Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)最新文献

{"title":"Characteristics of Metformin Transporter Coding Gene (SLC22A1 rs628031 and SLC47A1 rs2289669) in Healthy Indonesian Subject","authors":"Endang Susilowati","doi":"10.22487/j24428744..v.i.16295","DOIUrl":"https://doi.org/10.22487/j24428744..v.i.16295","url":null,"abstract":"Background: Metformin might be a first therapy for Type 2 diabetes; however, it had a lot of variation in glycemic response. Objective: to analyze the frequency of minor alleles of the OCT1 coding gene (SLC22A1 rs628031) and MATE1 coding gene (SLC47A1 rs2289669) as well as the genotypic variation of the interaction of these two genetic polymorphisms in healthy subjects of Indonesia. Material and Methods: Through inclusion criteria, the study employed an observational descriptive technique with 70 Indonesian Javanese healthy individuals. Subject health information was obtained from the complete blood routine test, serum glutamic oxaloacetic transaminase/ serum glutamic-pyruvic transaminase (SGOT/SGPT), complete urine test, and serum creatinine tests. All data were compared to the normal range. Results: The finding shows that the minor allele frequency on SLC22A1 rs628031 A>G and SLC47A1 rs2289669 G>A respectively at 53% and 36%. There are four SLC22A1 rs628031 and SLC47A1 rs2289669 genetic polymorphism interactions; 16 Wt/Wt (16.75%), 24 Wt/M (25%), 32 M/Wt (33.3%) and 24 M/M (25%). The discovery demonstrates that such minor allele frequencies of the SLC22A1 rs628031 OCT1 and SLC47A1 rs2289669 MATE1 genes in healthy Indonesian subjects are relatively high. The SLC22A1 rs628031 A>G and SLC47A1 rs2289669 G>A respectively at 53% and 36%, almost the same as the minor allele frequencies found in several other Asian countries eg. India, Japan, and China.  Conclusions: OCT1 coding genes (SLC22A1 rs628031 A>G) were found more dominant than MATE1 coding genes (SLC47A1 rs2289669 G>A) and both alleles are relatively high in healthy subjects of Indonesia, which can be used as information to explore the consequences of different genes' interactions on the Indonesian pharmacokinetic properties, and the efficacy variations of metformin in Type2 DM patients.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"66 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139526851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Mutation of RNA-dependent RNA Polymerase (RdRp) of Hepatitis C Virus on Affinities of Dasabuvir: Computational Study","authors":"M. Arba, S. T. Wahyudi","doi":"10.22487/j24428744..v.i.16613","DOIUrl":"https://doi.org/10.22487/j24428744..v.i.16613","url":null,"abstract":"Hepatitis C Virus (HCV) is one of the infectious diseases that has posed a serious threat to global public health for the past few decades. HCV is an RNA virus that infects the human liver and can lead to chronic liver damage, cirrhosis, and even liver cancer. Treatment for HCV infection has made rapid advancements in recent years, particularly with the development of more effective antiviral drugs. One of the drugs used in HCV therapy is dasabuvir. Dasabuvir is an RNA-dependent RNA polymerase (RdRp) inhibitor that functions to inhibit the replication of the HCV virus. The RdRp enzyme in HCV is represented by NS5B, and dasabuvir specifically targets this enzyme. Several reports have revealed mutations in HCV NS5B due to the use of dasabuvir. This study conducted a computational mutation analysis on NS5B of HCV resulting from dasabuvir usage. The research findings indicate that mutations in the HCV polymerase induced by dasabuvir usage lead to changes in dasabuvir's conformation and binding energy. Some mutations decrease binding energy, such as mutations C316N, C451S, and N411S. However, on the other hand, there are mutations that increase binding energy, such as M414V, A553V, and C445F. The decrease in binding energy is supported by increased hydrogen bonding interactions with Asp318, Gln446, and Tyr448, as well as the formation of new hydrogen bonds, such as hydrogen bonding with Ser288 in C451S and Arg200 in C451S. Meanwhile, the increase in binding energy is supported by decreased binding interactions with Asp318 and pi-pi interactions with Phe193. Hydrogen bonding with Asn291 also decreases, as seen in A553V, and is even lost in C445F. Future work will be devoted for designing new dasabuvir derivatives which having better affinited to NS5B of HCV.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"111 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139614133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Extraction Lannea coromandelica for Antioxidant Activity using Analytical Factorial Design Approach","authors":"M. Ar, Nur Hikma, B. Yasir, Asril Asril Burhan, Khairuddin Khairuddin","doi":"10.22487/j24428744..v.i.16106","DOIUrl":"https://doi.org/10.22487/j24428744..v.i.16106","url":null,"abstract":"Background: The yield of active compound in a plant can be affected by the extraction method, such as variety of solvent and extraction technique used. Objectives: This study aimed to optimize the yield of Lannea coromandelica leaf extract using several types of solvent and extraction techniques and evaluate the antioxidant activity of the extracts. Material and Methods: This study used a variety of solvent like distilled water, ethanol, n-hexane, and ethyl acetate with maceration, reflux, and sonication extraction techniques. The extract obtained was calculated for the percent yield and analyzed for their antioxidant activity using the DPPH method by UV -Vis Spectrophotometry with 523.5 nm maximum wavelength. The antioxidant activity was analyzed by factorial design analysis in Minitab 21 software. Results: The highest percentage yields was obtained from the extract with ethanol solvent, followed by distilled water, ethyl acetate and n-hexane. The highest extraction techniques was obtained from reflux and followed by maceration and sonication extracts. Analytical factorial design analysis showed that the linearity of solvent variation and extraction technique had a significant effect (P>0.05). From the analysis, it was found that there was a significant difference between the effect of the solvent on the antioxidant activities compared to the extraction technique. The extracts obtained have a very strong antioxidant activity against DPPH radicals. T Conclusions: L. coromandelica plant aquadest extract has potential to be developed in optimalization extraction method.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116627738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization of Ethanol Extract of Dioscorea alata L. Paoateno Variety of Banggai District, Central Sulawesi Islands","authors":"Ihwan Ismail, A. Khumaidi, Ayu Dinawati Putri, Rizki Primadia, Armini Syamsidi, Khilda Khaerati","doi":"10.22487/j24428744..v.i.16065","DOIUrl":"https://doi.org/10.22487/j24428744..v.i.16065","url":null,"abstract":"Background: Standardizing herbal medicines is crucial for assessing their quality and effectiveness. Objectives: This study aims to determine non-specific and specific standardization parameters for medicinal plants. Non-specific parameters include drying shrinkage, water content, total ash content, acid insoluble ash content, total bacteria, total mold, and metal limits (Pb, Hg, and Cd). Specific parameters involve organoleptic examination, identification of chemical content in extracts, dissolved compounds in specific solvents, total flavonoid content, and qualitative testing of anthocyanin content in the extract. Materials and Methods: An experimental laboratory approach was employed to extract Dioscorea alata L using 96% ethanol, which was later concentrated through a rotary evaporator to obtain a viscous extract. Specific and non-specific parameters were determined using standardized techniques. Results: The extract yielded 3.32% of the initial substance. Drying shrinkage was 19.7769±1.2682%, and specific gravity was 0.6192±0.1476 gram/ml for 5% m/v and 0.5101±3.9591 gram/ml for 10% m/v. Ash content was 0.6793%, with acid insoluble ash content at 0.1895%. Heavy metal contamination for Hg was 0.47 ppm, but undetected for Pb & Cd). The total plate number was 27 x 103 colonies/g, and negative Escherichia coli contamination. The mold count was 39 x 101 colonies/g. Additional specific parameters included the organoleptic properties of the viscous extract (purple color, characteristic odor, and sweet taste), water-soluble compound content (15.63%), ethanol-soluble compound content (14.73%), and a flavonoid content of 76.669 mg EQ/100 mg. Conclusions: The ethanol extract of Dioscorea alata complies with the standard requirements established by the Food and Drug Supervisory Agency. It presents as a viscous extract with a distinct odor, purple-black color, and sweet taste. The extract contains alkaloids, flavonoids, saponins, tannins, steroids, and phenolic compounds, with a total flavonoid content of 76.669 mg. Furthermore, it tested positive for anthocyanins.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122616197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Antidiabetic Pattern with Medication Adherence in Type 2 Diabetes Patients at Buleleng Hospital","authors":"Hubungan Antara, Pola Penggunaan, Antidiabetik dengan Kepatuhan, Pengobatan Pada, Pande Made, Desy Ratnasari, Gusti Ayu, Indira Ardeliani, Agustina Nila Yuliawati, Putu Dian, Marani Kurnianta","doi":"10.22487/j24428744..v.i.15908","DOIUrl":"https://doi.org/10.22487/j24428744..v.i.15908","url":null,"abstract":"Background: Type 2 diabetes mellitus (DM) is a chronic disease which requires long-term therapy. Medication adherence plays an important role for therapeutic success in patients with T2DM. Antidiabetic usage pattern might involve with some problems related to medication adherence. Objectives: The aim of this study was to analyze the association between antidiabetic usage pattern with medication adherence. Material and Methods: This observational study was conducted cross-sectionally involving 90 participants of T2DM  outpatient at Private Hospital in Buleleng Bali during July-September 2020. Patients were included if aged ≥18 years, received the same antidiabetic for three months before the study, signed informed consent, and provided with complete medical record data. Patients were excluded if appeared to be unwell, pregnant or breastfeeding. Demographic data and antidiabetic usage patterns were collected retrospectively based on the patient's medical records. Probabilistic Medication Adherence Scale (ProMAS) questionnaire was used to assess medication adherence. Data were analyzed with Kruskal-Wallis test. Results: The results showed that 55.6% patients were male, aged 46-65 years (61.1%), education predominantly by elementary school (37.8%), had suffered from DM for 5-10 years (46.7%), with comorbidities (50%), and without complications (77.8%). The antidiabetic usage pattern was dominated by a combination of two antidiabetics (53.3%). Most patients (42.2%) showed moderate-high medication adherence. There was no statistically significant association between antidiabetic usage pattern and medication adherence (p=0.275). Conclusions: A higher rate of medication adherence was found in patients taking combination of two antidiabetics compared to combination of three or four antidiabetics.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131065605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnopharmacology Study of Traditional Herbs as Anti-dandruff and Anti-baldness in Amarasi District, Kupang Regency","authors":"M. D. P. Upa, Marce Inggritha Taku Bessi, Yulius Baki Korassa","doi":"10.22487/j24428744..v.i.16119","DOIUrl":"https://doi.org/10.22487/j24428744..v.i.16119","url":null,"abstract":"Backgrounds: Hot weather in Indonesia can cause problems with hair and scalp health, including dandruff (seborrheic) and cause hair roots to become weak, making it easier for hair loss or alopecia to occur. The Amarasi people still do hair and scalp treatments with traditional plants. Objectives: This study aims to determine the ethnopharmacology of herbs as anti-dandruff and anti-baldness in Amarasi sub-district, Kupang district, including plant names, plant properties, plant parts, processing methods, usage methods and usage rules. Methods: This research is a qualitative descriptive study with an exploratory observational design. The data was obtained in the form of a survey by interviewing respondents with the help of a questionnaire. The sample in this study was a traditional healer (Hatra) who understood the use and use of anti-dandruff and anti-baldness drugs. Sampling was carried out using a purposive sampling techniq namely Hatra who were over 20 years old and had experience as a hatred for more than 3 years and above. The sample in this study was 17 traditional healers (Hatra). Results: result research shows that there are 18 plants consisting of 8 single plants and 16 herbs that are used and efficacious as anti-dandruff and anti-baldness. The plant parts used are leaves, fruit, seeds, sap/mucus, tube and oots. the method of processing plants for hair and scalp care by burning, splitting, fryinsqueezing and g, mashing, then, how to use it is washed, smearing, washedmassagingsaged. Rules for using plants 1-2 times a week. Conclusion: The Amarasi community has traditional plants and herbs that can be used as a treatment for scalp problems, including anti-dandruff, preventing hair loss and nourishing hair (anti-baldness). These plants based on research literacy studies conducted by previous researchers proved to have potential in the treatment of anti-dandruff and antibody.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115978059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technique Development in Improving the Solubility of Poorly Water Soluble Drugs (BCS II and IV)","authors":"Muhamad Reza Pahlevi, I. Sopyan, D. Gozali","doi":"10.22487/j24428744..v.i.15969","DOIUrl":"https://doi.org/10.22487/j24428744..v.i.15969","url":null,"abstract":"Orally active drugs are currently available on the market. API should have adequate solubility and permeability to enhance its therapeutic efficacy when administered orally and obtain optimum bioavailability. Almost 40% of New Chemical Entities had limited solubility or fell into BCS class II and IV. Our review aims to summarize and discuss the development of methods and characterization for increasing the solubility of poorly aqueous drugs from papers published in Google Scholar, NCBI, Science direct, Researchgate, and MDPI. We checked that the methods used such as solid dispersion, cocrystal formation, and coamorphous can increase the solubility of API which has an impact on increasing bioavailability. The successful formation of solid dispersions, cocrystals and coamorphs can be confirmed by the characterization of PXRD, DSC and SEM. In conclusion, drug solubility is an important aspect of pharmacological effects. Drugs with high solubility can provide fast solubility rates and high bioavailability, reducing the dose administered. Solid dispersion, cocrystals, and coamorphous techniques, have succeeded in increasing the solubility of BCS class II and IV drugs.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123110382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Combination of Cisplatin and Paclitaxel Chemotherapy on Tumor Mass in Nasopharyngeal Carcinoma Patients at Dr. Wahidin Sudirohusodo Hospital Makassar with the RECIST Method","authors":"Azima Hakim, Elly Wahyudin, N. Pieter","doi":"10.22487/j24428744..v.i.16236","DOIUrl":"https://doi.org/10.22487/j24428744..v.i.16236","url":null,"abstract":"Background: Nasopharyngeal Carcinoma (NPC) is a malignant tumor that grows from epithelial cells that line the surface of the nasopharynx and has a tumor position close to the base of the skull, vital structures, and anatomical locations that are difficult to reach and various symptoms are the cause of increased patient mortality and morbidity rates. This research aims to identify the most effective chemotherapy effect on reducing tumor mass in nasopharyngeal cancer patients. Material and Methods: This study was conducted retrospectively based on patient medical record data from January 2019 to December 2021 at Dr. Wahidin Sudirohusodo General Hospital. Inclusion criteria included NPC patients who received cisplatin, carboplatin, paclitaxel, and docetaxel chemotherapy and had complete data on tumor mass size before and after receiving chemotherapy from Series I to Series VI. The resulting assessment of tumor mass size was further categorized using RECIST. Results: A total of 166 NPC patients met the inclusion criteria. The results of the study obtained that NPC patients suffered more in men than women, most NPC patients were aged (41-50), Stage IVA had the highest percentage found in NPC patients, Histopathology based on WHO type III was most commonly found in 109 patients, 70 patients used the Cisplatin+Paclitaxel chemotherapy regimen, 55 patients used the Cisplatin+Paclitaxel chemotherapy regimen had a partial tumor mass response. Conclusions: The combination of Cisplatin + Paclitaxel has the most partial response to the tumor mass of NPC patients at Wahidin Sudirohusodo General Hospital, Makassar.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"597 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113997966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Sunscreen Cream Formulation Containing Ethanolic Extract of Avocado Leaves (Persea americana Mill.) or Mangosteen Rind (Garcinia mangostana L.) Combined with Octyl Methoxycinnamate","authors":"Vanessia Verda, William Leonardo, Deka Prismawan, D. Notario","doi":"10.22487/j24428744..v.i.16083","DOIUrl":"https://doi.org/10.22487/j24428744..v.i.16083","url":null,"abstract":"Background: Most sunscreens contain chemicals that can cause health and environmental problems. Natural actives can be an alternative to minimize the use of chemicals. Avocado leaves (Persea americana Mill.) and mangosteen peel (Garcinia mangostana L.) contain active compounds that have UV absorption. Objective: In this study, the optimal composition of a mixture of ethanol extracts of avocado leaves or mangosteen peel with octyl methoxycinnamate (OMC) was determined based on the Sun Protection Factor (SPF) and adhesive properties using Response Surface Methodology (RSM). Material and method: The optimal formula calculated with RSM was then made and underwent a series of tests, including a hedonic test with a scale of 0-9 on 30 respondents, a freeze-thaw stability test, and an accelerated stability test with the Arrhenius equation. Results: The RSM analysis showed that the optimal concentration of extract and OMC was 10% and 0.75% (avocado leaves) & 0.65% (mangosteen peel). The optimized formula resulted in adhesive properties and SPF of 7.41±0.03 and 16.52±0.16 (avocado leaves) & 7.43±0.04 and 15.84±0.15 (mangosteen peel) respectively. Both optimized formulations were physically stable against freeze-thaw and had a t90 of 29 minutes (avocado leaves) and 17 minutes (mangosteen peel). The average hedonic scale obtained was 7.8 (avocado leaves) and 7.9 (mangosteen peel), indicating that both optimized formulations were preferred by the respondents. Conclusions: The sunscreen formulation with an optimized combination of active ingredients from avocado leaf extract or mangosteen peel extract with OMC using RSM results in preparation with SPF value and physical properties that meet the requirements.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131987812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Phytochemical and Antioxidant Activity Evaluation of Lime (Citrus aurantifolia) Juice Powder","authors":"N. Rahmiati, Retno Sari, T. Wahyuni","doi":"10.22487/j24428744..v.i.16347","DOIUrl":"https://doi.org/10.22487/j24428744..v.i.16347","url":null,"abstract":"Background: Many chronic diseases that occur in society can be caused by free radicals. Excessive free radicals in the body can contribute to oxidative stress. Therefore, the role of antioxidants in needed to inhibit the effects of free radicals. Lime (Citrus aurantifolia) is a plant that contains several active compounds. The lime juice was reported to contain flavonoids and ascorbic acid which have several bioactivities including antioxidants. Objectives: This study aims to evaluate the chemical compounds and determine antioxidant activity in the lime juice powder of lime fruit collected from Ujung Pangkah, Gresik. Material and Methods: Lime was squeezed and dried by a freeze-dryer to remove the water content. The phytochemical profile of lime juice powder was evaluated by thin layer chromatography (TLC) method and ascorbic acid content in lime juice powder was determined further. The antioxidant activity was analyzed using the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) method. Results: The results of the study showed that lime juice powder contained flavonoids, saponins, terpenoids, and steroids. The ascorbic acid content was 0.38 mg/100mg. Antioxidant activities revealed strong antioxidant activity with an IC50 value of 32.59 mg/mL, while an IC50 value of ascorbic acid showed 8.57 mg/mL. Conclusions: Lime juice powder has potential as an antioxidant with an IC50 value of lime juice powder being categorized to possess very strong antioxidant activity.","PeriodicalId":206667,"journal":{"name":"Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125806242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}