Pediatrics international : official journal of the Japan Pediatric Society最新文献

{"title":"Leptin receptor and prolactin in pubertal disorders and chronic kidney disease.","authors":"Miguel A Villasís-Keever,&nbsp;Jessie N Zurita-Cruz,&nbsp;Juana Serret-Montoya,&nbsp;Claudia Del Carmen Zepeda-Martinez,&nbsp;Gabriela Alegria-Torres,&nbsp;Aly S Barradas-Vazquez,&nbsp;Beatriz C Hernández-Hernández,&nbsp;Sara R Alonso-Flores,&nbsp;Leticia Manuel-Apolinar,&nbsp;Leticia Damasio-Santana","doi":"10.1111/ped.15183","DOIUrl":"https://doi.org/10.1111/ped.15183","url":null,"abstract":"<p><strong>Background: </strong>Knowledge of chronic kidney disease (CKD) with pubertal disorders (PD) in adolescent boys is limited as few studies have explored this disorder. This study aimed to identify the usefulness of assessing hormonal parameters in male adolescents with CKD and their correlation with PD in a 12-month follow-up period.</p><p><strong>Methods: </strong>A prospective cohort study was conducted among male adolescents with CKD (stages IV and V). Data regarding the age at puberty onset were collected from the patients' clinical records and through interview. The patients were followed up for 12 months during their pubertal development. At the beginning, routine hormonal profile tests were performed to examine the patients' thyroid profile, prolactin levels, luteinizing hormone, follicle-stimulating hormone, testosterone, leptin, and receptor leptin. The hormonal profiles of patients with and without PD were compared. Comparisons between the groups were performed using the Student t-test and Fisher's exact tests. Logistic regression analysis was also performed.</p><p><strong>Results: </strong>Data of 64 patients (26/64 with PD) were analyzed. The median age was 15 years and the median time for CKD evolution was 11 months. No differences between groups were noted in the general or biochemical characteristics of the patients. The hormonal parameters, prolactin levels were higher and the free leptin and free thyroxine levels were lower in patients with PD. Leptin receptor levels of >0.90 ng/mL (risk ratio [RR], 8.6; P = 0.004) and hyperprolactinemia (RR, 21.3; P = 0.049) were the risk factors for PD.</p><p><strong>Conclusions: </strong>Leptin receptor levels of >0.90 ng/mL and hyperprolactinemia are associated with the development of PD in male adolescents with CKD.</p>","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e15183"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40461633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highest concentration of breast-milk-derived exosomes in colostrum.","authors":"Motoki Ohta,&nbsp;Shigeki Koshida,&nbsp;Itsuki Jimbo,&nbsp;Machi Oda,&nbsp;Ryo Inoue,&nbsp;Takamitsu Tsukahara,&nbsp;Masaki Terahara,&nbsp;Yoshitaka Nakamura,&nbsp;Yoshihiro Maruo","doi":"10.1111/ped.15346","DOIUrl":"https://doi.org/10.1111/ped.15346","url":null,"abstract":"<p><strong>Background: </strong>Exosomes are nanosized extracellular vesicles, that play important roles in intercellular immune regulation. They have potential therapeutic utility for neonatal diseases including necrotizing enterocolitis. Breast-milk-derived exosomes have recently shown beneficial effects on intestinal damage in vitro and in vivo. However, the chronological change in breast-milk-derived exosome concentrations after delivery are unclear.</p><p><strong>Methods: </strong>In this prospective study, we enrolled 17 mothers who delivered premature infants admitted to a neonatal intensive care unit in Japan. We measured the consecutive concentrations of breast-milk-derived exosomes in the mothers for 48 weeks after delivery.</p><p><strong>Results: </strong>The median concentration of breast-milk-derived exosomes was 1.62 × 10⁸ particles/ml in colostrum, showing a significant decrease after 2 weeks (P < 0.01). There was no association between the exosome concentration in colostrum and maternal perinatal factors including parity, mode of delivery, maternal age, and gestational age at delivery.</p><p><strong>Conclusions: </strong>We concluded that breast-milk-derived exosomes were the richest in colostrum. Our basic data regarding breast-milk-derived exosomes are expected to aid in the clinical application of exosomes for treating neonatal diseases.</p>","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e15346"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40462918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Japanese Sleep Questionnaire for preschoolers within a Malaysian context.","authors":"Subhashini Jayanath,&nbsp;Norhamizan Hamzah,&nbsp;Aishah Ahmad Fauzi,&nbsp;Aida Syarinaz Ahmad Adlan,&nbsp;Nor Asiah Muhamad,&nbsp;Azlin Zaiti Zainal,&nbsp;Ikuko Mohri,&nbsp;Masaya Tachibana","doi":"10.1111/ped.15123","DOIUrl":"https://doi.org/10.1111/ped.15123","url":null,"abstract":"<p><strong>Background: </strong>Childhood sleep practices impact growth, development, and long-term health. There is a paucity of sleep data pertaining to preschool children in Asia, especially South-East Asia.</p><p><strong>Methods: </strong>This cross-sectional study involved parents of well siblings, aged 2-6 years. It aimed to: (i) test the reliability of the English version of the Japanese Sleep Questionnaire for Preschoolers (JSQ-P), and (ii) obtain the prevalence, as well as describe, sleep-related issues. Ninety-one (91) parents (74.7%; mothers) self-administered the questionnaire in the pediatric clinic waiting area of a Malaysian tertiary hospital. Recruitment was from August to November 2020.</p><p><strong>Results: </strong>The English version of the JSQ-P has good internal consistency (Cronbach alpha = 0.85). Range of Cronbach alpha values for each item: 0.36-0.87. Many (77%) children slept at 10:00 p.m. or later, similar to parents' late bedtimes. One-third had difficulty waking up in the morning. There were significant strong positive correlations between some features of restless leg syndrome, daytime tiredness, morning symptoms, and obstructive sleep apnea symptoms. Co-sleeping was prevalent (97.9%). Mean screen time for those who had set time limits was 2.35 ± 1.68 h.</p><p><strong>Conclusions: </strong>The English-language translation of the JSQ-P is a questionnaire with good internal consistency that can be used in non-Japanese speaking countries. Parents need to be educated on healthy sleep and screen time practices to optimize children's sleep quality and quantity.</p>","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e15123"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40502955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiographic diagnosis for accurate assessment of congenital porto-systemic shunt and extrahepatic portal vein obstruction in children.","authors":"Yuji Doi,&nbsp;Sung-Hae Kim,&nbsp;Mizuhiko Ishigaki,&nbsp;Keisuke Sato,&nbsp;Jun Yoshimoto,&nbsp;Norie Mitsushita,&nbsp;Masaki Nii,&nbsp;Masaya Yamoto,&nbsp;Naoto Urushihara,&nbsp;Yasuhiko Tanaka","doi":"10.1111/ped.14856","DOIUrl":"https://doi.org/10.1111/ped.14856","url":null,"abstract":"<p><strong>Background: </strong>Congenital porto-systemic shunt (CPSS) is a rare disease and can cause fatal complications. Accurate angiographic assessment is mandatory for proper treatment. Although technically difficult, we developed assessment techniques and assessed their accuracy. One technique came from evaluating patients with extrahepatic portal vein obstruction (EHPVO).</p><p><strong>Methods: </strong>We conducted a single center retrospective study to evaluate the efficacy of angiographic diagnostic procedure for the assessment of CPSS and EHPVO, and its impact on patients' subsequent interventions and clinical course. Eight patients with CPSS and two patients with EHPVO who underwent diagnostic angiography were included. Assessment of the intrahepatic portal vein was performed in all patients. The route of the shunt, and portal vein pressure under shunt occlusion, were also evaluated for patients with CPSS. Evaluation was first attempted with a balloon angiographic catheter (standard method). Three additional techniques were performed as needed: (i) direct wedge-catheter injection without balloon inflation, (ii) use of occlusion balloon in two patients, and (iii) hybrid angiography with sheath placement directly into the superior mesenteric vein.</p><p><strong>Results: </strong>The standard method was sufficient in four patients. On the other hand, all three techniques were required in two patients each. One lost contact during follow up, but all other patients underwent optimal intervention. There were no complications related to the angiographic procedure.</p><p><strong>Conclusions: </strong>Use of direct wedge-catheter injection without balloon inflation, occlusion balloon, and hybrid catheterization improved the diagnostic yield in patients with CPSS or EHPVO.</p>","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e14856"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ped.14856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38947722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum free carnitine levels in children with Kawasaki disease.","authors":"Taichiro Muto,&nbsp;Nami Nakamura,&nbsp;Yu Masuda,&nbsp;Shingo Numoto,&nbsp;Shunsuke Kodama,&nbsp;Ryosuke Miyamoto,&nbsp;Tomohito Hayakawa,&nbsp;Hiromitsu Mori,&nbsp;Hideyuki Iwayama,&nbsp;Hirokazu Kurahashi,&nbsp;Hiroatsu Agata,&nbsp;Akihisa Okumura","doi":"10.1111/ped.14849","DOIUrl":"https://doi.org/10.1111/ped.14849","url":null,"abstract":"<p><strong>Background: </strong>Carnitine plays an essential role in the transfer of long-chain fatty acids to the mitochondria for β-oxidation. No study has characterized carnitine in children with Kawasaki disease (KD). The objective of this study was to elucidate the characteristics of serum free carnitine (FC) in hospitalized pediatric patients with KD.</p><p><strong>Methods: </strong>We retrospectively analyzed 45 patients with KD in whom serum FC levels were measured. We investigated the clinical and laboratory parameters before intravenous immunoglobulin was administered, including serum FC levels, according to the response to intravenous immunoglobulin (IVIG). We also analyzed the relationship among serum FC, laboratory data, and clinical variables.</p><p><strong>Results: </strong>IVIG was effective in 33 children (responders) and was ineffective in 12 children (non-responders). Serum FC levels were higher in non-responders than in responders: 35.3 μmol/L (range, 26.8-118.4 μmol/L) vs 31.4 μmol/L (range, 20.9-81.2 μmol/L), P <0.05. FC levels before IVIG in 80% of responders were below the normal range. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, and FC were higher in non-responders than in responders. FC levels were correlated with AST (R² = 0.364, P = 0.0015) and ALT (R² = 0.423, P < 0.001) levels.</p><p><strong>Conclusions: </strong>Free carnitine levels were elevated in some patients with KD, especially in those who were refractory to IVIG. Additionally, FC levels in children with KD correlated with ASL and ALT levels.</p>","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e14849"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ped.14849","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38991580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infantile spasms in Down syndrome responsive to phenobarbital.","authors":"Roddie Moraes Neto,&nbsp;Gustavo L Franklin,&nbsp;Ana Chrystina De Souza Crippa","doi":"10.1111/ped.15070","DOIUrl":"https://doi.org/10.1111/ped.15070","url":null,"abstract":"","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e15070"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40310759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The changing face of abuse cases in a pediatric intensive care unit: A single-center experience.","authors":"Fatih Varol,&nbsp;Ebru Sahin,&nbsp;Busra Ozgunay,&nbsp;Mehmet Cengiz,&nbsp;Zeynep Meva Altas,&nbsp;Sirin Guven","doi":"10.1111/ped.15293","DOIUrl":"https://doi.org/10.1111/ped.15293","url":null,"abstract":"<p><strong>Background: </strong>Due to the increase in abuse and neglect cases in recent years, the purpose of this study was to assess child abuse and neglect of patients who were hospitalized and followed up in our pediatric intensive care unit (PICU).</p><p><strong>Methods: </strong>A total of 34 abuse and neglect patients who were admitted to the PICU from August 2020 to March 2021 were included retrospectively in the study. Patients' clinical and demographic characteristics were obtained from our hospital's patient record system (HIS). Comorbidities and the mental status of the patients, affected systems, treatments, and outcomes were extracted.</p><p><strong>Results: </strong>In this study, 44.1% (n: 15) of the patients were male and 55.9% (n: 19) were female. Physical neglect such as foreign body aspiration, malnutrition, electrocution, drowning, traffic accident, and body collision was detected in 14 (41.2%) patients. Emotional neglect (taking drugs, alcohol, or suicide) was found in 19 (55.9%) of our patients. Only 1 (2.9%) patient presented with physical abuse.</p><p><strong>Conclusions: </strong>Perception of neglect varies among different cultures. Any infant or child who is admitted to the PICU with a history that is not consistent, a history of delay in seeking medical attention, a previous history of abuse or suspected abuse, or the absence of the primary caretaker at the appearance of illness should signal possible abuse. Health-care professionals should give more attention to these patients to prevent the overlooking and recurrence of neglect and abuse cases due to the intense work tempo in the PICU.</p>","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e15293"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40387633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of pediatric headache cases referred to a neurology department.","authors":"Keita Kanamori,&nbsp;Sahoko Miyama","doi":"10.1111/ped.15181","DOIUrl":"https://doi.org/10.1111/ped.15181","url":null,"abstract":"<p><strong>Background: </strong>Headaches are very common in children. The patients often have mild symptoms, but on occasion may have severe, secondary headaches. The present study aimed to clarify the details of children with headaches seen at the outpatient clinic of a pediatric neurological department.</p><p><strong>Methods: </strong>The present, retrospective observational study was conducted at a tertiary pediatric hospital in Japan and enrolled children referred to the neurology department outpatient clinic for headache between April 2018 and March 2021.</p><p><strong>Results: </strong>In total, 113 cases of headache were examined; of these, 99 (87.6%) were primary headaches, one case (0.9%) was a secondary headache, and 13 (11.5%) were unclassified or unspecified. There were 46 cases (40.7%) of tension-type headache (TTH), both confirmed and suspected, 30 cases (26.5%) of migraine, and 23 cases (20.4%) of a combination of the TTH and migraine. One case of secondary headache was attributed to an infection. Arachnoid cysts were found in seven patients (7.8%). Acute drug treatments were administered to 93 patients (82.3%), with acetaminophen being the most common drug, followed by ibuprofen. Prophylactic drug treatments were administered to 39 patients (34.5%), with goreisan (a Chinese herbal medicine containing Alisma orientale, Poria cocos, Polyporus umbellatus, Atractylodes lancea, and Cinnamomum cassia) being the most common (41%).</p><p><strong>Conclusions: </strong>Few cases of secondary headache and none of emergency headache were diagnosed. The prevalence of arachnoid cysts was higher than in the general pediatric population, suggesting that arachnoid cysts might be associated with headache.</p>","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":" ","pages":"e15181"},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40410316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of childhood growth and obesity curves in school health examinations.","authors":"J. Takaya, H. Higashino, Ryuzo Takaya, Hiromi Sakaguchi, Jitsuo Tanoue, Takashi Higashide, Hisako Moriguchi, Masatoshi Nakao, Shigeto Shigematsu","doi":"10.1111/ped.15182","DOIUrl":"https://doi.org/10.1111/ped.15182","url":null,"abstract":"BACKGROUND\u0000With the revision of the Japanese School Health and Safety Law in 2016, the use of growth and obesity curves has been recommended. This study aimed to determine the prevalence of growth and obesity curve creation in elementary and junior high schools using government-issued software in Japan between 2016 and 2019.\u0000\u0000\u0000METHODS\u0000A questionnaire survey was conducted with school nursing teachers in elementary and junior high schools in Osaka, Japan. The questionnaire was distributed and collected by e-mail between 1 and 31 March 2020.\u0000\u0000\u0000RESULTS\u0000The survey response rate was 87.1%. In total, 78.5% of the elementary schools, and 75.0% of the junior high schools had the software for creating the growth curves. The rate of adoption of growth curve creation using the software increased in elementary schools (from 16.2% in 2016 to 40.5% in 2019 and in junior high schools from 6.0% in 2016 to 33.6% in 2019. The detection rates of growth abnormalities also increased over the 4 years in elementary and junior high schools, as follows: short stature (2.48- and 3.81-fold, respectively), tall stature (2.77- and 4.77-fold, respectively), emaciation (2.62 and 4.85-fold, respectively), mild obesity (2.66 and 5.15-fold, respectively), moderate obesity (2.71- and 4.14-fold, respectively), and severe obesity (2.45- and 3.32-fold, respectively). The rates of receiving a recommendation slip and going on to consult a specialist for each growth abnormality were low.\u0000\u0000\u0000CONCLUSIONS\u0000By utilizing these curves, the detection rate of physical development abnormalities increased, but the rate of recommending a specialist consultation and the rate of actual consultation with a specialist were still low.","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123429594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous oral mite anaphylaxis in siblings, identified by the saturated saline flotation method.","authors":"Yosuke Yoshimoto, T. Oda, M. Kawamura, Kota Ikari, J. Tezuka","doi":"10.1111/ped.14989","DOIUrl":"https://doi.org/10.1111/ped.14989","url":null,"abstract":"","PeriodicalId":206308,"journal":{"name":"Pediatrics international : official journal of the Japan Pediatric Society","volume":"183 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124622090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}