{"title":"两个独立队列中17年累积的气流限制和肺功能下降发生率：日本红十字会熊本研究","authors":"Yuki Sato , Ayumi Onoue , Kentaro Machida , Hiromasa Inoue , Kenichi Kubota , Minoru Yoshida , Shinsuke Tsumura , Takuya Kitagawa , Kyohei Harada , Yuichi Matsuo , Kazuhiko Watanabe , Kazuaki Kawai , Hiroshi Yamato , Hisamitsu Omori","doi":"10.1016/j.resinv.2025.06.019","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated trends in the cumulative incidence of airflow limitation (AFL) and lung function decline over 17 years in two independent cohorts. Furthermore, this study focused on the possible effects of legal restrictions that came into effect in 2006 to prevent unwanted exposure to passive smoke on lung function decline in Japan.</div></div><div><h3>Methods</h3><div>Cohort 1 (1994–2011) and Cohort 2 (2002–2019) included 590 and 1012 participants, respectively. All participants were free of AFL at baseline, and they had no personal relationships each other. The association between the longitudinal category of smoking status and the cumulative incidence of AFL was assessed using logistic regression analysis. The annual FEV<sub>1</sub> decline was compared between Cohort 1 and 2, as well as before 2006 (pre) and after 2006 (post) within both cohorts.</div></div><div><h3>Results</h3><div>After adjusting for confounding factors, the odds ratio (OR) for developing AFL increased with smoking status and intensity in both Cohort 1 and 2. The annual FEV<sub>1</sub> decline in Cohort 2 was significantly slower than that in Cohort 1 for persistent never smokers. The annual decline in FEV<sub>1</sub> after 2006 (post) was significantly slower than that before 2006 (pre) in persistent never smokers in both Cohort 1 and 2.</div></div><div><h3>Conclusions</h3><div>Smoking remains a strong risk factor for the development of AFL and lung function decline in Japan. This study suggests that changes in the smoking environment may have preventative effects on lung function decline, especially in never smokers.</div></div>","PeriodicalId":20934,"journal":{"name":"Respiratory investigation","volume":"63 5","pages":"Pages 844-852"},"PeriodicalIF":2.4000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Seventeen-year cumulative incidence of airflow limitation and lung function decline in two independent cohorts: The Japanese Red Cross Kumamoto study\",\"authors\":\"Yuki Sato , Ayumi Onoue , Kentaro Machida , Hiromasa Inoue , Kenichi Kubota , Minoru Yoshida , Shinsuke Tsumura , Takuya Kitagawa , Kyohei Harada , Yuichi Matsuo , Kazuhiko Watanabe , Kazuaki Kawai , Hiroshi Yamato , Hisamitsu Omori\",\"doi\":\"10.1016/j.resinv.2025.06.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>This study evaluated trends in the cumulative incidence of airflow limitation (AFL) and lung function decline over 17 years in two independent cohorts. Furthermore, this study focused on the possible effects of legal restrictions that came into effect in 2006 to prevent unwanted exposure to passive smoke on lung function decline in Japan.</div></div><div><h3>Methods</h3><div>Cohort 1 (1994–2011) and Cohort 2 (2002–2019) included 590 and 1012 participants, respectively. All participants were free of AFL at baseline, and they had no personal relationships each other. The association between the longitudinal category of smoking status and the cumulative incidence of AFL was assessed using logistic regression analysis. The annual FEV<sub>1</sub> decline was compared between Cohort 1 and 2, as well as before 2006 (pre) and after 2006 (post) within both cohorts.</div></div><div><h3>Results</h3><div>After adjusting for confounding factors, the odds ratio (OR) for developing AFL increased with smoking status and intensity in both Cohort 1 and 2. The annual FEV<sub>1</sub> decline in Cohort 2 was significantly slower than that in Cohort 1 for persistent never smokers. The annual decline in FEV<sub>1</sub> after 2006 (post) was significantly slower than that before 2006 (pre) in persistent never smokers in both Cohort 1 and 2.</div></div><div><h3>Conclusions</h3><div>Smoking remains a strong risk factor for the development of AFL and lung function decline in Japan. This study suggests that changes in the smoking environment may have preventative effects on lung function decline, especially in never smokers.</div></div>\",\"PeriodicalId\":20934,\"journal\":{\"name\":\"Respiratory investigation\",\"volume\":\"63 5\",\"pages\":\"Pages 844-852\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Respiratory investigation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212534525000991\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiratory investigation","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212534525000991","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Seventeen-year cumulative incidence of airflow limitation and lung function decline in two independent cohorts: The Japanese Red Cross Kumamoto study
Background
This study evaluated trends in the cumulative incidence of airflow limitation (AFL) and lung function decline over 17 years in two independent cohorts. Furthermore, this study focused on the possible effects of legal restrictions that came into effect in 2006 to prevent unwanted exposure to passive smoke on lung function decline in Japan.
Methods
Cohort 1 (1994–2011) and Cohort 2 (2002–2019) included 590 and 1012 participants, respectively. All participants were free of AFL at baseline, and they had no personal relationships each other. The association between the longitudinal category of smoking status and the cumulative incidence of AFL was assessed using logistic regression analysis. The annual FEV1 decline was compared between Cohort 1 and 2, as well as before 2006 (pre) and after 2006 (post) within both cohorts.
Results
After adjusting for confounding factors, the odds ratio (OR) for developing AFL increased with smoking status and intensity in both Cohort 1 and 2. The annual FEV1 decline in Cohort 2 was significantly slower than that in Cohort 1 for persistent never smokers. The annual decline in FEV1 after 2006 (post) was significantly slower than that before 2006 (pre) in persistent never smokers in both Cohort 1 and 2.
Conclusions
Smoking remains a strong risk factor for the development of AFL and lung function decline in Japan. This study suggests that changes in the smoking environment may have preventative effects on lung function decline, especially in never smokers.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
