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Japanese journal of pediatric nephrology最新文献

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Hypogammaglobulinemia and infection after administration of rituximab for steroid-dependent nephrotic syndrome 利妥昔单抗治疗类固醇依赖性肾病综合征后低γ球蛋白血症和感染
Japanese journal of pediatric nephrology Pub Date : 1900-01-01 DOI: 10.3165/jjpn.oa.2019.0156
Yuji Tomii, Chisato Umeda, T. Nishino, Yoshitaka Watanabe, Koji Sakuraya, S. Fujinaga
{"title":"Hypogammaglobulinemia and infection after administration of rituximab for steroid-dependent nephrotic syndrome","authors":"Yuji Tomii, Chisato Umeda, T. Nishino, Yoshitaka Watanabe, Koji Sakuraya, S. Fujinaga","doi":"10.3165/jjpn.oa.2019.0156","DOIUrl":"https://doi.org/10.3165/jjpn.oa.2019.0156","url":null,"abstract":"The frequency of rituximab (RTX) use increases in complicated nephrotic syndrome (NS), raising concerns about infections associated with low IgG due to combination therapy with RTX and immunosuppressants. Between February 2008 and June 2017, we enrolled 74 children with complicated steroid-dependent NS (178 total RTX administrations, 13.8 years average patient age at time of administration) and retrospectively assessed prevalence of hypogammaglobulinemia (IgG level < 500 mg/dl) and infection. Twenty doses (11%) were associated with hypogammaglobulinemia at 6 months after RTX administration. The average age (6.1 vs 14.4 years old, p < 0.01) and serum IgG levels before administration of RTX (426 vs 656 mg/dl, p < 0.01) were significantly lower in the hypogammaglobulinemia group. Among 15 patients we were able to observe for 1 more year, 8 patients had persistent hypogammaglobulinemia, and the use of mycophenolate mofetil (MMF) was significantly higher (78 vs 17%, p < 0.05. IgG replacement therapy was performed in two patients whose IgG levels declined over time. In this study, only one varicella infection was noted. IgG replacement therapy should be considered on a case by case basis.","PeriodicalId":205802,"journal":{"name":"Japanese journal of pediatric nephrology","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127386721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Examination of the necessity of voiding cystourethrography in neonates with multicystic dysplastic kidney 新生儿多囊肾发育不良行排尿膀胱尿道造影的必要性探讨
Japanese journal of pediatric nephrology Pub Date : 1900-01-01 DOI: 10.3165/JJPN.OA.2020.0187
Takahiro Kirisawa, T. Uehara, Azusa Kawaguchi, Yoshinori Araki, Kazuyuki Nishinaka
{"title":"Examination of the necessity of voiding cystourethrography in neonates with multicystic dysplastic kidney","authors":"Takahiro Kirisawa, T. Uehara, Azusa Kawaguchi, Yoshinori Araki, Kazuyuki Nishinaka","doi":"10.3165/JJPN.OA.2020.0187","DOIUrl":"https://doi.org/10.3165/JJPN.OA.2020.0187","url":null,"abstract":"in children: multicentre randomised controlled non-inferiority trial. BMJ We conducted a retrospective study of the clinical feature of neonates with multicystic dysplastic kidney (MCDK). A total of 36 patients were analyzed, of whom 6 (16.7%) had vesicoureteral reflux (VUR). Among children with VUR, high-grade vesicoureteral reflux (grades 3 to 5) was observed in 5 (83%). Initially, all children with VUR were prescribed prophylactic antibiotics. Of the five children with high-grade VUR, VUR was resolved or downgraded to grade 1 in two. The remaining children showed no improvement, so endoscopic surgery (injection of Deflux at the ureteral orifice) was performed. All cases of reflux resolved after the first injection. No significant association was observed between anomaly of the contralateral kidney and overall VUR. Furthermore, the result remained the same even when considering the grade of VUR. In the present study, no prerequisite condition concerning the omission of VCUG (voiding cystourethrography) in neonates with MCDK was detected. In cases with only one normal kidney and a risk of developing reflux nephropathy, routine VCUG for neonates with MCDK is considered beneficial.","PeriodicalId":205802,"journal":{"name":"Japanese journal of pediatric nephrology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130075443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
森田賞　《基礎研究部門》　榊原菜々 森田赏《基础研究部门》榊原菜々
Japanese journal of pediatric nephrology Pub Date : 1900-01-01 DOI: 10.3165/jjpn.2022.3001
{"title":"森田賞　《基礎研究部門》　榊原菜々","authors":"","doi":"10.3165/jjpn.2022.3001","DOIUrl":"https://doi.org/10.3165/jjpn.2022.3001","url":null,"abstract":"","PeriodicalId":205802,"journal":{"name":"Japanese journal of pediatric nephrology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121441388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical usefulness of rituximab for early remission in anti-neutrophil cytoplasmic antibody associated vasculitis: a case report 利妥昔单抗对抗中性粒细胞细胞质抗体相关血管炎早期缓解的临床应用:1例报告
Japanese journal of pediatric nephrology Pub Date : 1900-01-01 DOI: 10.3165/jjpn.cr.2020.0179
Hitoshi Irabu, Shuya Kaneko, N. Inoue, M. Mizuta, Kazuyuki Ueno, M. Shimizu, A. Yachie
{"title":"Clinical usefulness of rituximab for early remission in anti-neutrophil cytoplasmic antibody associated vasculitis: a case report","authors":"Hitoshi Irabu, Shuya Kaneko, N. Inoue, M. Mizuta, Kazuyuki Ueno, M. Shimizu, A. Yachie","doi":"10.3165/jjpn.cr.2020.0179","DOIUrl":"https://doi.org/10.3165/jjpn.cr.2020.0179","url":null,"abstract":"","PeriodicalId":205802,"journal":{"name":"Japanese journal of pediatric nephrology","volume":"BC-26 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120989598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
症例報告部門　受賞者　谷口洋平 症例报告部门受赏者谷口洋平
Japanese journal of pediatric nephrology Pub Date : 1900-01-01 DOI: 10.3165/jjpn.181
{"title":"症例報告部門　受賞者　谷口洋平","authors":"","doi":"10.3165/jjpn.181","DOIUrl":"https://doi.org/10.3165/jjpn.181","url":null,"abstract":"","PeriodicalId":205802,"journal":{"name":"Japanese journal of pediatric nephrology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122627088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment strategies for C3 glomerulopathy C3肾小球病变的治疗策略
Japanese journal of pediatric nephrology Pub Date : 1900-01-01 DOI: 10.3165/jjpn.oa.2022.0212
K. Sugimoto, Hirotsugu Kitayama, Yudai Miyama, Masayoshi Yamada, Mika Nakajima, Ryutaro Serizawa
{"title":"Treatment strategies for C3 glomerulopathy","authors":"K. Sugimoto, Hirotsugu Kitayama, Yudai Miyama, Masayoshi Yamada, Mika Nakajima, Ryutaro Serizawa","doi":"10.3165/jjpn.oa.2022.0212","DOIUrl":"https://doi.org/10.3165/jjpn.oa.2022.0212","url":null,"abstract":"","PeriodicalId":205802,"journal":{"name":"Japanese journal of pediatric nephrology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131436292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four-year prognosis of multidrug combination therapy for Henoch-Schönlein purpura nephritis 多药联合治疗Henoch-Schönlein紫癜性肾炎4年预后分析
Japanese journal of pediatric nephrology Pub Date : 1900-01-01 DOI: 10.3165/jjpn.oa.2020.0190
Yuka Ezumi, Kazuna Yamamoto, Toshiki Masuda, S. Ichioka, T. Sakai, T. Sawai, K. Ogata, Y. Maruo
{"title":"Four-year prognosis of multidrug combination therapy for Henoch-Schönlein purpura nephritis","authors":"Yuka Ezumi, Kazuna Yamamoto, Toshiki Masuda, S. Ichioka, T. Sakai, T. Sawai, K. Ogata, Y. Maruo","doi":"10.3165/jjpn.oa.2020.0190","DOIUrl":"https://doi.org/10.3165/jjpn.oa.2020.0190","url":null,"abstract":"The long-term renal prognosis of Henoch-Schönlein purpura nephritis (HSPN) in children and the pathological changes before and after treatment has not yet been clarified, and the optimal treatment for HSPN remains unclear. In Japan, children with HSPN are treated according to the treatment guidelines for childhood immunoglobulin A nephropathy. Our study included 8 patients with HSPN who received multidrug combination therapy with azathioprine. All patients underwent renal biopsy at presentation, and 7 patients underwent follow-up biopsy after therapy. Four years after initiating treatment, no patients had decreased renal function compared to that pretreatment and 2 patients had proteinuria (urine protein-to-creatinine ratio: 0.15 – 0.5 g/gCr). Follow-up renal biopsy revealed chronic lesions in 3 patients, but there was no correlation between chronic lesions and remnant proteinuria. Multidrug combination therapy with azathioprine has certain therapeutic efficacy in alleviating HSPN in children.","PeriodicalId":205802,"journal":{"name":"Japanese journal of pediatric nephrology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133978776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise therapy during hospitalization for a pediatric patient with active IgA nephropathy: A case report 儿童活动性IgA肾病住院期间的运动治疗:1例报告
Japanese journal of pediatric nephrology Pub Date : 1900-01-01 DOI: 10.3165/jjpn.cr.2022.0208
Akinori Tabata, H. Yabe, Y. Mitake, T. Shirai, K. Kawamura
{"title":"Exercise therapy during hospitalization for a pediatric patient with active IgA nephropathy: A case report","authors":"Akinori Tabata, H. Yabe, Y. Mitake, T. Shirai, K. Kawamura","doi":"10.3165/jjpn.cr.2022.0208","DOIUrl":"https://doi.org/10.3165/jjpn.cr.2022.0208","url":null,"abstract":"","PeriodicalId":205802,"journal":{"name":"Japanese journal of pediatric nephrology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114572682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA syndrome) with a multiple renal artery and essential hypertension 半阴道梗阻和同侧肾异常(OHVIRA综合征)伴多肾动脉和原发性高血压
Japanese journal of pediatric nephrology Pub Date : 1900-01-01 DOI: 10.3165/jjpn.cr.2019.0154
Yuko Yamada, Yasuo Kawaba, Hiroki Yokoyama, K. Kitamoto, Shin’ichi Okada, S. Kanzaki
{"title":"Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA syndrome) with a multiple renal artery and essential hypertension","authors":"Yuko Yamada, Yasuo Kawaba, Hiroki Yokoyama, K. Kitamoto, Shin’ichi Okada, S. Kanzaki","doi":"10.3165/jjpn.cr.2019.0154","DOIUrl":"https://doi.org/10.3165/jjpn.cr.2019.0154","url":null,"abstract":"","PeriodicalId":205802,"journal":{"name":"Japanese journal of pediatric nephrology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134262057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal biopsy —The first step and another step— 肾活检-第一步，又一步
Japanese journal of pediatric nephrology Pub Date : 1900-01-01 DOI: 10.3165/jjpn.rv.2022.2001
Y. Ikezumi
{"title":"Renal biopsy —The first step and another step—","authors":"Y. Ikezumi","doi":"10.3165/jjpn.rv.2022.2001","DOIUrl":"https://doi.org/10.3165/jjpn.rv.2022.2001","url":null,"abstract":"","PeriodicalId":205802,"journal":{"name":"Japanese journal of pediatric nephrology","volume":"542 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131657159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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