Qom Univ Med Sci J最新文献_第8页

Evaluation of Anxiety and Stress Factors before Surgery From the Perspective of Patients Undergoing Spinal Surgery in the Operating Room of Peymaniyeh Hospital in Jahrom City 2021 术前焦虑和应激因素评估——以贾罗姆市佩曼尼亚医院手术室脊柱手术患者为例

Qom Univ Med Sci J Pub Date : 2021-12-01 DOI: 10.32598/qums.15.9.2469.2

Ebrahim Nasiri Formi, Reza Khorammakan, Zohreh Khodadadi Jahromi

{"title":"Evaluation of Anxiety and Stress Factors before Surgery From the Perspective of Patients Undergoing Spinal Surgery in the Operating Room of Peymaniyeh Hospital in Jahrom City 2021","authors":"Ebrahim Nasiri Formi, Reza Khorammakan, Zohreh Khodadadi Jahromi","doi":"10.32598/qums.15.9.2469.2","DOIUrl":"https://doi.org/10.32598/qums.15.9.2469.2","url":null,"abstract":"Background and Objectives: Surgery is always a great experience for the patient because surgery of any kind is a threat to the integrity of the body and life. This study was to evaluate the factors of anxiety and stress before surgery in patients who are candidates for spine surgery. Methods: The present study is a descriptive study that was performed on 120 patients who were candidates for spine surgery in of Peymaniyeh Hospital in Jahrom City 2021. Data collection tools were theoretical questionnaire and colleagues. Data were analyzed using SPSS v.22 and descriptive statistics such as frequency, percentage and Pearson correlation coefficient. Results: The results showed that the highest level of anxiety was related to the area of preoperative anxiety (85.1)and in this area, the components of fear of surgery and not knowing the time of surgery (93.3%)and in the area of stressors in relation to Operating room staff for preoperative care also included the components of the patient being left alone until the start of surgery and the observation and encounter of strangers such as anesthesiologists and operating room nurses, causing the most anxiety (88.3%)in patients. Conclusion: Based on the findings of this study, by identifying the factors affecting preoperative anxiety and eliminating them, the amount of preoperative anxiety can be minimized. Therefore, it is suggested to use various methods to educate patients to eliminate the factors affecting anxiety.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84288790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Correlation between Health Literacy and Mental Health and Quality of Life Indicators of Inactive Elderly to Lahijan City in 2021 2021年拉海市非活动老年人健康素养与心理健康及生活质量指标的相关性研究

Qom Univ Med Sci J Pub Date : 2021-12-01 DOI: 10.32598/qums.15.9.2411

S. Khodaparast, M. Farajpour Pirbasti, V. Bakhshalipour

{"title":"Investigating the Correlation between Health Literacy and Mental Health and Quality of Life Indicators of Inactive Elderly to Lahijan City in 2021","authors":"S. Khodaparast, M. Farajpour Pirbasti, V. Bakhshalipour","doi":"10.32598/qums.15.9.2411","DOIUrl":"https://doi.org/10.32598/qums.15.9.2411","url":null,"abstract":"Background and Objectives: Health literacy can affect the quality of life of the elderly due to its role in promoting appropriate decisions in the field of mental health. this study was conducted to investigate the correlation between health literacy and mental health and quality of life indicators of inactive elderly to Lahijan City in 2021. Methods: In this descriptive-correlational study, 200 elderly people were selected from Lahijan city. Health Literacy Questionnaire (HELIA), Goldberg Mental Health Questionnaire (GQH-28) and Quality of Life Questionnaire (SF-12) were used to collect data. The data were analyzed by SPSS v.23 using Kolmogorov–Smirnov test (test K–S), T-Test, Analysis of variance (ANOVA) statistical tests and pearson correlation coefficient were analyzed. Results: The results showed that the mean age of the elderly in the study was 64.9 years. The mean score of health literacy was 58.2 in terms of borderline health literacy, mental health 25.11 and quality of life 40.7 which were at the desired level and there was a statistically significant relationship between health literacy and mental health and quality of life indicators (P˂0.001). Conclusion: Considering the relationship between health literacy and mental health and quality of life, it seems necessary to pay more attention to promoting health literacy in the elderly and planning to improve the effective factors in quality of life improvement programs.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80468942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nurses’ Knowledge and Attitude Towards Pain Management: A Descriptive- analytical Study in Jahrom City 嘉伦市护士疼痛管理知识与态度的描述性分析研究

Qom Univ Med Sci J Pub Date : 2021-10-01 DOI: 10.32598/qums.15.7.2069.5

N. Kalani, Ghahreman Bemana, Nafiseh Esmaealpour, Saead Razavi, N. Hatami, M. Radmehr

{"title":"Nurses’ Knowledge and Attitude Towards Pain Management: A Descriptive- analytical Study in Jahrom City","authors":"N. Kalani, Ghahreman Bemana, Nafiseh Esmaealpour, Saead Razavi, N. Hatami, M. Radmehr","doi":"10.32598/qums.15.7.2069.5","DOIUrl":"https://doi.org/10.32598/qums.15.7.2069.5","url":null,"abstract":"Background and Objectives: Nurses spend more time with patients than other medical personnel and this requires proper decision making by nurses regarding proper and effective pain control in patients. Therefore, this study was conducted to determine the knowledge and attitude of nurses in Jahrom University of Medical Sciences towards pain management. Methods: This descriptive-analytical study was performed on 142 nurses working in hospitals of Jahrom University of Medical Sciences in 2021. Data collection tools in this study are demographic information questionnaire and nurseschr('39') knowledge and attitude questionnaire about pain. Data analysis was performed using SPSS software version 21 and descriptive statistical tests and inferential tests. Results: The Mean score of nurses chr('39')knowledge about pain management was 10.8±3.3 and the mean score of nurseschr('39') attitude towards pain management was 63.1±7.9. The level of knowledge of the majority of nurses was 130 (91.5%) and the level of attitude of the majority of nurses towards pain management was 112 (78.9%). Only 24 (16.9%) nurses had a positive attitude towards pain management. Pearson correlation coefficient showed a positive and significant relationship between knowledge score and nurseschr('39')attitude score (r=0.248, P=0.003). Conclusion: The results of the present study showed that most nurses do not have sufficient knowledge and attitude towards pain management. Therefore, training and holding retraining classes are recommended for all nurses in modern jobs.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87907001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Sleep Disorders in Patients With Multiple Sclerosis: A Cross-sectional Study in Qom Province, Iran 评估多发性硬化症患者的睡眠障碍:伊朗库姆省的一项横断面研究

Qom Univ Med Sci J Pub Date : 2021-10-01 DOI: 10.32598/qums.15.7.2308.1

Sepideh Paybast, Mohammad Aghaali, T. Sabokbar, Mohammad Hosien Asi, Sara Rahmati Aram, Freshete Shahab, S. A. Hejazi

{"title":"Evaluation of Sleep Disorders in Patients With Multiple Sclerosis: A Cross-sectional Study in Qom Province, Iran","authors":"Sepideh Paybast, Mohammad Aghaali, T. Sabokbar, Mohammad Hosien Asi, Sara Rahmati Aram, Freshete Shahab, S. A. Hejazi","doi":"10.32598/qums.15.7.2308.1","DOIUrl":"https://doi.org/10.32598/qums.15.7.2308.1","url":null,"abstract":"Background and Objectives: Multiple sclerosis is an autoimmune disease characterized by inflammation and demyelination of the central nervous system. About half of patients with MS complaint of sleep disorder which could be an indicator of the quality of life. The present study was conducted to evaluate the prevalence of sleep disturbances in patients with multiple sclerosis in Qom province. Methods: We included 120 patients from the MS community list and assessed the participants based on the demographic, Pittsburgh sleep quality index (PSQI) and Global Sleep Assessment (GSA) questionnaire. Data were analyzed using SPSS v. 23 software. Results: We showed that the majority of our patients (74.2) were women with a Mean±SD age of 33.95±8.01 years old. 90(75%) of our patients suffered from at least one sleep disturbance in which difficulty initiating or maintaining sleep were the main complaints. Age was estimated to be the main independent factor significantly associated with sleep disturbance. Except the gender, other studied variables had a considerable impact on certain types of sleep-related disorders. Conclusion: As sleep disorders is frequent and mainly undiagnosed in patients with MS, it is necessary to routine evaluate the patients for sleep disorders.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89123884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Media on Nursing Image in Societies: A Systematic Review 媒体对社会护理形象的影响:系统回顾

Qom Univ Med Sci J Pub Date : 2021-10-01 DOI: 10.32598/qums.15.7.2219.2

Sara Amaniyan, Monir Nobahar, Nayyereh Raiesdana

{"title":"The Effect of Media on Nursing Image in Societies: A Systematic Review","authors":"Sara Amaniyan, Monir Nobahar, Nayyereh Raiesdana","doi":"10.32598/qums.15.7.2219.2","DOIUrl":"https://doi.org/10.32598/qums.15.7.2219.2","url":null,"abstract":"Background and Objectives: The image of nursing has a considerable impact on identity and professional self-esteem in nurses. In this regard, the media can be an effective important factor in drawing a positive or negative image of the nursing profession. Thus, the aim of this study was to explore the effect of media on nursing image in societies. Methods In this systematic review, national and international electronic databases including SID, Magiran, IranMedex, Web of Science, Scopus, and PubMed were systematically searched in October 2020 to retrieve articles published up to 2020, using the keywords nursing profession, nursing image, nursing public image and Social/Mass media. According to the aim of study and inclusion criteria, 15 articles among all obtained articles were assessed to appraise their quality. Finally, the content of final selected articles was reported as extraction tables. Results The search yielded 958 articles, but consideration of inclusion criteria led to final selection of 7 articles. The most important effects of media on the image of nursing included the effect of media on the academic and clinical image of the profession, nursing professional roles, as well as gender and media bias towards the nursing profession. Conclusion More attention to media productions should be considered in order to improve the image of nursing. Additionally, with greater presence, nurses can find in media programs to introduce the reality of their profession the greater help this will be for the voices of nurses to be heard.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78895924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessing the Correlation Between the Level of Depressive Disorder and Quality of life in Employees Working in Covid-19 Reference Hospital in 2020 2020年新冠肺炎参考医院员工抑郁水平与生活质量相关性评估

Qom Univ Med Sci J Pub Date : 2021-10-01 DOI: 10.32598/qums.15.7.2433

A. Yusefi, P. Nikmanesh, S. Daneshi, M. Bayati, E. Rezabeigi Davarani

{"title":"Assessing the Correlation Between the Level of Depressive Disorder and Quality of life in Employees Working in Covid-19 Reference Hospital in 2020","authors":"A. Yusefi, P. Nikmanesh, S. Daneshi, M. Bayati, E. Rezabeigi Davarani","doi":"10.32598/qums.15.7.2433","DOIUrl":"https://doi.org/10.32598/qums.15.7.2433","url":null,"abstract":"Background and Objectives: The widespread prevalence of new coronavirus (COVID-19) worldwide can lead to many mental disorders. COVID-19 Care Frontline Staff, are one of the groups most strongly affected by the mental disorders caused by this disease. This study aimed to assess the correlation between the level of depressive disorder and quality of life in employees working in Covid-19 reference hospital in 2020. Methods: This was descriptive-correlation census study performed on 496 employees of Hazrat Ali Asghar (AS) Hospital in Shiraz as the reference hospital for treatment of COVID-19 in southern Iran. Data collection tools were standard Beck Depression Inventory (BDI) and WHOQOL-BREF quality of life questionnaires. Data were analyzed using descriptive and inferential statistical methods, Pearson correlation coefficient and t-test and ANOVA by SPSS v. 23 software at a significance level of α=0.05. Results: The Mean±SD score of depression and quality of life of the studied employees were 35.8±9.2 (out of 63), 60.7±14.8 (out of 120) respectively. 49.6% and 87.5% of the employees had moderate levels of depression and quality of life, respectively. There was a significant and inverse correlation between depression and employees' quality of life (r=-0.612, P<0.001). Also between depression with education level (P=0.04), marital status (P=0.01), and type of occupation (P=0.03), and between quality of life and marital status (P=0.03) were observed a statistically significant relation. Conclusion: Depression and quality of life of the employees were moderate level. Planning is recommended to improve the mental health of employees, use psychotherapy techniques such as cognitive behavioral therapy and mindfulness, develop and implement stress and anxiety management programs, and provide counseling services.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73683435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Explaining People's Experience of Life in the Context of Covid-19 Epidemic in Qom 解读库姆新冠肺炎疫情背景下人们的生活体验

Qom Univ Med Sci J Pub Date : 2021-10-01 DOI: 10.32598/qums.15.7.152.3

Z. Khalajinia, Zahra Abedini, Hoda Ahmari Tehran, A. Khoramirad

{"title":"Explaining People's Experience of Life in the Context of Covid-19 Epidemic in Qom","authors":"Z. Khalajinia, Zahra Abedini, Hoda Ahmari Tehran, A. Khoramirad","doi":"10.32598/qums.15.7.152.3","DOIUrl":"https://doi.org/10.32598/qums.15.7.152.3","url":null,"abstract":"Background and Objectives: Covid-19 disease is the most important issue in the world today that affects all aspects of life in a society. Therefore, the aim of this study was to explain people's experience of living in conditions of Covid-19 disease. Methods: The present study was performed with a qualitative approach using content analysis by the conventional method in Qom city health centers. The data were collected through in depth semi structured interviews with 20 participants through a purposeful sampling method and analyzed simultaneously. Results: From data analysis, 2 main categories including \"lifestyle change\" with two subcategories, \"change in activities and habits\", \"change in interests\" and other main categories of psychological effects with two subcategories \"anxiety and fear\" And \"feeling lonely\" is extracted. Conclusion: According to the findings of this study, the Covid-19 epidemic of Covid-19 disease has been associated with effects on lifestyle and mental health, changes in activities, habits, interests, and problems such as anxiety, sleep problems, stress, tension and loneliness. It is suggested that psychologists and specialists plan and implement effective interventions to reduce the psychological effects of this pandemic and increase people's adaptation to existing conditions. Also encourage people to have an active lifestyle.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84720714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Effects of Ethanol and Methanol Extracts of Ziziphus Spina-christi, Peganum Harmala, Salvia Officinalis, and Querqus Brantii on the Growth and Biofilm Formation by Staphylococcus Aureus in Vitro 酸枣、苦参、鼠尾草和槲皮乙醇和甲醇提取物对金黄色葡萄球菌体外生长和生物膜形成的影响

Qom Univ Med Sci J Pub Date : 2021-10-01 DOI: 10.32598/qums.15.7.2224.1

Maryam Monadi, H. Motamedi, Nazanin Sanei

{"title":"The Effects of Ethanol and Methanol Extracts of Ziziphus Spina-christi, Peganum Harmala, Salvia Officinalis, and Querqus Brantii on the Growth and Biofilm Formation by Staphylococcus Aureus in Vitro","authors":"Maryam Monadi, H. Motamedi, Nazanin Sanei","doi":"10.32598/qums.15.7.2224.1","DOIUrl":"https://doi.org/10.32598/qums.15.7.2224.1","url":null,"abstract":"Background and Objectives: Medicinal plants are one of the most important natural resources in each country. The aim of this study was to evaluate the anti-biofilm effect of ethanol and methanol extracts of Ziziphus spina-christi leaves, Peganum harmala, Salvia officinalis, and Querqus brantii on the growth and formation of biofilm by Staphylococcus aureus. Methods: Following evaluation of the susceptibility of the studied Staphylococcus aureus strain to various antibiotics, the growth inhibitory effect of extracts on the bacterium was investigated by disc diffusion method and then the inhibitory effect of the extracts on biofilm formation was evaluated in 96 well micro-titer plates. The means were compared with ANOVA test. Results: The results from antibacterial effect of the extracts showed that the methanol extract of Peganum harmala and Querqus brantii seeds at 350 and 450 mg/ml concentrations had a greater inhibitory effect on the growth of Staphylococcus aureus than other extracts as well as synthetic antibiotics. The results from anti-biofilm formation effect of the extracts showed that methanol extract of Salvia officinalis leaves and Querqus brantii seeds at 350 mg/ml concentration, and ethanol extract of Salvia officinalis leaves at 350 mg/ml concentration were the lowest concentrations that showed the greatest inhibitory effect on biofilm formation by Staphylococcus aureus. Other extracts inhibited biofilm formation by this bacterium in higher concentrations. The lowest anti-biofilm effect on Staphylococcus aureus was observed by ethanolic and methanolic extracts of Ziziphus spina-christi leaf. Conclusion: The studied extracts in this study, especially the methanol extracts of Salvia officinalis leaves and Peganum harmala seeds, and ethanol extract of Salvia officinalis leaves are good solutions for S. aureus infection and biofilms formation control and are suggested that be evaluated in In vivo experiments and clinical applications.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82197175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Investigating the Correlation Between Academic Procrastination With Emotional Intelligence and Self-efficacy in Operating Room Students of Shiraz University of Medical Sciences in 2019 2019年设拉子医科大学手术室学生学业拖延与情商、自我效能感的相关性研究

Qom Univ Med Sci J Pub Date : 2021-10-01 DOI: 10.32598/qums.15.7.2428.1

Farnoush Azizi, Azadeh Amiri, Mehrdad Rohaninasab, Maryam Paran

{"title":"Investigating the Correlation Between Academic Procrastination With Emotional Intelligence and Self-efficacy in Operating Room Students of Shiraz University of Medical Sciences in 2019","authors":"Farnoush Azizi, Azadeh Amiri, Mehrdad Rohaninasab, Maryam Paran","doi":"10.32598/qums.15.7.2428.1","DOIUrl":"https://doi.org/10.32598/qums.15.7.2428.1","url":null,"abstract":"Background and Objectives: Academic procrastination can have an adverse effect on students' educational, communicational, health, and career prospects. Therefore, recognizing the factors affecting academic procrastination among students is essential. The aim of this study was to determine the correlation between academic procrastination with emotional intelligence and self-efficacy among operating room students of Shiraz University of Medical Sciences. Methods: This descriptive cross-sectional correlational study was performed on 95 operating room students of Shiraz University of Medical Sciences. Data collection tools included demographic information questionnaires, academic procrastination questionnaire, Scherer general self-efficacy scale and schutte self-report emotional intelligence scale. Data were analyzed using one-way analysis of variance, Pearson correlation coefficient and simultaneous multiple regression by SPSS software version 21. Results: The Mean±‌SD scores of academic procrastination, self-efficacy and emotional intelligence were 20.6±‌8.7, 63.1±‌9.3 and 119.2±‌17.6, respectively. There was a significant and inverse correlation between academic procrastination with self-efficacy (P‌=‌ 0.001, r‌=‌ -0.339) and emotional intelligence (P‌=‌0.007, r‌=‌ -0.276). The results of regression analysis showed that the model of predicting academic procrastination based on self-efficacy is significant (P‌=‌0.035). Academic procrastination based on emotional intelligence was not significant (P‌=‌0.474). Conclusion: The results of this study show that academic procrastination is less among students with higher self-efficacy and emotional intelligence.","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85631079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Long-term Exposure to Aspartame on Histomorphometric, Histochemical and Expression of P53, Bcl-2 and Caspase-3 Genes in the Ovaries of Mice 长期接触阿斯巴甜对小鼠卵巢组织形态计量学、组织化学及P53、Bcl-2和Caspase-3基因表达的影响

Qom Univ Med Sci J Pub Date : 2021-09-01 DOI: 10.32598/qums.15.6.2350.1

Mohsan Hosseini, H. Morovvati, H. Anbara

{"title":"The Effect of Long-term Exposure to Aspartame on Histomorphometric, Histochemical and Expression of P53, Bcl-2 and Caspase-3 Genes in the Ovaries of Mice","authors":"Mohsan Hosseini, H. Morovvati, H. Anbara","doi":"10.32598/qums.15.6.2350.1","DOIUrl":"https://doi.org/10.32598/qums.15.6.2350.1","url":null,"abstract":"Background and Objectives: Aspartame is a non-nutritive and artificial sweetener which is widely used in diet and low calorie products and also in a variety of foods, drugs and hygiene products. The present study has been conducted in order to evaluation of the effects of aspartame on ovaries in female mice. Methods: In this experimental study, 36 adult female mice were randomly divided into four groups of nine each. For three groups aspartame was administered orally with the doses of 40, 80 and 160 mg/kg.BW respectively, and one group as the control group received normal saline for 91 days by gavage. Also a control group was considered. 24 hours after the last treatment, ovarian tissue and blood samples were collected and used for biochemical, histomorphological, histomorphometric, histochemical and gene expression studies. The obtained data were analyzed using One-Way Analysis of Variance (ANOVA) and Tukey’s test at the significance level of P<0.05. Results: In ovarian histomorphometric studies, aspartame at a dose of 160 mg/kg significantly reduced growing follicles and significantly increased atresia follicles. Also in biochemical studies caused a significant decrease in TAC and a significant increase in MDA compared to control group. In connection with the studied genes, aspartame at a dose of 160 mg/kg caused a significant decrease in the expression of Bcl-2 gene and also a significant increase in the expression of P53 and Caspase-3 genes compared to the control group. Conclusion: It seems that high dose aspartame can cause adverse effects on histomorphology, histomorphometry and expression of P53, Bcl-2 and Caspase-3 genes in rat ovaries","PeriodicalId":20805,"journal":{"name":"Qom Univ Med Sci J","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87515760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0