Prevention Research最新文献

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Abstract 2587: Investigating the impact of chemotherapy on gut microbiota and microbiota-derived metabolites and their link to inflammation and cardiometabolic disorders in children with cancer 摘要:研究化疗对癌症儿童肠道微生物群和微生物群衍生代谢物的影响及其与炎症和心脏代谢紊乱的关系
Prevention Research Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2587
A. Benmoussa, L. Levasseur, Shuxia Coté-Sergerie, V. Bélanger, E. Levy, C. Laverdière, A. Stintzi, D. Sinnett, V. Marcil
{"title":"Abstract 2587: Investigating the impact of chemotherapy on gut microbiota and microbiota-derived metabolites and their link to inflammation and cardiometabolic disorders in children with cancer","authors":"A. Benmoussa, L. Levasseur, Shuxia Coté-Sergerie, V. Bélanger, E. Levy, C. Laverdière, A. Stintzi, D. Sinnett, V. Marcil","doi":"10.1158/1538-7445.AM2021-2587","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2587","url":null,"abstract":"","PeriodicalId":20290,"journal":{"name":"Prevention Research","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90627887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 109: Vaccination with Polyclonal Antibody Stimulator (PAS) prevents pancreatic carcinogenesis in the KRAS mouse model 109 .在KRAS小鼠模型中,接种多克隆抗体刺激剂(PAS)可预防胰腺癌的发生
Prevention Research Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-109
Jill P. Smith, H. Cao, B. Kallakury, T. Phillips, L. Sutton, A. Cato
{"title":"Abstract 109: Vaccination with Polyclonal Antibody Stimulator (PAS) prevents pancreatic carcinogenesis in the KRAS mouse model","authors":"Jill P. Smith, H. Cao, B. Kallakury, T. Phillips, L. Sutton, A. Cato","doi":"10.1158/1538-7445.AM2021-109","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-109","url":null,"abstract":"","PeriodicalId":20290,"journal":{"name":"Prevention Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88693535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract LB222: Performance of polygenic risk scores for GI cancer prediction in an academic biobank 摘要LB222:多基因风险评分在学术生物库中用于胃肠道癌症预测的性能
Prevention Research Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-LB222
Louise Wang, H. Desai, A. Le, R. Hausler, S. Verma, A. Verma, R. Judy, A. Doucette, P. Gabriel, S. Damrauer, M. Ritchie, Daniel Rader, R. Kember, K. Maxwell
{"title":"Abstract LB222: Performance of polygenic risk scores for GI cancer prediction in an academic biobank","authors":"Louise Wang, H. Desai, A. Le, R. Hausler, S. Verma, A. Verma, R. Judy, A. Doucette, P. Gabriel, S. Damrauer, M. Ritchie, Daniel Rader, R. Kember, K. Maxwell","doi":"10.1158/1538-7445.AM2021-LB222","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-LB222","url":null,"abstract":"Background: Genome wide association studies (GWAS) have identified hundreds of common, low risk genetic variants significantly associated with a number of gastrointestinal cancers, but the predictive ability of individual variants or a polygenic risk score (PRS) derived from multiple variants is still unclear especially among minorities. Specific Aims: To evaluate the discriminatory ability of PRS models to differentiate cancer cases vs. controls in patients of European (EUR) and African (AFR) ancestry in an academic biobank. Methods: We identified 445 cases of esophageal, colon, and pancreatic cancers and 12,565 cancer-free controls. Genome-wide significant variants were selected for each of the cancers, and Plink 1.9 was used to generate a PRS, an effect size weighted sum of specific cancer associated alleles for each population. To determine the discriminatory ability of PRS, we performed multivariate logistic regressions in R controlling for age, sex, and the first 10 principal components. Results: There were 285 cases of colon (48.4% AFR), 63 cases of esophageal (34.9% AFR), and 97 cases of pancreatic cancer (51.5% AFR) vs. 12,565 controls (48.5% AFR). Among the EUR individuals, the PRScolon was significantly associated with colon cancer [OR 1.25 (1.06-4.48, p=0.007)] (Table 1). The discriminatory ability of the model comprised of age, gender and principal components was 0.680-0.732 in the respective cancer cancers and the AUC minimally increased to 0.688-0.747 after inclusion of the PRS in the model. Among AFR individuals, the discriminatory ability was overall higher in the full model (AUC 0.755-0.812) but PRS increased the AUC less in AFR vs. EUR. Conclusion: Colon, esophageal, and pancreatic cancer PRS models have a moderate discriminatory ability to identify cases. However, the individual contribution of PRS to the model was small. Further studies are needed to determine additional genetic predictors of cancer risk and how best to incorporate PRS into gastrointestinal cancer risk prediction models. Citation Format: Louise Wang, Heena Desai, Anh Le, Ryan Hausler, Shefali Verma, Anurag Verma, Renae Judy, Abigail Doucette, Peter Gabriel, Scott Damrauer, Marylyn Ritchie, Daniel Rader, Rachel Kember, Kara Maxwell. Performance of polygenic risk scores for GI cancer prediction in an academic biobank [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr LB222.","PeriodicalId":20290,"journal":{"name":"Prevention Research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87140927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2550: Participant's satisfaction with the cancer community awareness access research and education (C-CARE) project at urban and rural sites 2550:参与者对城市和农村地区癌症社区意识获取研究与教育(C-CARE)项目的满意度
Prevention Research Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2550
Ghadeer Albashir, S. J. Sojourner, Marlo M. Vernon, J. Moore, S. Looney, M. Tingen
{"title":"Abstract 2550: Participant's satisfaction with the cancer community awareness access research and education (C-CARE) project at urban and rural sites","authors":"Ghadeer Albashir, S. J. Sojourner, Marlo M. Vernon, J. Moore, S. Looney, M. Tingen","doi":"10.1158/1538-7445.AM2021-2550","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2550","url":null,"abstract":"","PeriodicalId":20290,"journal":{"name":"Prevention Research","volume":"689 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85719296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2522: Exploring the prognostic and predictive value of circulating tumor DNA in patients with advanced colorectal cancer and chemotherapy 摘要2522:探讨循环肿瘤DNA对晚期结直肠癌伴化疗患者预后的预测价值
Prevention Research Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2522
Xiu Liu, Xuan Zhang, K. Ou, Chelong Lu, Dong-Huan Zheng, Jun Liu, Qiang Xu, Lin Yang
{"title":"Abstract 2522: Exploring the prognostic and predictive value of circulating tumor DNA in patients with advanced colorectal cancer and chemotherapy","authors":"Xiu Liu, Xuan Zhang, K. Ou, Chelong Lu, Dong-Huan Zheng, Jun Liu, Qiang Xu, Lin Yang","doi":"10.1158/1538-7445.AM2021-2522","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2522","url":null,"abstract":"","PeriodicalId":20290,"journal":{"name":"Prevention Research","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83204896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 108: Inhibiting methionine aminopeptidase 2 prevents liver fibrosis and hepatocellular carcinoma 摘要:抑制蛋氨酸氨基肽酶2可预防肝纤维化和肝细胞癌
Prevention Research Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-108
Yongtao Wang, M. Sojoodi, G. Qiao, Zenan Lin, S. Barrett, L. Zukerberg, M. Lanuti, M. Qadan, K. Tanabe
{"title":"Abstract 108: Inhibiting methionine aminopeptidase 2 prevents liver fibrosis and hepatocellular carcinoma","authors":"Yongtao Wang, M. Sojoodi, G. Qiao, Zenan Lin, S. Barrett, L. Zukerberg, M. Lanuti, M. Qadan, K. Tanabe","doi":"10.1158/1538-7445.AM2021-108","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-108","url":null,"abstract":"","PeriodicalId":20290,"journal":{"name":"Prevention Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74550079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2599: Does tumor volume effect the spectroscopic classification of brain cancer patients 摘要:肿瘤体积是否影响脑癌患者的光谱分类
Prevention Research Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2599
A. G. Theakstone, Paul M. Brennan, M. Baker
{"title":"Abstract 2599: Does tumor volume effect the spectroscopic classification of brain cancer patients","authors":"A. G. Theakstone, Paul M. Brennan, M. Baker","doi":"10.1158/1538-7445.AM2021-2599","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2599","url":null,"abstract":"This study focuses on investigating the link between brain tumor volume and the spectroscopic classification between patients with known gliomas and healthy controls. Discrimination of brain cancer vs. non-cancer patients using serum-based ATR-FTIR diagnostics was first developed by Hands et al. achieving sensitivity and specificity values of 92.8% and 91.5% respectively. Cameron et al. then went on to stratifying between specific brain tumor types and was successful in providing a sensitivity of 90.1% and a specificity of 86.3%. Expanding on these studies, it is vital to determine if the size of a tumor has a direct effect on the sensitivity and specificity and whether or not it was only the larger tumors that were being identified as cancerous. A cohort of 90 patients whose tumor volumes were calculated using their MRI images (either T1-weighted contrast enhanced, T2-weighted or FLAIR images), including patients with high-grade glioblastoma multiforme (GBM), and low-grade gliomas such as anaplastic astrocytoma, astrocytoma, oligoastrocytoma and oligodendroglioma, were used for investigation. Utilizing ATR-FTIR spectroscopy coupled with machine learning algorithms these tumor patients were stratified against 87 healthy controls and were classified as either cancer or non-cancer. From these initial findings9 sensitivities, specificities and balanced accuracies were greater than 88% and cancer patients with tumor volumes as small as 0.2 cubic cm were correctly identified, demonstrating that classifications are not affected by tumor volume. Both small and low-grade gliomas were identified which shows great promise for this technique to be used as a screening tool or in diagnostics for early detection of brain tumors. Citation Format: Ashton G. Theakstone, Paul M. Brennan, Matthew J. Baker. Does tumor volume effect the spectroscopic classification of brain cancer patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 2599.","PeriodicalId":20290,"journal":{"name":"Prevention Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76359647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2560: Plasticity-related signaling pathways in the medial prefrontal cortex and hippocampus as potential targets of the antidepressant vortioxetine in reversing cognitive impairments after androgen deprivation therapy for prostate cancer 摘要:抗抑郁药vortioxetine逆转前列腺癌雄激素剥夺治疗后认知障碍的潜在靶点是内侧前额叶皮层和海马的可塑性相关信号通路
Prevention Research Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2560
Alexandra M. Vaiana, Román A. Fernández, J. Gelfond, T. Johnson-Pais, R. Leach, C. Ramamurthy, I. Thompson, D. Morilak
{"title":"Abstract 2560: Plasticity-related signaling pathways in the medial prefrontal cortex and hippocampus as potential targets of the antidepressant vortioxetine in reversing cognitive impairments after androgen deprivation therapy for prostate cancer","authors":"Alexandra M. Vaiana, Román A. Fernández, J. Gelfond, T. Johnson-Pais, R. Leach, C. Ramamurthy, I. Thompson, D. Morilak","doi":"10.1158/1538-7445.AM2021-2560","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2560","url":null,"abstract":"","PeriodicalId":20290,"journal":{"name":"Prevention Research","volume":"224 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73250300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2536: Mutational landscape of the bronchial epithelium of individuals at high risk for lung cancer 2536:肺癌高危人群支气管上皮的突变格局
Prevention Research Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2536
S. J. Rahman, Shilin Zhao, Shih-Kai Chu, Y. Zou, A. Hui, T. Stricker, Chen Heidi, M. Diehn, P. Massion
{"title":"Abstract 2536: Mutational landscape of the bronchial epithelium of individuals at high risk for lung cancer","authors":"S. J. Rahman, Shilin Zhao, Shih-Kai Chu, Y. Zou, A. Hui, T. Stricker, Chen Heidi, M. Diehn, P. Massion","doi":"10.1158/1538-7445.AM2021-2536","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2536","url":null,"abstract":"","PeriodicalId":20290,"journal":{"name":"Prevention Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79871807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2588: Oral administration of water extract fromEuglena gracilisprevents lung carcinoma growth in mice by alteration of intestinal microbiota 摘要:薄茅水提物通过改变小鼠肠道菌群来抑制肺癌的生长
Prevention Research Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2588
D. Upreti, Susumu Ishiguro, Mayme Loyd, Nicole Robben, P. Cote, Morgan Phillips, Ayaka Nakashima, Kengo Suzuki, J. Comer, M. Tamura
{"title":"Abstract 2588: Oral administration of water extract fromEuglena gracilisprevents lung carcinoma growth in mice by alteration of intestinal microbiota","authors":"D. Upreti, Susumu Ishiguro, Mayme Loyd, Nicole Robben, P. Cote, Morgan Phillips, Ayaka Nakashima, Kengo Suzuki, J. Comer, M. Tamura","doi":"10.1158/1538-7445.AM2021-2588","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2588","url":null,"abstract":"Euglena gracilis, a single-celled alga, is rich in nutrients and thus, used as a nutritional dietary supplement. This alga can be found in both fresh and saltwater and possesses characteristics of both plants and animals. Euglena gracilis extracts have a wide range of medicinal properties including stimulation of anticancer immunity against multiple types of cancers; however, the anticancer mechanism has not yet been fully elucidated. Therefore, a water extract from Euglena gracilis devoid of water-insoluble mature paramylons was evaluated as an anticancer agent against lung carcinoma. Two different extracts were prepared using dried powder from whole Euglena gracilis. First, partially purified water extract (EWE) was prepared by suspending dry powder in PBS and centrifugation at 10,000g for 20 min followed by a filtration using a 0.22µm pore size membrane. Second, boiled EWE (bEWE) was prepared by immersing unfiltered EWE in boiling water for 12 min followed by centrifugation at 10,000g for 10 min and filtration using 0.22µm pore size membrane. Both EWE and bEWE treatments inhibited the growth of lung carcinoma cells in vitro in a dose- and time-dependent manner. Furthermore, both extracts significantly inhibited the three-dimensional growth of Lewis Lung Carcinoma (LLC) cells. Flow cytometry analysis showed that the EWE treatment attenuates granulocytic myeloid-derived suppressor cells (MDSCs) in bone marrow cell cultures. The in vivo study was conducted using a mouse LLC orthotopic allograft model. Oral administration of EWE and bEWE (100-200 mg/kg/day) three weeks prior to LLC cell inoculation attenuated the tumor growth in the lungs of immunocompetent mice while decreasing the peripheral granulocytes. However, this attenuation was not seen for the extract treatment initiated after LLC cell inoculation. The tumor growth attenuation was more efficient with the bEWE treatment than with EWE treatment. The fecal microbiomes of the mice were analyzed by 16s rRNA gene amplicon sequencing which revealed that alpha diversity in three groups (EWE, bEWE, and PBS control) was similar, however, the microbial compositions of the EWE- and bEWE-treated mouse groups were more diversified than in the PBS group. Specifically, an increase in the ratio of Bacteroidetes to Firmicutes was observed, and a significant increase in Akkermansia and Muribaculum was detected in EWE- and bEWE- treated mice compared to PBS treated mice. These studies suggest that oral administration of partially purified water extracts from Euglena gracilis altered the intestinal microbiome and the alteration may attenuate host MDSCs, thereby preventing lung carcinoma growth. This study was supported by 2016EUGLENA-RC1 (MT), 2017EUGLENA-RC2 (MT and JC), Kansas State University College of Veterinary Medicine SMILE award (MT and JC), and NIH grant P20 RR017686 (MT). Citation Format: Deepa Upreti, Susumu Ishiguro, Mayme Loyd, Nicole Robben, Paige Cote, Morgan Phillips, Ayaka Nakashima, Kengo ","PeriodicalId":20290,"journal":{"name":"Prevention Research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90468705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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