{"title":"Influence of citrate copper-plating electrolyte, its components and ultra-dispersed diamonds additives on surface properties of steel","authors":"V. V. Yaskelchik, I. Zharsky, A. Chernik","doi":"10.29235/1561-8331-2022-58-1-26-35","DOIUrl":"https://doi.org/10.29235/1561-8331-2022-58-1-26-35","url":null,"abstract":"","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81391970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. L. Yurkshtovich, N. Yurkshtovich, N. Golub, R. I. Kosterova, Y. I. Pristromova, S. O. Solomevich, P. M. Bychkovsky
{"title":"Rheological properties and in vitro hydrolytic stability of the carboxymethylcellulose–dioxidine composition","authors":"T. L. Yurkshtovich, N. Yurkshtovich, N. Golub, R. I. Kosterova, Y. I. Pristromova, S. O. Solomevich, P. M. Bychkovsky","doi":"10.29235/1561-8331-2022-58-1-7-16","DOIUrl":"https://doi.org/10.29235/1561-8331-2022-58-1-7-16","url":null,"abstract":"The composition of carboxymethylcellulose–dioxydine was obtained and its structural, morphological and rheological characteristics in the processes of heat treatment and chemical hydrolysis were studied. Using IR spectroscopy, scanning electron microscopy, and viscometry, it has been established that the introduction of dioxidine into a solution of carboxymethylcellulose sodium salt with different molecular weights leads to partial disordering of hydrogen bonds between macromolecules, promotes thermal destruction of the polysaccharide and a decrease in the dynamic viscosity of solutions. Experimental kinetic curves of carboxymethylcellulose hydrolysis in the presence and absence of dioxidine were obtained, and it was shown that they could be described using a first-order equation. The hydrolysis rate coefficients were calculated, and it was shown that, as a result of heat treatment, as well as in the presence of an active substance, the rate of carboxymethylcellulose hydrolysis increased. The change in the rheological properties of carboxymethylcellulose sodium salt solutions with different degrees of polymerization in the presence of an antimicrobial substance should be taken into account when choosing the composition of viscous prolonged forms of biologically active substances. ","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80573821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Soldatov, L. N. Shachenkova, E. Kasandrovich, P. V. Nesteronok
{"title":"Titration of weak base fibrous anion exchangers in the presence of complex-forming divalent cations","authors":"V. Soldatov, L. N. Shachenkova, E. Kasandrovich, P. V. Nesteronok","doi":"10.29235/1561-8331-2021-57-4-391-399","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-391-399","url":null,"abstract":"Curves of potentiometric titration of fully protonized fibrous ion exchangers with potassium hydroxide against the background of 1 M KCl in the presence of chlorides of Ni2+, Со2+, Сu2+ and Ca2+ were obtained. The ion exchangers were synthesized by modifying of industrial polyacrylonitrile fiber with diethylenetriamine and triethylenetetraamine and predominantly contained functional groups R-CO-NH- (CH2CH2NH)nH (n = 2 or 3) and a small amount of carboxyl groups. The sorption of Ni2+, Со2+, Сu2+ и Ca2+by ion exchangers was calculated from the data obtained depending on the pH of the medium. It was found that the investigated ion exchangers with high selectivity sorb heavy metal ions in a wide range of acidity of solutions (pH 2–9) due to the formation of metal-polymer complexes with polyamine functional groups. The maximum sorption capacity is 1.5–2.7 and 4–5 meq/g for ion exchangers with n = 2 and 3, respectively.","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77054590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enzymatic hydrolysis of plant raw materials: state and prospects","authors":"V. S. Boltovsky","doi":"10.29235/1561-8331-2021-57-4-502-512","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-502-512","url":null,"abstract":"Plant raw materials are practically an inexhaustible natural resource, since they are constantly renewed in the process of plant photosynthesis, which determines the prospects for their use for industrial processing in various ways, including hydrolytic. The main biopolymer components of plant biomass in terms of their quantitative content are polysaccharides, the hydrolytic processing of which by acidic or enzymatic hydrolysis leads to the formation of monosaccharides and various products obtained from them. This review of scientific literature analyzes theoretical concepts and the current state of research on the development, improvement and prospects for the use of enzymatic hydrolysis of plant raw materials. The efficiency of this process and the composition of the resulting products largely depend on the features of the supramolecular structure of cellulose, the content of hemicelluloses and lignin in the raw material, the balance and activity of the cellulase complex of enzymes. It is shown that the main directions of development and improvement of the processes of enzymatic hydrolysis of plant raw materials at present are the production and use of more effective strains of microorganisms that produce highly active enzymes, the directed creation of complex enzymes (hydrolyzing not only cellulose, but also hemicellulose, as well as destroying lignin), the development of methods for pretreatment of raw materials to increase the reactivity of cellulose and remove lignin and improve the processes of fermentolysis.","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81346595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interconnection of phospholipolysis and monooxygenase catalysis","authors":"N. M. Litvinko","doi":"10.29235/1561-8331-2021-57-4-488-501","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-488-501","url":null,"abstract":"A review of the main experimental results in the field of studying the interaction in vivo and in vitro of enzyme systems responsible for the metabolism of arachidonic acid is presented. Metabolic events from its release from phospholipids (phospholipase A2) to its transformation (cytochromes P450) into the most important intracellular messengers of external signal transmission to the internal “language of the cell” are discussed.","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82877242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. V. Mineeva, Y. Faletrov, V. A. Starovoytova, V. Shkumatov
{"title":"Synthesis of new thiazolo[3,2-a]pyrimidine derivatives and in silico analysis of their bioactivity","authors":"I. V. Mineeva, Y. Faletrov, V. A. Starovoytova, V. Shkumatov","doi":"10.29235/1561-8331-2021-57-4-456-462","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-456-462","url":null,"abstract":"An effective method of synthesis thiazolo[3,2-a]pyrimidine derivatives was developed and the compounds with n-pentyl or β-acetoxycyclopropyl as well as fluorescent benzo[f]coumarin substituents were obtained with yields 60 % and more. Using computational (in silico) approaches we demonstrated the ability of the obtained compounds to permeate lipid bilayer as well as their affinity to some protein kinases (compounds 4 and 6 bind with a protein kinase AKT1 with PDB code 3о96; Autodock Vina-computed energy of binding (Ebind) values were -10.9 and -10.6 kcal/mol, respectively), acethylcholine esterase and some human cytochromes P450 (for P450 3A4, pdb 5vcd, Ebind -12.3 kcal/mol).","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82628608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Ismailov, K. Babakhanova, A. A. Sadriddinov, M. A. Babahanova, D. Saidova
{"title":"Surface and optical properties of calcium carbonate paper","authors":"I. Ismailov, K. Babakhanova, A. A. Sadriddinov, M. A. Babahanova, D. Saidova","doi":"10.29235/1561-8331-2021-57-4-472-479","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-472-479","url":null,"abstract":"The article investigates the surface and optical properties of calcium carbonate paper obtained at the UzbekChinese enterprise Fergana stone paper company (Uzbekistan), in order to identify the possibility of their use at printing enterprises for printing multicolor products using traditional printing methods. According to the results of a quantitative assessment of the surface quality by the indirect Beck method, we can say that paper sample 1 has a smoothness like coated paper (750–1500 s), paper samples 2 and 3 – like calendered paper, so that these paper samples can be recommended for prints with increased quality requirements. Smaller values of roughness Ra and small depressions, expressed by darkening in the topographic AFM images, characterized sufficient homogeneity and density of the structure. It was also revealed that the surface of the paper samples has a high ability to specularly reflect the incident light, since the percentage of surface reflection is similar to that of coated papers. Samples of paper have a whiteness of about 90 % and do not have a tint, since the difference between the maximum and minimum values of the reflection coefficients on a white stack is not more than 10 %. The tested paper samples can be recommended without restrictions for double-sided printing, since the opacity index is more than 92 %.","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84094227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Akulova, A. Salamianski, G. Melnikova, D. A. Nekrashevich, Yu. V. Sinkevich, I. Chishankov, V. Agabekov
{"title":"Protective Langmuir–Blodgett coatings based on long-chain fatty acids","authors":"V. Akulova, A. Salamianski, G. Melnikova, D. A. Nekrashevich, Yu. V. Sinkevich, I. Chishankov, V. Agabekov","doi":"10.29235/1561-8331-2021-57-4-480-487","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-480-487","url":null,"abstract":"The morphology and tribotechnical properties of Langmuir–Blodgett (LB) monolayers and multilayers of some fatty acids, such as nervonic (NA), cerotic (CA) and montanic acids (OCA), was investigated. It was established that the wear resistance of silicon surface coated by LB monolayer of OCA is greater by 11 and 1.3 times in comparison with the LB monomolecular films of NA and CA, respectively. The multilayer of OCA, formed by 140 layers, increases the stability of steel surface by 35 times.","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":"309 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72391930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preparation and characterization of recombinant human glutathione transferase P1 and screening of novel enzyme inhibitors","authors":"S. N. Gilevich, Yu. V. Brechka","doi":"10.29235/1561-8331-2021-57-4-438-455","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-438-455","url":null,"abstract":"Human glutathione transferase P1 (GSTP1) plays an important role in the second phase of xenobiotic biotransformation and in the regulation of apoptotic signal pathways. Directed screening of new enzyme inhibitors is an actual task since selective suppression of GSTP1 activity in tumor cells may substantially increase their sensitivity to chemotherapy. Known methods to obtain recombinant GSTP1 with a hexahistidine tag in the structure are complex, laborious, and suffer from significant losses of the enzyme activity. With the aim to create a simple and effective bacterial expression system for tagless GSTP1 posessing native structure and high activity, in the present work the full-length gstp1 gene was cloned into the pTXB1 plasmid vector, followed by transformation of E. coli cells. The optimized expression level amounted to 30–32 mg of the enzyme per liter of broth. Using glutathione-containing affinity membranes, the purified enzyme was isolated from bacterial lysate with the yield of 75.7 % and specific activity of 102.6 U/mg protein. The enzyme homogeneity was confirmed by gel-electrophoretic and mass-spectrometric data. Physico-chemical and catalytic properties of recombinant GSTP1 practically coincided with those of the native erythrocytary enzyme. The results of in silico and in vitro screening allowed to reveal structural factors and interactions determining the efficiency of the enzyme inhibition by carbocyclic and N-heterocyclic ligands. The preferable orientation of “good” inhibitors in the GSTP1 H-site was also established. Three strong enzyme inhibitors were found: 1,10-phenanthroline-5,6-dione, Alizarin Red S, and indigo carmine, with their respective IC50 values of 31, 16 and 2.3 μM. The new inhibitors are of certain interest for the development of novel lead structures with potential antitumor activity.","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74346210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. S. Martsinkevich, K. F. Chernyavskaya, V. Tarasevich
{"title":"Synthesis of chalcone-based pyrimidine derivatives and their antimicrobial activity","authors":"D. S. Martsinkevich, K. F. Chernyavskaya, V. Tarasevich","doi":"10.29235/1561-8331-2021-57-4-431-437","DOIUrl":"https://doi.org/10.29235/1561-8331-2021-57-4-431-437","url":null,"abstract":"A series of substituted chalcones and pyrimidine derivatives on their base was synthesized. Obtained compounds were tested for antimicrobial activity and ability to increase activity of known antimicrobial substances. Pyrimidine products shown good activity against Staphylococcus aureus and Candida tropicalis. These compounds also could increase activity of modified polyguanidines against Staphylococcus aureus.","PeriodicalId":20798,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Chemical Series","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82133410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}