Proceedings of the National Academy of Sciences of Belarus, Chemical Series最新文献_第9页

Influence of citrate copper-plating electrolyte, its components and ultra-dispersed diamonds additives on surface properties of steel 柠檬酸盐镀铜电解液及其组分和超分散金刚石添加剂对钢表面性能的影响

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2022-03-10 DOI: 10.29235/1561-8331-2022-58-1-26-35

V. V. Yaskelchik, I. Zharsky, A. Chernik

引用次数: 0

Rheological properties and in vitro hydrolytic stability of the carboxymethylcellulose–dioxidine composition 羧甲基纤维素-二氧化二胺组合物的流变性能及体外水解稳定性

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2022-03-09 DOI: 10.29235/1561-8331-2022-58-1-7-16

T. L. Yurkshtovich, N. Yurkshtovich, N. Golub, R. I. Kosterova, Y. I. Pristromova, S. O. Solomevich, P. M. Bychkovsky

{"title":"Rheological properties and in vitro hydrolytic stability of the carboxymethylcellulose–dioxidine composition","authors":"T. L. Yurkshtovich, N. Yurkshtovich, N. Golub, R. I. Kosterova, Y. I. Pristromova, S. O. Solomevich, P. M. Bychkovsky","doi":"10.29235/1561-8331-2022-58-1-7-16","DOIUrl":"https://doi.org/10.29235/1561-8331-2022-58-1-7-16","url":null,"abstract":"The composition of carboxymethylcellulose–dioxydine was obtained and its structural, morphological and rheological characteristics in the processes of heat treatment and chemical hydrolysis were studied. Using IR spectroscopy, scanning electron microscopy, and viscometry, it has been established that the introduction of dioxidine into a solution of carboxymethylcellulose sodium salt with different molecular weights leads to partial disordering of hydrogen bonds between macromolecules, promotes thermal destruction of the polysaccharide and a decrease in the dynamic viscosity of solutions. Experimental kinetic curves of carboxymethylcellulose hydrolysis in the presence and absence of dioxidine were obtained, and it was shown that they could be described using a first-order equation. The hydrolysis rate coefficients were calculated, and it was shown that, as a result of heat treatment, as well as in the presence of an active substance, the rate of carboxymethylcellulose hydrolysis increased. The change in the rheological properties of carboxymethylcellulose sodium salt solutions with different degrees of polymerization in the presence of an antimicrobial substance should be taken into account when choosing the composition of viscous prolonged forms of biologically active substances. ","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80573821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Titration of weak base fibrous anion exchangers in the presence of complex-forming divalent cations 弱碱纤维阴离子交换剂在形成络合物的二价阳离子存在下的滴定

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2021-12-03 DOI: 10.29235/1561-8331-2021-57-4-391-399

V. Soldatov, L. N. Shachenkova, E. Kasandrovich, P. V. Nesteronok

引用次数: 0

Enzymatic hydrolysis of plant raw materials: state and prospects 植物原料酶解研究现状与展望

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2021-12-03 DOI: 10.29235/1561-8331-2021-57-4-502-512

V. S. Boltovsky

{"title":"Enzymatic hydrolysis of plant raw materials: state and prospects","authors":"V. S. Boltovsky","doi":"10.29235/1561-8331-2021-57-4-502-512","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-502-512","url":null,"abstract":"Plant raw materials are practically an inexhaustible natural resource, since they are constantly renewed in the process of plant photosynthesis, which determines the prospects for their use for industrial processing in various ways, including hydrolytic. The main biopolymer components of plant biomass in terms of their quantitative content are polysaccharides, the hydrolytic processing of which by acidic or enzymatic hydrolysis leads to the formation of monosaccharides and various products obtained from them. This review of scientific literature analyzes theoretical concepts and the current state of research on the development, improvement and prospects for the use of enzymatic hydrolysis of plant raw materials. The efficiency of this process and the composition of the resulting products largely depend on the features of the supramolecular structure of cellulose, the content of hemicelluloses and lignin in the raw material, the balance and activity of the cellulase complex of enzymes. It is shown that the main directions of development and improvement of the processes of enzymatic hydrolysis of plant raw materials at present are the production and use of more effective strains of microorganisms that produce highly active enzymes, the directed creation of complex enzymes (hydrolyzing not only cellulose, but also hemicellulose, as well as destroying lignin), the development of methods for pretreatment of raw materials to increase the reactivity of cellulose and remove lignin and improve the processes of fermentolysis.","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81346595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Interconnection of phospholipolysis and monooxygenase catalysis 磷脂分解与单加氧酶催化的相互联系

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2021-12-03 DOI: 10.29235/1561-8331-2021-57-4-488-501

N. M. Litvinko

引用次数: 0

Synthesis of new thiazolo[3,2-a]pyrimidine derivatives and in silico analysis of their bioactivity 新噻唑[3,2-a]嘧啶衍生物的合成及其生物活性的硅分析

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2021-12-03 DOI: 10.29235/1561-8331-2021-57-4-456-462

I. V. Mineeva, Y. Faletrov, V. A. Starovoytova, V. Shkumatov

引用次数: 1

Surface and optical properties of calcium carbonate paper 碳酸钙纸的表面及光学性能

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2021-12-03 DOI: 10.29235/1561-8331-2021-57-4-472-479

I. Ismailov, K. Babakhanova, A. A. Sadriddinov, M. A. Babahanova, D. Saidova

{"title":"Surface and optical properties of calcium carbonate paper","authors":"I. Ismailov, K. Babakhanova, A. A. Sadriddinov, M. A. Babahanova, D. Saidova","doi":"10.29235/1561-8331-2021-57-4-472-479","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-472-479","url":null,"abstract":"The article investigates the surface and optical properties of calcium carbonate paper obtained at the UzbekChinese enterprise Fergana stone paper company (Uzbekistan), in order to identify the possibility of their use at printing enterprises for printing multicolor products using traditional printing methods. According to the results of a quantitative assessment of the surface quality by the indirect Beck method, we can say that paper sample 1 has a smoothness like coated paper (750–1500 s), paper samples 2 and 3 – like calendered paper, so that these paper samples can be recommended for prints with increased quality requirements. Smaller values of roughness Ra and small depressions, expressed by darkening in the topographic AFM images, characterized sufficient homogeneity and density of the structure. It was also revealed that the surface of the paper samples has a high ability to specularly reflect the incident light, since the percentage of surface reflection is similar to that of coated papers. Samples of paper have a whiteness of about 90 % and do not have a tint, since the difference between the maximum and minimum values of the reflection coefficients on a white stack is not more than 10 %. The tested paper samples can be recommended without restrictions for double-sided printing, since the opacity index is more than 92 %.","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84094227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Protective Langmuir–Blodgett coatings based on long-chain fatty acids 基于长链脂肪酸的保护性Langmuir-Blodgett涂层

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2021-12-03 DOI: 10.29235/1561-8331-2021-57-4-480-487

V. Akulova, A. Salamianski, G. Melnikova, D. A. Nekrashevich, Yu. V. Sinkevich, I. Chishankov, V. Agabekov

引用次数: 0

Preparation and characterization of recombinant human glutathione transferase P1 and screening of novel enzyme inhibitors 重组人谷胱甘肽转移酶P1的制备、表征及新型酶抑制剂的筛选

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2021-12-03 DOI: 10.29235/1561-8331-2021-57-4-438-455

S. N. Gilevich, Yu. V. Brechka

{"title":"Preparation and characterization of recombinant human glutathione transferase P1 and screening of novel enzyme inhibitors","authors":"S. N. Gilevich, Yu. V. Brechka","doi":"10.29235/1561-8331-2021-57-4-438-455","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-438-455","url":null,"abstract":"Human glutathione transferase P1 (GSTP1) plays an important role in the second phase of xenobiotic biotransformation and in the regulation of apoptotic signal pathways. Directed screening of new enzyme inhibitors is an actual task since selective suppression of GSTP1 activity in tumor cells may substantially increase their sensitivity to chemotherapy. Known methods to obtain recombinant GSTP1 with a hexahistidine tag in the structure are complex, laborious, and suffer from significant losses of the enzyme activity. With the aim to create a simple and effective bacterial expression system for tagless GSTP1 posessing native structure and high activity, in the present work the full-length gstp1 gene was cloned into the pTXB1 plasmid vector, followed by transformation of E. coli cells. The optimized expression level amounted to 30–32 mg of the enzyme per liter of broth. Using glutathione-containing affinity membranes, the purified enzyme was isolated from bacterial lysate with the yield of 75.7 % and specific activity of 102.6 U/mg protein. The enzyme homogeneity was confirmed by gel-electrophoretic and mass-spectrometric data. Physico-chemical and catalytic properties of recombinant GSTP1 practically coincided with those of the native erythrocytary enzyme. The results of in silico and in vitro screening allowed to reveal structural factors and interactions determining the efficiency of the enzyme inhibition by carbocyclic and N-heterocyclic ligands. The preferable orientation of “good” inhibitors in the GSTP1 H-site was also established. Three strong enzyme inhibitors were found: 1,10-phenanthroline-5,6-dione, Alizarin Red S, and indigo carmine, with their respective IC50 values of 31, 16 and 2.3 μM. The new inhibitors are of certain interest for the development of novel lead structures with potential antitumor activity.","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74346210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of chalcone-based pyrimidine derivatives and their antimicrobial activity 查尔酮基嘧啶衍生物的合成及其抗菌活性

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2021-12-03 DOI: 10.29235/1561-8331-2021-57-4-431-437

D. S. Martsinkevich, K. F. Chernyavskaya, V. Tarasevich

引用次数: 0