Phytomedicine最新文献

{"title":"Corrigendum to \"Targeting USP4 to inhibit TGF-β signaling: the antifibrotic potential of isovitexin in renal interstitial fibrosis\" [Phytomedicine 155 (2026) 158141].","authors":"Jianhui Fan, Yuqi Liu, Shihong Zhan, Huayu Ling, Jiamin Yan, Leyi Xie, Weiguang Wang, Xiao Xiao, Ao Li","doi":"10.1016/j.phymed.2026.158842","DOIUrl":"https://doi.org/10.1016/j.phymed.2026.158842","url":null,"abstract":"","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":" ","pages":"158842"},"PeriodicalIF":11.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Total glucosides of paeony modulates leucine metabolism by inhibiting SLC7A5, antagonizing mTOR signaling to suppress head and neck squamous cell carcinoma\" [Phytomedicine 159 (2026) 158576].","authors":"Yuanqiang Li, Gaofeng Hu, Wenyuan Niu, Lizhuo Zhang, Jiaming Ge, Jie Xuan, Xuefei Yu, Shang Ma, Mengjia Li, Ziqiang Zhang, Ke Luo, Xing Jia, Qinglin Li","doi":"10.1016/j.phymed.2026.158843","DOIUrl":"https://doi.org/10.1016/j.phymed.2026.158843","url":null,"abstract":"","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":" ","pages":"158843"},"PeriodicalIF":11.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: 8th International Symposium on Phytochemicals in Medicine and Food.","authors":"Jihang Chen, Fang Wang, Jianbo Xiao","doi":"10.1016/j.phymed.2026.158847","DOIUrl":"https://doi.org/10.1016/j.phymed.2026.158847","url":null,"abstract":"","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":" ","pages":"158847"},"PeriodicalIF":11.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Oleuropein aglycone aldehyde as a SARS-CoV-2 main protease inhibitor\" [Phytomedicine 160 (2026) 158643].","authors":"Md Sofequl Islam Mukim, Sangeun Jeon, Bohyeon Kim, Shivani Rajoriya, Divya Misra, Hee-Ju Lee, Jaeyoung Kwon, Jin Wook Cha, Cheol-Ho Pan, Won-Keun Kim, Seungtaek Kim, Dae-Geun Song","doi":"10.1016/j.phymed.2026.158815","DOIUrl":"https://doi.org/10.1016/j.phymed.2026.158815","url":null,"abstract":"","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":" ","pages":"158815"},"PeriodicalIF":11.3,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149063984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Ginsenoside Rg1 alleviates cognitive impairment in vascular dementia by modulating Adcy1/Kdr-mediated cholinergic synapse and PI3K-AKT pathway\" [Phytomedicine, 143 (2025) 156882].","authors":"Yuheng Wang, Xiaolu Wei, Huijun Wang, Yan Zhang, Pengyue Li, Yawen Zhou, Shan Jiang, Yan Rong, Lihua Chen, Haiyu Zhao","doi":"10.1016/j.phymed.2026.158758","DOIUrl":"https://doi.org/10.1016/j.phymed.2026.158758","url":null,"abstract":"","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":" ","pages":"158758"},"PeriodicalIF":11.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Total saponins from Panax japonicus mediate the paracrine interaction between adipocytes and macrophages to promote lipolysis in the adipose tissue during aging via the NLRP3 inflammasome/GDF3/ATGL axis\" [Phytomedicine 2025 Jan:136:156304].","authors":"Fangqi Xia, Yaqi Hu, Yaqi Wang, Mengzhen Xue, Leiqi Zhu, Yuanyang Li, Yifan Zhang, Shuwen Wang, Rui Wang, Qi Yuan, Yumin He, Ding Yuan, Jihong Zhang, Chengfu Yuan","doi":"10.1016/j.phymed.2026.158575","DOIUrl":"10.1016/j.phymed.2026.158575","url":null,"abstract":"","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":" ","pages":"158575"},"PeriodicalIF":11.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative rhein and hydroxy fatty acid ester prodrugs for the treatment of chronic inflammation.","authors":"Lu Han, Tao Zang, Zhi-Peng Li, Yao Deng, Jun-Qi Liu, Ying-Xin He, Ting-Ting Li, Si-Ting Li, Zi-Ling Zhang, Xiao-Ping Liao, Hao Ren, Dong-Hao Zhao, Jian Sun","doi":"10.1016/j.phymed.2026.158565","DOIUrl":"10.1016/j.phymed.2026.158565","url":null,"abstract":"<p><strong>Background: </strong>Chronic inflammation is related to heart disease, diabetes, cancer, arthritis, and bowel diseases. The rhubarb-derived natural product rhein is highly effective at treating chronic inflammation. However, the gastrointestinal side effects and liver disorders of rhein have limited the long-term clinical application. Herein, we developed a series of rhein-hydroxy fatty acid prodrugs to alleviate the side effects of rhein while enhancing its therapeutic activity.</p><p><strong>Purpose: </strong>We developed a novel method to overcome the side effects of rhein and enhance its pharmacological activity. The aim was to synthesize rhein hydroxy fatty acid ester prodrugs that retain anti‑inflammatory activity and alleviate gastrointestinal side effects.</p><p><strong>Methods: </strong>A series of rhein hydroxy fatty acid ester prodrugs were synthesized by linking rhein with hydroxy fatty acid. The chemical structure of these prodrugs was characterized by Fourier transform infrared spectroscopy (FTIR), hydrogen proton nuclear magnetic resonance (¹H NMR), and high-resolution mass spectrum (HRMS). The cytotoxicity of rhein-hydroxy fatty acid ester prodrugs was evaluated using RAW 264.7 and Caco-2 cells. Additionally, in vitro anti-inflammatory, antioxidant, and anti-apoptotic effects were assessed. The targeted rhein-hydroxy fatty acid ester prodrug was verified using the DSS-induced mouse colitis model.</p><p><strong>Results: </strong>In vitro studies demonstrate that the target compound R-15HA is markedly superior to both the free drug and diacerein in mitigating inflammation, oxidative damage, and apoptosis, while showing almost no cytotoxicity at final concentrations below 160 μmol·L⁻¹. Furthermore, Western blot analysis revealed that R-15HA inhibited the TLR4/NF-κB/MAPK more effectively than free rhein and 15-hydroxypentadecanoic acid. Molecular dynamics simulations demonstrated that the R-15HA compound exhibits a good binding capability with the TLR4 protein. Rhein can partially prevent weight loss, liver and spleen indices colon shortening, expression of proinflammatory cytokines, and epithelial damage, while rhein-hydroxy fatty acid prodrugs R-15HA have a more pronounced effect than rhein in dextran sulfate sodium (DSS)-induced colitis.</p><p><strong>Conclusion: </strong>Overall, our novel rhein-hydroxy fatty acid ester prodrugs are promising candidates for chronic inflammation in clinical therapy. This study might reveal an avenue to develop rhein hydroxy fatty acid ester prodrugs with satisfactory pharmacological activity to resolve various inflammatory diseases.</p>","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":"159 ","pages":"158565"},"PeriodicalIF":11.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Huangqi-Danshen Decoction Alleviates Cardiac Fibrosis Following Myocardial Infarction by Inhibiting USP22 to Enhance the Ubiquitination of BRD4.","authors":"Jiaqi Hao, Mengkai Lu, Muxin Zhang, Lin Lin, Yuanlong Hu, Lei Zhang, Chao Li","doi":"10.1016/j.phymed.2026.158618","DOIUrl":"10.1016/j.phymed.2026.158618","url":null,"abstract":"<p><strong>Background: </strong>Myocardial fibrosis is a critical pathological process in the development of heart failure following myocardial infarction (MI). The Huangqi-Danshen decoction (HDD) has shown cardioprotective effects in clinical practice. Nonetheless, the precise molecular mechanisms underlying its antifibrotic effects remain to be elucidated.</p><p><strong>Objective: </strong>This study aimed to systematically investigate the therapeutic effects of HDD on myocardial fibrosis post-MI and to determine the underlying molecular mechanisms.</p><p><strong>Methods: </strong>An MI model was established in mice by ligating the left anterior descending coronary artery. Cardiac function and morphology were evaluated using echocardiography and histological analysis. In in vitro experiments, TGF-β1-stimulated human cardiac fibroblasts were treated with HDD-containing serum. The underlying mechanism of HDD was investigated using proteomic screening and molecular biology techniques.</p><p><strong>Results: </strong>HDD markedly improved cardiac function and attenuated myocardial fibrosis in MI mice. Proteomic analysis identified BRD4 as a key epigenetic target of HDD. HDD reduced BRD4 expression and H3K27ac levels, accompanied by decreased fibrosis-related marker expression. BRD4 overexpression or TSA treatment counteracted the inhibitory effects of HDD on H3K27ac and fibrotic markers, supporting the involvement of the BRD4/H3K27ac axis. Mechanistically, HDD promoted ubiquitin-proteasome-dependent BRD4 degradation by disrupting the interaction between BRD4 and the deubiquitinase USP22. USP22 overexpression reversed, whereas USP22 knockdown largely phenocopied, the antifibrotic effects of HDD.</p><p><strong>Conclusion: </strong>HDD ameliorates myocardial fibrosis by targeting the USP22-BRD4 axis, promoting BRD4 degradation and inhibiting H3K27ac-mediated profibrotic transcription, offering a novel epigenetic therapeutic strategy.</p>","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":"159 ","pages":"158618"},"PeriodicalIF":11.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148606783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-targeting cancer and SARS-CoV-2: The host-directed mechanisms of Spatholobus suberectus Dunn (Jixueteng).","authors":"Kumar Ganesan, Jianping Chen","doi":"10.1016/j.phymed.2026.158560","DOIUrl":"10.1016/j.phymed.2026.158560","url":null,"abstract":"<p><strong>Background: </strong>Spatholobus suberectus Dunn (SSD), known in traditional Chinese medicine as Jixueteng, has historically been used to treat conditions characterized by blood stasis. Modern research has validated its anticancer potential. Recent studies reveal broad-spectrum antiviral activity.</p><p><strong>Purpose: </strong>This review synthesizes these two research frontiers. It proposes a unified host-directed therapy paradigm as the core mechanism underlying SSD's dual therapeutic capability.</p><p><strong>Methods: </strong>A comprehensive analysis of peer-reviewed literature was conducted. This included phytochemical studies, in vitro and in vivo pharmacological investigations, and computational modeling related to SSD. Emphasis was placed on integrating the latest mechanistic findings on its antiviral action against SARS-CoV-2 with its established anticancer profile.</p><p><strong>Results: </strong>SSD contains bioactive flavonoids, such as isoliquiritigenin and procyanidins. These compounds enable multi-target interactions with host proteins. In cancer, SSD acts as a host-directed anticancer agent by inhibiting lactate dehydrogenase A, activating AMP-activated protein kinase, inducing apoptosis and pyroptosis, and arresting the cell cycle at the G2/M checkpoint. Against SARS-CoV-2, SSD functions as a direct inhibitor of the host angiotensin-converting enzyme 2 receptor. It blocks viral entry with pan-variant efficacy validated in vivo. The anticancer evidence for SSD is extensive and derived from multiple independent laboratories. The antiviral data are currently more limited. Published studies have identified SSD as active against SARS-CoV-2 and demonstrated that isoliquiritigenin inhibits viral replication via NRF2 activation. Mechanistic ACE2-targeting data remain preliminary. A comparative synthesis reveals that SSD's efficacy in both oncology and virology converges on the modulation of host protein targets. SSD targets dysregulated host enzymes in cancer and a hijacked host receptor in viral infection. This strategy provides a high barrier to therapeutic resistance.</p><p><strong>Conclusion: </strong>SSD represents a promising natural host-directed therapeutic platform. Its dual ability to disrupt cancer cell physiology and inhibit SARS-CoV-2 entry via distinct host targets positions it as a potential template for developing resistance-evasive strategies against complex diseases. Future efforts must focus on isolating the precise ACE2-inhibiting compounds, optimizing disease-specific delivery, and advancing translational studies to realize its clinical potential.</p>","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":"159 ","pages":"158560"},"PeriodicalIF":11.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-guided discovery of withangulatin A as a novel inducer of megakaryocytic differentiation through direct targeting of TYK2 in leukemia.","authors":"Feng Xiao, Yan Sun, Hui Song, Yang Pan, Peng Zhao, Jianfei Qiu, Chunmao Yuan, Xiaojiang Hao, Jue Yang","doi":"10.1016/j.phymed.2026.158587","DOIUrl":"10.1016/j.phymed.2026.158587","url":null,"abstract":"<p><strong>Background: </strong>Leukemia is an aggressive hematological malignancy. Effective differentiation-inducing agents for non-acute promyelocytic leukemia (non-APL), especially those derived from natural products, remain unavailable. Withanolides isolated from Physalis angulata var. villosa possess diverse anticancer activities, yet their potential to induce leukemia cell differentiation has not been systematically investigated.</p><p><strong>Aim: </strong>To identify withanolides capable of inducing megakaryocytic differentiation in leukemia cells and elucidate their underlying mechanisms.</p><p><strong>Methods: </strong>A library of 113 withanolides was screened using machine learning models. Candidate compounds were evaluated in K562 and HEL leukemia cells via cell viability assays, differentiation analyses, and RNA-seq. A syngeneic leukemia mouse model and primary human non-APL samples were used for biological validation. Target engagement was assessed by molecular docking, SPR, CETSA, and DARTS.</p><p><strong>Results: </strong>Machine learning-guided screening identified withangulatin A (WA) as the most potent candidate. WA significantly inhibited leukemia cell proliferation and induced megakaryocytic differentiation, but not erythroid maturation. Transcriptomic analyses revealed activation of megakaryopoiesis-associated programs and enrichment of platelet activation and PKC signaling pathways. Mechanistically, WA coordinately activated both the JAK2/STAT3 and PKC/MAPK cascades. TYK2 was identified as a direct functional target of WA. Notably, pharmacological inhibition or genetic silencing of TYK2 attenuated WA-induced signaling activation and megakaryocytic differentiation. WA also promoted megakaryocytic differentiation in primary non-APL cells. In vivo, WA alleviated splenomegaly, promoted megakaryocytic differentiation, prolonged survival, and showed no detectable systemic toxicity.</p><p><strong>Conclusion: </strong>WA is a novel natural inducer of megakaryocytic differentiation via direct targeting and activation of TYK2, highlighting its potential for differentiation therapy in non-APL leukemia.</p>","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":"159 ","pages":"158587"},"PeriodicalIF":11.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}