Respiratory investigation最新文献

{"title":"Corrigendum to 'Tumor cavitation at durvalumab initiation predicts poor survival in stage III NSCLC after concurrent chemoradiotherapy: A single-center retrospective cohort study' [Respir Investig 64/5 (2026) 101503].","authors":"Hiroaki Ota, Shota Sogabe, Yosuke Murakami, Kazuki Uchida, Takafumi Kawabata, Yuri Hiramatsu, Mitsukuni Sakabe, Katsuya Cho, Ryuta Yamamoto, Ryunosuke Ooi, Takeya Sugimoto, Kohei Yoshimine, Saori Nishizawa, Hiromi Ide, Minako Hanaka, Kazunori Tobino","doi":"10.1016/j.resinv.2026.101517","DOIUrl":"https://doi.org/10.1016/j.resinv.2026.101517","url":null,"abstract":"","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":" ","pages":"101517"},"PeriodicalIF":2.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Inhaled granulocyte–macrophage colony-stimulating factor for autoimmune pulmonary alveolar proteinosis: From pathogenesis to clinical practice’ [Respir Investig 64/5 (2026) 101486]","authors":"Ryushi Tazawa","doi":"10.1016/j.resinv.2026.101506","DOIUrl":"10.1016/j.resinv.2026.101506","url":null,"abstract":"","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 5","pages":"Article 101506"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of short-term, low-dose pulmonary vasodilators for chronic thromboembolic pulmonary hypertension: a retrospective pilot study","authors":"Hideki Shima,&nbsp;Takahiro Sato,&nbsp;Ichizo Tsujino,&nbsp;Shuhei Yoshikawa,&nbsp;Taku Komori,&nbsp;Junichi Nakamura,&nbsp;Isao Yokota,&nbsp;Satoshi Konno","doi":"10.1016/j.resinv.2026.101473","DOIUrl":"10.1016/j.resinv.2026.101473","url":null,"abstract":"<div><h3>Background</h3><div>Chronic thromboembolic pulmonary hypertension (CTEPH) is treated with pulmonary endarterectomy, pulmonary vasodilators (PVs), and balloon pulmonary angioplasty (BPA). PV therapy may be initiated before BPA; however, dose adjustment can delay BPA. Therefore, short-term, low-dose administration is sometimes used to enable earlier BPA; however, its efficacy and safety remain unclear.</div></div><div><h3>Methods</h3><div>Twenty patients with World Health Organization functional class III/IV CTEPH, who received low-dose PVs (riociguat or selexipag) and underwent right heart catheterization and first BPA within 60 days, were retrospectively analyzed. Hemodynamic parameters and brain natriuretic peptide (BNP) levels were compared before and after PV therapy. First-session BPA complications were evaluated.</div></div><div><h3>Results</h3><div>After a median of 18 days of therapy, mean pulmonary arterial pressure (mPAP) decreased from 42 to 40 mmHg (mean difference, −2.1 mmHg; 95% confidence limits [CL], −4.2 to −0.02; p = 0.0482), pulmonary vascular resistance (PVR) decreased from 829 to 632 dyne s·cm⁻⁵ (mean difference, −197 dyne s·cm⁻⁵; 95% CL, −227 to −117; p &lt; 0.0001), and BNP decreased from 284 to 146 pg/mL (mean difference, −139 pg/ml; 95% CL, −203 to −75; p = 0.0002). Cardiac output and cardiac index increased significantly. Higher baseline mPAP and PVR values were associated with greater reductions in the corresponding parameters. BPA-related complications occurred in four patients (20%), all of which involved hemoptysis from peripheral lesions.</div></div><div><h3>Conclusion</h3><div>Short-term, low-dose PV therapy before BPA was associated with improvements in hemodynamic parameters and BNP levels. Baseline mPAP, PVR, and cardiac index may predict treatment response. Prospective studies are needed to refine pre-BPA strategies.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 4","pages":"Article 101473"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148332650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible impact of sputum viscoelastic changes and airway fungal colonization on asthma exacerbation: Observations from 7 patients with severe asthma receiving biologics","authors":"Haruhiko Ogawa,&nbsp;Yuka Uchida","doi":"10.1016/j.resinv.2026.101385","DOIUrl":"10.1016/j.resinv.2026.101385","url":null,"abstract":"<div><div>We report a case series of 7 patients with severe asthma who initiated biologic therapy due to frequent exacerbations. Sputum viscoelasticity was measured using a benchtop rheometer (Rheomuco®). After initiation of biologic therapy, sputum viscoelastic parameters, which are affected by cytokine-induced inflammation, generally decreased. However, 5 patients with asthma exacerbations showed abnormally elevated rheological parameters in the high-strain region (HSR), particularly <em>γ</em>_C, and positive sputum fungal culture results. After initiation of low-dose itraconazole therapy, a decrease in <em>γ</em>_C and improvement in asthma symptoms were observed. Two patients with suppressed rheological parameters in HSR did not experience exacerbations. These observations raise the possibility that fungal colonization in the airway of severe asthma may contribute to asthma exacerbations. Large prospective controlled trials are needed to determine whether eradicating fungi from the airways and suppressing HSR parameters can reduce exacerbations in patients with severe asthma with fungal colonization (here designated as SAFC).</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 4","pages":"Article 101385"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific epidemiological and clinical differences in spontaneous pneumothorax: A cross-sectional cohort study in Japan","authors":"Masashi Takeda,&nbsp;Yoshifumi Sano,&nbsp;Yasutaka Ihara,&nbsp;Noriyoshi Sawabata,&nbsp;Toshiro Obuchi,&nbsp;Kenji Tsuboshima,&nbsp;Noriyuki Matsutani,&nbsp;Shouichi Okamoto,&nbsp;Hitoshi Igai,&nbsp;Akihiro Hayashi","doi":"10.1016/j.resinv.2026.101470","DOIUrl":"10.1016/j.resinv.2026.101470","url":null,"abstract":"<div><h3>Background</h3><div>Pneumothorax is less common in females than in males, presenting with distinct features, including catamenial pneumothorax (CP) and lymphangioleiomyomatosis (LAM). However, its clinical characteristics in female patients remain poorly understood. We elucidated the clinical characteristics of pneumothorax in female patients and compared them with those of male patients.</div></div><div><h3>Methods</h3><div>This nationwide observational study of 1747 patients with spontaneous pneumothorax was conducted in Japan using a large inpatient database. We characterized spontaneous pneumothorax in female patients and examined sex-specific differences in age distribution and subtype prevalence.</div></div><div><h3>Results</h3><div>A distinctive trimodal age distribution was observed among females, with the second peak predominantly corresponding to CP and LAM in females of reproductive age. Age was associated with an increased likelihood of secondary spontaneous pneumothorax compared with primary spontaneous pneumothorax, beginning at &gt;35 years in females compared with 60 years in males. Male patients exhibited a bimodal distribution, highlighting age- and sex-specific onset patterns. When CP and LAM cases were excluded, there was no substantial difference in spontaneous pneumothorax occurrence between sexes.</div></div><div><h3>Conclusions</h3><div>We highlight the importance of sex-specific evaluation of spontaneous pneumothorax. The trimodal distribution in female patients suggests different underlying mechanisms across age groups. Improved recognition of female-specific subtypes such as CP and LAM, along with multidisciplinary approaches, may lead to more accurate diagnoses and optimized management strategies.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 4","pages":"Article 101470"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Transcutaneous CO2 and O2 monitoring during walking with a high-flow nasal cannula in patients with chronic obstructive pulmonary disease” [Respir Invest, Volume 63, Issue 5, September 2025, Pages 887–897]","authors":"Akira Umeda,&nbsp;Akane Morito,&nbsp;Masahiro Ishizaka,&nbsp;Akihiro Ito,&nbsp;Yukihiro Ogawa,&nbsp;Yuki Kawai,&nbsp;Yuta Hanawa,&nbsp;Naotaka Onodera,&nbsp;Yoshiaki Endo,&nbsp;Isato Fukushi,&nbsp;Kotaro Takeda,&nbsp;Taichi Mochizuki,&nbsp;Yasushi Inoue,&nbsp;Yasuo To,&nbsp;Seiichiro Sakao,&nbsp;Kenji Tsushima,&nbsp;Kazuyuki Chibana,&nbsp;Hideaki Yamasawa,&nbsp;Satoshi Fuke,&nbsp;Sarah Kesler,&nbsp;Yasumasa Okada","doi":"10.1016/j.resinv.2025.101366","DOIUrl":"10.1016/j.resinv.2025.101366","url":null,"abstract":"","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 4","pages":"Article 101366"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the need for drainage in pleural infection: A comparison of clinical guidelines","authors":"Sunao Mikura,&nbsp;Sho Matsushita,&nbsp;Yoji Hirayama,&nbsp;Toshihiko Takada,&nbsp;Shunichi Fukuhara","doi":"10.1016/j.resinv.2026.101477","DOIUrl":"10.1016/j.resinv.2026.101477","url":null,"abstract":"<div><h3>Background</h3><div>Pleural infection requires early identification of individuals who are unlikely to respond to antibiotic therapy and may require drainage. Although several algorithms—Light's classification, the American College of Chest Physicians (ACCP) consensus statement, and the British Thoracic Society (BTS) 2003 and 2023 guidelines—are available, their predictive performance remains uncertain.</div></div><div><h3>Methods</h3><div>This retrospective diagnostic accuracy study analyzed individuals with pleural infection treated at two municipal hospitals between 2017 and 2023. Missing data were handled using multiple imputation. The outcome, the need for drainage, was defined as chest tube insertion, video-assisted thoracoscopic surgery, repeated thoracentesis with intrapleural fibrinolytic therapy, open decortication, or death attributable to pleural infection. The predictive performance of the four algorithms was evaluated using sensitivity and specificity.</div></div><div><h3>Results</h3><div>Of the 215 individuals included, 57.7% experienced the outcome. Sensitivity/specificity were 70.9/74.7% for Light's classification, 85.5/46.5% for ACCP statement, 53.1/85.9% for BTS 2003 guideline, and 68.1/70.4% for BTS 2023 guideline. Thus, ACCP statement showed the highest sensitivity but lowest specificity, whereas BTS 2003 demonstrated the opposite pattern.</div></div><div><h3>Conclusions</h3><div>The choice of algorithms should depend on clinical context: ACCP statement may be preferred when minimizing missed cases is critical, whereas BTS 2003 guideline may be more appropriate for older adults or persons with frailty, where avoiding unnecessary invasive procedures is a priority.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 4","pages":"Article 101477"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing virtual bronchoscopic navigation route to small peripheral pulmonary lesions using lateral decubitus computed tomography with ultrathin bronchoscope: A single-center retrospective study","authors":"Yuki Takigawa,&nbsp;Ken Sato,&nbsp;Kotaro Miyake,&nbsp;Keisuke Shiraha,&nbsp;Mayu Goda,&nbsp;Suzuka Matsuoka,&nbsp;Jun Nishimura,&nbsp;Hiromi Watanabe,&nbsp;Kenichiro Kudo,&nbsp;Keiichi Fujiwara","doi":"10.1016/j.resinv.2026.101474","DOIUrl":"10.1016/j.resinv.2026.101474","url":null,"abstract":"<div><h3>Background</h3><div>To evaluate the effectiveness of lateral-decubitus position computed tomography (LDCT) for bronchoscopic biopsies of peripheral pulmonary lesions (PPLs) in patients who underwent the procedure.</div></div><div><h3>Patients and methods</h3><div>In this retrospective single-center study, we included patients who underwent ultrathin bronchoscopy for PPLs after virtual bronchoscopic navigation (VBN) was conducted using supine computed tomography (SCT) and LDCT. LDCT was conducted with the target side up when bronchial route reconstruction using SCT was challenging. The primary outcome was the bronchial generation reached by VBN based on SCT and LDCT. Secondary outcomes included target lung volume, close-to-the-lesion achievement, concordance with bronchoscopic route, and specific diagnostic yield.</div></div><div><h3>Results</h3><div>Twelve patients were included in the study. The median length of the target lesion was 13 mm. The median bronchial generation reached using VBN increased from 3.5 on SCT to 5 on LDCT. The median target lung volume on SCT was 963.5 mL, which increased to 1116.5 mL on LDCT. The close-to-the-lesion method was achieved in 91.7% using an ultrathin bronchoscope. The actual bronchial routes toward the target lesions were concordant with VBN based on LDCT in 58.3%. A specific pathological diagnosis was made in 66.7% using ultrathin bronchoscopy.</div></div><div><h3>Conclusions</h3><div>LDCT may improve virtual bronchoscopic route reconstruction compared with SCT. This practical and low-risk approach may facilitate navigation planning for challenging PPLs when conventional SCT-based route reconstruction is insufficient.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 4","pages":"Article 101474"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148331818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimulation of fibroblast proliferation by growth factors from HCoV-229E-infected human nasal epithelial cells and influenza virus-infected alveolar epithelial cells: Roles of TGF-β1 and FGF-basic","authors":"Mutsuo Yamaya,&nbsp;Akiko Kikuchi,&nbsp;Xue Deng,&nbsp;Mitsuru Sugawara,&nbsp;Kazuhiro Nomura,&nbsp;Akihiko Hagino,&nbsp;Jun Suzuki,&nbsp;Haruki Momma,&nbsp;Hidekazu Nishimura,&nbsp;Ryoichi Nagatomi,&nbsp;Shin Takayama","doi":"10.1016/j.resinv.2026.101471","DOIUrl":"10.1016/j.resinv.2026.101471","url":null,"abstract":"<div><h3>Background</h3><div>The roles of transforming growth factor (TGF)-β₁, fibroblast growth factor basic (FGF-b) and interleukin (IL)-6 released from human coronavirus (HCoV)-229 E-infected human nasal epithelial (HNE) cells and 2009 pandemic influenza virus-infected type II human alveolar epithelial (A549) cells in fibroblast proliferation were studied to elucidate the early mechanisms of airway and lung remodeling initiated by viral infection through epithelial-derived activation of fibroblasts.</div></div><div><h3>Methods</h3><div>The number of human fetal lung fibroblasts (MRC-5) cocultured with virus-infected HNE cells or A549 cells, which were cultured using air−interface methods, and the levels of growth factors in supernatants were measured.</div></div><div><h3>Results</h3><div>The number of MRC-5 cells cocultured with virus-infected HNE cells or A549 cells was greater than that of MRC-5 cells cocultured with uninfected cells. Treatment of MRC-5 cells and cocultured virus-infected HNE or A549 cells with an <em>anti</em>-TGF-β₁ antibody and an <em>anti</em>-FGF-b antibody reduced the number of MRC-5 cells. The levels of TGF-β₁ and FGF-b in the supernatants of MRC-5 cells cocultured with virus-infected epithelial cells were greater than those in the supernatants of MRC-5 cells cocultured with uninfected cells. Addition of an <em>anti</em>-TGF-β₁ antibody reduced FGF-b levels after viral infection. IL-6 levels were increased in HCoV-229 E-infected HNE cells, and treatment with an <em>anti</em>-IL-6 antibody reduced the number of MRC-5 cells cocultured with HCoV-229 E-infected HNE cells. Administration of the p38 MAPK phosphorylation inhibitor SB203580 reduced the number of MRC-5 cells.</div></div><div><h3>Conclusions</h3><div>HNE cells and A549 cells may release TGF-β₁, FGF-b and IL-6, which increase fibroblast proliferation after viral infection partly via MAPK activation.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 4","pages":"Article 101471"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of allergic bronchopulmonary aspergillosis/Aspergillus sensitization in chronic obstructive pulmonary disease: A systematic review and meta-analysis","authors":"Anuj Ajayababu,&nbsp;Abin Antony,&nbsp;Bhoomit Goyal,&nbsp;Animesh Ray","doi":"10.1016/j.resinv.2026.101469","DOIUrl":"10.1016/j.resinv.2026.101469","url":null,"abstract":"<div><h3>Background</h3><div>Although classically associated with asthma and cystic fibrosis, allergic bronchopulmonary aspergillosis (ABPA) is increasingly recognized in patients with other risk factors, including COPD. This systematic review synthesizes available evidence on the association between COPD and <em>Aspergillus</em> sensitization (AS)/ABPA to determine their prevalence.</div></div><div><h3>Methods</h3><div>PubMed, Embase, SCOPUS, and Web of Science databases were searched from inception to June 30, 2025, without language restrictions. Summary data from studies reporting the proportion of COPD patients with AS or ABPA were included, while individual case reports, studies reporting misdiagnosis and those without data on prevalence were excluded. The primary outcome assessed was prevalence of ABPA/AS in patients with COPD.</div></div><div><h3>Findings</h3><div>946 records were identified from the initial search. Overall 23 original studies, eight reporting prevalence of ABPA in 1529 COPD patients and 17 reporting AS in 3505 COPD patients were included in the meta-analysis. The pooled prevalence of ABPA and <em>Aspergillus</em> sensitization in COPD patients diagnosed based on spirometry criteria was 2.1% [95% CI: 0.1%-5.8%] and 10.4% [95% CI: 7.0%-14.3%] respectively. Overall estimates of both showed significant heterogeneity [I² = 63.7% for ABPA and 83.7% for AS]. Prevalence of ABPA was higher in studies [4.4% (95% CI: 2.7%-6.3%)] using IgE <em>Aspergillus</em> as entry criteria as compared to those using other tests (skin tests, total IgE) [1.3% (95% CI: 0.0%-5.1%)].</div></div><div><h3>Interpretation</h3><div>This systematic review highlights COPD as a potentially significant risk factor for both ABPA (∼2.1%) and <em>Aspergillus</em> sensitization (∼10.4%).</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"64 4","pages":"Article 101469"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}