Advanced Medical Research最新文献

{"title":"The Importance of Empowering Self-Management Skills in Diabetes Mellitus","authors":"Pramila Thapa, Onur Oral, G. Nomikos","doi":"10.62836/amr.v3i1.182","DOIUrl":"https://doi.org/10.62836/amr.v3i1.182","url":null,"abstract":"Background: This narrative review article aims to provide an understanding of diabetes mellitus, including its causes, health risks, and ways to prevent and prevent them, empowering self-management skills in managing this health problem. Materials and Methods: In the search for scientific literature for this review, data from the US National Library of Medicine (PubMed), MEDLINE, PsycINFO, and SportDiscus were used, and the terms ‘’ self-management skills’’, diabetes mellitus’’.’’ metabolic health’’. “regular physical activity’’ was used. The relevant literature has also taken its source from the research of relevant articles from reference lists derived from data searches. Results: Diabetes mellitus is a complex condition that involves some different processes, including insulin secretion, insulin action, and glucose metabolism. It would be beneficial to continue researching the various aspects of diabetes management and to gain a deeper understanding of the underlying mechanisms of this disease. Conclusion: Diabetes mellitus is a condition that requires a multifaceted approach to management. It involves dysfunction in insulin secretion, insulin action, and glucose metabolism. Empowering individuals with the skills to manage this metabolic health problem can contribute to significant health benefits in the prevention and treatment of this disease.","PeriodicalId":202943,"journal":{"name":"Advanced Medical Research","volume":"6 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141684687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Study of Probiotic Enteral Nutrition to Improve Intestinal Flora and Chemotherapy-related Complications in Gastric Cancer Patients Undergoing Chemotherapy","authors":"Lan Yang, Xia Zhang, Xia Yang, Yaning Wei, Liying Chen, Yuzhu Liang, Shitong Liu, Xiaoxi Wu, Panxiang Li","doi":"10.58195/amr.v1i1.52","DOIUrl":"https://doi.org/10.58195/amr.v1i1.52","url":null,"abstract":"OBJECTIVE: In the treatment of gastric cancer patients undergoing chemotherapy, it is important to investigate the effect of probiotic enteral nutrition not only to improve intestinal flora, but also to improve chemotherapy-related complications. METHODS: From September 2021 to September 2022, 60 patients with gastric cancer combined with nutritional risk who were hospitalized in the Department of Medical Oncology of our hospital were selected and then divided into 3 groups: 1. control group: patients were given dietary guidance while chemotherapy. 2. enteral nutrition group: oral nutrition therapy was given while chemotherapy. 3. combined probiotics group: enteral nutrition combined with probiotics was given while chemotherapy. treatment. For all study subjects, the following study indexes were examined at the time of admission and after chemotherapy: 1. intestinal flora 2. hematological indexes: white blood cells, red blood cells, platelets, blood albumin, prealbumin, T-cell subsets, immunoglobulins, etc. 3. physical indexes: body weight, body composition. 4. symptomatic indexes: stool properties and frequency, severity of nausea and vomiting. RESULTS: From the results, before treatment, there was basically no difference in intestinal flora among the three groups. After treatment, the intestinal flora of patients in the combined probiotic group was relatively low. It can be seen that probiotics can contribute to the reduction of intestinal flora, P<0.05; before treatment, there was basically no difference in the hematological indexes of patients in the three groups. After treatment, the hematological indexes of patients in the combined probiotic group were relatively normal. It can be seen that probiotics can contribute to the normalization of hematological indexes, p<0.05; before treatment, there was basically no difference in either the weight of the patients in the three groups or their body composition. After treatment, the body indexes of patients in the combined probiotic group returned to normal. It can be seen that probiotics can promote the return of body indexes to normal; before treatment, there was basically no difference in the stool properties and frequency, or the severity of nausea and vomiting among the three groups of patients. After treatment, the patients in the combined probiotic group had normalized their symptoms. It can be seen that probiotics can contribute to the normalization of symptom indexes. CONCLUSION: When treating patients with gastric cancer chemotherapy, applying probiotics to them can effectively improve both the number of intestinal flora and hematological indicators, as well as physical indicators and symptom indicators, which in turn can promote patients' remission and recovery from symptoms.","PeriodicalId":202943,"journal":{"name":"Advanced Medical Research","volume":"273 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129049492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problems and Reflections of Academic Team Building in the Clinical Practice of Accelerated Rehabilitation Surgery","authors":"Daxing Sun, Fei Wu","doi":"10.58195/amr.v1i1.16","DOIUrl":"https://doi.org/10.58195/amr.v1i1.16","url":null,"abstract":"Enhanced recovery after surgery, the advancement of ERAS concept and minimally invasive surgical techniques have greatly accelerated the recovery of patients after surgery. However, due to the relatively lagging development of the inherent clinical cooperation team model and operational procedures at this stage, the advantages of ERAS have not been fully utilized, and the widespread promotion and popularization of ERAS have been limited. Reviewing the global clinical practice and research progress of ERAS, the problems in ERAS team building are analyzed from the following aspects. First, ERAS team building requires simultaneous development of concept and technology; second, ERAS team building model suitable for national conditions; third, the \"invisible burden\" of ERAS team clinical work; fourth, how to integrate ERAS team building with hierarchical diagnosis and treatment; fifth, the challenges and opportunities of ERAS team building. Fifth, the challenges and opportunities of ERAS team building. In conclusion, ERAS team building should be aimed at promoting ERAS technology and benefiting patients.","PeriodicalId":202943,"journal":{"name":"Advanced Medical Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131881769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Diagnosis and Treatment of Enteropathy-associated T-cell Lymphoma","authors":"Y. Miao, Qiaojiajie Zhao","doi":"10.58195/amr.v1i1.13","DOIUrl":"https://doi.org/10.58195/amr.v1i1.13","url":null,"abstract":"To investigate the clinical characteristics of enteropathy-associated T-cell lymphoma(EATL) and to give treatment strategies. METHODS:  From 2019. 02-2022. 02, 10 patients with enteropathy-associated T-cell lymphoma were seen in our hospital, their clinical data were retrospectively analyzed, and practical treatment plans were provided. Results:None of the patients had a history of intestinal disease and all presented to the hospital because of symptoms occurring in the gastrointestinal tract.Five patients had intestinal perforation and underwent dissection, three had small bowel masses and underwent surgery, and two had T-cell lymphoma and underwent related treatment. Six patients had lesions in the small intestine and the others had lesions in the rectum. According to AnnArbor clinical d staging, 9 patients(90%) had stage I+II and 1 patient(10%) had stage III. Gastrointestinal lymphoma AnnArbor clinical staging was the same as lugano clinical staging. 6 patients with B symptoms, 6 with physical status score ≥ 2, 5 with IPI > 2, 6 with PIT > 6; all patients had normal examination regardless of bone marrow examination, β2-microglobulin, or glycoconjugate antigen-125, erythrocyte sedimentation rate. 1 patient with anemia, 6 with decreased albumin, 2 with with elevated lactate dehydrogenase, and 1 case with increased C-reactive protein. According to immunohistochemical hints, 6 cases were CD56 positive and 4 in situ hybridization EBER positive; in the mid-term evaluation of combined patients, the complete remission(CR) rate was 90% in 10 patients; in the DA-EPOCH regimen, the complete remission(CR) rate was 80% in 10 patients. At the completion of 6 chemotherapy courses, all chemotherapy patients were in complete remission(CR) at the end of the period assessment, but 3 of them relapsed within one year, and the disease could not be controlled with the implementation of second-line regimen and chemotherapy again. The follow-up period was 1-25 months, with a high follow-up rate of 100% up to the follow-up time, and 6 patients died, with an overall 2-year survival rate of 40%. Conclusion: Enteropathy-associated T-cell lymphoma is highly aggressive, and after chemotherapy, patients can be treated but are prone to relapse. The use of allogeneic hematopoietic stem cell transplantation(ASCT) becomes the first-line consolidation therapy, which cannot obtain long-term efficacy and needs to be explored.","PeriodicalId":202943,"journal":{"name":"Advanced Medical Research","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117339816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features, Treatment and Prognosis Analysis of T-cell non-Hodgkin's Lymphoma","authors":"Y. Miao, Qiaojiajie Zhao","doi":"10.58195/amr.v1i1.12","DOIUrl":"https://doi.org/10.58195/amr.v1i1.12","url":null,"abstract":"Objective: Regarding T-cell non-Hodgkin's lymphoma, it is important to explore both its clinical characteristics and treatment methods, as well as to make a good prognostic analysis. Methods: From 2017.02 to 2022.02, 40 patients with T-cell non-Hodgkin's lymphoma were seen in our hospital, and their data were implemented retrospectively. RESULTS: According to certain indicators of patients, they were divided into low-risk group (0-1 factors), low-medium-risk group (2 factors), high-medium-risk group (3 factors), and high-risk group (4-5 factors); after first-line treatment, the 3-year overall survival rates of patients with CR, PR, SD, and PD were 71%, 46%, 0%, and 0%, respectively; after treatment with CHOP-like regimens and other chemotherapy regimens, CR, PR, SD, and PD patients had 5-year overall survival rates of 44%, 36%, 0%, and 0%, respectively; after first-line treatment, CR patients were 16, PR patients were 16, and the effective rate was 80%, and SD+PD was 8. The CHOP-like regimen was used to treat 9 patients with CR, 9 patients with PR, 6 patients with SD, and 4 patients with PD; other chemotherapy regimens were used to treat 2 patients with CR, 4 patients with PR, 3 patients with SD, and 3 patients with PD, with an efficiency rate of 60% and an inefficiency rate of 40%. Conclusion: T-cell non-Hodgkin's lymphoma is easy to be misdiagnosed, and the prognosis analysis should be explored according to its clinical characteristics, combined with the treatment regimen, in order to ensure a significant treatment effect.","PeriodicalId":202943,"journal":{"name":"Advanced Medical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122236455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the ability of neurology departments in general hospitals to treat neuropsychiatric disorders","authors":"Lei Li, Lixin Zhang","doi":"10.58195/amr.v1i1.15","DOIUrl":"https://doi.org/10.58195/amr.v1i1.15","url":null,"abstract":"Due to the \"stigma\" of psychiatric diseases, most patients with psychiatric diseases prefer to be treated in general hospitals or combined Chinese and Western medicine hospitals, while patients with internal diseases are mostly seen in neurology departments. At present, there are few neurologists in general hospitals in China who are capable of treating neuropsychiatric disorders, and they do not have enough experience in treating such disorders. In this paper, we present a review of the current status of neuropsychiatric and psychiatric disorders in general hospitals and Chinese and Western medicine hospitals, and propose recommendations to strengthen the capacity of neurology departments in general hospitals to treat neuropsychiatric disorders.","PeriodicalId":202943,"journal":{"name":"Advanced Medical Research","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130517618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Molecular Cytogenetic Abnormalities in Lymphoma and Their Clinical Relevance","authors":"Y. Miao, Qiaojiajie Zhao","doi":"10.58195/amr.v1i1.14","DOIUrl":"https://doi.org/10.58195/amr.v1i1.14","url":null,"abstract":"Objective: To investigate the issue of molecular cytogenetic abnormalities in lymphoma and to study their clinical relevance. Methods: First, medium-term chromosomes of healthy men and women were prepared. Normal human peripheral blood lymphocytes were stimulated with PHA, treated with MTX synchronization, blocked with colchicine, cultured for 3 days, routinely treated with hypotonicity, cells were obtained, and steam-dried method was used to drop slices for backup. Next, comparative genomic hybridization. Preparation of probes; processing of normal human mid-term split images; hybridization; washing of slices after hybridization; staining; fluorescence microscopy observation, uptake and analysis of fluorescence signals. Results: Lymphoma CGH test results; Relationship between CGH abnormalities and lymphoma histological subtypes:Hodgkin's lymphoma CGH abnormalities, diffuse large B-cell lymphoma (DLBCL) CGH abnormalities, follicular lymphoma (FL) CGH abnormalities, and follicular lymphoma (FL) CGH abnormalities; Correlation between CGH test results and lymphoma clinical features: CGH test results and lymphoma patients, the type of CGH abnormality correlated with the clinical features of lymphoma, simple CGH abnormalities and complex CGH abnormalities correlated with the clinical features of lymphoma patients, and CGH abnormalities at specific chromosomal sites correlated with the clinical features of lymphoma. Conclusion:Conventional model analysis examines both chromosomal translocations and gene deletions or spreads, fails to observe the full picture of the lymphoma genome, and fails to detect new chromosomal abnormalities.","PeriodicalId":202943,"journal":{"name":"Advanced Medical Research","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134156037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}