Pediatrics international : official journal of the Japan Pediatric Society最新文献

{"title":"Estimating the insertion length of pediatric peripherally inserted central catheters.","authors":"H. Ota, K. Ide, Taro Watanabe, N. Nishimura, S. Nakagawa","doi":"10.1111/ped.15128","DOIUrl":"https://doi.org/10.1111/ped.15128","url":null,"abstract":"BACKGROUND\u0000It is difficult to determine the insertion length of peripherally inserted central catheters (PICCs) without fluoroscopy. The objectives of this study were to examine the relationship between the length from the anterior axillary point to the level of the carina (Lcarina ) and patient's height, and to obtain possible estimation formulas that can be considered for validation in future studies.\u0000\u0000\u0000METHODS\u0000We retrospectively analyzed PICCs from the upper arm in the pediatric intensive care unit (PICU) between May 2017 and September 2018. We evaluated the relationship between Lcarina and the patient's height using linear regression. We also conducted simulated performance assessment of simplified formulas based on the observed relationships.\u0000\u0000\u0000RESULTS\u0000Fifty-four PICCs from the right arm and 49 from the left for patients at the median age of 1 year were analyzed. The following linear correlations between Lcarina and the patient's height were observed: 0.105 × height (cm) + 1.53 (cm) (P < 0.001, R2 = 0.71) from the right arm, and 0.125 × height (cm) + 1.21 (cm) (P < 0.001, R2 = 0.65) from the left arm. In the simulated performance assessment, with a simplified formula, [0.1 × height (cm) + 1 (cm)], 93% (50/54) of the PICCs from the right arm and 96% (47/49) from the left arm were expected to be inserted in the subclavian vein, innominate vein, or superior vena cava.\u0000\u0000\u0000CONCLUSIONS\u0000The level of the carina was correlated with the patient's height. A simplified formula, 0.1 × height (cm) + 1, seemed to perform acceptably and appeared to be worth validating in future studies.","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126697545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right esophageal lung with esophageal atresia and left bronchial stenosis.","authors":"K. Morita, Insu Kawahara, Hiroki Yashita, T. Hatakeyama","doi":"10.1111/ped.14982","DOIUrl":"https://doi.org/10.1111/ped.14982","url":null,"abstract":"","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131407445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiology and outcome of acute recurrent pancreatitis and chronic pancreatitis.","authors":"S. Getsuwan, P. Tanpowpong, C. Lertudomphonwanit, Thitiporn Junhasavasdikul, Thipwimol Tim-Aroon, S. Treepongkaruna","doi":"10.1111/ped.15145","DOIUrl":"https://doi.org/10.1111/ped.15145","url":null,"abstract":"BACKGROUND\u0000Owing to the lack of data, we aimed to determine the etiology and outcome of acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) in children in Southeast Asia.\u0000\u0000\u0000METHODS\u0000This retrospective study was conducted at a university hospital in Bangkok, Thailand. We included patients aged <18 years who were diagnosed with pancreatitis from 2000 to 2021.\u0000\u0000\u0000RESULTS\u0000Among 155 patients with pancreatitis, 21 (13.5%) were diagnosed with either ARP (n = 7) or CP (n = 14). Clinical manifestations of CP included chronic abdominal pain (n = 10, 71.4%), steatorrhea (n = 8, 57.1%), and diabetes mellitus (n = 1, 7.1%). Positive radiological findings compatible with CP were detected from an abdominal ultrasound, computed tomography, magnetic resonance cholangiopancreatography in 70%, 90.9%, and 92.9% of patients, respectively. Genetic, metabolic, and pancreaticobiliary causes were the major causes of ARP/CP (23.8% each) and the etiologies were unidentified in one-fifth of the patients. Patients with metabolic diseases who had AP were at-risk of developing ARP (hazards ratio [HR], 4.7, 95% confidence interval [CI]: 1.5-13.9). Children with ARP or CP were younger than those with AP (P = 0.04). Approximately two-thirds of patients with CP had growth faltering and they had more episodes of hospitalization due to acute attacks when compared to patients with ARP ( 4 [interquartile range [IQR], 3-6] vs. 3 [IQR, 2-3]; P = 0.02).\u0000\u0000\u0000CONCLUSION\u0000Genetic, metabolic, and pancreaticobiliary diseases were the common etiologies of ARP and CP among children living in a developing country in Southeast Asia. The burden of CP included malnutrition and frequent hospitalization. The findings emphasize the importance of an early etiological diagnosis and monitoring for pancreatic insufficiency in ARP/CP.","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":"5 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131659013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of hematoma as a complication in pediatric kidney biopsies.","authors":"H. Nagata, Hiroshi Tamura, Yuko Hidaka, T. Ikeda, H. Nakazato","doi":"10.1111/ped.15189","DOIUrl":"https://doi.org/10.1111/ped.15189","url":null,"abstract":"BACKGROUND\u0000Kidney biopsies are crucial in the diagnosis of kidney diseases but they carry the risk of various complications, most commonly hematoma. Here we tried to identify the predictors of hematomas as a complication of kidney biopsies and we constructed an algorithm to stratify the risk.\u0000\u0000\u0000METHODS\u0000The present report retrospectively reviewed 118 pediatric percutaneous kidney biopsies of native kidneys in 102 children (59 females) with the median age of 9 years (range: 1-19 years) at Kumamoto University Hospital between August 2008 and October 2019. We defined hematoma size using the hematoma index: the short axis of the hematoma/major axis of the kidney on ultrasonography. The inclusion criteria for a hematoma as a complication of a kidney biopsy were hematoma index ≥0.1 and the presence of concomitant, post-kidney biopsy fever or flank pain.\u0000\u0000\u0000RESULTS\u0000Eight patients presented with a hematoma as a complication. All had hematoma index ≥0.1 and age ≥6 years. On univariate logistic analysis, these patients had a larger hemoglobin (Hgb) decrease on post-biopsy day 1, which was unrelated to a Hgb decrease 2 h after the biopsy, than the patients with no hematoma. All eight patients with a hematoma presented with a fever or flank pain on post-biopsy days 5 to 7, underscoring the need to observe patients with decreased Hgb carefully for about 1 week after a biopsy.\u0000\u0000\u0000CONCLUSION\u0000Predictors of hematoma as a complication in children after a kidney biopsy were hematoma index ≥0.1, age >6 years, and Hgb decrease ≥15% on post-biopsy day 1.","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132553195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An infected urachal cyst presenting as repeated cystitis in a child.","authors":"M. Fukuhara, Y. Uchida, Y. Yamaguchi, Tomoe Sato, T. Izaki","doi":"10.1111/ped.15086","DOIUrl":"https://doi.org/10.1111/ped.15086","url":null,"abstract":"","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134366252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bloom syndrome for which second chromosomal analysis led to early diagnosis.","authors":"Mai Yoshida, Yutaro Tomobe, Seiichi Tomotaki, F. Niwa, M. Kawai","doi":"10.1111/ped.15020","DOIUrl":"https://doi.org/10.1111/ped.15020","url":null,"abstract":"","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133361073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delay in diagnosis of blood disorders due to corticosteroid administration.","authors":"Kentaro Fujimori, K. Sakamoto, M. Kato, D. Tomizawa, A. Ishiguro","doi":"10.1111/ped.14997","DOIUrl":"https://doi.org/10.1111/ped.14997","url":null,"abstract":"","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132420431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Index for the appropriate vancomycin dosing in premature neonates and infants.","authors":"Aiju Endo,&nbsp;Atsushi Nemoto,&nbsp;Kazumi Hanawa,&nbsp;Takahiro Ishikawa,&nbsp;Mai Koshiishi,&nbsp;Yuki Maebayashi,&nbsp;Yohei Hasebe,&nbsp;Atsushi Naito,&nbsp;Yoshifumi Kobayashi,&nbsp;Katsuhiko Isobe,&nbsp;Yayoi Kawano,&nbsp;Takehisa Hanawa","doi":"10.1111/ped.14905","DOIUrl":"https://doi.org/10.1111/ped.14905","url":null,"abstract":"<p><strong>Background: </strong>In neonates, vancomycin (VCM) is used to treat Gram-positive bacterial infections. However, VCM blood concentrations are affected by gestational age, bodyweight (BW), and renal function. The initial VCM dose adjustment can therefore be difficult, and few reports have evaluated this issue. In this study, we investigated the factors determining the appropriate VCM dosing schedule in neonates, especially premature infants.</p><p><strong>Methods: </strong>The VCM dosage and trough concentrations were retrospectively investigated from the initial treatment to maintenance therapy in neonatal intensive care unit patients who underwent therapeutic drug monitoring. We examined the average single-administration VCM dosage during maintenance therapy. We then compared the actual VCM dose with that calculated using an index comprising six items that influence the VCM daily dose (postnatal age, gestational age, BW, serum creatinine level, urine output, and lactate level).</p><p><strong>Results: </strong>Twenty premature infants were included. The average BW of patients at the initial VCM administration was 975 g. During maintenance therapy, the average VCM dose was 8.4 mg/kg, and the median trough concentration was 12.4 μg/mL. When we applied the six-item index, 18 of 20 patients (90%) had concordant results between the actual VCM dosing schedule and the VCM calculated using the index.</p><p><strong>Conclusions: </strong>The average VCM dose and six-item index can facilitate the transition from the initial VCM dose to an appropriate dose in many cases and contribute to early treatment in low-birthweight infants with more variable BW, distribution volumes, and renal function. In conclusion, our six-item index may help standardize VCM administration in premature infants.</p>","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e14905"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ped.14905","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39127862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing norms on the Japanese version of the Eyberg Child Behavior Inventory.","authors":"Fumie Ito,&nbsp;Miyuki Matano,&nbsp;Ikuko Kato,&nbsp;Yukifumi Monden,&nbsp;Yuki Sunohara,&nbsp;Masako Kawasaki,&nbsp;Hitoe Kimura,&nbsp;Shima Furuichi,&nbsp;Regina Bussing,&nbsp;Yuka Oe,&nbsp;Nobuaki Morita,&nbsp;Yoshiharu Kim,&nbsp;Elizabeth Brestan-Knight,&nbsp;Sheila Eyberg,&nbsp;Toshiko Kamo","doi":"10.1111/ped.14910","DOIUrl":"https://doi.org/10.1111/ped.14910","url":null,"abstract":"<p><strong>Background: </strong>The Eyberg Child Behavior Inventory (ECBI) is one of the standardized parent rating scales used to identify disruptive behavior problems in children in Western countries. This study aimed to determine norms for the Japanese version of the ECBI, including clinical cutoff scores among the general population in Japan.</p><p><strong>Methods: </strong>This study established norms for the Japanese version of the ECBI using a sample of 1,992 parents of children aged 2-7, living in Japan. The research evaluates the validity and the reliability of the ECBI scores for the Intensity Scale and the Problem Scale. After validation, a clinical cutoff value of the ECBI scores was calculated, setting the cutoff to above the +1 standard deviation (SD) level based on the population distribution.</p><p><strong>Results: </strong>The means of the Intensity and Problem Scale scores were 100.07 and 6.57, respectively. Cronbach's α for both the Intensity and the Problem scores was 0.91. At this point, we propose cutoff scores of 125 for the Intensity Scale and 14 for the Problem Scale.</p><p><strong>Conclusions: </strong>Our results suggest that the Japanese version of the ECBI is highly reliable and may be useful as a tool for assessing behavior problems in children.</p>","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e14910"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ped.14910","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39161039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute lymphoblastic leukemia in infants: A quarter century of nationwide efforts in Japan.","authors":"Daisuke Tomizawa,&nbsp;Takako Miyamura,&nbsp;Katsuyoshi Koh,&nbsp;Eiichi Ishii","doi":"10.1111/ped.14935","DOIUrl":"https://doi.org/10.1111/ped.14935","url":null,"abstract":"<p><p>Acute lymphoblastic leukemia (ALL) with KMT2A gene rearrangement (KMT2A-r) in infants is a biologically and clinically unique disease and one of the most difficult to cure forms of pediatric leukemia. Multicenter clinical trials have been carried out in Japan since the mid-1990s by introducing allogeneic hematopoietic stem cell transplantation (HSCT) in first remission, which led to a modest improvement in outcome of infants with KMT2A-r ALL. Because of the emerging evidence that HSCT does not benefit every infant with KMT2A-r ALL, the Japanese Pediatric Leukemia/Lymphoma Study Group trial MLL-10 introduced risk stratification using age and presence of central nervous system leukemia, and introduced intensive chemotherapy, including high-dose cytarabine in early consolidation; indication of HSCT was restricted to the patients with high-risk features. The trial resulted in excellent 3-year event-free survival of 66.2% (standard error, 5.6%) and overall survival of 83.9% (standard error, 4.3%) for 75 patients with KMT2A-r ALL recruited between 2011 and 2015. This Japanese experience and the results of the infant ALL trials worldwide suggest the importance of introducing effective therapy in the early phase of therapy, thus clearing minimal residual disease as rapidly as possible. However, further improvement in outcome is unlikely with conventional treatment approaches. Introduction of biology-driven novel agents and/or immunotherapies through international collaboration would be key solutions to overcome the disease.</p>","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e14935"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39257869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}