Pleura and Peritoneum最新文献

{"title":"Acute respiratory distress syndrome (ARDS) after pressurized intraperitoneal aerosol chemotherapy with oxaliplatin: a case report.","authors":"Emilie Thibaudeau,&nbsp;Corinne Brianchon,&nbsp;Jean-Luc Raoul,&nbsp;Frédéric Dumont","doi":"10.1515/pp-2021-0126","DOIUrl":"https://doi.org/10.1515/pp-2021-0126","url":null,"abstract":"<p><p>Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new drug delivery method for intraabdominal cavity chemotherapy. It combines the benefits of a minimally invasive approach (low morbidity and easy to repeat) with the pharmacokinetic advantages of intraperitoneal administration and tolerance seems excellent. We would like to report one case of a serious adverse event, acute respiratory distress syndrome, which is likely related to oxaliplatin administration; all signs disappeared within a few days.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 4","pages":"167-170"},"PeriodicalIF":1.8,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39962924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISSPP 2021 2nd Congress of the International Society for the Study of Pleura and Peritoneum.","authors":"Janika Kugel","doi":"10.1515/pp-2021-0141","DOIUrl":"https://doi.org/10.1515/pp-2021-0141","url":null,"abstract":"","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 3","pages":"eA1-eA78"},"PeriodicalIF":1.8,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39564811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can pressurised intraperitoneal aerosol chemotherapy with oxaliplatin (PIPAC-O+) be added to standard treatment for resectable high-risk gastric cancer patients? A study protocol.","authors":"Jessica L Reid,&nbsp;Harsh A Kanhere,&nbsp;Peter J Hewett,&nbsp;Timothy J Price,&nbsp;Guy J Maddern,&nbsp;Markus I Trochsler","doi":"10.1515/pp-2021-0132","DOIUrl":"https://doi.org/10.1515/pp-2021-0132","url":null,"abstract":"<p><strong>Objectives: </strong>Gastric cancer remains one of the most fatal cancers, despite an intensive treatment regime of chemotherapy-surgery-chemotherapy. Peritoneal metastatic disease is commonly diagnosed post treatment regime and once established, patients are likely to die in 3-9 months. Systemic chemotherapy does not increase survival for these patients due to the poor vascularisation of this area. We are proposing the addition of pressurised intraperitoneal aerosol chemotherapy (PIPAC) to the treatment regime for curative patients as a preventive measure to reduce the risk of peritoneal metastases occurring.</p><p><strong>Methods: </strong>This is a prospective, single centre, non-randomised, open-label pilot trial evaluating the addition of PIPAC to the standard multimodal treatment pathway. Patients will undergo standard neoadjuvant chemotherapy with four cycles of fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT), then PIPAC, followed by gastrectomy. Four cycles of FLOT will be administered post-surgery. Primary outcome is safety and feasibility, assessed by perioperative morbidity and possible interruptions of the standard multimodal treatment pathway.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 4","pages":"151-154"},"PeriodicalIF":1.8,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39962921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragmatic peritoneal metastases mimicking liver metastases.","authors":"Barbara Noiret,&nbsp;Clarisse Eveno","doi":"10.1515/pp-2021-0120","DOIUrl":"https://doi.org/10.1515/pp-2021-0120","url":null,"abstract":"","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 3","pages":"137-138"},"PeriodicalIF":1.8,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39564810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of pre-analytical sample preparation on drug concentration measurements in peritoneal tissue: an <i>ex-vivo</i> study.","authors":"Arianna Castagna,&nbsp;Iaroslav Sautkin,&nbsp;Frank-Jürgen Weinreich,&nbsp;Hannah Heejung Lee,&nbsp;Alfred Königsrainer,&nbsp;Marc André Reymond,&nbsp;Giorgi Nadiradze","doi":"10.1515/pp-2020-0151","DOIUrl":"https://doi.org/10.1515/pp-2020-0151","url":null,"abstract":"<p><strong>Objectives: </strong>Biopsy morphology (surface/depth ratio) and sample processing might affect pharmacological measurements in peritoneal tissue.</p><p><strong>Methods: </strong>This is an <i>ex-vivo</i> study on inverted bovine urinary bladders (IBUB). We compared cisplatin (CIS) and doxorubicin (DOX) concentration in 81 standardized transmural punch biopsies of different diameters (6 and 12 mm). Then, we assessed the effect of dabbing the peritoneal surface before analysis. After automatized tissue homogenization with ceramic beads followed by lyophilisation, DOX concentration was quantified by high-performance liquid chromatography (HPLC), CIS concentration by atomic absorption spectroscopy. Experiments were performed in triplicate; the analysis was blinded to the sample origin. Comparisons were performed using non-parametric tests.</p><p><strong>Results: </strong>Concentrations are given in mean (CI 5-95%). Results were reproducible between experiments (for CIS p=0.783, for DOX p=0.235) and between different localizations within the IBUB (for CIS p=0.032, for DOX p=0.663). Biopsy diameter had an influence on CIS tissue concentration (6 mm biopsies: 23.2 (20.3-26.1), vs. 12 mm biopsies: 8.1 (7.2-9.2) ng/mg, p<0.001) but not on DOX: (0.46, 0.29-0.62) vs. 0.43 (0.33-0.54) ng/mg respectively, p=0.248). Dabbing the peritoneal surface reduced DOX tissue concentration (dry biopsies: 0.28 (0.12-0.43) vs. wet biopsies: 0.64 (0.35-0.93) ng/mg, p=0.025) but not CIS (23.5 (19.0-28.0) vs. 22.9 (18.9-26.9) ng/mg, respectively, p=0.735).</p><p><strong>Conclusions: </strong>Measurements of drug concentration in peritoneal tissue can be influenced by the biopsy's surface/depth ratio and after drying the biopsy's surface<b>.</b> This influence can reach a factor three, depending on the drug tested<b>.</b> The biopsy technique and the pre-analytical sample preparation should be standardized to ensure reliable pharmacological measurements in peritoneal tissue.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 3","pages":"131-136"},"PeriodicalIF":1.8,"publicationDate":"2021-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2020-0151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39564809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A human <i>ex vivo</i> coculture model to investigate peritoneal metastasis and innovative treatment options.","authors":"Dina Mönch,&nbsp;Jana Koch,&nbsp;Annika Maaß,&nbsp;Nicole Janssen,&nbsp;Thomas Mürdter,&nbsp;Philipp Renner,&nbsp;Petra Fallier-Becker,&nbsp;Wiebke Solaß,&nbsp;Matthias Schwab,&nbsp;Marc-H Dahlke,&nbsp;Hans J Schlitt,&nbsp;Tobias Leibold","doi":"10.1515/pp-2021-0128","DOIUrl":"https://doi.org/10.1515/pp-2021-0128","url":null,"abstract":"<p><strong>Objectives: </strong>Peritoneal metastasis (PM) is commonly observed in patients with colorectal cancer (CRC). The outcome of these patients is poor, with an average survival of only six months without therapy, which requires a better understanding of PM biology and new treatment strategies.</p><p><strong>Methods: </strong>We established and characterized a human <i>ex vivo</i> peritoneal model to investigate the mechanisms of peritoneal seeding and possible treatment options. For this, CRC cell lines and patient-derived tumor organoids were cultured together with human peritoneum to investigate the invasion of malignant cells and the effects of local chemotherapy.</p><p><strong>Results: </strong>Fresh human peritoneum was cultured for up to three weeks in a stainless steel ring system, allowing for survival of all peritoneal structures. Peritoneal cell survival was documented by light microscopy and immunohistochemical staining. Further, immunohistological characterization of the tissue revealed CD3-positive T-lymphocytes and vimentin-positive fibroblasts within the peritoneum. In addition, extracellular matrix components (collagens, matrix metalloproteinases) were localized within the tissue. Coculture with CRC cell lines and patient-derived CRC organoids revealed that cancer cells grew on the peritoneum and migrated into the tissue. Coculture with CRC cells confirmed that hyperthermal treatment at 41 °C for 90 min significantly enhanced the intracellular entry of doxorubicin. Moreover, treatment with mitomycin C under hyperthermic conditions significantly reduced the amount of cancer cells within the peritoneum.</p><p><strong>Conclusions: </strong>This human <i>ex vivo</i> peritoneal model provides a stringent and clinically relevant platform for the investigation of PM and for further elucidation of possible treatment options.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 3","pages":"121-129"},"PeriodicalIF":1.8,"publicationDate":"2021-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2021-0128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39564808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological regression of gastrointestinal peritoneal metastases after systemic chemotherapy.","authors":"Laura Toussaint,&nbsp;Hugo Teixeira Farinha,&nbsp;Jean-Luc Barras,&nbsp;Nicolas Demartines,&nbsp;Christine Sempoux,&nbsp;Martin Hübner","doi":"10.1515/pp-2021-0118","DOIUrl":"https://doi.org/10.1515/pp-2021-0118","url":null,"abstract":"<p><strong>Objectives: </strong>Peritoneal metastases (PM) are relatively resistant to systemic chemotherapy, and data on histological response to therapy is rare. The aim of this study was to quantify the treatment response of PM after systemic chemotherapy.</p><p><strong>Methods: </strong>Retrospective monocentric cohort study of 47 consecutive patients with PM from gastrointestinal origin undergoing surgery (cytoreduction: CRS + Hyperthermic IntraPEritoneal Chemotherapy [HIPEC] or Pressurized IntraPeritoneal Aerosol Chemotherapy [PIPAC]) after prior systemic chemotherapy from 1.2015 to 3.2019. Tumor response was assessed using the 4-scale Peritoneal Regression Grading System (PRGS) (4: vital tumor to 1: complete response).</p><p><strong>Results: </strong>Patients had a median of 2 (range: 1-7) lines and 10 (3-39) cycles of prior systemic chemotherapy. A median of four biopsies (range: 3-8) was taken with a total of 196 analyzed specimens. Twenty-four biopsies (12%) showed no histological regression (PRGS4), while PRGS 3, two and one were diagnosed in 37 (19%), 39 (20%), and 69 (49%) specimens, respectively. A significant heterogeneity was found between peritoneal biopsies in 51% patients. PRGS correlated strongly with peritoneal spread (PCI, p<0.0001), and was improved in patients with more than nine cycles of systemic chemotherapy (p=0.04). Median survival was higher in patients with PRGS < 1.8 (Quartiles one and 2) than higher (Q3 and Q4), but the difference did not reach significance in this small cohort.</p><p><strong>Conclusions: </strong>PRGS is an objective too to describe histological response of PM of GI origin after systemic chemotherapy. This response differs significantly between patients, allowing to distinguish between chemosensitive and chemoresistant tumors.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 3","pages":"113-119"},"PeriodicalIF":1.8,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39564807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced recovery after surgery (ERAS) in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC): a cross-sectional survey.","authors":"Geetu Bhandoria,&nbsp;Sohan Lal Solanki,&nbsp;Mrugank Bhavsar,&nbsp;Kalpana Balakrishnan,&nbsp;Cherukuri Bapuji,&nbsp;Nitin Bhorkar,&nbsp;Prashant Bhandarkar,&nbsp;Sameer Bhosale,&nbsp;Jigeeshu V Divatia,&nbsp;Anik Ghosh,&nbsp;Vikas Mahajan,&nbsp;Abraham Peedicayil,&nbsp;Praveen Nath,&nbsp;Snita Sinukumar,&nbsp;Robin Thambudorai,&nbsp;Ramakrishnan Ayloor Seshadri,&nbsp;Aditi Bhatt","doi":"10.1515/pp-2021-0117","DOIUrl":"https://doi.org/10.1515/pp-2021-0117","url":null,"abstract":"<p><strong>Objectives: </strong>Enhanced recovery after surgery (ERAS) protocols have been questioned in patients undergoing cytoreductive surgery (CRS) with/without hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancies. This survey was performed to study clinicians' practice about ERAS in patients undergoing CRS-HIPEC.</p><p><strong>Methods: </strong>An online survey, comprising 76 questions on elements of prehabilitation (n=11), preoperative (n=8), intraoperative (n=16) and postoperative (n=32) management, was conducted. The respondents included surgeons, anesthesiologists, and critical care specialists.</p><p><strong>Results: </strong>The response rate was 66% (136/206 clinicians contacted). Ninety-one percent of respondents reported implementing ERAS practices. There was encouraging adherence to implement the prehabilitation (76-95%), preoperative (50-94%), and intraoperative (55-90%) ERAS practices. Mechanical bowel preparation was being used by 84.5%. Intra-abdominal drains usage was 94.7%, intercostal drains by 77.9% respondents. Nasogastric drainage was used by 84% of practitioners. The average hospital stay was 10 days as reported by 50% of respondents. A working protocol and ERAS checklist have been designed, based on the results of our study, following recent ERAS-CRS-HIPEC guidelines. This protocol will be prospectively validated.</p><p><strong>Conclusions: </strong>Most respondents were implementing ERAS practices for patients undergoing CRS-HIPEC, though as an extrapolation of colorectal and gynecological guidelines. The adoption of postoperative practices was relatively low compared to other perioperative practices.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 3","pages":"99-111"},"PeriodicalIF":1.8,"publicationDate":"2021-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2021-0117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39564806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontmatter","authors":"","doi":"10.1515/pp-2021-frontmatter2","DOIUrl":"https://doi.org/10.1515/pp-2021-frontmatter2","url":null,"abstract":"","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"163 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77487053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ISSPP PIPAC database: design, process, access, and first interim analysis.","authors":"Michael Bau Mortensen,&nbsp;Olivier Glehen,&nbsp;Philipp Horvath,&nbsp;Martin Hübner,&nbsp;Kim Hyung-Ho,&nbsp;Alfred Königsrainer,&nbsp;Marc Pocard,&nbsp;Marc Andre Reymond,&nbsp;Jimmy So,&nbsp;Claus Wilki Fristrup","doi":"10.1515/pp-2021-0108","DOIUrl":"https://doi.org/10.1515/pp-2021-0108","url":null,"abstract":"<p><strong>Objectives: </strong>Several trials have documented the favorable safety profile, and promising clinical results of pressurized intraperitoneal aerosol chemotherapy (PIPAC) directed treatment in different types of peritoneal malignancies. However, until the results of randomized trials are available, the quality of documentation and acceptance by the users may be improved through a worldwide registry. The International Society for the Study of Pleura and Peritoneum (www.ISSPP.org) facilitated this process by creating a dedicated focus group and providing the funding needed for the creation and implementation of an international database. This article describes the design and the journey of establishing this international database and the first, preliminary results from the ISSPP PIPAC online database.</p><p><strong>Methods: </strong>In 2019 the ISSPP PIPAC Registry Group started to create a database with a minimal dataset relevant to many diseases and applicable in different framework conditions. The task was divided into three phases including design, testing, implementation, protocol, handbook, legal requirements, as well as registry rules and bylaws for the registry group.</p><p><strong>Results: </strong>The ISSPP PIPAC online database has six key elements (patient, consent, treatment, complications, response evaluation and follow-up). Following design, testing and implementation the database was successfully launched in June 2020. Ten institutions reported on 459 PIPAC procedures in 181 patients during the first 6 months, and the recorded data were comparable to the present literature.</p><p><strong>Conclusions: </strong>A new international multicenter PIPAC database has been developed, tested and implemented under the auspices of ISSPP. The database is accessible through the ISSPP website (www.ISSPP.org), and PIPAC institutions worldwide are highly encouraged to participate.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 3","pages":"91-97"},"PeriodicalIF":1.8,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2021-0108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39564805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}