[睾丸素和阿尔茨海默病]。

Q4 Medicine
K O Kuznetsov, R R Khaidarova, R H Khabibullina, E S Stytsenko, V I Filosofova, I R Nuriakhmetova, E M Hisameeva, G S Vazhorov, F R Khaibullin, E A Ivanova, K V Gorbatova
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引用次数: 0

摘要

阿尔茨海默病(AD)是一种神经退行性疾病,一半的病例会导致痴呆。哮喘常见于65岁以上的人群。该病的发病是多因素的,包括遗传因素、营养失调、线粒体功能障碍、氧化应激和衰老。性激素对阿尔茨海默病的发展有重要影响,女性的发病率高于男性。考虑到T对维持正常脑功能的显著影响,本研究旨在评估雄激素剥夺疗法(ADT)以及睾酮治疗对AD发生和进展风险的影响。虽然临床研究之间存在一些不一致,但雄激素对脑功能有显著影响,对AD患者有益。低水平的循环雄激素应该被认为是阿尔茨海默病和记忆丧失的重要危险因素。由于男性血浆中的T水平降低,服用它可以改善认知能力和记忆力,因此应该在疾病的早期阶段开始治疗。在患有AD的男性和女性中,雄激素可以改善精神状态,减缓疾病的进展,提供保护作用。在未来,有必要在更大的人群中进行研究,考虑人格因素和更具体的方法来评估AD患者的认知功能和T治疗的因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

[Testosterone and Alzheimer's disease].

[Testosterone and Alzheimer's disease].

Alzheimer's disease (AD) is a neurodegenerative disease that causes dementia in half of the cases. Asthma is usually found in people over 65 years of age. The etiopathogenesis of the disease is multifactorial and includes genetic factors, nutritional disorders, mitochondrial dysfunction, oxidative stress, and aging. Sex hormones have an important influence on the development of AD, as evidenced by a higher incidence in women than in men. Considering the significant influence of T on the maintenance of normal brain function, the present study is aimed at evaluating the impact of androgen deprivation therapy (ADT), as well as testosterone therapy, on the risk of AD development and progression. Although there is some clinical inconsistency between studies, androgens have a significant effect on brain function and are beneficial for AD patients. Low levels of circulating androgens should be considered as a significant risk factor for the development of AD and memory loss. With a reduced level of T in the plasma of men, its administration improves cognitive performance and memory, treatment should be started at an early stage of the disease. In men and women with AD, androgens improve mental state and slow the progression of the disease, providing a protective effect. In the future, it is necessary to conduct studies on a large population, taking into account personality factors and a more specific approach to assessing cognitive functions and the causal relationship of T administration in AD.

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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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