"abstract":"Quality assurance (QA) is the management technique used to provide adequate confidence that a product, service, or result will satisfy requirements for quality and be fit for use. Each monitoring program or assessment must strive to generate data that is precise, dependable, and sufficient for the specified purpose. Data quality objectives are qualitative and quantitative standards that are used to create a system that will keep the level of uncertainty within permitted boundaries and at an acceptable level. Quality assurance will boost public and funding body confidence. Unconfirmed observations should not be used until they can be verified. Robust pharmaceutical quality assurance system ensures that products are effective and safe. Following good manufacturing practices (GMP) and enacting comprehensive inspection policies help drug manufacturers produce the highest quality products and avoid reputation-damaging incidents. Product Quality Review (PQR) is a mechanism to ensure that data captured by the Pharmaceutical Quality System (PQS) is reviewed for trends. This tool can support a continuous improvement environment. PQRs are designed for the purpose of identifying and implementing recommendations for required improvements. Quality control and quality assurance jobs are all about ensuring the medication has been manufactured correctly and is safe to use, as well as having its desired effect. Without these two functions of quality management, a pharmaceutical organisation would struggle to achieve consistency in its output. Quality assurance (QA) is any systematic process of determining whether a product or service meets specified requirements. QA establishes and maintains set requirements for developing or manufacturing reliable products.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80407537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on medicinal Use of Pumpkin Seed on Human Health","authors":"Ganesh G. Dhakad, Megha S. Nannaware, Gauri V. Wagh, Abhijit V. Shrirao, N. Kochar, A. Chandewar","doi":"10.52711/2321-5836.2023.00012","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00012","url":null,"abstract":"The pumpkin belongs to the family of Cucurbitaceae, is a well-known edible plant that has been frequently used as functional food or herbal medicine. Pumpkins contain rich unsaturated fatty acids, phytoestrogens and vitamins E in their seeds that have potential pharmaceutical, nutraceutical, and cosmeceutical properties. Information regarding their nutritional components and therapeutic properties of pumpkin seeds has expanded dynamically in the recent years and this review focus on the three main components of pumpkin seeds that described before. Several types of unsaturated fatty acids are the dominant component in pumpkin seeds which can play a role in the disease prevention and promote health. Pumpkin seeds also contain the important phytoestrogen compounds, i.e., secoisolariciresinol and lariciresinol that have estrogenic-like effect such as preventing hyperlipidemia and osteoporosis for menopausal women. Phytoestrogens in pumpkin seeds also could be related to a reduced hormone-dependent tumor. Pumpkin seeds are rich in vitamin E contents as an emerging free radical scavenger, anti-aging and antioxidant such as a-tocopherol and g-tocopherol. Findings of these studies prove that patents field for the innovation product of pumpkin seeds holds promise for the future along with their immense nutraceutical properties.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"14 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78029174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Silver Nanoparticles","authors":"Varsha S. Marathe, Akanksha P. Nikum, Gautam S. Marathe, Sulbha G. Patil","doi":"10.52711/2321-5836.2023.00017","DOIUrl":"https://doi.org/10.52711/2321-5836.2023.00017","url":null,"abstract":"Nanoparticles are defined as particulate dispersions or solid particles with a size between 10 and 1000 nm. A one billionth of a metre scale is the simplest unit of measurement for nanotechnology. Silver nanoparticles superiority over silver in bulk forms is primarily due to the size, shape, composition, crystallinity, and structure of AgNPs. Silver nanoparticles synthesis can be achieved by physical, chemical and green methods. Evaporation-condensation and laser ablation processes are used in the physical synthesis of silver nanoparticle. Evaporation-condensation has been used to create a number of metal nanoparticles in the past, including fullerene, lead sulphide, cadmium sulphide, gold, and silver. Chemical reduction, photo-induced reduction, micro-emulsion, microwave-assisted synthesis, UV-initiated photo-reduction, electrochemical synthetic technique, and irradiation procedures are some of the chemical processes utilised to create nanoparticles. The temperature, pH, concentration, type of precursor, reducing and stabilising agents, and the molar ratio of surfactant and precursor are some of the reaction parameters that control how NPs form and grow in the chemical method. Utilizing biological organisms like bacteria, mould, algae, and plants allows for one-step synthesis. Proteins and enzymes found in plants and microbes are used in the reduction process to create nanoparticles. Silver nanoparticles function as nanoscale antennas at the plasmon resonant wavelength, boosting the strength of a nearby electromagnetic field. Raman spectroscopy, which uses molecules distinctive vibrational modes to identify them, is one spectroscopic method that benefits from the strengthened electromagnetic field. The plasmonic Au/Ag hollow-shelled NIR SERS probes were put together on silica nanospheres, which showed a redshift in the plasmonic extinction band in the NIR optical window region (700–900 nm). Animal tissues that were 8 mm deep showed a measurable signal in the NIR-SERS nanoprobe signals for single particle detection. Silver nanoparticles size-tunable absorption spectra can be used to multiplex optical attributes for point-of-care diagnostics. Silver nanoparticles have antimicrobial, anti-neoplastic, antioxidant, and antidiabetic activity. Silver nanoparticles also shows some kind of toxicity like Oral toxicity, Immunotoxicity, Neurotoxicity, Environmental toxicity, Reproductive toxicity etc.","PeriodicalId":20945,"journal":{"name":"Research Journal of Pharmacology and Pharmacodynamics","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81435902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}