Examination of the necessity of voiding cystourethrography in neonates with multicystic dysplastic kidney

Abstract

in children: multicentre randomised controlled non-inferiority trial. BMJ We conducted a retrospective study of the clinical feature of neonates with multicystic dysplastic kidney (MCDK). A total of 36 patients were analyzed, of whom 6 (16.7%) had vesicoureteral reflux (VUR). Among children with VUR, high-grade vesicoureteral reflux (grades 3 to 5) was observed in 5 (83%). Initially, all children with VUR were prescribed prophylactic antibiotics. Of the five children with high-grade VUR, VUR was resolved or downgraded to grade 1 in two. The remaining children showed no improvement, so endoscopic surgery (injection of Deflux at the ureteral orifice) was performed. All cases of reflux resolved after the first injection. No significant association was observed between anomaly of the contralateral kidney and overall VUR. Furthermore, the result remained the same even when considering the grade of VUR. In the present study, no prerequisite condition concerning the omission of VCUG (voiding cystourethrography) in neonates with MCDK was detected. In cases with only one normal kidney and a risk of developing reflux nephropathy, routine VCUG for neonates with MCDK is considered beneficial.