Proceedings of the Western Pharmacology Society最新文献_第7页

Neonatal monosodium glutamate administration increases aminooxyacetic acid (AOA) susceptibility effects in adult mice. 新生小鼠给药谷氨酸钠增加成年小鼠对氨基乙酸(AOA)的敏感性。

Proceedings of the Western Pharmacology Society Pub Date : 2009-01-01

Alfonso Efraín Campos-Sepúlveda, Maria Elena Martínez Enríquez, Raúl Rodríguez Arellanes, Luz Elena Peláez, Alyn Lizeth Rodríguez Amézquita, Alyne Cadena Razo

引用次数: 0

Angiotensin II augments renal vasoconstriction via AT1 receptors in L-NAME-induced hypertensive rats. 血管紧张素II通过AT1受体增强l - name诱导的高血压大鼠肾血管收缩。

Proceedings of the Western Pharmacology Society Pub Date : 2009-01-01

Felipe Francisco Rivera-Jardón, Patricia Castro-Moreno, Edgar Saúl Figueroa-Guillén, Itzell Alejandrina Gallardo-Ortíz, Daniel Godínez-Hernández, Maximiliano Ibarra-Barajas

{"title":"Angiotensin II augments renal vasoconstriction via AT1 receptors in L-NAME-induced hypertensive rats.","authors":"Felipe Francisco Rivera-Jardón, Patricia Castro-Moreno, Edgar Saúl Figueroa-Guillén, Itzell Alejandrina Gallardo-Ortíz, Daniel Godínez-Hernández, Maximiliano Ibarra-Barajas","doi":"","DOIUrl":"","url":null,"abstract":"The renal renin angiotensin system modulates blood pressure via the action of angiotensin II at type 1 (AT1) and type 2 (AT2) angiotensin receptors. It has been proposed that there is an increased pressor response to angiotensin II (ANG II) in the hypertensive rat kidney. We determined the role of the AT1 receptor in L-NAME-induced hypertension. Male Wistar rats (250-300 g) were divided into control (tap water) and L-NAME (50 mg/kg/day/2 weeks) treated groups. Concentration-response curves to ANG II were constructed in isolated perfused kidneys and AT1 receptor expression was determined by Western blot in the renal cortex, medulla and papilla. ANG II evoked an increase in perfusion pressure in kidneys of both control and L-NAME-treated rats in a concentration-related manner. In L-NAME-treated rats, a greater maximal effect was observed compared to control rats (160 +/- 13 vs. 138 +/- 8 mmHg; p<0.05, respectively), suggesting that L-NAME promoted ANG II hypersensitivity. In both, control and L-NAME groups, the response to ANG II was blocked by the selective AT1 receptor antagonist losartan (1 x 10(-8) and 3.16 x 10(-8) M). AT1 receptor expression in kidney cortex, medulla and papilla did not show significant differences between groups. Our results demonstrate that AT1 receptor stimulation is related to renal vasculature hypersensitivity in L-NAME-induced hypertension.","PeriodicalId":20701,"journal":{"name":"Proceedings of the Western Pharmacology Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30293310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed-onset heparin-induced thrombocytopenia type-2 during fondiparinux (Arixtra) therapy. fondiparinux (Arixtra)治疗期间迟发性肝素诱导的2型血小板减少症。

Proceedings of the Western Pharmacology Society Pub Date : 2009-01-01

Chirag Modi, Dhaval Satani, Kelly L Cervellione, Jose Cervantes, Jonas Gintautas

引用次数: 0

A rare case of uterine leiomyosarcoma metastasis to the duodenum. 子宫平滑肌肉瘤转移至十二指肠1例。

Proceedings of the Western Pharmacology Society Pub Date : 2009-01-01

Jitendra K Patel, Kelly L Cervellione, Muhammad Sulh, Avani A Patel, Jonas Gintautas

引用次数: 0

Antihyperalgesia induced by Heliopsis longipes extract. 百合提取物抗痛觉过敏作用。

Proceedings of the Western Pharmacology Society Pub Date : 2009-01-01

Mario I Ortiz, Raquel Cariño-Cortés, Nury Pérez-Hernández, Héctor Ponce-Monter, Eduardo Fernández-Martínez, Gilberto Castañeda-Hernández, Iliana I Acosta-Madrid, Virginia G Cilia-López

{"title":"Antihyperalgesia induced by Heliopsis longipes extract.","authors":"Mario I Ortiz, Raquel Cariño-Cortés, Nury Pérez-Hernández, Héctor Ponce-Monter, Eduardo Fernández-Martínez, Gilberto Castañeda-Hernández, Iliana I Acosta-Madrid, Virginia G Cilia-López","doi":"","DOIUrl":"","url":null,"abstract":"Heliopsis longipes is an herbaceous plant found in Mexico. Heliopsis longipes is traditionally used for its analgesic and anesthetic properties. Plant extracts may represent a therapeutic advantage for the clinical treatment of pain. Therefore, the main objective of this study was to determine the possible antihyperalgesic effect produced by the Heliopsis longipes ethanolic extract (HLEE) in the Hargreaves model of thermal hyperalgesia in the mouse. HLEE was administrated systemically to mice and the antihyperalgesic effect was evaluated using the thermal hyperalgesia test. Oral Administration of HLEE produced a dose-dependent antihyperalgesic effect. Previously, it was reported that Heliopsis longipes extract was able to release GABA in mice temporal cortex slices. Therefore, it is likely that the antihyperalgesic effect observed in our study could result from GABA liberation and its inhibition of excessive excitation of nociceptive circuits in the thalamus and cortex evoked by tissue injury. Our results suggest that HLEE may represent a therapeutic advantage for the clinical treatment of inflammatory pain.","PeriodicalId":20701,"journal":{"name":"Proceedings of the Western Pharmacology Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30290579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic activity of four Mexican medicinal plants. 四种墨西哥药用植物的细胞毒活性。

Proceedings of the Western Pharmacology Society Pub Date : 2009-01-01

Elisa Vega-Avila, Adolfo Espejo-Serna, Francisco Alarcón-Aguilar, Rodolfo Velasco-Lezama

引用次数: 0

Sub-acute effects of the 17beta-aminoestrogen pentolame and estradiol on hemostasis in the rat. 17 - β -氨基雌激素、戊醇和雌二醇对大鼠亚急性止血的影响。

Proceedings of the Western Pharmacology Society Pub Date : 2009-01-01

Cristina Lemini

{"title":"Sub-acute effects of the 17beta-aminoestrogen pentolame and estradiol on hemostasis in the rat.","authors":"Cristina Lemini","doi":"","DOIUrl":"","url":null,"abstract":"This work describes the sub-acute treatment of male Wistar rats with estradiol (E2) and the 17beta-aminoestrogen pentolame (AEP) on the hemostatic screening tests: blood clotting time (BCT), prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT) and fibrinogen concentrations (FIB). Animals received five consecutive subcutaneous (s.c.) doses of E2 (1 and 10 mg/kg) and AEP (5, 10 and 20 mg/kg) and the course of blood clotting times (BTC) was followed 24, 48, 72 and 96 hr after finishing treatment. Five injections of equivalent doses (0.1, 1, 10, 100 or 1000 microg/kg) of both steroids were performed. In all experiments a control group (propylenglycol 1 ml/kg) was included. Individual blood samples were obtained (under anesthesia) from the iliac artery and PT, aPTT, TT, and FIB were determined according to previous reported techniques. Forty-eight hr after treatment, E2 decreased BCT (10%) while AEP increased BCT 87% in a dose dependent manner. Only E2 significantly decreased FIB concentration (p<0.5; 25%) while AEP induced a dose dependent increase in FIB from 18 to 88%, (p < 0.05). AEP produced biphasic responses on aPTT (+24 % and -15%; p<0.05) and decreased TT from 11 to 14%, (p<0.01). AEP aPTT vs. FIB showed a r2=-0.99, (p < 0.05). Pentolame showed disparate effects compared with E2 on the blood clotting parameters and exerts its most important effects on the common coagulation pathway.","PeriodicalId":20701,"journal":{"name":"Proceedings of the Western Pharmacology Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30290574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antinociceptive interaction between benfotiamine and resveratrol in capsaicin-induced licking. 苯福胺和白藜芦醇在辣椒素诱导的舔舐中的抗伤害性相互作用。

Proceedings of the Western Pharmacology Society Pub Date : 2009-01-01

Rosa Mariana Montiel-Ruiz, Gerardo Reyes-García, Francisco Flores-Murrieta, Myrna Déciga-Campos

{"title":"Antinociceptive interaction between benfotiamine and resveratrol in capsaicin-induced licking.","authors":"Rosa Mariana Montiel-Ruiz, Gerardo Reyes-García, Francisco Flores-Murrieta, Myrna Déciga-Campos","doi":"","DOIUrl":"","url":null,"abstract":"In an attempt to provide more direct evidence concerning the possible antinociceptive effect of resveratrol-benfotiamine combination on neurogenic pain, we investigated whether resveratrol and benfotiamine administered alone or in combination decrease capsaicin induced nociception in mice. Before testing, the animals were placed individually in transparent glass cylinders, 20 cm in diameter, serving as observation chambers. After the adaptation period, 20 microL of capsaicin (1.6 microg/paw) were injected under the skin of the dorsal of the right hind paw. Animals were observed individually for 5 min after capsaicin injection. The amount of time spent licking the injected paw was timed with a chronometer and was considered as indicative of nociception. Animals were pretreated with resveratrol (56.2-177 mg/kg, i.p.), benfotiamine (100-1000 mg/kg, p.o.) and their combinations (11:1, 22:2, 44:4; 88:8 mg/kg benfotiamine:resveratrol). It was observed that resveratrol (ED50 = 104 +/- 8.2 mg/kg) was able to produce more important decrement of capsaicin-induced licking than benfotiamine (ED50 = 529.4 +/- 85.2 mg/kg). In addition, a synergistic interaction was observed between benfotiamine and resveratrol, suggesting that this combination could be useful in neurogenic nociception.","PeriodicalId":20701,"journal":{"name":"Proceedings of the Western Pharmacology Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30290577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet aggregation in whole blood, a new approach for understanding the antiplatelet effect of N-(3-hydroxy-1,3,5(10)-estratrien-17b-yl) butylamine (buame). 全血血小板聚集:了解N-(3-羟基-1,3,5(10)-雌二醇-17b-基)丁胺抗血小板作用的新途径

Proceedings of the Western Pharmacology Society Pub Date : 2009-01-01

Aurora de la Peña, Mirthala Flores, Benjamin Valente-Acosta, Leslie Quintanar-Trejo, Claudia Hernández-Méndez, Sergio Muñoz-Martínez, Fernanda Gatica-Lavin, Enrique Pinzón

{"title":"Platelet aggregation in whole blood, a new approach for understanding the antiplatelet effect of N-(3-hydroxy-1,3,5(10)-estratrien-17b-yl) butylamine (buame).","authors":"Aurora de la Peña, Mirthala Flores, Benjamin Valente-Acosta, Leslie Quintanar-Trejo, Claudia Hernández-Méndez, Sergio Muñoz-Martínez, Fernanda Gatica-Lavin, Enrique Pinzón","doi":"","DOIUrl":"","url":null,"abstract":"We have previously reported the effect of a compound derived from estradiol containing a radical amino butyl at the 17-beta position which has shown anticoagulant effects in whole blood and antiplatelet effects in light transmission aggregometry where platelets are isolated from other blood cells. In contrast, whole blood aggregometry includes the platelet interactions with blood elements such as erythrocytes and leukocytes. We examined the cooperative effect between leukocytes, erythrocytes and platelets and the antiplatelet effect of Buame in whole blood aggregometry, a tool to assess platelet function in its physiological environment. Buame (5-500 microM) dissolved in DMSO was tested in platelet aggregation induced by ADP (1.25 microM) or collagen (1 microg/mL) and the response recorded over 5 min. Controls were run with DMSO and the average control aggregation was taken as 100%. Results were obtained in both whole blood and platelet aggregometry. Buame was able to inhibit the secondary aggregation induced with ADP suggesting impairment in thromboxane A2 production. Also the first and second aggregation phases were inhibited when collagen-induced platelet activation was employed. This concentration-dependent pattern was shown in both whole blood and platelet aggregometry assays. When tested in light transmission aggregometry, a higher concentration of Buame was required in order to inhibit to the same degree ADP- or collagen-induced platelet aggregation (30 microM ,114 microM) than that required in the whole blood assay (IC50 84 microM, 191 microM). Interactions among different cell types in whole blood may modify the response of Buame-treated platelets to agonists suggesting a cooperative mechanism.","PeriodicalId":20701,"journal":{"name":"Proceedings of the Western Pharmacology Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30293311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical response in patients with dengue fever to oral calcium plus vitamin D administration: study of 5 cases. 5例登革热患者口服钙加维生素D的临床反应分析。

Proceedings of the Western Pharmacology Society Pub Date : 2009-01-01

Emilio Sánchez-Valdéz, Melissa Delgado-Aradillas, José Angel Torres-Martínez, José Martín Torres-Benítez

{"title":"Clinical response in patients with dengue fever to oral calcium plus vitamin D administration: study of 5 cases.","authors":"Emilio Sánchez-Valdéz, Melissa Delgado-Aradillas, José Angel Torres-Martínez, José Martín Torres-Benítez","doi":"","DOIUrl":"","url":null,"abstract":"A dengue epidemic is one of the most important public health problems in the tropical and subtropical areas of the World. In 2005, 7,062 dengue cases were reported in Tamaulipas on Mexico's eastern coast, including 1,832 (26%) cases classified as Dengue Hemorrhagic Fever (DHF). Dengue fever (DF) is characterized by fever, intense headache, myalgias, arthralgias, rash, nausea and vomiting. A proportion of infected persons may develop DHF characterized by prominent hemorrhagic manifestations associated with thrombocytopenia. An immune mechanism of thrombocytopenia due to increased platelet destruction appears to be operative in patients with DHF. Excessive capillary permeability may lead to Dengue Shock Syndrome (DSS). Patients with DHF/DSS who also have prolonged fever (> 5 days) are at high risk for concurrent bacteremia. Standard treatment is limited to electrolytic solutions, rest, measurements of body temperature, blood pressure, hematocrit, platelet count, and administration of antipyretics like paracetamol when fever is too high. Extracellular calcium plays a key role in platelet aggregation and for the regulation of the immune response in personsinfected with Dengue Virus (DV), and dihydroxy-vitamin D has recently been found to alter IL-12 expression anddendritic cell maturation. We report the cases of five patients who received oral calcium carbonate plus Vitamin D3, who improved overall clinical condition and reduced the duration of signs and symptoms of DF.","PeriodicalId":20701,"journal":{"name":"Proceedings of the Western Pharmacology Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30147746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0