Proceedings of the National Academy of Sciences of Belarus, Medical series最新文献

{"title":"Elimination of defects in a welded joint in a niobium superconducting resonator","authors":"A. A. Burin, V. Zaleski, I. L. Pobol","doi":"10.29235/1561-8358-2023-68-1-18-23","DOIUrl":"https://doi.org/10.29235/1561-8358-2023-68-1-18-23","url":null,"abstract":"The possible reasons for the appearance of defects during welding of a niobium superconducting coaxial halfwave resonator (HWR) are investigated, which consist in the deviation of the shape of the welded surface from the given one, in the deviation of the angle of incidence of the beam from the perpendicular to the welded surface, in fluctuations in the thickness of the welded edges, and also the presence of some instability (pulsation) accelerating voltage, beam currents and focusing of the electron beam gun. The possibilities of preventing the appearance of defects during welding are determined, which consist in regulating the operating parameters of the electron beam gun depending on possible errors in the manufacture and preparation of the welded edges. Methods for elimination of defects in welding of niobium superconducting coaxial HWR are studied. A method has been developed for repairing defects in welded joints such as burn-throughs on the type of resonator under study using electron-beam deposition. The results of measuring the resonant frequency of the HWR before the onset and after the recovery of burn-through are presented, which showed that the melting of the hole did not lead to a change in the electrical characteristics. Vacuum and cryogenic tests at liquid nitrogen temperature confirmed the tightness of the welded joints. The results obtained can be used in the development of basic technologies for the restoration and repair of expensive and difficult-to-manufacture elements of accelerator technology – superconducting high-frequency resonators made of high-purity niobium sheet.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80041179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-lived radionuclides radiotoxicity ranking the nuclear fuel cycle of the Belarusian NPP","authors":"N. V. Harbachova, J. A. Korchova, N. Kuzmina, N. Kulich, S. Yacko","doi":"10.29235/1561-8358-2023-68-1-72-81","DOIUrl":"https://doi.org/10.29235/1561-8358-2023-68-1-72-81","url":null,"abstract":"Using a methodical approach to the potential biological hazard (radiotoxicity) assessment of radionuclides, computational studies and a comparative analysis of the contributions to the total radiotoxicity of long-lived fission products and actinides accumulated in the nuclear fuel cycle of the Belarusian NPP were carried out. In order to estimate correctly the 237Np isotope mass at the long-term stage of SNF management, the mathematical model of the nuclear fuel cycle of the Belarusian NPP of the code CUB was modified to take into account the transmutation chain of 241Pu, 241Am and 237Np isotopes. The initial concentrations for the main radiation-hazardous radionuclides at the time of fuel unloading from the VVER1200 reactor core are presented in the database “Radiation Characteristics of Spent Nuclear Fuel of the Belarusian NPP” developed by the authors. The database development is carried out in accordance with the recommendations of the RB-093-20 “Radiation and thermophysical characteristics of spent nuclear fuel of pressurized water power reactors and high-power channel reactors”. The main characteristics used in the nuclear fuel cycle simulation in the CUB code, such as the total mass of spent nuclear fuel (2492 tons), the number of spent fuel assemblies (5294) and the average burnup, are taken in accordance with the Spent Fuel Management Strategy of the Belarusian NPP data. It is shown that at the stage up to 100 years, the main contributors to the total radiotoxicity are the isotopes of 238Pu, 239Pu, 240Pu, 243Am, 241Pu, 241Am, 237Np, where contributions of three last of them are 0.07, 49.0 and 0.007%, respectively. But 5000 years later, the contribution of 241Am will be 0.24%, and the isotope 237Np – up to 0.1% of the total actinides radiotoxicity. The results obtained can be used to substantiate for the recovery degree requirements of 237Np, 241Pu, 241Am during the SNF of the Belarusian NPP reprocessing.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89615191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific patterns of adaptive human kinematics","authors":"V. Lukashevich, V. V. Ponomarev, S. Gubkin, M. I. Tarasevich, S. M. Mankevich","doi":"10.29235/1814-6023-2023-20-1-82-88","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-1-82-88","url":null,"abstract":"A study of healthy individuals (n = 90) was carried out under standardized environmental conditions using tests of adaptive kinematics in the form of a battery of postural tests. A model of adaptive kinematics of healthy individuals, resistant to personal (age and anthropometric) uncertainties, has been developed. 34 criteria selected from a total pool of 170 indicators were used as relevant parameters underlying the developed biomechanical model.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90151907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-hospital clinical course, outcome and complications among patients vaccinated against COVID-19","authors":"T. Kalenchic, S. Kabak, O. V. Losevich, M. A. Glazkina","doi":"10.29235/1814-6023-2023-20-1-34-41","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-1-34-41","url":null,"abstract":"This retrospective case-series analysis evaluated 403 fully vaccinated with Vero Cell or Sputnik V vaccines patients hospitalized in the 6th City Clinical Hospital of Minsk in the period between January 01 and February 28, 2022 with the main diagnosis of “coronavirus infection (COVID-19)”. The diagnosis was confirmed by PCR or SARS-CoV-2 virus antigen tests, as well as chest computed tomography data.The study revealed higher prevalence of older patients (over 65 years) infected with the SARS-CoV-2 virus and hospitalized in early 2022, at the height of the wave of the pandemic due to the spread of the Omicron variant. Most patients (91.8 %) had moderate symptoms. More than half of them received oxygen support. A relatively small number of inpatient, only 8 persons (1.9 %), were hospitalized in the intensive care unit (ICU) and four of them needed mechanical ventilation. Comorbid conditions and high incidence of mortality (63.5 %) were common in ICU patients. Hypertension and obesity prevailed in the structure of comorbid pathology of all inpatient persons (74.2 and 24.3 %, respectively). Patients of therapeutic departments had relatively short length of stay in the hospital, as well as low in-hospital mortality (0.5 %) and low incidence of complications (5.3 %).","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88420932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental model of precancerous lesions of the oral mucosa","authors":"N. Karpuk, S. Rubnikovich, M. Medvedev","doi":"10.29235/1814-6023-2023-20-1-71-81","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-1-71-81","url":null,"abstract":"Oral mucosal cancer (OMC) is a serious public health problem. Studies were performed on 210 males of white mongrel rats weighing 180–200 g. The animals were randomly divided into 3 groups of 7 subgroups, with 10 rats in each group. The rats of the first group were included in the diet by dissolving a solution 4-NQO (carcinogen) in drinking water at a concentration of 50 mg/ml. The animals of the second group were applied by carcinogen dissolved in drinking water at a concentration of 50 mg/ml to the ОМС of the lower lip and the tongue three times a day (at 9:00, 2:00, and 7:00 pm) in combination with exposure to a 3D device with a traumatic element.The method of experimental modeling of pre-tumor lesions of the oral mucosa was developed. It included a combined local exposure to the solution 4-NQO and the 3D device with a traumatic element on the rat lower lip OMC. It has the following advantages over the existing models: the development of hyperplasia and dysplasia of lower lip ОМС epithelium is achieved after 12 weeks in 100 % of animals, and in the comparison group – in 20 % of rats (р < 0.05); no carcinogen affection of other gastrointestinal organs, as indicated by no reduction of live body weight gain before the development of ОМС changes required from the experimental model (р >< 0.05); visually accessible localization of pathological epithelial changes on the lower lip ОМС, and in the comparison group on the tongue root.>","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82215251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability assessment of PE_PGRS genes and DNA repair, replication, and recombination genes in Mycobacterium tuberculosis","authors":"V. Slizen, L. Surkova, G. L. Gurevich","doi":"10.29235/1814-6023-2023-20-1-42-57","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-1-42-57","url":null,"abstract":"The variability assessment of PE/PPE genes, as well as of DNA repair, replication, and recombination system genes may drive the concept of mechanisms of Mycobacterium tuberculosis evolution and adaptation.The aim is to study the variability of PE_PGRS genes, 3R-system genes (DNA repair, recombination, and replication) to assess the mechanisms of evolutionary changes in M. tuberculosis.Whole genome sequencing of M. tuberculosis 11502 (the Beijing genotype subtype B0/W148 cluster 100-32), M. tuberculosis 5005 (the Beijing genotype subtype B0/W148), M. tuberculosis 4860 (the LAM genotype) strains was performed. They were isolated from patients with newly diagnosed pulmonary tuberculosis. Genomes were uploaded to the GanBank, NCBI: M. tuberculosis 11502 – access code: CP070338.1, M. tuberculosis 5005 – access code: CP053092.1, M. tuberculosis 4860 – access code: CP049108.1. A reference genome (M. tuberculosis H37Rv; NC_000962.3) was used for genetic analysis. In the M. tuberculosis 11502 genome, 44.4 ± 6.8 % of genes (24 genes out of 54) were revealed in the mutations related to the 3R system, while in M. tuberculosis 4860– 29.6 ± 6.2 % (16 genes out of 54). In the 3R system genes, a slight shift of mutations towards replacement by adenine and thymine was revealed, while the entire genome of M. tuberculosis 11502 (compared to M. tuberculosis H37Rv) demonstrated mutations, resulting in a slight accumulation of G + C. Mutations in the 3R system genes may lead to the suboptimal activity of proteins responsible for the DNA-repair, resulting in the upsurge of mutation frequency and promoting adaptive evolution. PE_PGRS genes in the genome of M. tuberculosis 11502, 4860, and 5005 exhibited a high variability and their variability diverged among different members of this gene family. A high level of tetranucleotides CGGC was found in the majority of PE_PGRS family genes, where their proportion varied from 2.11 to 8.42 %, while an average proportion of CGGC in the M. tuberculosis genome was 1.62 %. Some genes in the M. tuberculosis genome were detected to carry no tetranucleotides CGGC (Rv0011, Rv0100, Rv0460, Rv0616A, Rv0691A, Rv0722, Rv0863, Rv0909, Rv1038c, Rv1197, Rv2347c, Rv2452c, and Rv3330c). The DNA conformation analysis at the mutation sites in the genes, associated with resistance to anti-tuberculosis drugs, showed that the secondary DNA structures were mainly formed by nucleotides CGGC, GCGC, GGG, GGGG, CTGC, and mutations occurred, predominantly, at the sites of forming secondary DNA structures (hairpins) where the redistribution of energy and charges can influence the accuracy of replication and result in replication errors and a mutation event. A number of additional factors can influence the probability of a mutation event. These are the factors that can neutralize the energy changes in the DNA secondary structures, and can affect the accuracy of DNA-repair and replication (mutations in the gyrA gene, in the 3R-system genes).","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72526301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Character of wound microflora and resistance to antibiotics: monitoring results 2012–2020","authors":"L. Titov, V. A. Gorbunov, A. N. Kharkhal, O. Yanovich, N. N. Levshina, E. G. Blyga, S. Y. Sudak, A. N. Bukhantsova, N. V. Bonda, L. Tkach, S. B. Voitik, T. N. Botina","doi":"10.29235/1814-6023-2023-20-1-58-70","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-1-58-70","url":null,"abstract":"The aim of the study was to improve the microbiological diagnosis of surgical infections, collect and analyze the data on the spectrum of surgical microflora and monitoring of antibiotic resistance in the period from 2012 to 2020.The research material was the separation of surgical wounds of patients, cultures of gram-negative and gram-positive bacteria isolated from the biological material of patients by the bacteriological method, the results of testing the sensitivity of bacterial cultures to antibiotics by diffusion into agar and using semi-automatic analyzers VITEK-2.A 9-year multicenter monitoring of the species composition of bacteria associated with wound infections revealed a high frequency of isolation of a number of conditionally pathogenic microorganisms – Escherichia spp., Klebsiella spp., Pseudomonas spp., Acinetobacter spp., Enterococcus spp., Streptococcus spp., Staphylococcus spp., Citrobacter spp., Proteus spp. In the period from 2012 to 2020, the amount of information entered into the computer database about these bacterial strains increased 1.4–2.0 times. Monitoring of bacterial resistance to antibiotics during this period showed a high level and dynamics to 3rd generation cephalosporins, carbapenems, and other classes. The lowest levels of resistance were found among the strains of Escherichia and the highest – Klebsiella, Pseudomonas and Acinetobacter. Staphylococci are characterized by high percentage of methicillin-resistant strains.Gram-negative (Escherichia, Klebsiella, Pseudomonas, Acinetobacter) and gram-positive (Enterococci, Streptococci, Staphylococci) are detected in the surgical patients with UTI with a high frequency. Surgical pathogens are characterized by a high level of resistance to 3rd generation cephalosporin, carbapenems, and other antibiotics. Long-term monitoring of bacterial resistance to antibiotics makes it possible to increase the effectiveness of laboratory diagnostics of surgical infections, to assess a resistance level of pathogens, an antibacterial therapy strategy and a medical aid quality.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83746500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of the completeness of the metabolic response in patients with diffused large B-cell lymphoma","authors":"V. A. Kalenik, N. Konoplya, P. Dziameshka, S. Krasny","doi":"10.29235/1814-6023-2023-20-1-7-16","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-1-7-16","url":null,"abstract":"","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81058525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare localization of diverticula of the colon","authors":"I. A. Hadji-Ismail, O. Rummo, A. Varabei, O. I. Senkevich, E. I. Marakhouskaja","doi":"10.29235/1814-6023-2023-20-1-28-33","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-1-28-33","url":null,"abstract":"","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90873454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the significance of the activity of liver arginase and Kupffer cells in the development of secondary atherogenic dyslipidemia and the formation of thyroid status in rats with experimental peritonitis","authors":"E. N. Chepeleva, F. Vismont","doi":"10.29235/1814-6023-2023-20-1-17-27","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-1-17-27","url":null,"abstract":"","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89293311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}