Journal of Alzheimer’s & Neurodegenerative Diseases最新文献_第2页

The Scientific Search for the Soul in the Higgs Field 在希格斯场对灵魂的科学探索

Journal of Alzheimer’s & Neurodegenerative Diseases Pub Date : 2020-12-30 DOI: 10.24966/and-9608/100049

S. Goradia

引用次数: 1

Shopping Activities for Preventing Housebound 防止居家购物活动

Journal of Alzheimer’s & Neurodegenerative Diseases Pub Date : 2019-11-12 DOI: 10.24966/and-9608/100029

Yuki Hayashi

引用次数: 0

Dose-Dependent Anticonvulsant and Protective Effects of Metformin in Kainate Induced Temporal Lobe Epilepsy 剂量依赖性二甲双胍抗惊厥及对海钠盐诱导颞叶癫痫的保护作用

Journal of Alzheimer’s & Neurodegenerative Diseases Pub Date : 2019-11-12 DOI: 10.24966/AND-9608/100026

F. Nikbakht, Cellular

{"title":"Dose-Dependent Anticonvulsant and Protective Effects of Metformin in Kainate Induced Temporal Lobe Epilepsy","authors":"F. Nikbakht, Cellular","doi":"10.24966/AND-9608/100026","DOIUrl":"https://doi.org/10.24966/AND-9608/100026","url":null,"abstract":"Introduction: Metformin, the most commonly prescribed antidiabetic drug, has been shown to be effective in controlling seizures in some studies. However, there are some reports of proconvulsant activity of metformin in diabetic patients. The aim of the present study was to investigate the effects of metformin dosage on anti-seizure and neuronal protective activity. Method: Male Wistar rats were randomly divided into 5 groups as follows: 1-control/vehicle group, 2Kainic acid (KA), 3-metformin+KA (50 mg/kg), 4-metformin+KA (100 mg/kg), 5metformin+KA (200 mg/ kg). Temporal lobe epilepsy (TLE) was induced by injection of 0.5 μg kainite into the left lateral ventricle. Metformin was administered orally for two weeks before the induction of TLE. Results: We found that metformin at higher doses (100 and 200 mg/ kg) significantly suppressed the progression of seizure in TLE and ameliorated the neuronal loss in the hippocampus induced by KA. However, the low dose of metformin had no effect. Conclusion: We concluded that metformin may be a potential agent for the treatment of epilepsy and seizure and this effect is dose-dependent.","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114004705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Relationship between Perioperative Gut Microbiome and POCD 围手术期肠道菌群与POCD的关系

Journal of Alzheimer’s & Neurodegenerative Diseases Pub Date : 2019-11-12 DOI: 10.24966/and-9608/100025

Peng-chong Liang

引用次数: 0

CWPT (Color Words Pick-Out Test) Available for Classifying the Slight Disorder on the Preclinical Stage of Dementia CWPT(颜色词挑选测试)可用于痴呆临床前阶段轻微障碍的分类

Journal of Alzheimer’s & Neurodegenerative Diseases Pub Date : 2019-11-12 DOI: 10.24966/and-9608/100028

T. Shimura

{"title":"CWPT (Color Words Pick-Out Test) Available for Classifying the Slight Disorder on the Preclinical Stage of Dementia","authors":"T. Shimura","doi":"10.24966/and-9608/100028","DOIUrl":"https://doi.org/10.24966/and-9608/100028","url":null,"abstract":"Objective: Before concept of mild cognitive impairment (MCI) and preclinical stage of dementia (PCSD) our study started to detect slight declines in the brain. The purpose of this study is to clarify the basis of the ability of the devised CWPT (Color Word Pick-out Test) to detect slight disorder and classify it at the MCI and PCSD. Methods: CWPT is an application of Stroop effect and is including an examination of episodic memory to obtain the evidence and 1 activation of the prefrontal lobe using an inferred spectroscopy, 2 criterion-related validity using CWPT, WCST, HCL, FAB and MMSE 3 sensitivity and specificity using MMSE and CWPT are examined. Results: 1 It is found using a near infrared spectroscopy that CWPT is the most effective test for the brain activation, in comparison with quick repetition of 4-5numbers in order, in reverse order, Kawashima arithmetic drill and KPT (Kana Pick-out Test). 2 among the histograms obtained from 22 healthy aging people, only CWPT and WCST show normal distributions besides CWPT has good correlation with WCST. 3 Sensitivity and specificity are calculated using MMSE as a true condition and CWPT as a predicted condition for 29 subjects with dementia. Sensitivity becomes 0.963 and specificity becomes 1.0 by the cutoff of the average-1.5SD of CWPT. Conclusion: As a result of these analyses, it has been suggested that CWPT can be used to classify the level of disorder during MCI and the preclinical stage of dementia.","PeriodicalId":205994,"journal":{"name":"Journal of Alzheimer’s & Neurodegenerative Diseases","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130124447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Commentary about the Function of Selenoprotein SELENOK for the Prevention and Treatment of Alzheimer’s Disease 硒蛋白SELENOK在阿尔茨海默病防治中的作用综述

Journal of Alzheimer’s & Neurodegenerative Diseases Pub Date : 2019-11-12 DOI: 10.24966/and-9608/100027

Changgui Chen

引用次数: 0