Polish journal of pharmacology最新文献_第9页

A multicenter, placebo-controlled, double-blind study of efficacy of a new form of carbamazepine (Carbatrol) in refractory epileptic patients. 一项多中心、安慰剂对照、双盲研究一种新型卡马西平(卡巴罗)治疗难治性癫痫患者的疗效。

Polish journal of pharmacology Pub Date : 2004-03-01

Wojciech Sobaniec, Wojciech Kułak, Joanna Smigielska-Kuzia, Leszek Boćkowski, Jerzy Majkowski, Joanna Jedrzejczak

{"title":"A multicenter, placebo-controlled, double-blind study of efficacy of a new form of carbamazepine (Carbatrol) in refractory epileptic patients.","authors":"Wojciech Sobaniec, Wojciech Kułak, Joanna Smigielska-Kuzia, Leszek Boćkowski, Jerzy Majkowski, Joanna Jedrzejczak","doi":"","DOIUrl":"","url":null,"abstract":"Carbatrol (CBR) is a new multiple-unit, sustained-release dosage form of carbamazepine (CBZ) developed by Pharmavene. We present a multicenter, outpatient, randomized, double-blind parallel group study (No PI 101) carried out in two centers in Poland. CBR was evaluated in 47 patients with uncontrolled partial onset seizures. During the 28-day baseline period, patients were required to have at least two seizures and to take CBZ at a therapeutic level, a second antiepileptic drug was allowed but not valproic acid (VPA ). Patients were randomized to VPA or to CBR (dosages 800, 1200, 1600 mg/day). Criteria for escape relative to baseline were: two-fold increase in monthly seizure frequency, two-fold increase in 2-day seizure frequency, two-fold increase in weekly seizure frequency, single generalized tonic-clonic seizure (GTCs) if none occurred during baseline or prolongation of GTCs. The primary efficacy variable was the number of patients escaping in each treatment group. Nineteen patients on VPAand 7 on CBR met escape criteria. CBR adverse experiences were all mild or moderate in severity. CBR therapy was effective in the treatment of partial complex seizures with or without generalization.","PeriodicalId":20292,"journal":{"name":"Polish journal of pharmacology","volume":"56 2","pages":"195-201"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24529942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of selected cardiological drugs on oxidative status. 选定的心脏病药物对氧化状态的影响。

Polish journal of pharmacology Pub Date : 2004-03-01

Maria Kopff, Edward Kowalczyk, Anna Kopff

{"title":"Influence of selected cardiological drugs on oxidative status.","authors":"Maria Kopff, Edward Kowalczyk, Anna Kopff","doi":"","DOIUrl":"","url":null,"abstract":"The aim of the study was to determine the effect of the often applied drugs in cardiovascular diseases (metoprolol, acetylsalicylic acid, simvastatin and molsidomine) on antioxidative/oxidative balance in vivo. The determination of oxidative status was based on measurements of concentration of: thiobarbituric acid reactive substances (TBARS - lipid peroxidation products), protein carbonyl groups (marker of proteins oxidative injury), nitrotyrosine (marker of NO-mediated tissue damage) and sulfhydryl groups (protein oxidation product). The assays were performed in the plasma and whole blood of rabbits after three weeks of daily intragastric administration of the drugs mentioned above. It was shown that all drugs except acetylsalicylic acid caused an increase in the plasma and hemolysate levels of TBARS. No changes in nitrotyrosine concentration were observed after drug administration. The content of carbonyl groups did not change after administration of metoprolol, but increased significantly after simvastatin and molsidomine administration. Blood sulfhydryl group concentration was not changed by metoprolol but it significantly decreased after acetylsalicylic acid and increased significantly after molsidomine administration.","PeriodicalId":20292,"journal":{"name":"Polish journal of pharmacology","volume":"56 2","pages":"265-9"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24531020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of an aminothiazole derivative on ethanol- and thermally oxidized sunflower oil-induced toxicity. 氨基噻唑衍生物对乙醇和热氧化葵花籽油毒性的作用。

Polish journal of pharmacology Pub Date : 2004-03-01

K Aruna, R Rukkumani, P Sureshvarma, V P Menon

{"title":"Role of an aminothiazole derivative on ethanol- and thermally oxidized sunflower oil-induced toxicity.","authors":"K Aruna, R Rukkumani, P Sureshvarma, V P Menon","doi":"","DOIUrl":"","url":null,"abstract":"It is a known fact that ethanol increases lipid levels in humans and experimental animals. In this study, we have investigated the effect of dendrodoine analogue (DA), DA-[4-amino-5-benzoyl-2-(4-methoxyphenylamino)-thiazole], on alcohol- and thermally oxidized sunflower oil-induced hyperlipidemia. Ethanol was given to animals at a dose of 5 ml of 20% solution and thermally oxidized sunflower oil at a level of 15% (15 g oil/100 g feed). Our results showed increased activity of aspartate transaminase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) and increased levels of cholesterol, triglycerides and phospholipids in the plasma of groups given alcohol, thermally oxidized oil and alcohol + thermally oxidized oil when compared with normal control group. The levels of tissue (liver and kidney) cholesterol and triglycerides were increased significantly in groups treated with alcohol, thermally oxidized oil and alcohol + thermally oxidized oil when compared with normal control rats. The levels were decreased when DA was given along with alcohol and thermally oxidized oil. The level of phospholipids decreased significantly in the liver and kidney of rats administered alcohol, thermally oxidized oil and alcohol + thermally oxidized oil when compared with normal control rats. The level increased when DA was administered along with alcohol and thermally oxidized oil. The activity of phospholipase A and C increased significantly in the liver of groups given alcohol, thermally oxidized oil and alcohol + thermally oxidized oil when compared with normal control rats, whereas the activity was decreased upon DA treatment. The obtained results indicate that DA can decrease the lipid levels in alcohol- and thermally oxidized oil-treated rats.","PeriodicalId":20292,"journal":{"name":"Polish journal of pharmacology","volume":"56 2","pages":"233-40"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24529944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central role of cAMP in the inhibition of glycogen breakdown and gluconeogenesis promoted by leptin and insulin in perfused rat liver. cAMP在大鼠灌注肝中抑制瘦素和胰岛素促进的糖原分解和糖异生中的中心作用。

Polish journal of pharmacology Pub Date : 2004-03-01

Glaucia R Borba-Murad, Márcia Vardanega-Peicher, Sharize B Galende, Rui Curi, Helenir M Souza, Erica G Mario, Bruna K Bassoli, Roberto B Bazotte

{"title":"Central role of cAMP in the inhibition of glycogen breakdown and gluconeogenesis promoted by leptin and insulin in perfused rat liver.","authors":"Glaucia R Borba-Murad, Márcia Vardanega-Peicher, Sharize B Galende, Rui Curi, Helenir M Souza, Erica G Mario, Bruna K Bassoli, Roberto B Bazotte","doi":"","DOIUrl":"","url":null,"abstract":"Leptin showed less prominent inhibiting effect on the activation of hepatic glycogen breakdown and gluconeogenesis promoted by cAMP. The role of cAMP in the inhibition of glycogen breakdown and gluconeogenesis induced by physiological levels of leptin (10 ng/ml) and insulin (20 microU/ml) in the perfused liver was investigated. Insulin but not leptin inhibited (p < 0.05) the activation of glycogen breakdown promoted by cAMP (3 microM). Contrary to cAMP, the activation of glycogen catabolism promoted by 8-Br-cAMP (0.3 microM), a cAMP analogue more resistant to hydrolysis by phosphodiesterase 3B (PD3B), was inhibited (p < 0.05) not only by insulin (20 microU/ml) but also by leptin (10 ng/ml). The effect of leptin, however, was less intense than that of insulin. To verify the participation of the intracellular levels of cAMP, the experiments were repeated with N(6)-monobutyryl-cAMP (N(6)-MB-cAMP), a cAMP analogue, which is not metabolized by PD3B. The activation of glycogen breakdown promoted by N(6)-MB-cAMP (0.3 microM) was not affected by leptin or insulin. In agreement with the results regarding glycogen catabolism, insulin and leptin at 50 ng/ml but not leptin at 10 ng/ml inhibited (p < 0.05) the activation of gluconeogenesis promoted by cAMP (7.5 microM). Taken together, these results led us to postulate that the convergent signaling pathways of these two hormones causing the inhibition of glycogen catabolism and gluconeogenesis involve a reduction of intracellular cAMP. Thus, cAMP levels may play an important role in the cross talk between both hormones and for the insulin-like effects of leptin.","PeriodicalId":20292,"journal":{"name":"Polish journal of pharmacology","volume":"56 2","pages":"223-31"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24529945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Losartan may prevent the elevation of plasma glucose levels induced by chronic stress. 氯沙坦可以预防慢性应激引起的血糖水平升高。

Polish journal of pharmacology Pub Date : 2004-03-01

Yağiz Uresin, Bahar Erbaş, Mehmet Ozek

引用次数: 0

Riluzole enhances the anti-seizure action of conventional antiepileptic drugs against pentetrazole-induced convulsions in mice. 利鲁唑能增强常规抗癫痫药物对戊四唑致小鼠惊厥的抗癫痫作用。

Polish journal of pharmacology Pub Date : 2004-03-01

Kinga K Borowicz, Andrzej Sekowski, Edyta Drelewska, Stanisław J Czuczwar

引用次数: 0

Receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide in the goose cerebral cortex. 鹅大脑皮层血管活性肠肽和垂体腺苷酸环化酶激活多肽受体。

Polish journal of pharmacology Pub Date : 2004-03-01

Jolanta B Zawilska, Paweł Niewiadomski, Jerzy Z Nowak

{"title":"Receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide in the goose cerebral cortex.","authors":"Jolanta B Zawilska, Paweł Niewiadomski, Jerzy Z Nowak","doi":"","DOIUrl":"","url":null,"abstract":"Receptors for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the goose cerebral cortex were characterized using two approaches: (1) in vitro radioreceptor binding of [(125)I]-VIP, and (2) effects of peptides from the VIP/PACAP/secretin family on cyclic AMP formation. The binding of [(125)I]-VIP to goose cortical membranes was rapid, stable, and reversible. Saturation analysis resulted in a linear Scatchard plot, suggesting binding to a single class of receptor binding sites with a high affinity (K(d)=0.76 +/- 0.13 nM) and high capacity (B(max)=70 +/- 7 fmol/mg of protein). Various peptides displaced the specific binding of 0.12 nM [(125)I]-VIP to the goose cerebral cortical membranes in a concentration-dependent manner. The relative rank order of potency of the tested peptides to inhibit [(125)I]-VIP binding to the goose cerebrum was: PACAP(38) asymptotically equal to mammalian VIP > or = PACAP(27) asymptotically equal to chicken VIP >>> PHI (peptide histidine-isoleucine) >> secretin (inactive). About 52% of specific [(125)I]-VIP binding sites in the goose cerebral cortex was sensitive to 5'-guanylimidodiphosphate [Gpp(NH)p], a nonhydrolyzable analogue of GTP. PACAP(38) and PACAP(27) potently stimulated cyclic AMP formation in the goose cerebral cortical slices in a concentration-dependent manner, displaying EC(50) values of 45.5 nM and 51.5 nM, respectively. Chicken VIP was markedly less potent than both forms of PACAP, mammalian VIP only weakly affected the nucleotide production, while effects evoked by PHI were negligible. It is concluded that the cerebral cortex of goose contains VPAC type receptors that are labeled with [(125)I]-VIP and are positively linked to cyclic AMP formation. In addition, the observed stronger action of PACAP, when compared to VIP, on cyclic AMP production in this tissue suggests its interaction with both PAC(1) and VPAC receptors.","PeriodicalId":20292,"journal":{"name":"Polish journal of pharmacology","volume":"56 2","pages":"203-11"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24529943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of topiramate on mechanical allodynia in neuropathic pain model in rats. 托吡酯对大鼠神经性疼痛模型机械异常性痛的影响。

Polish journal of pharmacology Pub Date : 2004-03-01

Anna Wieczorkiewicz-Płaza, Paweł Płaza, Ryszard Maciejewski, Mirosław Czuczwar, Krzysztof Przesmycki

引用次数: 0

Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage. 褪黑素在减少氧化细胞和分子损伤中的药理效用。

Polish journal of pharmacology Pub Date : 2004-03-01

Russel J Reiter, Dun-Xian Tan, Eloisa Gitto, Rosa M Sainz, Juan C Mayo, Josefa Leon, Lucien C Manchester, Vijayalaxmi, Ertugrul Kilic, Ulkan Kilic

{"title":"Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage.","authors":"Russel J Reiter, Dun-Xian Tan, Eloisa Gitto, Rosa M Sainz, Juan C Mayo, Josefa Leon, Lucien C Manchester, Vijayalaxmi, Ertugrul Kilic, Ulkan Kilic","doi":"","DOIUrl":"","url":null,"abstract":"This review briefly summarizes the actions of melatonin in reducing molecular damage caused by free radicals and associated oxygen- and nitrogen-based reactants. All the mechanisms by which melatonin is protective of such a wide variety of molecules, i.e. lipids, proteins, DNA, etc., and in such widely diverse areas of the cell and different organs are likely not yet all identified. Melatonin actions that have been identified include its ability to directly neutralize a number of toxic reactants and stimulate antioxidative enzymes. Furthermore, several metabolites that are formed when melatonin neutralizes damaging reactants are themselves scavengers suggesting that there is a cascade of reactions that greatly increase the efficacy of melatonin in styming oxidative mutilation. Suggested, but less well defined, processes which may contribute to melatonin's ability to reduce oxidative stress include stimulation of glutathione synthesis (an important antioxidant which is at high concentrations within cells), reducing electron leakage from the mitochondrial electron transport chain (which would reduce free radical generation), limiting cytokine production and inflammatory processes (actions that would also lower toxic reactant generation), and synergistic effects with other classical antioxidants (e.g. vitamins C, E and glutathione). Clearly which of these multiple mechanisms contribute to melatonin's high efficacy in curtailing oxidative damage remains to be clarified. Likewise, it is possible that the key action of melatonin in reducing molecular damage induced by oxygen and nitrogen-based metabolites remains to be identified. Finally, the review summarizes some of the large amount of data documenting the ability of melatonin to limit molecular and organ damage in two situations, i.e. ischemia-reperfusion and ionizing radiation, where free radicals are generally conceded as being responsible for much of the resulting tissue destruction.","PeriodicalId":20292,"journal":{"name":"Polish journal of pharmacology","volume":"56 2","pages":"159-70"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24528901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic basis of neurodegeneration in familial Alzheimer's disease. 家族性阿尔茨海默病神经变性的遗传基础。

Polish journal of pharmacology Pub Date : 2004-03-01

Anna Kowalska

引用次数: 0