发布求助
文献互助 智能选刊 最新文献

Psychopharmacology series最新文献

筛选
英文 中文
Genetic polymorphism in drug oxidation. 药物氧化中的基因多态性。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_16
W Kalow
{"title":"Genetic polymorphism in drug oxidation.","authors":"W Kalow","doi":"10.1007/978-3-642-74430-3_16","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_16","url":null,"abstract":"<p><p>Of the two clearly established drug oxidation polymorphisms, only the one referred to as debrisoquine polymorphism affects many drugs. The only known polymorphic substrates of mephenytoin hydroxylase are mephenytoin and mephobarbital. Relatively recently discovered drug substrates of debrisoquine hydroxylase are propafenone, diltiazem, and codeine. The list of substrates contains 28 items. The fate of slightly less than half of these is clinically affected in poor metabolizers, and several of the latter drugs are no longer marketed. There are many reasons why a failure of metabolism may not alter the fate of a drug sufficiently to affect its clinical use. Of interest and clinical importance is the inhibition of debrisoquine hydroxylase by inhibitors such as quinidine and by some neuroleptics; also the simultaneous use of two substrates has led to serious toxicity by mutual metabolic inhibition. The study of these oxidation polymorphisms has been instructive not only for formal pharmacogenetics but also for the understanding of problems of therapy in patients without genetic defects.</p>","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"148-62"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13828600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Effects of serotonergic agonists on neuroendocrine responses of rhesus monkeys and patients with depression and anxiety disorders. 血清素激动剂对恒河猴及抑郁焦虑障碍患者神经内分泌反应的影响。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_10
G R Heninger, D S Charney, L H Price, P Delgado, S Woods, W Goodman
{"title":"Effects of serotonergic agonists on neuroendocrine responses of rhesus monkeys and patients with depression and anxiety disorders.","authors":"G R Heninger,&nbsp;D S Charney,&nbsp;L H Price,&nbsp;P Delgado,&nbsp;S Woods,&nbsp;W Goodman","doi":"10.1007/978-3-642-74430-3_10","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_10","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"94-104"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13829347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The use of human liver banks in pharmacogenetic research. 人肝库在药物遗传学研究中的应用。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_17
C von Bahr, F P Guengerich, G Movin, C Nordin
{"title":"The use of human liver banks in pharmacogenetic research.","authors":"C von Bahr,&nbsp;F P Guengerich,&nbsp;G Movin,&nbsp;C Nordin","doi":"10.1007/978-3-642-74430-3_17","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_17","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"163-71"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13828601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Role of pharmacogenetics in drug development. 药物遗传学在药物开发中的作用。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_23
L P Balant, A E Balant-Gorgia
{"title":"Role of pharmacogenetics in drug development.","authors":"L P Balant,&nbsp;A E Balant-Gorgia","doi":"10.1007/978-3-642-74430-3_23","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_23","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"211-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13828606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theoretical and practical implications of a controlled trial of an alpha 2-adrenoceptor antagonist in the treatment of depression. α 2-肾上腺素受体拮抗剂治疗抑郁症的对照试验的理论和实践意义。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_11
S A Montgomery
{"title":"Theoretical and practical implications of a controlled trial of an alpha 2-adrenoceptor antagonist in the treatment of depression.","authors":"S A Montgomery","doi":"10.1007/978-3-642-74430-3_11","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_11","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"105-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13717757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Benzodiazepine receptor subtypes and their possible clinical significance. 苯二氮卓受体亚型及其可能的临床意义。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_14
W Sieghart
{"title":"Benzodiazepine receptor subtypes and their possible clinical significance.","authors":"W Sieghart","doi":"10.1007/978-3-642-74430-3_14","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_14","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"131-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-642-74430-3_14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13717759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Targets for neurotransmitter receptor research using PET scan: the neuroleptic binding site. PET扫描研究神经递质受体的靶点:抗精神病药结合部位。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_3
J C Baron, J L Martinot, H Cambon, J P Boulenger, M F Poirier, V Caillard, J Blin, J D Huret, C Loc'h, B Maziere
{"title":"Targets for neurotransmitter receptor research using PET scan: the neuroleptic binding site.","authors":"J C Baron,&nbsp;J L Martinot,&nbsp;H Cambon,&nbsp;J P Boulenger,&nbsp;M F Poirier,&nbsp;V Caillard,&nbsp;J Blin,&nbsp;J D Huret,&nbsp;C Loc'h,&nbsp;B Maziere","doi":"10.1007/978-3-642-74430-3_3","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_3","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"20-31"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13717761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neurotransmitter interactions as a target of drug action. 神经递质相互作用作为药物作用的靶标。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_5
W Z Potter, J K Hsiao, H Agren
{"title":"Neurotransmitter interactions as a target of drug action.","authors":"W Z Potter,&nbsp;J K Hsiao,&nbsp;H Agren","doi":"10.1007/978-3-642-74430-3_5","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_5","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"40-51"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13717767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Animal pharmacology of raclopride, a selective dopamine D2 antagonist. 选择性多巴胺D2拮抗剂raclopride的动物药理作用。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_13
H Hall, S O Ogren, C Köhler, O Magnusson
{"title":"Animal pharmacology of raclopride, a selective dopamine D2 antagonist.","authors":"H Hall,&nbsp;S O Ogren,&nbsp;C Köhler,&nbsp;O Magnusson","doi":"10.1007/978-3-642-74430-3_13","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_13","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"123-30"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-642-74430-3_13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13828598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
From animal experiments to clinical dosing: some aspects of preclinical development of antidepressants. 从动物实验到临床给药:抗抑郁药临床前开发的一些方面。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_33
A Delini-Stula
{"title":"From animal experiments to clinical dosing: some aspects of preclinical development of antidepressants.","authors":"A Delini-Stula","doi":"10.1007/978-3-642-74430-3_33","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_33","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"287-95"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13829340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信