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Polish journal of pharmacology and pharmacy最新文献

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The involvement of serotonin and noradrenaline in the psychopathological processes of stress and depression: animal models and the effect of antidepressant drugs. 血清素和去甲肾上腺素在应激和抑郁的精神病理过程中的作用:动物模型和抗抑郁药物的作用。
Polish journal of pharmacology and pharmacy Pub Date : 1991-07-01
A Płaźnik, W Kostowski
{"title":"The involvement of serotonin and noradrenaline in the psychopathological processes of stress and depression: animal models and the effect of antidepressant drugs.","authors":"A Płaźnik, W Kostowski","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 4","pages":"301-22"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood-brain barrier permeability during acute and chronic electroconvulsive seizures. 急性和慢性电痉挛发作时血脑屏障通透性。
Polish journal of pharmacology and pharmacy Pub Date : 1991-07-01
B Oztaş, M Kaya
{"title":"Blood-brain barrier permeability during acute and chronic electroconvulsive seizures.","authors":"B Oztaş,&nbsp;M Kaya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of chronic electroconvulsive seizure on the blood brain barrier permeability to albumin was investigated in the male rats. Evans blue was used as a blood brain barrier tracer. The following situations were studied: Acute electroshock: a. one electroshock stimulus, b. ten electroshock stimuli. Chronic electroshock: a) group of animals were pretreated with electroshock given as one electroshock (ES) every other day (ES x 7); b) chronic electroshock + one electroshock, c) chronic electroshock + ten repeated electroshocks. As a result, chronic electroshock per se does not effect the blood-brain barrier permeability.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 4","pages":"259-63"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of dopamine in rewarded behavior: ability, insight, drive or incentive? 多巴胺在奖励行为中的作用:能力、洞察力、驱动力还是激励?
Polish journal of pharmacology and pharmacy Pub Date : 1991-07-01
P Willner, R Muscat, G Phillips
{"title":"The role of dopamine in rewarded behavior: ability, insight, drive or incentive?","authors":"P Willner,&nbsp;R Muscat,&nbsp;G Phillips","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 4","pages":"291-300"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Captopril lacks the antidepressant-like activity in animal models. 卡托普利在动物模型中缺乏类似抗抑郁药的活性。
Polish journal of pharmacology and pharmacy Pub Date : 1991-07-01
L Baran, J Siwanowicz, G Nowak, E Przegaliński
{"title":"Captopril lacks the antidepressant-like activity in animal models.","authors":"L Baran,&nbsp;J Siwanowicz,&nbsp;G Nowak,&nbsp;E Przegaliński","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Captopril, an angiotensin converting enzyme inhibitor, was evaluated for a potential antidepressive activity in several animal models. The drug administered in doses of 3-30 mg/kg ip neither affected the reserpine- or apomorphine-induced hypothermia in mice nor reduced the immobility time in the forces swimming test in mice and rats. Moreover, captopril administered repeatedly (10 mg/kg ip, twice daily for 14 days) neither changed the density or affinity of cortical beta-adrenoceptors nor modified the nomifensine-induced locomotor hyperactivity in rats. These results suggest that captopril has no antidepressant-like activity in animal models.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 4","pages":"265-70"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12833044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and pharmacological properties of derivatives of alpha-amino-beta-(p-chlorobenzoyl)-propionic acid and alpha-amino-gamma-(p-chlorophenyl)-tetrahydrofuran-2-one. α -氨基-(对氯苯甲酰)-丙酸和α -氨基-(对氯苯甲酰)-四氢呋喃-2-酮衍生物的合成及药理性质。
Polish journal of pharmacology and pharmacy Pub Date : 1991-07-01
R Zabska, T Jakóbiec, R Dobek, M Wilimowski, J Barczyńska, L Kedzierska-Goździk, W Wojewódzki, M Rutkowska, E Duś, A Szelag
{"title":"Synthesis and pharmacological properties of derivatives of alpha-amino-beta-(p-chlorobenzoyl)-propionic acid and alpha-amino-gamma-(p-chlorophenyl)-tetrahydrofuran-2-one.","authors":"R Zabska,&nbsp;T Jakóbiec,&nbsp;R Dobek,&nbsp;M Wilimowski,&nbsp;J Barczyńska,&nbsp;L Kedzierska-Goździk,&nbsp;W Wojewódzki,&nbsp;M Rutkowska,&nbsp;E Duś,&nbsp;A Szelag","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several new alpha-aminoderivatives of gamma-(p-chlorophenyl)-tetrahydrofuran-2-one were synthesized. alpha-Aminoderivatives of beta-(p-chlorobenzoyl)-propionic acid 2-13 were used as the substrates. After the reduction with NaBH4 at 10-12 degrees C and cyclization the compounds were converted into the appropriate derivatives of tetrahydrofuran-2-one 16-26. In pharmacological tests compounds 9 and 26 abolished the aggressiveness in isolated mice while compound 8 showed antiinflammatory activity.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 4","pages":"271-80"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The development of our understanding of the mechanism of action of antidepressant drugs. 我们对抗抑郁药物作用机制的认识的发展。
Polish journal of pharmacology and pharmacy Pub Date : 1991-07-01
J Vetulani
{"title":"The development of our understanding of the mechanism of action of antidepressant drugs.","authors":"J Vetulani","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 4","pages":"323-38"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the role of serotonin in drug reward: studies with the place conditioning procedure. 5 -羟色胺在药物奖赏中的作用:运用场所条件反射程序的研究。
Polish journal of pharmacology and pharmacy Pub Date : 1991-05-01
C Spyraki, G Nomikos
{"title":"On the role of serotonin in drug reward: studies with the place conditioning procedure.","authors":"C Spyraki,&nbsp;G Nomikos","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 3","pages":"221-9"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13120543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidepressants given repeatedly: pharmacological evaluation of their action. 反复服用抗抑郁药:其作用的药理学评价。
Polish journal of pharmacology and pharmacy Pub Date : 1991-05-01
J Maj
{"title":"Antidepressants given repeatedly: pharmacological evaluation of their action.","authors":"J Maj","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 3","pages":"241-54"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12826091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Light-dark phase differences in behavioral effects of moclobemide in rats. 莫氯贝胺对大鼠行为影响的光暗相差异。
Polish journal of pharmacology and pharmacy Pub Date : 1991-05-01
Z Górka, W Zajaczkowski
{"title":"Light-dark phase differences in behavioral effects of moclobemide in rats.","authors":"Z Górka,&nbsp;W Zajaczkowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Effects of single and repeated administration of the MAO-A-inhibitor moclobemide (MOC) on the spontaneous locomotor activity and the locomotor hyper- and hypoactivity induced by d-amphetamine and clonidine, resp., in male Wistar rats were studied in both the light (L) and the dark (D) phase of the diurnal cycle (L:0700-1900 h). In the light phase, two hours after single administration, MOC (10 and 50 mg/kg po) increased the basal activity and a dose of 50 mg/kg decreased the exploratory and gross activities and enhanced the effects of amphetamine and clonidine. On the other hand, in the dark phase MOC (50 mg/kg) increased the gross activity and potentiated amphetamine hyperactivity. Only exploration was diminished to the same extent as in the light phase. After repeated administration MOC increased only the gross activity in the light phase. In the dark phase, however, MOC diminished exploration and potentiated the d-amphetamine hyperactivity. MOC, in both doses used, diminished food and water consumption and the body weight gain during the treatment period. These results demonstrate that MOC influences the behavior of rats in a phase-dependent manner after both single and repeated administration.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 3","pages":"177-86"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13119146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetic parameters of thiamazole in hyperthyroid patients responding rapidly and slowly to the treatment. 甲状腺机能亢进患者对噻马唑药代动力学参数的快速反应和缓慢反应。
Polish journal of pharmacology and pharmacy Pub Date : 1991-05-01
A Syrenicz, B Gawrońska-Szklarz, J Wójcicki, S Czekalski
{"title":"Pharmacokinetic parameters of thiamazole in hyperthyroid patients responding rapidly and slowly to the treatment.","authors":"A Syrenicz,&nbsp;B Gawrońska-Szklarz,&nbsp;J Wójcicki,&nbsp;S Czekalski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pharmacokinetic parameters of thiamazole were compared in two groups of patients with hyperthyroidism due to Graves-Basedow disease, differing in the period required to achieve clinical euthyrosis (less than 28 days, group R, n = 23, and not less than 35 days, group D, n = 18) after treatment with the \"full\" dose of the drug. The drug absorption from the GI tract in both groups was similar, but the serum concentrations of the drug (Cmax and AUC) were higher, and distribution volume and total clearance lower in the R than in D group. No evidence was found for the importance of initial plasma levels of thyroxine or triiodothyronine on pharmacokinetic parameters of thiamazole.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"43 3","pages":"207-12"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13120540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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