Prenatal Diagnosis最新文献_第9页

Quality of Evidence for Prenatal Down Syndrome Screening: An Umbrella Review. 产前唐氏综合征筛查的证据质量：概括性回顾。

IF 3.1 2区医学

Prenatal Diagnosis Pub Date : 2026-08-01 Epub Date: 2026-06-02 DOI: 10.1002/pd.70191

Yuehua Zhang, Yingying Wang, Xinlong Wang, Ling Liu, Kaijuan Wang

{"title":"Quality of Evidence for Prenatal Down Syndrome Screening: An Umbrella Review.","authors":"Yuehua Zhang, Yingying Wang, Xinlong Wang, Ling Liu, Kaijuan Wang","doi":"10.1002/pd.70191","DOIUrl":"10.1002/pd.70191","url":null,"abstract":"Objective: Many systematic reviews (SRs) report the accuracy of prenatal Down syndrome screening, but their methodological quality has not been comprehensively evaluated. This umbrella review assessed the quality, compared non-invasive prenatal testing (NIPT) with traditional screening, and evaluated the findings' robustness.Method: We searched MEDLINE, Embase, and multiple other databases from inception to March 24, 2026, for SRs, including gray literature sources as specified in the methods. Methodological quality, risk of bias, and evidence certainty were assessed using AMSTAR 2, ROBIS, and GRADE. The study was registered with PROSPERO (CRD42024597291).Results: Of 42 included SRs, NIPT and combined screening were the most common. AMSTAR 2 ratings indicated that 88.1% (37/42) of SRs were of low or critically low confidence; 66.7% SRs were judged to have a high risk of bias; and high-quality evidence was scarce (9.6%). Despite this, NIPT's higher accuracy was maintained in sensitivity analyses, showing higher sensitivity (93.0%-100.0%) and specificity (96.0%-100.0%) than traditional methods, which showed wider performance variation (e.g., biochemical screening sensitivity: 28.0%-89.0%).Conclusion: The methodological quality of SRs evaluating Down syndrome screening is limited. Nevertheless, NIPT consistently shows higher accuracy than traditional screening. NIPT implementation should be prioritized where feasible, while future primary research requires large, prospective studies.","PeriodicalId":20387,"journal":{"name":"Prenatal Diagnosis","volume":" ","pages":"1434-1446"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural History of Fetal Non-Nuchal Lymphatic Malformations: A Single Center Retrospective Study. 胎儿非颈部淋巴畸形的自然史：单中心回顾性研究。

IF 3.1 2区医学

Prenatal Diagnosis Pub Date : 2026-08-01 Epub Date: 2026-07-10 DOI: 10.1002/pd.70211

Yada Kunpalin, Dilkash Kajal, Lennart Van der Veeken, David Chitayat, Manuel Carcao, Paolo Campisi, Greg Ryan, Shiri Shinar, Tim Van Mieghem

{"title":"Natural History of Fetal Non-Nuchal Lymphatic Malformations: A Single Center Retrospective Study.","authors":"Yada Kunpalin, Dilkash Kajal, Lennart Van der Veeken, David Chitayat, Manuel Carcao, Paolo Campisi, Greg Ryan, Shiri Shinar, Tim Van Mieghem","doi":"10.1002/pd.70211","DOIUrl":"10.1002/pd.70211","url":null,"abstract":"Objective: To document the natural history and complications of second- and third-trimester non-nuchal lymphatic malformations (LM) and identify predictors of these complications.Methods: We conducted a single-centre retrospective review of fetuses diagnosed with LMs between January 2015 and January 2024. Lesion size was quantified using the lymphatic malformation volume ratio (LVR): LVR = 0.523 x width x length x height (cm3) / head circumference (cm). Outcomes and LVR growth trends were analyzed using Student's t-test and a linear mixed-effects model.Results: Eighteen cases were included (10 cervical, 8 axillary). Uncomplicated cervical LMs grew at 0.3 cm2/week (p < 0.001). Intralesional bleeding (n = 3) was associated with LVR > 11 cm2 and significantly higher growth rates (2.6 vs. 0.3 cm2/week; p = 0.005). All cases with LVR > 5 cm2 required subsequent tracheostomy after birth. Axillary LMs grew at 0.21 cm2/week. One case with bleeding had LVR 4.4 cm2. Median LVR was significantly lower in vaginal deliveries compared with complicated births (2.0 vs. 7.3 cm2; p = 0.03). All LVR > 4 cm2 led to delivery complications.Conclusion: Higher LVR predicts haemorrhage and airway intervention in cervical LMs, and delivery complications in axillary LMs. These exploratory observations warrant confirmation in larger prospective cohorts.","PeriodicalId":20387,"journal":{"name":"Prenatal Diagnosis","volume":" ","pages":"1354-1363"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148423518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal Magnetic Resonance Imaging Assessment of Fetal Airway Dimensions: Establishing an Anthropometric Database. 胎儿气道尺寸的产前磁共振成像评估：建立人体测量数据库。

IF 3.1 2区医学

Prenatal Diagnosis Pub Date : 2026-08-01 Epub Date: 2026-04-02 DOI: 10.1002/pd.70140

Juliette Houssin, Ahmed El Ahmadi, Robinson Gravier-Dumonceau, Richard Nicollas, Eric Moreddu

{"title":"Prenatal Magnetic Resonance Imaging Assessment of Fetal Airway Dimensions: Establishing an Anthropometric Database.","authors":"Juliette Houssin, Ahmed El Ahmadi, Robinson Gravier-Dumonceau, Richard Nicollas, Eric Moreddu","doi":"10.1002/pd.70140","DOIUrl":"10.1002/pd.70140","url":null,"abstract":"Objective: Fetal airway anomalies can severely impair breathing at birth, potentially causing brain injury or death. Thus, early prenatal diagnosis is essential. While MRI is the most effective imaging modality for evaluating fetal airways, normative MRI data remain scarce.Method: This retrospective study analyzed fetal MRIs performed at a tertiary-care center between January 2, 2018, and October 11, 2023. Measurements of the trachea and pharynx-including diameters, lengths, and volumes-were collected from axial, sagittal, and coronal slices. Statistical tests included ANOVA, t-test, Wilcoxon, chi-square, and Fisher's exact tests, with significance set at p ≤ 0.05.Results: MRI data from 278 fetuses-either healthy or with non-airway-affecting anomalies-were analyzed. Airway dimensions significantly increased with gestational age. Tracheal axial diameter ranged from 1.70 to 2.00 mm (p = 0.001), coronal diameter from 2.20 to 3.10 mm (p = 0.001), and sagittal length from 33.1 to 35.9 mm (p = 0.003) between the fifth-sixth and ninth gestational months. Head position influenced pharyngeal but not tracheal measurements.Conclusion: This study provides the first MRI-based normative data for fetal airways, offering valuable reference values for prenatal assessment. MRI proves effective in monitoring airway development and planning neonatal respiratory management.","PeriodicalId":20387,"journal":{"name":"Prenatal Diagnosis","volume":" ","pages":"1330-1338"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variation in the Genetic Workup of Polyhydramnios: An International and Inter-Specialty Survey. 羊水过多的遗传变异：一项国际和跨专业调查。

IF 3.1 2区医学

Prenatal Diagnosis Pub Date : 2026-08-01 Epub Date: 2026-03-10 DOI: 10.1002/pd.70110

Roni Zemet, Yuval Yaron, Lena Sagi-Dain

{"title":"Variation in the Genetic Workup of Polyhydramnios: An International and Inter-Specialty Survey.","authors":"Roni Zemet, Yuval Yaron, Lena Sagi-Dain","doi":"10.1002/pd.70110","DOIUrl":"10.1002/pd.70110","url":null,"abstract":"Objective: To evaluate international and interprofessional variability in the definition and genetic evaluation of polyhydramnios, and to identify factors influencing clinical decision-making.Method: An international electronic survey was distributed to healthcare professionals, addressing definitions of polyhydramnios, criteria for recommending invasive diagnostic prenatal testing, and preferred genetic testing strategies. Responses were analyzed by geographic region and professional specialty.Results: A total of 154 clinicians from diverse regions completed the survey. Most defined polyhydramnios using absolute ultrasound values rather than percentiles. While 17.8% recommended invasive diagnostic testing for any pregnancy with polyhydramnios, 41.8% did so only when additional anomalies were present. Maternal-fetal medicine specialists were less likely to recommend invasive diagnostic testing (e.g., amniocentesis), particularly for mild isolated cases, whereas geneticists and genetic counselors were more likely to recommend prenatal genetic testing. US-based respondents were more likely to recommend only fetal chromosome analysis, whereas Israeli respondents tended to recommend advanced molecular diagnostics even in isolated cases.Conclusion: Substantial variability was noted in the genetic evaluation of polyhydramnios, driven by specialty and geographic factors. These findings highlight the absence of a consistent evidence base and underscore the need for studies defining diagnostic yield by clinical scenario and testing modality to inform evidence-based decision-making, while recognizing that practice patterns also reflect local resources and healthcare systems.","PeriodicalId":20387,"journal":{"name":"Prenatal Diagnosis","volume":" ","pages":"1323-1329"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of a Flexible Versus Rigid Fetoscope in the Simulated Management of Twin-to-Twin Transfusion Syndrome. 柔性与刚性胎儿镜在双胎输血综合征模拟治疗中的表现。

IF 3.1 2区医学

Prenatal Diagnosis Pub Date : 2026-08-01 Epub Date: 2026-07-05 DOI: 10.1002/pd.70213

Emmanuel Rault, Jerome Massardier, Elsa Limouzin, Mona Massoud, Cyril Huissoud, Anthony Atallah

{"title":"Performance of a Flexible Versus Rigid Fetoscope in the Simulated Management of Twin-to-Twin Transfusion Syndrome.","authors":"Emmanuel Rault, Jerome Massardier, Elsa Limouzin, Mona Massoud, Cyril Huissoud, Anthony Atallah","doi":"10.1002/pd.70213","DOIUrl":"10.1002/pd.70213","url":null,"abstract":"Objective: To assess the feasibility and operative performance of a flexible fetoscope (FF) compared with a rigid fetoscope (RF) in the simulated management of twin-to-twin transfusion syndrome (TTTS) with anterior placentation.Method: A randomized, non-blinded crossover trial was conducted during a national training session for fetal surgeons. Twenty participants each performed a simulated Solomonization procedure using both the FF and RF in a high-fidelity TTTS simulator. The FF consisted of a single-use flexible video-endoscope inserted into a 10 Fr, 230-mm stainless steel cannula. Outcomes included the visualization of the recipient cord insertion, the completeness of Solomonization, operative time, tangential vessel approach, and spatial analysis of the Solomonization path to quantify equatorial deviation and its direction relative to the intertwin membrane.Results: No statistically significant differences were observed between the FF and RF in recipient cord insertion visualization (80% vs. 40%, p = 0.17), complete Solomonization (95% vs. 70%, p = 0.58) and total procedure duration (11.30 ± 3.09 vs. 9.00 ± 2.36 min; p = 0.08). The overall vessel approach angle was slightly more perpendicular with the FF (median 3.5[IQR 3.0-4.7]) than with the RF (3.0[2.2-3.7]; p = 0.08). Spatial analysis revealed a larger equatorial deviation area with the FF (31.1 ± 10.3 vs. 17.8 ± 7.1 cm2; p = 0.01) and a more anterior trajectory (signed deviation 15.6 ± 10.2 vs. -15.0 ± 17.0 cm2; p < 0.01).Conclusion: Flexible fetoscopy appears feasible in the setting of anterior placentation in simulated TTTS surgery, supporting its potential clinical value and the need for dedicated training before clinical translation.","PeriodicalId":20387,"journal":{"name":"Prenatal Diagnosis","volume":" ","pages":"1472-1479"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal Screening for Common Aneuploidy in Southeast Asian Countries: A Systematic Review of Challenges and Opportunities. 东南亚国家常见非整倍体的产前筛查：挑战与机遇的系统回顾。

IF 3.1 2区医学

Prenatal Diagnosis Pub Date : 2026-08-01 Epub Date: 2026-05-23 DOI: 10.1002/pd.70171

Rapphon Sawaddisan, Lucinda Freeman, Erin Turbitt, Alison McEwen

{"title":"Prenatal Screening for Common Aneuploidy in Southeast Asian Countries: A Systematic Review of Challenges and Opportunities.","authors":"Rapphon Sawaddisan, Lucinda Freeman, Erin Turbitt, Alison McEwen","doi":"10.1002/pd.70171","DOIUrl":"10.1002/pd.70171","url":null,"abstract":"Southeast Asian (SEA) countries face persistent challenges in equitable healthcare delivery. Given the high prevalence of aneuploidy, increasing use of advanced prenatal screening technologies, and challenges reported in other regions, this study aimed to identify and assess existing policies and guidelines as well as the enablers and barriers to implementing prenatal aneuploidy screening in SEA. Using the PRISMA framework, we searched seven databases, conducted web searches, reviewed reference lists, and gathered input from key informants. Narrative synthesis was used to interpret and summarise data. We included 83 published documents and verbal insights from four key informants, identifying 17 topics on enablers and barriers grouped into four domains: (1) policies and guidelines, (2) healthcare infrastructure, (3) access to screening, and (4) culture and attitudes of healthcare providers and parents. Effective implementation requires surveillance of aneuploidy and screening practices to understand their impact on public health and national economies. Policy development should consider test performance, healthcare capacity, infrastructure readiness, budget, stakeholder perceptions, cultural norms, and legal frameworks, and be translated into clear guidelines. Sustainable implementation depends on continuous monitoring, ongoing education, collaboration, and regular policy updates.","PeriodicalId":20387,"journal":{"name":"Prenatal Diagnosis","volume":" ","pages":"1393-1410"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148006186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung Size Measurement in Left-Sided Congenital Diaphragmatic Hernia: Does Position of the Fetus Affect Results? 左侧先天性膈疝肺大小测量：胎儿位置影响结果吗？

IF 3.1 2区医学

Prenatal Diagnosis Pub Date : 2026-08-01 Epub Date: 2026-07-12 DOI: 10.1002/pd.70222

Rogelio Cruz-Martínez, Paola Rivera-Carrillo, Rosa Villalobos-Gómez, Andrea Peláez-Jiménez, Adriana Cisneros-Martínez, Savino Gil-Pugliese, Saulo Molina-Giraldo

{"title":"Lung Size Measurement in Left-Sided Congenital Diaphragmatic Hernia: Does Position of the Fetus Affect Results?","authors":"Rogelio Cruz-Martínez, Paola Rivera-Carrillo, Rosa Villalobos-Gómez, Andrea Peláez-Jiménez, Adriana Cisneros-Martínez, Savino Gil-Pugliese, Saulo Molina-Giraldo","doi":"10.1002/pd.70222","DOIUrl":"10.1002/pd.70222","url":null,"abstract":"Objective: To compare the difference in lung size measurement in fetuses with left-sided congenital diaphragmatic hernia (L-CDH) by means of the observed/expected lung-to-head ratio (O/E-LHR) in two different fetal positions.Method: Prospective cohort of L-CDH fetuses, with O/E-LHR measurements by one experienced investigator but with the fetus in two positions: with the contralateral lung close and one with the lung away from the ultrasound probe. A Bland-Altman analysis was performed to assess the agreement between lung measurements in both fetal positions.Results: 49 L-CDH fetuses underwent paired assessments of lung size at a mean gestational age of 28.8 (17.7-37.7) weeks. Lung size estimation with the lung distant to the probe consistently underestimates the O/E-LHR values compared to measurements obtained using the lung close to the probe. On average, O/E-LHR values were 11.3% (95% confidence intervals (CI), 7.5%-15.0%) higher when the lung was close to the probe. When the lung was distant to the probe, a higher proportion of CDH fetuses were classified in a more severe group than when it was evaluated close to the probe (p < 0.01). A consistently lower survival rate was expected when the lung was evaluated distant to the ultrasound probe.Conclusions: Lung size estimation in L-CDH fetuses may be affected by fetal position, which may affect postnatal prognosis, prediction of survival and eligibility for fetal therapy.","PeriodicalId":20387,"journal":{"name":"Prenatal Diagnosis","volume":" ","pages":"1480-1485"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twin Anemia Polycythemia Sequence: Pretreatment Characteristics and Outcomes Stratified by Management Approach. 双胞贫血，红细胞增多症序列：预处理特点和按管理方法分层的结果。

IF 3.1 2区医学

Prenatal Diagnosis Pub Date : 2026-08-01 Epub Date: 2026-06-17 DOI: 10.1002/pd.70199

Camille F Shantz, Karim Ibrahim Dit Nasrallah, Jena L Miller, Amelia Jiang-Yu, Antonia Varthaliti, Sarah Millard, Michelle L Kush, Ahmet A Baschat, Mara Rosner

{"title":"Twin Anemia Polycythemia Sequence: Pretreatment Characteristics and Outcomes Stratified by Management Approach.","authors":"Camille F Shantz, Karim Ibrahim Dit Nasrallah, Jena L Miller, Amelia Jiang-Yu, Antonia Varthaliti, Sarah Millard, Michelle L Kush, Ahmet A Baschat, Mara Rosner","doi":"10.1002/pd.70199","DOIUrl":"10.1002/pd.70199","url":null,"abstract":"Objective: To compare Twin Anemia Polycythemia Sequence (TAPS) cases by treatment modality.Methods: Single-center, retrospective review of TAPS without Twin to Twin Transfusion Syndrome undergoing expectant management (EM), intrauterine transfusion +/- partial exchange transfusion (IUT/pET), fetoscopic laser surgery (FLS), or selective fetal reduction (SFR).Results: In 52 TAPS cases, 36 (69%) were spontaneous and 16 (31%) postlaser. 15 (29%) underwent EM, 9 (17%) IUT/pET, 22 (42%) FLS, and 6 (12%) SFR. FLS and SFR groups had higher median middle cerebral artery (MCA) discordance (p = 0.007). IUT/pET had later median gestational age (GA) at diagnosis (weeks): 20.9 for FLS, 18.0 for SFR, 21.4 for EM, and 25.6 for IUT/pET (p = 0.001). FLS was associated with isolated polyhydramnios (p = 0.027), and SFR with isolated oligohydramnios (p = 0.005). Treatment to delivery interval (weeks) was 5.4 for IUT/pET, 11.0 for FLS, and 20.6 for SFR (p < 0.001). Median GA at delivery was latest in SFR (p = 0.003). Perinatal survival for EM, IUT/pET, FLS and SFR was 93.3%, 94.4%, 87.5%, and 50%, respectively.Conclusion: Gestational age, fluid abnormalities, and MCA discordance differed across treatment groups. Placentation, TAPS etiology, and coexisting sFGR were more evenly distributed across management strategies indicating they were less influential factors in management decisions. Outcomes were overall favorable and did not differ across management groups.","PeriodicalId":20387,"journal":{"name":"Prenatal Diagnosis","volume":" ","pages":"1447-1454"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal Diagnosis of Posterior Urethral Valves: Timing of Diagnosis and Mid-Term Renal Function When Second and Third Trimester Ultrasounds Are Systematically Performed. 后尿道瓣膜的产前诊断：在妊娠中期和晚期系统进行超声检查时的诊断时机和中期肾功能。

IF 3.1 2区医学

Prenatal Diagnosis Pub Date : 2026-08-01 Epub Date: 2026-04-21 DOI: 10.1002/pd.70155

Silvia Pecorelli, Mathilde Glenisson, Matthieu Peycelon, Etienne Suply, Sébastien Faraj, Marc-David Leclair, Thomas Blanc, Nicolas Kalfa, Pauline Clermidi, Alexis P Arnaud, Alice Faure, Quentin Ballouhey, Nadia Boudaoud, Yann Chaussy, Luke Harper

{"title":"Prenatal Diagnosis of Posterior Urethral Valves: Timing of Diagnosis and Mid-Term Renal Function When Second and Third Trimester Ultrasounds Are Systematically Performed.","authors":"Silvia Pecorelli, Mathilde Glenisson, Matthieu Peycelon, Etienne Suply, Sébastien Faraj, Marc-David Leclair, Thomas Blanc, Nicolas Kalfa, Pauline Clermidi, Alexis P Arnaud, Alice Faure, Quentin Ballouhey, Nadia Boudaoud, Yann Chaussy, Luke Harper","doi":"10.1002/pd.70155","DOIUrl":"10.1002/pd.70155","url":null,"abstract":"Objective: The impact of prenatal diagnosis timing in posterior urethral valves is unclear. We aimed to compare renal function between patients with suspected PUV diagnosed before or after 28 weeks of gestation in a population who underwent systematic T2 and T3 ultrasounds.Methods: We performed a retrospective analysis of a prospective cohort of patients with prenatally suspected and postnatally confirmed PUV. Patients were stratified by timing of prenatal ultrasound detection of urinary tract abnormalities (T2 vs T3). We compared nadir creatinine and mid-term eGFR (> 5 years of follow-up).Results: 72 boys with postnatally confirmed PUV were included. Thirty-seven patients (51%) were diagnosed before 28 weeks' gestation (T2 group). This early group had significantly higher NC values (median 38 vs. 26 μmol/L, p < 0.05) and lower eGFR at mid-term follow-up (median 85 vs. 105 mL/min/1.73 m2, p < 0.05) compared to the T3 group.Conclusions: PUV suspected during the second trimester of gestation is associated with significantly worse NC and mid-term renal function compared with those suspected later in pregnancy (T3). Reports of prenatal diagnosis of PUV should dichotomize between T2 and T3 diagnoses. The true rate of PUV that could be diagnosed prenatally is higher than expected.","PeriodicalId":20387,"journal":{"name":"Prenatal Diagnosis","volume":" ","pages":"1339-1344"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetoscopic Vesicostomy for Lower Urinary Tract Obstruction: A Proposal for a New Surgical Technique. 胎儿镜膀胱造口术治疗下尿路梗阻：一种新手术技术的建议。

IF 3.1 2区医学

Prenatal Diagnosis Pub Date : 2026-08-01 Epub Date: 2026-07-06 DOI: 10.1002/pd.70212

Marcio Lopes Miranda, Kleber Cursino de Andrade, Marcos Caetano, Patricia Traballi Carvalho Pegolo, Renato Ximenes, Rodrigo Ruano

引用次数: 0