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Use of subtherapeutical dose of cisplatin and vitamin C against murine Dalton's lymphoma. 使用亚治疗剂量的顺铂和维生素C治疗小鼠道尔顿淋巴瘤。
Polish journal of pharmacology and pharmacy Pub Date : 1992-07-01
S B Prasad, A Giri, J Arjun
{"title":"Use of subtherapeutical dose of cisplatin and vitamin C against murine Dalton's lymphoma.","authors":"S B Prasad,&nbsp;A Giri,&nbsp;J Arjun","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The antitumor activity of subtherapeutical dose of cisplatin and vitamin C combinations was studied against murine Dalton's lymphoma in vivo. The sequence-dependent synergistic antitumor effect of vitamin C and cisplatin was shown to lead to the regression of the tumor resulting in a significant increase in the host survivals with tumor free hosts. Decrease in tumor pH noted in the treated tumor bearing mice and involvement of host's immune system could be an important step in this sequence-dependent antitumor activity of vitamin C and cisplatin.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"44 4","pages":"383-91"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12461536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of peptide YY on pancreatic blood flow and oxygen consumption. 肽YY对胰腺血流量和耗氧量的影响。
Polish journal of pharmacology and pharmacy Pub Date : 1992-05-01
W W Pawlik, P Gustaw, R Sendur, K Czarnobilski, O D Hottenstein, S J Konturek
{"title":"Effects of peptide YY on pancreatic blood flow and oxygen consumption.","authors":"W W Pawlik,&nbsp;P Gustaw,&nbsp;R Sendur,&nbsp;K Czarnobilski,&nbsp;O D Hottenstein,&nbsp;S J Konturek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Peptide YY (PYY) is a recently discovered polypeptide which has been proposed as physiological inhibitor of pancreatic exocrine secretion. The purpose of this study was to evaluate the effects of exogenous PYY on pancreatic blood flow and oxygen consumption. In anesthetized dogs, the superior pancreatico-duodenal artery blood flow (SPBF), pancreatic microcirculatory blood flow (PBF) and pancreatic oxygen consumption (PVO2) were determined. Control values for SPBF, PVO2 and PBF averaged 43.3 ml/min, 1.8 ml/min, and 57.5 ml/min/100g of tissue, respectively. Following iv injection of PYY at doses of 200 and 400 pmol/kg the values of SPBF decreased by 12 +/- 1% and 22 +/- 2%, respectively. PVO2 was reduced by those doses of PYY by 9 +/- 1 and 17 +/- 3%, respectively. PBF was also reduced by 16 +/- 2 and 34 +/- 2%, respectively after those doses of PYY. Pretreatment with phentolamine reversed the blood flow and PVO2 responses to PYY because SPBF, PVO2 and PBF were significantly increased above the control level. However, after additional pretreatment with propranolol the pancreatic vascular and metabolic responses to PYY were abolished. The above pancreatic responses to PYY were also significantly reduced after acute adrenalectomy. The experimental data indicate that adrenergic pathway is involved in the mechanism of action of PYY on the pancreatic circulation.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"44 3","pages":"289-98"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12639881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutagenic and clastogenic activity of the chloro-nitroimidazole radiosensitizer P40 in vitro and in vivo. 氯硝基咪唑放射增敏剂P40的体内外致突变活性。
Polish journal of pharmacology and pharmacy Pub Date : 1992-05-01
M Konopacka, M Wideł, E Grzybowska, J Suwiński
{"title":"Mutagenic and clastogenic activity of the chloro-nitroimidazole radiosensitizer P40 in vitro and in vivo.","authors":"M Konopacka,&nbsp;M Wideł,&nbsp;E Grzybowska,&nbsp;J Suwiński","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The hypoxic radiosensitizer 1-(2-hydroxy-3-methoxypropyl)-2-chloro-4-nitroimidazole [P40] was investigated for its mutagenic activity in bacterial Ames test as well as for genotoxic activity in micronucleus assay in vivo. This nitroimidazole showed the weak mutagenicity towards TA100 strain (base pair substitution) and towards TA98 strain (frameshift) only in the highest concentration. P40 induced also a significant increase in the frequency of micronucleated polychromatic erythrocytes (PCEs) at the doses of 0.6 mg/g and 1.2 mg/g. The maximum time response was at 48 h. The decrease of percentage of PCEs suggested the possible cytotoxicity on bone marrow cells after treatment with P40. Positive results in this battery short-term tests provide evidence of clastogenic activity of P40.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"44 3","pages":"299-306"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12639882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and some central pharmacological properties of new 5(1H)oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic esters. 新型5(1H)氧-2,3-二氢咪唑[1,2-a]嘧啶-6-羧酸酯的合成及一些主要药理性质
Polish journal of pharmacology and pharmacy Pub Date : 1992-05-01
D Matosiuk, T Tkaczyński, E Jagiełło-Wójtowicz, M Wielosz, G Szurska, A Chodkowska, W Janusz, Z Kleinrok
{"title":"Synthesis and some central pharmacological properties of new 5(1H)oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic esters.","authors":"D Matosiuk,&nbsp;T Tkaczyński,&nbsp;E Jagiełło-Wójtowicz,&nbsp;M Wielosz,&nbsp;G Szurska,&nbsp;A Chodkowska,&nbsp;W Janusz,&nbsp;Z Kleinrok","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Six new 5(1H)oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic ethyl esters bearing an aromatic substituent in position 1 or 2 were obtained. Pharmacological studies on the central action of these derivatives were carried out on mice and rats. The highest activity showed compounds 1 and 2 which produced analgesic effects in mice.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"44 3","pages":"307-18"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12639879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of single and prolonged ethanol administration on the sensitivity of central GABA-A and benzodiazepine receptors in vivo. 单次和长时间乙醇给药对体内中枢GABA-A和苯二氮卓受体敏感性的影响。
Polish journal of pharmacology and pharmacy Pub Date : 1992-05-01
A Szmigielski, H Szmigielska, I Wejman
{"title":"The effect of single and prolonged ethanol administration on the sensitivity of central GABA-A and benzodiazepine receptors in vivo.","authors":"A Szmigielski,&nbsp;H Szmigielska,&nbsp;I Wejman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The response of GABA-modulin to various doses of diazepam and muscimol was used as an index of the sensitivity of central benzodiazepine and GABA-A receptors, respectively. Diazepam and muscimol induced a dose-dependent increase in cytosol GABA-modulin activity in rat nucleus accumbens, hippocampus and cerebellum. A single dose of ethanol (1 g/kg po) potentiated the action of diazepam and muscimol. Prolonged treatment with ethanol (5 g/kg/day for 21 days) did not affect the action of diazepam. In contrast, the effect of muscimol was greatly reduced. In the rats pretreated for 21 days with ethanol five times higher doses of muscimol than in control group were necessary to induce a statistically significant increase of GABA-modulin in the cytosol of the nucleus accumbens, hippocampus and cerebellum. Those results show that a single dose of ethanol enhances GABA-ergic transmission, whereas prolonged treatment with ethanol induces subsensitivity of GABA-A but not benzodiazepine receptors in the limbic system and in cerebellum.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"44 3","pages":"271-80"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12509284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of C-terminal cholecystokinin fragments in the circulatory system of rats. c端胆囊收缩素片段对大鼠循环系统的影响。
Polish journal of pharmacology and pharmacy Pub Date : 1992-05-01
R J Wiśniewska, G Kupryszewski
{"title":"The influence of C-terminal cholecystokinin fragments in the circulatory system of rats.","authors":"R J Wiśniewska,&nbsp;G Kupryszewski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of C-terminal unsulfated cholecystokinin octapeptide (CCK-8US) and its fragments C-terminal heptapeptide (CCK-7), C-terminal hexapeptide (CCK-6) and C-terminal pentapeptide (CCK-5) were studied on the arterial blood pressure and the isolated rat heart. CCK-8US had only slight hypertensive and no cardiac effects. CCK-5, CCK-6 and CCK-7 had no effect on the arterial blood pressure, the cardiac contraction amplitude and the heart rate. Only CCK-7 increased coronary outflow of the isolated rat heart. CCK-8US and C-terminal fragments; CCK-7 have little effect on the circulation of the rat.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"44 3","pages":"281-7"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12641368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidepressant effect of carbamazepine--the role of dopaminergic and noradrenergic agents. 卡马西平的抗抑郁作用——多巴胺能和去甲肾上腺素能药物的作用。
Polish journal of pharmacology and pharmacy Pub Date : 1992-05-01
A Słuzewska, A Chodera
{"title":"Antidepressant effect of carbamazepine--the role of dopaminergic and noradrenergic agents.","authors":"A Słuzewska,&nbsp;A Chodera","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fourteen days of treatment with 20 mg/kg/day carbamazepine (CBZ) reduced the immobility time in the behavioral \"despair\" test in rats. Two blockers of dopaminergic receptors: haloperidol (0.5 mg/kg) and sulpiride (100 mg/kg) antagonized the reduction of immobility caused by CBZ. The anti-immobility effect of CBZ was also counteracted by clonidine (0.1 mg/kg) an agonist of presynaptic alpha 2 adrenoreceptors and propranolol (5 mg/kg) beta-adrenolytic drug.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"44 3","pages":"209-15"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12641362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The anxiolytic-like effects of 5-hydroxytryptamine3 (5-HT3) receptor antagonists. 5-羟色胺3 (5-HT3)受体拮抗剂的抗焦虑作用。
Polish journal of pharmacology and pharmacy Pub Date : 1992-05-01
M Filip, L Baran, J Siwanowicz, E Chojnacka-Wójcik, E Przegaliński
{"title":"The anxiolytic-like effects of 5-hydroxytryptamine3 (5-HT3) receptor antagonists.","authors":"M Filip,&nbsp;L Baran,&nbsp;J Siwanowicz,&nbsp;E Chojnacka-Wójcik,&nbsp;E Przegaliński","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of six 5-HT3 receptor antagonists: ondansetron (0.01-3 mg/kg ip), granisetron (0.01-1 mg/kg ip), zacopride (0.01-3 mg/kg ip), tropisetron (0.001-0.1 mg/kg ip), MDL 72222 (0.01-3 mg/kg ip) and DAU 6215 (0.01-3 mg/kg sc) were examined in the conflict drinking test (Vogel test) and in the elevated plus-maze test in rats. Ondansetron (0.1-0.3 or 1 mg/kg), zacopride (0.1-1 mg/kg) and tropisetron (0.01 mg/kg) increased the punished responding in the Vogel test and showed anxiolytic effects in the elevated plus-maze test. Their effects were limited to a narrow dose range and were not dose-dependent. Granisetron (0.1 mg/kg) exhibited an anti-conflict activity, but was ineffective in the elevated plus-maze test. MDL 72222 and DAU 6215 were ineffective in both those tests. On the other hand, diazepam (2.5-10 mg/kg), used as a reference drug, was active in either procedure and its effects were dose-dependent. These results indicate that an anxiolytic-like activity is not a common characteristic of 5-HT3 receptor antagonists. Moreover, even the anxiolytic action of drugs which were active in the experimental models used should be accepted with caution.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"44 3","pages":"261-9"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12639872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of accumbens serotonin in stress-induced locomotor suppression in rats. 伏隔核血清素在应激诱导大鼠运动抑制中的作用。
Polish journal of pharmacology and pharmacy Pub Date : 1992-05-01
A Płaźnik, R Stefański, W Pałejko, W Kostowski
{"title":"The role of accumbens serotonin in stress-induced locomotor suppression in rats.","authors":"A Płaźnik,&nbsp;R Stefański,&nbsp;W Pałejko,&nbsp;W Kostowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of post-footshock injections of serotonergic agonists into the nucleus accumbens on formation of the open field deficit, has been studied in rats. It was found that the deficient open field behavior, examined 24 h after learned helplessness training, was not modified by local injection of serotonin, buspirone, ipsapirone and ICS 205 930, as well as by peripherally administered citalopram. It is concluded that accumbens serotonin system does not seem to contribute to the balance in the activity of local dopaminergic and GABAergic neurotransmitter mechanisms, previously shown to mediate some behavioral effects of stressors.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"44 3","pages":"241-9"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12639874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basic central pharmacological properties of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. 白屈菜硫代磷酸生物碱衍生物的基本药理性质。
Polish journal of pharmacology and pharmacy Pub Date : 1992-05-01
Z Kleinrok, E Jagiełło-Wójtowicz, B Matuszek, A Chodkowska
{"title":"Basic central pharmacological properties of thiophosphoric acid alkaloid derivatives from Chelidonium majus L.","authors":"Z Kleinrok,&nbsp;E Jagiełło-Wójtowicz,&nbsp;B Matuszek,&nbsp;A Chodkowska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (Ukrain, UKSR-222) on the central nervous system (CNS) of mice and rats was studied. Intraperitoneal (ip) administration of Ukrain in doses of 9.5 and 19 mg/kg for mice depressed spontaneous motor activity, decreased body temperature and potentiated the action of hexobarbital. Only in a dose of 19 mg/kg Ukrain produced analgesic action in the hot plate test. It had no protective effect against electroshock or pentetrazol-induced seizures. In rats, ip administration of Ukrain in dose of 14 and 28 mg/kg potentiated the action of amphetamine and apomorphine but had no effect on catalepsy induced by haloperidol. Ukrain used in dose 9.5, 14, 19 and 28 mg/kg antagonized the head twitches induced by 5-HTP and hyperthermia-induced by m-CPP. Biochemical studies indicated that Ukrain did not affect the NA and DA concentrations in the whole rats' brain and did not affect the 5-HT and 5-HIAA concentrations in the whole brain of rats. These findings demonstrate that the central action of Ukrain involves the stimulation of the dopaminergic system and the inhibition of the serotoninergic system.</p>","PeriodicalId":20276,"journal":{"name":"Polish journal of pharmacology and pharmacy","volume":"44 3","pages":"227-39"},"PeriodicalIF":0.0,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12641363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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