Problemy endokrinologii最新文献_第8页

[Diagnosis and tactics of managing a patient with central diabetes insipidus on the example of a clinical case]. 【中枢性尿崩症的诊断与处理——以一例临床病例为例】。

Problemy endokrinologii Pub Date : 2022-07-20 DOI: 10.14341/probl13103

N N Katamadze, E A Pigarova, L K Dzeranova

{"title":"[Diagnosis and tactics of managing a patient with central diabetes insipidus on the example of a clinical case].","authors":"N N Katamadze, E A Pigarova, L K Dzeranova","doi":"10.14341/probl13103","DOIUrl":"https://doi.org/10.14341/probl13103","url":null,"abstract":"Диагностика и дифференциальная диагностика пациентов с несахарным диабетом нередко представляют собой сложную задачу для врачей различных специальностей. Данный клинический случай посвящен описанию пациента с длительным анамнезом идиопатического несахарного диабета центрального генеза, у которого резко снизилась потребность в десмопрессине за последний год наблюдения. Проведение проб с осмотической стимуляцией (тест с водной депривацией, инфузионная проба с гипертоническим раствором) позволило ответить на вопрос о сохранении заболевания, а также определить дальнейший план ведения с учетом физиологических особенностей.","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10492284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Congenital hyperinsulinism as a part of Kabuki syndrome]. [先天性高胰岛素血症是歌舞伎综合征的一部分]。

Problemy endokrinologii Pub Date : 2022-07-20 DOI: 10.14341/probl13145

A R Benina, M A Melikyan

引用次数: 0

[Metformin and malignant neoplasms: a possible mechanism of antitumor action and prospects for use in practice]. [二甲双胍与恶性肿瘤：抗肿瘤作用的可能机制及实际应用前景]。

Problemy endokrinologii Pub Date : 2022-07-14 DOI: 10.14341/probl13097

K O Kuznetsov, E R Safina, D V Gaimakova, Ya S Frolova, I Yu Oganesyan, A G Sadertdinova, K A Nazmieva, A H Islamgulov, A R Karimova, A M Galimova, E V Rizvanova

{"title":"[Metformin and malignant neoplasms: a possible mechanism of antitumor action and prospects for use in practice].","authors":"K O Kuznetsov, E R Safina, D V Gaimakova, Ya S Frolova, I Yu Oganesyan, A G Sadertdinova, K A Nazmieva, A H Islamgulov, A R Karimova, A M Galimova, E V Rizvanova","doi":"10.14341/probl13097","DOIUrl":"10.14341/probl13097","url":null,"abstract":"Metformin is a first-line antidiabetic drug for the treatment of type 2 diabetes mellitus (DM2); its molecular target is AMP-activated protein kinase (AMPK), which is involved in many metabolic processes. Metformin not only reduces blood glucose levels and improves insulin sensitivity, but also inhibits lipolysis and reduces cardiovascular risk in patients with DM2. In recent years, it has been proven that metformin slows down the aging process, stimulates hair growth, eliminates cognitive impairment, and also has an antitumor effect. Most basic studies have shown that metformin inhibits the growth of tumor cells and promotes cellular apoptosis, while clinical studies show contradictory results. This discrepancy can be explained by the difference in the concentration of metformin between basic and clinical studies. The maximum daily dose of metformin for patients with DM2 is 2500 mg / day, and the dose used in basic research was much higher. Metformin directly activates the AMPK signaling pathway, inhibits the production of reactive oxygen species, induces the activation of mTORC1, inhibits cyclin D1, which leads to a reduction in the risk of the occurrence and development of malignant neoplasms. In addition, metformin indirectly inhibits tumor growth, proliferation, invasion and metastasis by reducing the concentration of glucose in the blood, insulin resistance, as well as by reducing inflammation and affecting the tumor microenvironment. Glycolysis plays an important role in the energy metabolism of tumors, and metformin is able to have an inhibitory effect on it. Currently, studies of the mechanism of antitumor effects of metformin are becoming more extensive and in-depth, but there are still some contradictions.","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Diabetic gastroenteropathy: modern methods of diagnosis and treatment]. 糖尿病性肠胃病:现代诊疗方法。

Problemy endokrinologii Pub Date : 2022-07-13 DOI: 10.14341/probl13082

K O Kuznetsov, A Ju Mikheeva, A A Ishmukhametova, T A Tolstykh, A R Gallyametdinova, Z U Botirova, A A Zabirova, A Sh Sharipova, A B Shaikhlislamova, D R Abdrakhmanova

{"title":"[Diabetic gastroenteropathy: modern methods of diagnosis and treatment].","authors":"K O Kuznetsov, A Ju Mikheeva, A A Ishmukhametova, T A Tolstykh, A R Gallyametdinova, Z U Botirova, A A Zabirova, A Sh Sharipova, A B Shaikhlislamova, D R Abdrakhmanova","doi":"10.14341/probl13082","DOIUrl":"https://doi.org/10.14341/probl13082","url":null,"abstract":"Diabetes mellitus is a chronic disease with a growing prevalence worldwide, however, the prevalence of its complications, including gastroenteropathy, is also increasing. The pathophysiology of diabetic gastroenteropathy (DH) combines hyperglycemia, vagus nerve dysfunction, decreased expression of nitric oxide synthase in the myenteric plexus, changes in the interstitial Cajal cell network, as well as oxidative stress. Clinical signs of DH are gastroesophageal reflux, gastroparesis, constipation, abdominal pain and diarrhea. Among the diagnostic methods are manometry with pH measurement (assessment of esophageal motility), gastric emptying scintigraphy, respiratory test (to assess gastroparesis), aspiration and cultivation of the contents of the jejunum (to diagnose bacterial overgrowth syndrome). To date, there is no definitive treatment for DH - an interdisciplinary approach is aimed at slowing the progression of the disease, relieving symptoms and restoring gastrointestinal function. Patients are recommended a diet low in simple sugars and high in fiber; optimization of glycemic control with a target glycemia of less than 180 mg/dl. As for drug therapy, the use of prokinetics and antiemetics is justified, and in case of excessive bacterial growth syndrome, antibacterial therapy (rifaximin) is carried out. Modern approaches to the treatment of DH are also accumulating, including the use of botulinum toxin, pyloroplasty and electrical stimulation of the stomach in individual patients. Despite the constant development of new treatments, they are not yet able to completely cure DH in the near future, which makes it necessary to conduct further research in this area.","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10548997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Family form of nephrogenic X-linked diabetes indiabetes]. [肾源性x连锁糖尿病的家族形式]。

Problemy endokrinologii Pub Date : 2022-07-13 DOI: 10.14341/probl13098

V V Klepalova, O S Pushkareva, N V Iziurova, A V Aksenov

{"title":"[Family form of nephrogenic X-linked diabetes indiabetes].","authors":"V V Klepalova, O S Pushkareva, N V Iziurova, A V Aksenov","doi":"10.14341/probl13098","DOIUrl":"https://doi.org/10.14341/probl13098","url":null,"abstract":"There is a global trend towards an increase in the prevalence of diabetes insipidus. Symptoms of nephrogenic diabetes insipidus with X-linked inheritance appear in men, in women with heterozygous mutations, are characterized by an isolated symptom complex of polyuria, polydipsia, hypostenuria. In children, more often than in adults, with fluid restriction, a clinic of water-deficient dehydration develops with hypernatremia, hyperthermia, and plasma hyperosmolality. This manuscript presents a case of Nephrogenic diabetes insipidus, X-linked familial form in male patients.At the same time, in the family along the female line, the mother and grandmother also had an increased need for water, the use of minirin was ineffective. In the older brother and younger brother, clinical manifestations of diabetes insipidus in the form of severe thirst and polyuria were noted from infancy, after the examination, the diagnosis was made - diabetes insipidus and desmopressin was prescribed.Due to the lack of effect from the use of desmopressin, the analysis of exons and adjacent sections of the introns of the AQP2 and AVPR2 genes was carried out by PCR and subsequent direct sequencing. No mutations were found in the AQP2 gene. The hemizygous substitution S315I was found in the AVPR2 gene. The familial form X was confirmed - linked nephrogenic diabetes insipidus. A hypothiazide was recommended, against the background of constant intake of which only a slight positive trend is observed.","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10640858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[FGF23 tumor induced osteomalacia]. [FGF23]肿瘤诱导骨软化症。

Problemy endokrinologii Pub Date : 2022-07-11 DOI: 10.14341/probl13130

S A Gronskaia, Zh E Belaya, G A Melnichenko

{"title":"[FGF23 tumor induced osteomalacia].","authors":"S A Gronskaia, Zh E Belaya, G A Melnichenko","doi":"10.14341/probl13130","DOIUrl":"https://doi.org/10.14341/probl13130","url":null,"abstract":"Tumor induced osteomalacia is a rare acquired disease. The cause is a mesenchymal tumor secreting fibroblast growth factor 23 (FGF23). An excessive amount of FGF 23 disrupts the metabolism of phosphorus and vitamin D, which leads to severe paraneoplastic syndrome, manifested in the form of multiple fractures, severe pain in the bones and generalized myopathy. With oncogenic osteomalacia, a complete cure is possible with radical resection of the tumor. Unfortunately, localization, small size of formations and rare frequency of occurrence lead to the fact that the disease remains unrecognized for a long time and leads to severe, disabling consequences. A step-by-step approach to diagnosis improves treatment outcomes. First, a thorough anamnesis is collected, then functional visualization is performed and the diagnosis is confirmed by anatomical visualization of the tumor. After that, the method of choice is a surgical treatment. If resection is not possible, then conservative therapy with active metabolites of vitamin D and phosphorus salts is indicated. New therapeutic approaches, such as the antibody to FGF23 or the pan-inhibitor of receptors to FGF, are actively developing. This article provides an overview of modern approaches to the diagnosis and treatment of this disease.","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Primary hypothyroidism and postmenopause as the causes of delayed diagnosis of panhypopituitarism in a patient with nonfunctional pituitary adenoma]. [原发性甲状腺功能减退和绝经后作为无功能垂体腺瘤患者全垂体功能减退症延迟诊断的原因]。

Problemy endokrinologii Pub Date : 2022-07-05 DOI: 10.14341/probl13128

E G Ryzhkova, D O Ladygina

{"title":"[Primary hypothyroidism and postmenopause as the causes of delayed diagnosis of panhypopituitarism in a patient with nonfunctional pituitary adenoma].","authors":"E G Ryzhkova, D O Ladygina","doi":"10.14341/probl13128","DOIUrl":"https://doi.org/10.14341/probl13128","url":null,"abstract":"Hypopituitarism is a state of complete or partial deficiency of pituitary hormones, including adrenal insufficiency, hypothyroidism, hypogonadism, growth hormone deficiency, and, rarely, diabetes insipidus.The article describes a clinical case of hypopituitarism due to a pituitary tumor in a postmenopausal woman. Difficulties in diagnosing hypopituitarism were due to a history of primary hypothyroidism. The first identified component of panhypopituitarism in the patient, (central hypothyroidism) had previously been seen as laboratory indications of medication-induced hyperthyroidism.The non-specific nature of the clinical symptoms, as well as a relatively rare combination of endocrine diseases, led to a long examination period and delayed diagnosis of the pituitary tumor.Whether the development of hypopituitarism in a patient with a nonfunctional pituitary tumor is an indication for transsphenoidal pituitary surgery remains a controversial issue. The decision for surgery is made taking into account the characteristics of the course of the disease in a particular patient. In this clinical case, a conservative tactic was chosen with hormone replacement therapy for glucocorticoid and thyroid deficiency.","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10492285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Testosterone and Alzheimer's disease]. [睾丸素和阿尔茨海默病]。

Problemy endokrinologii Pub Date : 2022-06-24 DOI: 10.14341/probl13136

K O Kuznetsov, R R Khaidarova, R H Khabibullina, E S Stytsenko, V I Filosofova, I R Nuriakhmetova, E M Hisameeva, G S Vazhorov, F R Khaibullin, E A Ivanova, K V Gorbatova

{"title":"[Testosterone and Alzheimer's disease].","authors":"K O Kuznetsov, R R Khaidarova, R H Khabibullina, E S Stytsenko, V I Filosofova, I R Nuriakhmetova, E M Hisameeva, G S Vazhorov, F R Khaibullin, E A Ivanova, K V Gorbatova","doi":"10.14341/probl13136","DOIUrl":"https://doi.org/10.14341/probl13136","url":null,"abstract":"Alzheimer's disease (AD) is a neurodegenerative disease that causes dementia in half of the cases. Asthma is usually found in people over 65 years of age. The etiopathogenesis of the disease is multifactorial and includes genetic factors, nutritional disorders, mitochondrial dysfunction, oxidative stress, and aging. Sex hormones have an important influence on the development of AD, as evidenced by a higher incidence in women than in men. Considering the significant influence of T on the maintenance of normal brain function, the present study is aimed at evaluating the impact of androgen deprivation therapy (ADT), as well as testosterone therapy, on the risk of AD development and progression. Although there is some clinical inconsistency between studies, androgens have a significant effect on brain function and are beneficial for AD patients. Low levels of circulating androgens should be considered as a significant risk factor for the development of AD and memory loss. With a reduced level of T in the plasma of men, its administration improves cognitive performance and memory, treatment should be started at an early stage of the disease. In men and women with AD, androgens improve mental state and slow the progression of the disease, providing a protective effect. In the future, it is necessary to conduct studies on a large population, taking into account personality factors and a more specific approach to assessing cognitive functions and the causal relationship of T administration in AD.","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10548996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Donohue syndrome and use of continuous subcutaneous IGF1 pump therapy]. [Donohue综合征与持续皮下IGF1泵治疗的应用]。

Problemy endokrinologii Pub Date : 2022-06-22 DOI: 10.14341/probl13121

M A Melikyan, T E Ivannikova, N V Milovanova, A A Kolodkina, O B Bezlepkina, N G Mokryshevа

{"title":"[Donohue syndrome and use of continuous subcutaneous IGF1 pump therapy].","authors":"M A Melikyan, T E Ivannikova, N V Milovanova, A A Kolodkina, O B Bezlepkina, N G Mokryshevа","doi":"10.14341/probl13121","DOIUrl":"https://doi.org/10.14341/probl13121","url":null,"abstract":"Donohue syndrome (DS), also called Leprechaunism, is the most severe form of insulin resistance associated with biallelic mutations in INSR gene (OMIM: 147670). The approximate incidence of this syndrome is 1 per 1000000 births. Patients are present with typical clinical features such as intrauterine growth retardation, facial dysmorphism, severe metabolic disturbances, hepatomegaly and hypertrophic cardiomyopathy. Most DS patients die within the first two years of life due to respiratory infections, severe hypoglycemia or progressive cardiomyopathy. Treatment options are limited and no specific therapy exist for DS. Given the similarities between insulin and insulin-like growth factor 1 (IGF-1) receptors, recombinant human IGF-1 (rhIGF-1) has been used to treat severe insulin resistance including DS.We report the case of a male patient with genetically confirmed Donohue syndrome, successfully treated with continuous subcutaneous IGF1 infusion via insulin pump. We observed improvement of glycemic control, liver function and cardiac hypertrophy regression following 15-month IGF1 therapy.","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10548995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Syndrome of hypocalсiuric hypercalcemia. Is it rare? Two clinical cases in an outpatient clinic]. 低钙高钙血症综合征。罕见吗?2例门诊病例]。

Problemy endokrinologii Pub Date : 2022-06-17 DOI: 10.14341/probl13125

M A Sviridonova

引用次数: 0