Prevention, Early Detection, and Interception最新文献

{"title":"Abstract 4215: Patient and screening characteristics associated with positive lung cancer screening examinations","authors":"L. Henderson, S. Sites, T. Tailor, S. C. Bearden, R. Huamani, A. Throneburg, Max Nagle, M. Rivera","doi":"10.1158/1538-7445.AM2019-4215","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2019-4215","url":null,"abstract":"Introduction. The likelihood of having a positive low dose computed tomography (LDCT) lung cancer screening (LCS) examination that requires workup may vary according to patients’ characteristics and risk factors. The purpose of this study is to evaluate patient characteristics associated with positive LCS exams. Methods. We utilized data from 1684 LDCT exams conducted for LCS at five academic and community sites from 2015-2018. During the screening visit, patients were asked to complete a comprehensive questionnaire including socio-demographics, smoking history, occupational and environmental exposures, family history of lung cancer, and comorbid conditions. Information on the LCS examination, including the radiologists’ Lung Reporting and Data System (Lung-RADS) assessment, was obtained from the radiologist report. We dichotomized Lung-RADS into negative (Lung-RADS 1 (negative) or 2 (benign appearance or behavior)) and positive (Lung-RADS 3 (probably benign), 4A (suspicious), or 4B (suspicious)) based on the management recommendation of continuing with annual screening in 12 months or requiring follow-up before 12 months. We compared Lung-RADS results (positive versus negative) by patient characteristics using chi-square tests and examined predictors of positive LCS exams using multivariate logistic regression, reporting adjusted odds ratios (aORs) and 95% confidence intervals (95%CI). Results. Screened patients ranged in age from 50-78 years, with 46.7% less than 65 years and 53.3% ages 65 or older. Approximately 53.3% were male and 46.7% were female; 84.5% were White, 11.8% were African American, and 3.7% were other races. The majority (76.5%) of screened patients were overweight or obese. Two-thirds (68.5%) of patients had more than one LCS exam. Most (85.0%) LCS exams were negative while 15.0% were positive. There were no significant differences in Lung-RADS assessment by race, gender, education, or body mass index. Lung-RADS were significantly more likely to be positive in those ages 65 and older versus those ages less than 65 (aOR=1.47, 95%CI: 1.03-2.10) and in baseline versus subsequent screening exams (aOR=0.43, 95%CI: 0.30-0.62). Conclusion. Predictors of having a positive LCS exam requiring work-up before the next recommended annual screening test include being aged 65 and older and having a baseline LCS examination. Citation Format: Louise M. Henderson, Samantha Sites, Tina Tailor, Sara C. Bearden, Roger Huamani, Allison Throneburg, Max Nagle, M Patricia Rivera. Patient and screening characteristics associated with positive lung cancer screening examinations [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4215.","PeriodicalId":20357,"journal":{"name":"Prevention, Early Detection, and Interception","volume":"290 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80228840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract 2425: Moderate to vigorous physical activity reduces visceral adipose tissue in obese breast cancer survivors undergoing a weight loss intervention","authors":"C. Fabian, J. Klemp, J. Burns, E. Vidoni, Lauren Nye, C. Befort, Jill M. Hamilton-Reeves, D. Sullivan, T. Phillips, S. Hursting, B. Kimler","doi":"10.1158/1538-7445.SABCS18-2425","DOIUrl":"https://doi.org/10.1158/1538-7445.SABCS18-2425","url":null,"abstract":"Background: Body composition, adipose distribution, and fitness are likely superior to BMI alone in predicting outcomes in obese breast cancer survivors. Visceral adipose tissue (VAT) is thought to be disproportionately responsible for the metabolic and inflammatory changes linking obesity and breast cancer recurrence. Purpose: Feasibility of achievement of high volume moderate-to-vigorous physical activity (MVPA) and its effect on body composition including VAT and other risk biomarkers in older sedentary, obese breast cancer survivors participating in a behavioral weight loss intervention. Methods: Modest caloric restriction (350-500 kcal per day) was combined with a study provided YMCA membership and twice weekly personal trainer sessions. MVPA (40-80% of heart rate reserve in older women) was assessed by Garmin Vivoactive smart watches linked to GarminConnect. Total activity was escalated from 100 minutes week 1 to a total of 300 minutes per week by week 9 with a goal of > 200 min/wk as MVPA. Women were evaluated pre- and post-intervention for peak oxygen consumption (VO2peak), body composition by dual energy x-ray absorptiometry (GE Lunar iDXA), and serum levels of adipokines, cytokines, and hormones. Results: 18 breast cancer survivors were enrolled and completed the 3 months of the behavioral weight loss intervention which included the YMCA membership and twice weekly personal trainer. Median age was 60, 11 had received prior chemotherapy, and 13 were currently taking aromatase inhibitors. Median (and range) baseline anthropomorphic values were BMI 37 (31-43) kg/m2, total mass 95 (76-125) kg, total fat 46 (34-66) kg, and VAT 1.7 (1.0-3.0) kg. All but one had a baseline VAT > 1.17 kg, consistent with elevated risk of metabolic syndrome. 17/18 achieved at least 150 min/wk of MVPA, with a median of 176 (range 55-291) min/wk for weeks 9-12. Fitness measured as VO2peak increased from 18.9 (13.7-25.3) to 21.1 (17.1-31.4) ml/kg/min (p=0.0003; Wilcoxon signed rank test). At 3 months, significant reductions were observed for total mass (median 7%), fat mass (median 13%), and VAT (median 20%, range 1-41%)(p Conclusion: High volume moderate-to-vigorous physical activity can be achieved by older, sedentary, obese breast cancer survivors; and this translates to favorable modulation of body composition including VAT measures and serum risk biomarkers. Citation Format: Carol J. Fabian, Jennifer R. Klemp, Jeffrey M. Burns, Eric D. Vidoni, Lauren Nye, Christie A. Befort, Jill M. Hamilton-Reeves, Debra K. Sullivan, Teresa A. Phillips, Stephen D. Hursting, Bruce F. Kimler. Moderate to vigorous physical activity reduces visceral adipose tissue in obese breast cancer survivors undergoing a weight loss intervention [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2425.","PeriodicalId":20357,"journal":{"name":"Prevention, Early Detection, and Interception","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90468260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract LB-250: The alteration of the colonic microbial community and metabolomic profile in humans: Results from a 90-day double-blinded, randomized interventional trial","authors":"M. Aslam, C. Bassis, I. Bergin, K. Knuver, Ananda Sen, D. Turgeon, J. Varani","doi":"10.1158/1538-7445.AM2019-LB-250","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2019-LB-250","url":null,"abstract":"Introduction: The bacteria making up the microbial community of the gastrointestinal tract, by virtue of their ability to produce pro-carcinogenic bile acids and anti-carcinogenic short chain fatty acids (SCFA), are thought to influence the colonic health. Methods: Thirty healthy human subjects (at risk for colorectal cancer) were enrolled in a three-arm, 90-day double-blinded, randomized interventional trial in which Aquamin, a calcium- and magnesium-rich, multi-mineral product was compared to calcium alone and placebo for effects on the colonic microbial community and metabolomic profile. Aquamin and calcium (carbonate) alone groups provided 800 mg of calcium per day from the respective sources. Colonic tissue and stool samples were obtained endoscopically from unpreped sigmoid colon with a flexible sigmoidoscope before and after the intervention and were subjected to microbial and metabolomic analysis. Illumina® MiSeq sequencing of the V4 region of 16S rRNA genes was used to assess the bacterial populations represented in both colon mucosal biopsies and fecal material and qPCR was used to obtain an estimate of total bacterial DNA in each tissue and stool specimen. In parallel, a 2-step extraction procedure followed by liquid chromatography-mass spectrometry was used to assess bile acids and SCFA. Results: As far as safety and tolerability is concerned, there were no serious adverse events to report during the trial with Aquamin or calcium. Compared to pretreatment values from both colonic biopsies and stool specimens, intervention with Aquamin led to a reduction in total bacterial load (based on qPCR). Treatment with calcium alone produced intermediary changes in total bacterial DNA while no reduction was observed with placebo. Based on sequencing of the V4 region of 16S rRNA genes, there were significant pre-post differences, but intra-subject variability was less than the variability between individuals. In spite of the high variability, greater pre-post interventional differences were seen with Aquamin relative to calcium alone and placebo. Differences between Aquamin and calcium alone reached statistical significance. Several operational taxonomic units representing major microbial phyla present in the colon (i.e., actinobacteria, bacteroidetes, and firmicutes) were reduced in response to Aquamin compared to placebo. Reductions were also seen with calcium but these were intermediary between Aquamin and placebo. In parallel with microbial changes, we observed a reduction in total bile acid levels and an increase in the level of acetate (an SCFA) in stool specimens from Aquamin-treated subjects. No or minimal change in bile acids or SCFAs was observed with calcium alone or placebo. Some of the primary bile acids (cholate and Chenodeoxycholate/deoxycholate) and the secondary bile acids (alpha-Murocholate, hyocholate, hyodeoxycholate, and omega-Muricholate) were significantly reduced with Aquamin. Additionally, on eicosanoids assessment in col","PeriodicalId":20357,"journal":{"name":"Prevention, Early Detection, and Interception","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87400919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract 2729: Development of a targeted liquid biopsy for early gynecologic cancer detection leads to discovery of a highly prevalent genomic landscape of cancer driver gene mutations in uterine tissue from women without cancer","authors":"Deep Pandya, S. Tomita, O. Camacho, S. Swierczek, Catalina Camacho, K. Engelman, Stephanie Polukort, M. M. Padron, Jordan Rosefigura, J. Irish, L. Chuang, V. Andikyan, Samantha Cohen, P. Fiedler, S. Sieber, I. Shih, J. Billaud, B. Reva, R. Sebra, P. Dottino, J. Martignetti","doi":"10.1158/1538-7445.AM2019-2729","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2019-2729","url":null,"abstract":"Introduction: Ovarian and endometrial cancers are, respectively, the most lethal and most frequent female reproductive tract malignancies. Currently, there are no effective screening methodologies or protocols for these cancers. We hypothesized that the use of ultra-deep, targeted gene sequencing on a highly specific and gynecologic cancer-focused analyte source, namely, uterine lavage fluid, could detect somatic mutations associated with these cancers. Using these highly sensitive NGS-based assays, we demonstrated both (1) the ability to detect tumor-specific mutations in uterine lavage from women even with microscopic stage IA ovarian and endometrial cancers and (2) the existence of highly prevalent populations of cancer driver gene mutated cells in uterine tissue from women without cancer. Methods: In total, and following written informed consent, samples were prospectively collected and analyzed from two institutions from more than 250 women at the time of their surgery. Sequencing was performed using both Ion Torrent and Illumina-based sequencing and additional orthogonal mutation validation was performed using dPCR and Sanger sequencing. Results: Targeted sequencing of cellular and cell free DNA isolated from uterine lavage samples was performed on all samples in a blinded fashion. Histopathologic diagnosis and sample decoding, revealed that lavage mutations were present in nearly all women with ovarian and endometrial cancer, even those with microscopic stage IA disease. These mutations were demonstrated to be tumor-specific by sequencing their respective tumors. Notably, we also identified mutations in approximately half of all women without any evidence of cancer. To define the possible origin of these mutations in normal tissue, we analyzed uterine tissue from women without cancer. Two hundred biopsy samples were obtained from 24 uterine samples following hysterectomy for non-cancerous conditions. Remarkably, sequencing revealed relatively high allele fraction cancer-associated mutations in more than half of these samples. The overwhelming majority of samples harbored low frequency mutations. Conclusions: Our studies demonstrate the ability to detect with very high sensitivity, tumor-specific somatic mutations in women with ovarian and endometrial cancers; suggesting the future possibility of earlier diagnosis and better outcomes. At the same time, our studies again highlight caveats regarding NGS-based results for cancer screening. Finally, the identification of a previously unknown, highly prevalent, cancer-driver mutation landscape in apparently normal uterine tissue opens the door onto new areas of biologic exploration for understanding tumorigenesis and the protective mechanisms which inhibit cancer development. Citation Format: Deep S. Pandya, Shannon Tomita, Olga Camacho, Sabina Swierczek, Catalina Camacho, Kelsey Engelman, Stephanie Polukort, Maria Mercedes Padron, Jordan RoseFigura, Jon Irish, Linus Chuang, Vaagn Andikyan, Sama","PeriodicalId":20357,"journal":{"name":"Prevention, Early Detection, and Interception","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87475991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract 1619: Cervical cancer screening knowledge and behavior among female undergraduates","authors":"J. Agboeze, M. Nwali, N. Ezeani","doi":"10.1158/1538-7445.AM2019-1619","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2019-1619","url":null,"abstract":"Background; Cervical cancer is a highly preventable disease that disproportionally affects women in developing countries with an estimated incidence rate of 33 cases per 100,000 women in Nigeria.. Over the year’s awareness and uptake of cervical cancer screening services have remained poor in developing countries. Lack of knowledge and poor attitude towards the disease and risk factors can affect screening practice and development of preventive behavior for cervical cancer Objective; This study assessed the level of knowledge and barriers towards cervical cancer screening among female university students. Method; We conducted a cross-sectional study of 234 female students at Ebonyi State University Abakaliki Nigeria from March to July 2017 using multistage sampling technique. Apretested questionnaire was used to collect data on socio-demographic characteristics, knowledge, and screening history. Data were analysed with Epi info version 7.1.4. Results; Participants’ mean age was 22 years (sd=3).Of the respondents 79.5% were not aware of cervical cancer screening while 58.9% and 78.5% had poor knowledge on cervical cancer and Human papilomavirus vaccination respectively. Major sources of information were health workers 70% and 35% Radio while only 4.0% have had Pap smear test. Common barriers include lack of centres where such services are obtainable 88% and fear of cancer being discovered 9%. Reported risk factors were multiple sexual partners 24.2% and early onset of sexual intercourse 19.8%. A significant association was found between institutional and personal barriers and having a Pap smear test. Conclusion Comprehensive education on cervical cancer screening in universities is critical in reducing the morbidity and mortality associated with cervical cancer. Few screening centres contributed to poor cervical screening uptake. Note: This abstract was not presented at the meeting. Citation Format: Joseph Agboeze, Matthew Igwe Nwali, Nkiru Ezeani. Cervical cancer screening knowledge and behavior among female undergraduates [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1619.","PeriodicalId":20357,"journal":{"name":"Prevention, Early Detection, and Interception","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89538047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract 2734: Poly-ligand profiling of plasma samples as a potential predictor of prostate biopsy results","authors":"Xixi Wei, Xiaowei Liu, R. Santhanam, D. Magee, Anthony W. Helmstetter, M. Miglarese, D. Spetzler","doi":"10.1158/1538-7445.SABCS18-2734","DOIUrl":"https://doi.org/10.1158/1538-7445.SABCS18-2734","url":null,"abstract":"","PeriodicalId":20357,"journal":{"name":"Prevention, Early Detection, and Interception","volume":"170 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80653884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract 646: Pre conception paternal DDT exposure and programming of metabolic dysfunction and breast cancer risk in offspring","authors":"R. S. D. Cruz, H. Cao, C. C. Fontelles, Apsra Nasir, M. I. Cruz, S. Assis","doi":"10.1158/1538-7445.SABCS18-646","DOIUrl":"https://doi.org/10.1158/1538-7445.SABCS18-646","url":null,"abstract":"","PeriodicalId":20357,"journal":{"name":"Prevention, Early Detection, and Interception","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79702775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract 3312: Appropriate follow-up for patients with suspicious lung cancer screening findings: Lessons learned from Federally Qualified Health Centers","authors":"Lesley Watson, M. Cotter, Robert A. Smith, K. Sharpe","doi":"10.1158/1538-7445.AM2019-3312","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2019-3312","url":null,"abstract":"Background: Low-dose CT (LDCT) lung cancer screening is associated with improved outcomes in high-risk adults, but uptake remains low and such medical advances are often not available in low-resource areas. The American Cancer Society (ACS) launched a pilot program focused on establishing effective processes to refer and screen patients for lung cancer in under-resourced areas in West Virginia and Tennessee. ACS partnered with two Federally Qualified Health Centers (FQHCs) and accredited screening facilities to refer and screen patients, and to identify critical facilitators, barriers, and lessons learned in implementing LDCT and moving patients through the screening continuum. Methods: Annual site visits in 2017 and 2018 captured data on implementation, progress, and lessons learned. ACS evaluators conducted 47 key informant interviews with staff from both study sites, including navigators, clinical staff, and administrators. Interviews were recorded and transcribed verbatim. Evaluators used transcripts and project notes to conduct a thematic analysis to assess factors associated with effective implementation and improved outcomes. Results: Participants shared a wealth of insight on program implementation, including lessons learned about forming successful partnerships, personnel and resource requirements, determining screening eligibility, and conducting shared decision-making. One key area where site teams had to overcome implementation challenges was in determining appropriate follow-up testing for patients with suspicious or borderline suspicious findings (L-RADS 3 or 4). Some referring primary care providers were confused by existing clinical guidelines, unsure of when to order LDCT versus chest-CT, and felt ill-equipped to determine the optimal follow-up tests. There was confusion about the difference between billing follow-up exams as “screening” versus “diagnostic.” Program leaders investigated these and other matters and came to consensus on the most practical, logical solutions. One study site also initiated a lung nodule team to discuss suspicious findings in-depth. This practice allowed the team to review clinical history and gain consensus around appropriate diagnostic testing for individual patients, and its implementation went well enough for the team to recommend it to ACS as a potential best practice for future programs. Conclusions: By identifying challenges in conducting follow-up testing after LDCT and successful means of overcoming these challenges, this pilot study can inform practitioners in means of overcoming challenges that may enable underserved populations to move successfully through the lung cancer screening continuum. In so doing, this study may promote further reduction in cancer health disparities. Citation Format: Lesley Watson, Megan M. Cotter, Robert A. Smith, Katherine Sharpe. Appropriate follow-up for patients with suspicious lung cancer screening findings: Lessons learned from Federally Qualified Health Cen","PeriodicalId":20357,"journal":{"name":"Prevention, Early Detection, and Interception","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78980663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract 1622: Role of 3d volumetric and perfusion imaging for detecting early changes in pancreatic adenocarcinoma","authors":"S. Rahmanuddin, E. Borazanci, V. Chung, D. Cridebring, R. Korn, Joyce Ho, William J. Boswell, D. Hoff","doi":"10.1158/1538-7445.am2019-1622","DOIUrl":"https://doi.org/10.1158/1538-7445.am2019-1622","url":null,"abstract":"","PeriodicalId":20357,"journal":{"name":"Prevention, Early Detection, and Interception","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83448764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract 666: Determination of biomarkers for neuronal damage in bortezomib (BTZ) induced peripheral neuropathy (BIPN)","authors":"Paramjot Kaur, Theodore lemuel Mathuram, Vineela Nagamalla, J. Patel, Thiagarajan Venkatesan, A. Fernandez-Fernandez, M. Cheng, A. Rathinavelu","doi":"10.1158/1538-7445.SABCS18-666","DOIUrl":"https://doi.org/10.1158/1538-7445.SABCS18-666","url":null,"abstract":"","PeriodicalId":20357,"journal":{"name":"Prevention, Early Detection, and Interception","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87818427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}