Progress in the chemistry of organic natural products最新文献_第6页

The Search for Anticancer Agents from Tropical Plants. 从热带植物中寻找抗癌药物。

Progress in the chemistry of organic natural products Pub Date : 2018-01-01 DOI: 10.1007/978-3-319-93506-5_1

Joshua M Henkin, Yulin Ren, Djaja Djendoel Soejarto, A Douglas Kinghorn

{"title":"The Search for Anticancer Agents from Tropical Plants.","authors":"Joshua M Henkin, Yulin Ren, Djaja Djendoel Soejarto, A Douglas Kinghorn","doi":"10.1007/978-3-319-93506-5_1","DOIUrl":"https://doi.org/10.1007/978-3-319-93506-5_1","url":null,"abstract":"Many of the clinically used anticancer agents in Western medicine are derived from secondary metabolites found in terrestrial microbes, marine organisms, and higher plants, with additional compounds of this type being currently in clinical trials. If plants are taken specifically, it is generally agreed that the prospects of encountering enhanced small organic-molecule chemical diversity are better if tropical rather than temperate species are investigated in drug discovery efforts. Plant collection in tropical source countries requires considerable preparation and organization to conduct in a responsible manner that abides by the provisions of the 1992 Rio Convention of Biological Diversity and the 2010 Nagoya Protocol on Access to Genetic Resources. Correct taxonomic identifications and enhanced procedures for processing and documenting plant samples when collected in often difficult terrain are required. Phytochemical aspects of the work involve solvent fractionation, known compound dereplication, preliminary in vitro testing, and prioritization, leading to \"activity-guided fractionation\", compound structure determination, and analog development. Further evaluation of lead compounds requires solubility, formulation, preliminary pharmacokinetics, and in vivo testing in suitable models. Covering the work of the authors carried out in two sequential multidisciplinary, multi-institutional research projects, examples of very promising compounds discovered from plants acquired from Africa, Southeast Asia, the Americas, and the Caribbean region, and with potential anticancer activity will be mentioned. These include plant secondary metabolites of the diphyllin lignan, cyclopenta[b]benzofuran, triterpenoid, and tropane alkaloid types.","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"107 ","pages":"1-94"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-319-93506-5_1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36459668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Molecular Targets of the Phytocannabinoids: A Complex Picture. 植物大麻素的分子靶点:一个复杂的图景。

Progress in the chemistry of organic natural products Pub Date : 2017-01-01 DOI: 10.1007/978-3-319-45541-9_4

P. Morales, D. Hurst, P. Reggio

引用次数: 303

Xanthine Alkaloids: Occurrence, Biosynthesis, and Function in Plants. 黄嘌呤生物碱:在植物中的存在、生物合成和功能。

Progress in the chemistry of organic natural products Pub Date : 2017-01-01 DOI: 10.1007/978-3-319-49712-9_1

H. Ashihara, K. Mizuno, T. Yokota, A. Crozier

引用次数: 46

A Critical Evaluation of the Quality of Published 13C NMR Data in Natural Product Chemistry. 天然产物化学中已发表的13C核磁共振数据质量的关键评价。

Progress in the chemistry of organic natural products Pub Date : 2017-01-01 DOI: 10.1007/978-3-319-49712-9_3

W. Robien

引用次数: 15

Molecular Pharmacology of Phytocannabinoids. 植物大麻素的分子药理学。

Progress in the chemistry of organic natural products Pub Date : 2017-01-01 DOI: 10.1007/978-3-319-45541-9_3

Sarah E Turner, C. Williams, L. Iversen, Benjamin J. Whalley

引用次数: 149

Natural Product Molecular Fossils. 天然产物分子化石。

Progress in the chemistry of organic natural products Pub Date : 2017-01-01 DOI: 10.1007/978-3-319-45618-8_1

H. Falk, K. Wolkenstein

引用次数: 15

Synthesis of Phytocannabinoids. 植物大麻素的合成。

Progress in the chemistry of organic natural products Pub Date : 2017-01-01 DOI: 10.1007/978-3-319-45541-9_2

Michael A. Schafroth, E. Carreira

引用次数: 11

Progress in the Chemistry of Organic Natural Products 有机天然产物化学研究进展

Progress in the chemistry of organic natural products Pub Date : 2017-01-01 DOI: 10.1007/978-3-319-45618-8

A. Kinghorn, H. Falk, S. Gibbons, J. Kobayashi

引用次数: 23

The Iboga Alkaloids. 伊博加生物碱。

Progress in the chemistry of organic natural products Pub Date : 2017-01-01 DOI: 10.1007/978-3-319-49712-9_2

C. Lavaud, G. Massiot

引用次数: 30

Secondary Metabolites from Higher Fungi. 高等真菌次生代谢物。

Progress in the chemistry of organic natural products Pub Date : 2017-01-01 DOI: 10.1007/978-3-319-59542-9_1

He-Ping Chen, Ji-Kai Liu

{"title":"Secondary Metabolites from Higher Fungi.","authors":"He-Ping Chen, Ji-Kai Liu","doi":"10.1007/978-3-319-59542-9_1","DOIUrl":"https://doi.org/10.1007/978-3-319-59542-9_1","url":null,"abstract":"Secondary metabolites of higher fungi (mushrooms) are an underexplored resource compared to plant-derived secondary metabolites. An increasing interest in mushroom natural products has been noted in recent years. This chapter gives a comprehensive overview of the secondary metabolites from higher fungi, with 765 references highlighting the isolation, structure elucidation, biological activities, chemical syntheses, and biosynthesis of pigments, nitrogen-containing compounds, and terpenoids from mushrooms. Mushroom toxins are also included in each section.In a section on pigments of higher fungi, pigments are classified into four categories, namely, those from the shikimate-chorismate, acetate-malonate, and mevalonate biosynthetic pathways, and pigments containing nitrogen, with 145 references covering the years 2010-2016.In a section on other nitrogen-containing compounds of higher fungi, compounds are categorized primarily into nitrogen heterocycles, nucleosides, non-protein amino acids, cyclic peptides, and sphingolipids, with 65 references covering the years 2010-2016. In turn, in a section describing terpenoids of higher fungi, the sesquiterpenoids and diterpenoids are thoroughly elaborated, spanning the years 2001-2016, and 2009-2016, respectively. The divergent biosynthetic pathways from farnesyl pyrophosphate to sesquiterpenoids are also described. Selected triterpenoids with novel structures and promising biological activities, including lanostanes and ergostanes, are reported from the genus Ganoderma, and the fungi Antrodia cinnamomea and Poria cocos. In addition, cucurbitanes and saponaceolides are also compiled in this section.","PeriodicalId":20703,"journal":{"name":"Progress in the chemistry of organic natural products","volume":"106 ","pages":"1-201"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-319-59542-9_1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35282787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53