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Problems Of Biological, Medical And Pharmaceutical Chemistry最新文献

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EVALUATION OF ANTI-ULCER ACTIVITY OF BIOLOGICALLY ACTIVE COMPOUNDS IN ALDER LEAVES 桤木叶中生物活性化合物抗溃疡活性的评价
Problems Of Biological, Medical And Pharmaceutical Chemistry Pub Date : 2022-01-01 DOI: 10.29296/25877313-2022-07-03
O. V. Mushkina, N. Gurina
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引用次数: 0
Studying the chemical composition of the essential oil of the aboveground part of Artemisia marschalliana Spreng. Natural populations of Dagestan 对黄花蒿地上部挥发油的化学成分进行了研究。达吉斯坦的自然种群
Problems Of Biological, Medical And Pharmaceutical Chemistry Pub Date : 2022-01-01 DOI: 10.29296/25877313-2022-12-08
F. Vagabova, A. Aliev
{"title":"Studying the chemical composition of the essential oil of the aboveground part of Artemisia marschalliana Spreng. Natural populations of Dagestan","authors":"F. Vagabova, A. Aliev","doi":"10.29296/25877313-2022-12-08","DOIUrl":"https://doi.org/10.29296/25877313-2022-12-08","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84249103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of HPLC-MS/MS for the quantitative analysis of neuroactive amino acids in rat brain homogenates after derivatization with 9-fluorenylmethyl chloroformate 采用高效液相色谱-质谱联用技术对9-氟酰氯甲酸甲酯衍生大鼠脑匀浆中神经活性氨基酸进行定量分析
Problems Of Biological, Medical And Pharmaceutical Chemistry Pub Date : 2022-01-01 DOI: 10.29296/25877313-2022-05-06
N. Popov, V. Balabanyan, M. B. Petrova, N. Kolgina, G. A. Petrov
{"title":"The use of HPLC-MS/MS for the quantitative analysis of neuroactive amino acids in rat brain homogenates after derivatization with 9-fluorenylmethyl chloroformate","authors":"N. Popov, V. Balabanyan, M. B. Petrova, N. Kolgina, G. A. Petrov","doi":"10.29296/25877313-2022-05-06","DOIUrl":"https://doi.org/10.29296/25877313-2022-05-06","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85500451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological screening of Serratula coronata L. herbal extract 冠锯齿草提取物的药理筛选
Problems Of Biological, Medical And Pharmaceutical Chemistry Pub Date : 2022-01-01 DOI: 10.29296/25877313-2022-03-06
I. Lupanova, O. L. Saybel, E. V. Ferubko, E. N. Kurmanova, A.I. Radimitch, V. Kolkhir, P. G. Mizina
{"title":"Pharmacological screening of Serratula coronata L. herbal extract","authors":"I. Lupanova, O. L. Saybel, E. V. Ferubko, E. N. Kurmanova, A.I. Radimitch, V. Kolkhir, P. G. Mizina","doi":"10.29296/25877313-2022-03-06","DOIUrl":"https://doi.org/10.29296/25877313-2022-03-06","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90745494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disorders in the blood system in cancer patients with purulent-septic complications 癌症患者脓毒性并发症的血液系统紊乱
Problems Of Biological, Medical And Pharmaceutical Chemistry Pub Date : 2022-01-01 DOI: 10.29296/25877313-2022-06-01
O. Somonova, A. Elizarova, T. V. Davydova, V. N. Blindar, N. Borisenko, M. M. Dobrovolskaya, U. Kornyushenko, E. Golovnya, J.A. Nesterova
{"title":"Disorders in the blood system in cancer patients with purulent-septic complications","authors":"O. Somonova, A. Elizarova, T. V. Davydova, V. N. Blindar, N. Borisenko, M. M. Dobrovolskaya, U. Kornyushenko, E. Golovnya, J.A. Nesterova","doi":"10.29296/25877313-2022-06-01","DOIUrl":"https://doi.org/10.29296/25877313-2022-06-01","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90276703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dipeptide BDNF mimetic GSB-106 prevents depression-like behavior and cognitive impairment caused by ischemic stroke in rats 二肽BDNF模拟物GSB-106预防大鼠缺血性中风引起的抑郁样行为和认知障碍
Problems Of Biological, Medical And Pharmaceutical Chemistry Pub Date : 2022-01-01 DOI: 10.29296/25877313-2022-02-08
P. Povarnina, D. M. Nikiforov, O. N. Vorontsova, T. Gudasheva
{"title":"Dipeptide BDNF mimetic GSB-106 prevents depression-like behavior and cognitive impairment caused by ischemic stroke in rats","authors":"P. Povarnina, D. M. Nikiforov, O. N. Vorontsova, T. Gudasheva","doi":"10.29296/25877313-2022-02-08","DOIUrl":"https://doi.org/10.29296/25877313-2022-02-08","url":null,"abstract":"Relevance. Depression and cognitive impairment are common complications of acute cerebrovascular accidents. Disorders of hippocampal neuroplasticity associated with a decrease in BDNF expression are considered as one of the causes of these complicatio ns. A dimeric dipeptide mimetic of the BDNF loop 4, (bis (N - monosuccinyl -L- seryl -L- lysine) hexamethylenediamide) (GS B-106) was created at the V.V. Zakusov Research Institute of Pharmacology. GSB - 106 demonstrated antidepressant, neuroprotective and neuroregenera-tive properties in in vivo experiments. Objective . Experiments were performed on 40 male rats Wistar weighing 2 40–280 g. Purpose of the study is to investigate the effect of GSB - 106 on depression - like behavior and memory impairments in rats induced by middle cerebral artery occlusion (MCAO). Material and methods . GSB - 106 was injected intraperitoneally at a dose of 0.1 mg/kg for 21 days after surgery. Depressive - like behavior was detected in the forced swimming test, and memory impairments – in the novel object recognition test. Conclusions . GSB - 106 is a promising compound for further development as a drug for the treatment of post - stroke depression and cognitive impairment.","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90522309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of the free radical reactions in whole blood of Wistar rats under stress-induced physical exercise 应激性体育锻炼Wistar大鼠全血中自由基反应的测定
Problems Of Biological, Medical And Pharmaceutical Chemistry Pub Date : 2022-01-01 DOI: 10.29296/25877313-2022-01-08
O. Puzikova, I. Ralchenko
{"title":"Determination of the free radical reactions in whole blood of Wistar rats under stress-induced physical exercise","authors":"O. Puzikova, I. Ralchenko","doi":"10.29296/25877313-2022-01-08","DOIUrl":"https://doi.org/10.29296/25877313-2022-01-08","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78915119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The study of the physico-chemical properties of the substance efavirenz 依非韦伦物质理化性质的研究
Problems Of Biological, Medical And Pharmaceutical Chemistry Pub Date : 2022-01-01 DOI: 10.29296/25877313-2022-02-04
S. Zolotov, E. Ponomarev, I. A. Dain, N. Demina, A. Zolotova, V. M. Retivov, G. A. Buzanov
{"title":"The study of the physico-chemical properties of the substance efavirenz","authors":"S. Zolotov, E. Ponomarev, I. A. Dain, N. Demina, A. Zolotova, V. M. Retivov, G. A. Buzanov","doi":"10.29296/25877313-2022-02-04","DOIUrl":"https://doi.org/10.29296/25877313-2022-02-04","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75837042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical, chemical and technological aspects of a gel for oral administration Lycopus europaeus L. herb dry extract 从物理、化学和工艺等方面研究了一种口服给药凝胶剂——石蒜草本干提取物
Problems Of Biological, Medical And Pharmaceutical Chemistry Pub Date : 2022-01-01 DOI: 10.29296/25877313-2022-09-03
O. Semkina, V. I. Zvereva, M. A. Dzhavakhyan, N.P. Pavets
{"title":"Physical, chemical and technological aspects of a gel for oral administration Lycopus europaeus L. herb dry extract","authors":"O. Semkina, V. I. Zvereva, M. A. Dzhavakhyan, N.P. Pavets","doi":"10.29296/25877313-2022-09-03","DOIUrl":"https://doi.org/10.29296/25877313-2022-09-03","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82757712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the rate of release of active substances from solutions of hydroxymethylpropyl cellulose and hydroxyethyl cellulose for selecting the optimal polymer for the development of ear drops 比较羟甲基丙基纤维素和羟乙基纤维素溶液中活性物质的释放速度，选择最佳聚合物用于滴耳液的研制
Problems Of Biological, Medical And Pharmaceutical Chemistry Pub Date : 2022-01-01 DOI: 10.29296/25877313-2022-02-05
Balloul Ghadeer, D. Martceva, E. Zhilyakova, N. Boyko, A. B. Abdulhadi, Mahmoud Dawood alrubaye Wissam
{"title":"Comparison of the rate of release of active substances from solutions of hydroxymethylpropyl cellulose and hydroxyethyl cellulose for selecting the optimal polymer for the development of ear drops","authors":"Balloul Ghadeer, D. Martceva, E. Zhilyakova, N. Boyko, A. B. Abdulhadi, Mahmoud Dawood alrubaye Wissam","doi":"10.29296/25877313-2022-02-05","DOIUrl":"https://doi.org/10.29296/25877313-2022-02-05","url":null,"abstract":"","PeriodicalId":20508,"journal":{"name":"Problems Of Biological, Medical And Pharmaceutical Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87327494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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