查尔酮基嘧啶衍生物的合成及其抗菌活性

Q4 Chemistry

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2021-12-03 DOI:10.29235/1561-8331-2021-57-4-431-437

D. S. Martsinkevich, K. F. Chernyavskaya, V. Tarasevich

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引用次数: 0

摘要

合成了一系列取代查尔酮及其基上的嘧啶衍生物。对所得化合物进行了抗菌活性和增强已知抗菌物质活性的能力测试。嘧啶产物对金黄色葡萄球菌和热带念珠菌具有良好的抗氧化活性。这些化合物还可以提高修饰多胍对金黄色葡萄球菌的活性。

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Synthesis of chalcone-based pyrimidine derivatives and their antimicrobial activity

A series of substituted chalcones and pyrimidine derivatives on their base was synthesized. Obtained compounds were tested for antimicrobial activity and ability to increase activity of known antimicrobial substances. Pyrimidine products shown good activity against Staphylococcus aureus and Candida tropicalis. These compounds also could increase activity of modified polyguanidines against Staphylococcus aureus.

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来源期刊

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Chemistry-Chemistry (miscellaneous)

CiteScore

0.30

自引率

0.00%

发文量