Pleura and Peritoneum最新文献

{"title":"Current practice and perceptions of safety protocols for the use of intraperitoneal chemotherapy in the operating room: results of the IP-OR international survey.","authors":"Daniel Clerc,&nbsp;Martin Hübner,&nbsp;K R Ashwin,&nbsp;S P Somashekhar,&nbsp;Beate Rau,&nbsp;Wim Ceelen,&nbsp;Wouter Willaert,&nbsp;Naoual Bakrin,&nbsp;Nathalie Laplace,&nbsp;Mohammed Al Hosni,&nbsp;Edgar Luis Garcia Lozcano,&nbsp;Sebastian Blaj,&nbsp;Pompiliu Piso,&nbsp;Andrea Di Giorgio,&nbsp;Giuseppe Vizzelli,&nbsp;Cécile Brigand,&nbsp;Jean-Baptiste Delhorme,&nbsp;Amandine Klipfel,&nbsp;Rami Archid,&nbsp;Giorgi Nadiradze,&nbsp;Marc A Reymond,&nbsp;Olivia Sgarbura","doi":"10.1515/pp-2020-0148","DOIUrl":"10.1515/pp-2020-0148","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the risk perception and the uptake of measures preventing environment-related risks in the operating room (OR) during hyperthermic intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosol chemotherapy (PIPAC).</p><p><strong>Methods: </strong>A multicentric, international survey among OR teams in high-volume HIPEC and PIPAC centers: Surgeons (Surg), Scrub nurses (ScrubN), Anesthesiologists (Anest), Anesthesiology nurses (AnesthN), and OR Cleaning staff (CleanS). Scores extended from 0-10 (maximum).</p><p><strong>Results: </strong>Ten centers in six countries participated in the study (response rate 100%). Two hundred and eleven responses from 68 Surg (32%), 49 ScrubN (23%), 45 Anest (21%), 31 AnesthN (15%), and 18 CleanS (9%) were gathered. Individual uptake of protection measures was 51.4%, similar among professions and between HIPEC and PIPAC. Perceived levels of protection were 7.57 vs. 7.17 for PIPAC and HIPEC, respectively (p<0.05), with Anesth scoring the lowest (6.81). Perceived contamination risk was 4.19 for HIPEC vs. 3.5 for PIPAC (p<0.01). Information level was lower for CleanS and Anesth for HIPEC and PIPAC procedures compared to all other responders (6.48 vs. 4.86, and 6.48 vs. 5.67, p<0.01). Willingness to obtain more information was 86%, the highest among CleanS (94%).</p><p><strong>Conclusions: </strong>Experience with the current practice of safety protocols was similar during HIPEC and PIPAC. The individual uptake of protection measures was rather low. The safety perception was better for PIPAC, but the perceived level of protection remained relatively low. The willingness to obtain more information was high. Intensified, standardized training of all OR team members involved in HIPEC and PIPAC is meaningful.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 1","pages":"39-45"},"PeriodicalIF":1.8,"publicationDate":"2021-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2020-0148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39149250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival and pleurodesis outcome in patients with malignant pleural effusion - a systematic review.","authors":"Maged Hassan,&nbsp;Elinor Harriss,&nbsp;Rachel M Mercer,&nbsp;Najib M Rahman","doi":"10.1515/pp-2020-0147","DOIUrl":"https://doi.org/10.1515/pp-2020-0147","url":null,"abstract":"<p><p>Malignant pleural effusion (MPE) is a common condition that presents with progressive breathlessness. Long term solutions are often required due to recurrence of effusion after simple drainage. Pleurodesis is one of the main options resorted to for long term control of MPE. There is data to suggest there may be a survival benefit for patients with MPE who achieve successful pleurodesis. A systematic review was carried out to explore this correlation and results suggest that there could be a survival difference according to pleurodesis outcome in patients with MPE. Fifteen studies (reported in 13 papers) were included; 13 (86.6%) of the studies showed survival difference in favour of pleurodesis success. The median [interquartile range] difference in survival between the two groups among the different studies was five [3.5-5.8] months. Most of the included studies suffered moderate to severe risk of bias and, thus, large prospective studies of patients undergoing pleurodesis are required to ascertain this effect.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 1","pages":"1-5"},"PeriodicalIF":1.8,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2020-0147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39149247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Priorities, actions and risks in the COVID-19 pandemic: a flash SoMe survey among surgical oncologists.","authors":"Delia Cortés-Guiral,&nbsp;Olivia Sgarbura,&nbsp;Mohammad Alyami,&nbsp;Kazuhiro Yoshida,&nbsp;Yuichiro Doki,&nbsp;Hironori Ishigami,&nbsp;Fabian Grass,&nbsp;Martin Hübner","doi":"10.1515/pp-2020-0142","DOIUrl":"https://doi.org/10.1515/pp-2020-0142","url":null,"abstract":"<p><strong>Objectives: </strong>Corona virus-induced disease 19 (COVID-19) pandemic has globally affected the surgical treatment of cancer patients and has challenged the ethical principles of surgical oncologists around the world. Not only treatment but also diagnosis and follow-up have been disrupted.</p><p><strong>Methods: </strong>An online survey was sent through Twitter and by the surgical societies worldwide. The survey consisted of 29 closed-ended questions and was conducted over a period of 24 days beginning in March 26, 2020.</p><p><strong>Results: </strong>Overall, 394 surgical oncologists from 41 different countries answered the questionnaire. The predominant guiding principle was \"saving lives\" 240 (62%), and the different aspects of lock-down found hence large support (mean 7.1-9.3 out of 10). Shut-down of elective surgery and modification of cancer care found a mean support of 7.0 ± 3.0 and 5.8 ± 3.1, respectively. Modification of cancer care longer than two weeks was considered unacceptable to 114 (29%) responders. Hundred and fifty six (40%) and 138 (36%) expect \"return to normal\" beyond six months for surgical practice and cancer care, respectively.</p><p><strong>Conclusions: </strong>Surgical oncologists show strong and long-lasting support for lock-down measures aiming to save lives. The impact of the pandemic on surgical oncology is perceived controversially, but the majority was forced already now to accept what is inacceptable for many of their colleagues.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 1","pages":"7-12"},"PeriodicalIF":1.8,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2020-0142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39149248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of malignant pleural mesothelioma in a large North East UK pleural centre.","authors":"Declan C Murphy,&nbsp;Alexander Mount,&nbsp;Fiona Starkie,&nbsp;Leah Taylor,&nbsp;Avinash Aujayeb","doi":"10.1515/pp-2020-0144","DOIUrl":"https://doi.org/10.1515/pp-2020-0144","url":null,"abstract":"<p><strong>Objectives: </strong>The National Mesothelioma Audit 2020 showed Northumbria to have low rates of histopathological confirmation, treatment and one-year survival rates for malignant pleural mesothelioma (MPM). We hypothesized that an internal analysis over a 10-year period provides valuable insights into presentation, diagnosis, treatment and outcomes.</p><p><strong>Methods: </strong>A single-centre retrospective case series of all confirmed MPM patients between 1 January 2009 and 31 December 2019 was performed. Demographics, clinical, radiological and histopathological characteristics and outcomes were collected. Statistical analysis was performed using SPSS V26.0.</p><p><strong>Results: </strong>A total of 247 patients had MPM. About 86% were male, mean age 75.7 years. Dyspnoea (77.4%) and chest pain (38.5%) were commonest symptoms. 64.9 and 71.4% had pleural thickening and effusion, respectively. About 86.8% had at least one attempt to obtain a tissue biopsy, but histopathological confirmation in only 108 (43.7%). About 66.3% with PS 0 and 1 (62.7% of total cohort) had at least one anti-cancer therapy. Death within 12 months was associated with disease progression within 6 months (p≤0.001). Chemotherapy (p≤0.001) and epithelioid histological subtype (p=0.01) were protective.</p><p><strong>Conclusions: </strong>This study confirms known epidemiology of MPM, demonstrates variability in practices and highlights how some NMA recommendations are not met. This provides the incentive for a regional mesothelioma multi-disciplinary meeting.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 1","pages":"20200144"},"PeriodicalIF":1.8,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2020-0144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38868822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of morbidity and mortality in patients submitted to cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for ovarian carcinomatosis: a multicenter study.","authors":"Antonio Macrì,&nbsp;Fabio Accarpio,&nbsp;Vincenzo Arcoraci,&nbsp;Francesco Casella,&nbsp;Franco De Cian,&nbsp;Pierandrea De Iaco,&nbsp;Elena Orsenigo,&nbsp;Franco Roviello,&nbsp;Giovanni Scambia,&nbsp;Edoardo Saladino,&nbsp;Marica Galati","doi":"10.1515/pp-2020-0139","DOIUrl":"10.1515/pp-2020-0139","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this retrospective study is to assess the incidence of morbidity and mortality related to cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) and to evaluate their predictors, in patients with peritoneal metastasis of ovarian origin.</p><p><strong>Methods: </strong>A retrospective multicenter study was carried out investigating results from eight Italian institutions. A total of 276 patients met inclusion criteria. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis.</p><p><strong>Results: </strong>Overall morbidity was 71.4%, and severe complications occurred in 23.9% of the sample; 60-day mortality was 4.3%. According to univariate logistic regression models, grade 3-4 morbidity was related to Peritoneal Cancer Index (PCI) (OR 1.06; 95% CI 1.02-1.09; p<0.001), number of intraoperative blood transfusions (OR 1.21; 95% CI 1.10-1.34; p<0.001), Completeness of Cytoreduction (CC) score (OR 1.68; 95% CI 1.16-2.44; p=0.006) and number of anastomoses (OR 1.32; 95% CI 1.00-1.73; p=0.046). However, at the multivariate logistic regression analysis, only the number of intraoperative blood transfusions (OR 1.17; 95% CI 1.5-1.30; p=0.004) and PCI (OR 1.04; 95% CI 1.01-1.08; p=0.010) resulted as key predictors of severe morbidity. Furthermore, using multivariate logistic regression model, ECOG score (OR 2.45; 95% CI 1.21-4.93; p=0.012) and the number of severe complications (OR 2.16; 95% CI 1.03-4.52; p=0.042) were recorded as predictors of exitus within 60 days.</p><p><strong>Conclusions: </strong>The combination of CRS and HIPEC for treating peritoneal metastasis of ovarian origin has acceptable morbidity and mortality and, therefore, it can be considered as an option in selected patients.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"6 1","pages":"21-30"},"PeriodicalIF":1.8,"publicationDate":"2020-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2020-0139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39149249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaesthesia considerations and techniques for Pressurised IntraPeritoneal Aerosol Chemotherapy (PIPAC).","authors":"Venkatesan Shree,&nbsp;Tian Jin Lim,&nbsp;Lyn Li Lean,&nbsp;Bok Yan Jimmy So,&nbsp;Guowei Kim","doi":"10.1515/pp-2019-0013","DOIUrl":"https://doi.org/10.1515/pp-2019-0013","url":null,"abstract":"<p><p>Pressurised IntraPeritoneal Aerosol Chemotherapy (PIPAC) is a novel surgical technique to administer aerosolized chemotherapy into the abdominal cavity as treatment for peritoneal metastasis from various cancers. As the surgery is unique and there are concerns about occupational hazards, specific anaesthetic setup and techniques are required. Notably, our institution's experience with PIPAC has enlightened us that anaesthesia requirements during PIPAC are generally uncomplicated and that the majority of the patients undergoing PIPAC do not require invasive monitoring, advanced intra or postoperative analgesia like epidurals or PCA. The need for postoperative intensive unit care is also not required in routine PIPAC cases. We describe the anaesthetic considerations involved and the detailed preparation of staff, space, anaesthetic equipment and drugs to facilitate the appropriate modifications for anaesthesia monitoring and maintenance for an elective set up as well as our standard operating procedure for an emergency situation should it arise.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"5 4","pages":"20190013"},"PeriodicalIF":1.8,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2019-0013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25363727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritoneal biopsy frozen section: cachexia manifesting as signet ring-like cells.","authors":"Lakhdar Khellaf,&nbsp;Philippe Rouanet","doi":"10.1515/pp-2020-0143","DOIUrl":"https://doi.org/10.1515/pp-2020-0143","url":null,"abstract":"<p><p>Peritoneal metastases from signet ring cell adenocarcinoma may be overlooked at laparoscopy, resulting in problematic false-negative diagnoses. Conversely, false-positive diagnoses are rarely reported. For the surgeon, cachexia may rise suspicion for peritoneal metastases by exhibiting a worrisome micronodular appearance of the peritoneum, and atrophic adipocytes looks like signet ring cells at the microscopical level. Being aware of this underdiagnosed condition may help avoiding unfortunate false-positive diagnoses of peritoneal metastases during intraoperative consultation.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"5 4","pages":"20200143"},"PeriodicalIF":1.8,"publicationDate":"2020-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2020-0143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25364198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technique of pressurized intrathoracic aerosol chemotherapy (PITAC) for malignant pleural effusion.","authors":"Gabrielle Drevet,&nbsp;Jean-Michel Maury,&nbsp;Naoual Bakrin,&nbsp;François Tronc","doi":"10.1515/pp-2020-0129","DOIUrl":"https://doi.org/10.1515/pp-2020-0129","url":null,"abstract":"<p><strong>Objectives: </strong>Malignant pleural effusion (MPE) is a devastating evolution of several malignancies. Pressurized intrathoracic aerosol chemotherapy (PITAC) might be a novel therapy option in MPE.</p><p><strong>Methods: </strong>PITAC is considered for patients with MPE with a performance status <2 and without other metastatic sites. General anesthesia is administered and a double-lumen bronchial tube is inserted. The patient is placed in a lateral decubitus position, and the operation is performed after ipsilateral lung exclusion. Two 12-mm balloon trocars are inserted-one in the seventh intercostal space in the mid-axillary line and one in the fifth intercostal space in the anterior axillary line. Extent of pleural disease and volume of MPE are documented. MPE is removed and parietal pleural biopsy are performed. An intrathoracic pressure of 12 mmHg CO₂ is established, and a combination of Cisplatin (10.5 mg/m² in a total volume of 150 cc NaCl 0.9%) and Doxorubicin (2.1 mg/m² in a total volume of 50 cc NaCl 0.9%) are aerosolized via nebulizer in the pleural cavity. Vital signs and nebulization are remote-controlled. After 30 min, the remaining toxic aerosol is exhausted using a closed surgical smoke evacuation system. A 24Fr chest tube is inserted in postero-apical position with continuous negative pressure of 20 cm H₂O. When needed, PITAC may be repeated every six weeks in alternate with systemic chemotherapy.</p><p><strong>Results: </strong>In our hands, the technique above has shown to be feasible and safe.</p><p><strong>Conclusions: </strong>Further studies are needed to assess the potential symptomatic and oncological benefits of PITAC in MPE.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"5 4","pages":"20200129"},"PeriodicalIF":1.8,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2020-0129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25363729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the outcomes of rigid medical thoracoscopy in a large UK district general hospital.","authors":"Avinash Aujayeb,&nbsp;Karl Jackson","doi":"10.1515/pp-2020-0131","DOIUrl":"https://doi.org/10.1515/pp-2020-0131","url":null,"abstract":"<p><strong>Objectives: </strong>Local anesthetic medical thoracoscopy (LAT) is a well-established diagnostic, therapeutic, and preventative intervention in undiagnosed pleural effusions with a high diagnostic sensitivity and low complication rates. There is a large variability in practice. We describe a nine-year experience in a large district general hospital in England.</p><p><strong>Methods: </strong>Two hundred seventy-five patients had LAT between January 2010 and December 2018. Data on outcomes and complications were obtained from the patients' notes, electronic records, laboratory, and radiographic findings.</p><p><strong>Results: </strong>The main diagnoses were malignant pleural mesothelioma (MPM) (n=110, 40%), chronic inflammation/fibrinous pleuritis (77, 28%), lung cancer (26, 9.5%), and breast cancer (16, 6%). LAT failed to diagnose cancer in 7/275 patients (false-negative rate 2.5%, diagnostic sensitivity 97.5%). Out of the 105 patients with chronic inflammation/fibrinous pleuritis or atypical proliferative processes, 21 (20%) were subsequently diagnosed with malignancy. Talcum pleurodesis was performed in 146 patients, and was successful in 86%. Seventy eight (28%) patients had trapped lung; 27 of those had a repeat procedure. The median length of stay was 3.96 days. There was one hospital death (0.3% mortality). Complications of LAT included pleural (3, 1%) and wound infections (4, 1.4%), persistent air leaks (9, 3.2%), subcutaneous emphysema (10, 3.6%), and tumor extension to the access port (1, 0.3%).</p><p><strong>Conclusions: </strong>In this cohort, LAT was safe, effective, and enabled high diagnostic sensitivity. Further areas of study include optimal sedation and anesthetic pathways and combining LAT with indwelling pleural catheters (IPC).</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"5 4","pages":"20200131"},"PeriodicalIF":1.8,"publicationDate":"2020-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2020-0131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25363730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth factors in the regulation of reparative response in the presence of peritoneal damage.","authors":"Irina A Shurygina,&nbsp;Мichael G Shurygin,&nbsp;Lubov V Rodionova,&nbsp;Nataliya I Ayushinova","doi":"10.1515/pp-2020-0114","DOIUrl":"https://doi.org/10.1515/pp-2020-0114","url":null,"abstract":"<p><strong>Objectives: </strong>To study the expression of growth factors in the regulation of tissue repair after peritoneal damage tissue response to peritoneal damage.</p><p><strong>Methods: </strong>Experimental study in 35 male Wistar rats determining the evolution over time of the tissue response to aseptic peritoneal damage. A standardized bowel and peritoneal lesions were created in the right lower quadrant by laparotomy. Then, tissular expression of growth factors was evaluated by multiplex polymerase chain reaction at seven timepoints between 6 h and 30 days, postoperatively.</p><p><strong>Results: </strong>Tissular responses of granulocyte-stimulating factors (Csf2, Csf3), connective tissue growth factor (Ctgf), epidermal growth factors and receptor (Egf, Egfr), fibroblast growth factors (Fgf2, 7 and 10), heparin binding EGF-like growth factor (Hbegf), hepatocyte growth factor (Hgf), insulin-like growth factor-1 (Igf1), mitogenic transforming growth factors (Tgfa, Tgfb1, Tgfbr3), and vascular endothelial growth factor A (Vegfa) were biphasic with a first expression peak at day 3, followed by a more pronounced peak at day 14.</p><p><strong>Conclusions: </strong>We observed a long-lasting, widespread response of tissular growth factors for at least two weeks after peritoneal damage. To be clinically effective, the prophylaxis of postoperative adhesions might be needed for an extended period of time.</p>","PeriodicalId":20231,"journal":{"name":"Pleura and Peritoneum","volume":"5 4","pages":"20200114"},"PeriodicalIF":1.8,"publicationDate":"2020-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pp-2020-0114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25363728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}