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Hydroxy metabolites of tricyclic antidepressants: evaluation of relative cardiotoxicity. 三环抗抑郁药的羟基代谢物:相对心脏毒性的评估。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_26
B G Pollock, J M Perel
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引用次数: 18
Pharmacokinetic and clinical significance of genetic variability in psychotropic drug metabolism. 精神药物代谢遗传变异的药代动力学及临床意义。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_20
K Brøsen, L F Gram
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引用次数: 9
The potential of positron-emission tomography for pharmacokinetic and pharmacodynamic studies of neuroleptics. 正电子发射断层扫描在抗精神病药的药代动力学和药效学研究中的潜力。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_4
L Farde, F A Wiesel, L Nilsson, G Sedvall
{"title":"The potential of positron-emission tomography for pharmacokinetic and pharmacodynamic studies of neuroleptics.","authors":"L Farde, F A Wiesel, L Nilsson, G Sedvall","doi":"10.1007/978-3-642-74430-3_4","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_4","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"32-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13717766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Therapeutic drug monitoring of tricyclic antidepressants: a means of avoiding toxicity. 三环类抗抑郁药的治疗药物监测:避免毒性的一种手段。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_27
S H Preskorn
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引用次数: 7
Neuroleptic drug levels in erythrocytes and in plasma: implications for therapeutic drug monitoring. 红细胞和血浆中的抗精神病药物水平:对治疗药物监测的意义。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_28
D L Garver
{"title":"Neuroleptic drug levels in erythrocytes and in plasma: implications for therapeutic drug monitoring.","authors":"D L Garver","doi":"10.1007/978-3-642-74430-3_28","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_28","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"244-56"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13717762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical effects of selective serotonin reuptake inhibitors. 选择性血清素再摄取抑制剂的临床效果。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_9
P Bech
{"title":"Clinical effects of selective serotonin reuptake inhibitors.","authors":"P Bech","doi":"10.1007/978-3-642-74430-3_9","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_9","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"81-93"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13829346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Active metabolites of neuroleptics in plasma and CSF: implications for therapeutic drug monitoring. 血浆和脑脊液中抗精神病药的活性代谢物:治疗药物监测的意义。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_29
E Mårtensson, G Nyberg
{"title":"Active metabolites of neuroleptics in plasma and CSF: implications for therapeutic drug monitoring.","authors":"E Mårtensson, G Nyberg","doi":"10.1007/978-3-642-74430-3_29","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_29","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"257-62"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13717763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Negative symptoms in schizophrenia: a target for new drug development. 精神分裂症的阴性症状:新药开发的目标
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_8
H Y Meltzer, J Zureick
{"title":"Negative symptoms in schizophrenia: a target for new drug development.","authors":"H Y Meltzer, J Zureick","doi":"10.1007/978-3-642-74430-3_8","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_8","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"68-77"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13717768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
Inhibitors of the microsomal oxidation of psychotropic drugs: selectivity and clinical significance. 精神药物微粒体氧化抑制剂:选择性和临床意义。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_18
L F Gram, K Brøsen
{"title":"Inhibitors of the microsomal oxidation of psychotropic drugs: selectivity and clinical significance.","authors":"L F Gram, K Brøsen","doi":"10.1007/978-3-642-74430-3_18","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_18","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"172-80"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13828602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Genetic polymorphism in drug oxidation. 药物氧化中的基因多态性。
Psychopharmacology series Pub Date : 1989-01-01 DOI: 10.1007/978-3-642-74430-3_16
W Kalow
{"title":"Genetic polymorphism in drug oxidation.","authors":"W Kalow","doi":"10.1007/978-3-642-74430-3_16","DOIUrl":"https://doi.org/10.1007/978-3-642-74430-3_16","url":null,"abstract":"<p><p>Of the two clearly established drug oxidation polymorphisms, only the one referred to as debrisoquine polymorphism affects many drugs. The only known polymorphic substrates of mephenytoin hydroxylase are mephenytoin and mephobarbital. Relatively recently discovered drug substrates of debrisoquine hydroxylase are propafenone, diltiazem, and codeine. The list of substrates contains 28 items. The fate of slightly less than half of these is clinically affected in poor metabolizers, and several of the latter drugs are no longer marketed. There are many reasons why a failure of metabolism may not alter the fate of a drug sufficiently to affect its clinical use. Of interest and clinical importance is the inhibition of debrisoquine hydroxylase by inhibitors such as quinidine and by some neuroleptics; also the simultaneous use of two substrates has led to serious toxicity by mutual metabolic inhibition. The study of these oxidation polymorphisms has been instructive not only for formal pharmacogenetics but also for the understanding of problems of therapy in patients without genetic defects.</p>","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"7 ","pages":"148-62"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13828600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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