Egyptian Retina Journal最新文献_第7页

Primary intravitreal bevacizumab injection as a monotherapy versus combined intravitreal bevacizumab with argon laser photocoagulation in management of diabetic macular edema: A comparative study 初级玻璃体内注射贝伐单抗作为单一疗法与联合玻璃体内贝伐单抗与氩激光光凝治疗糖尿病黄斑水肿的比较研究

Egyptian Retina Journal Pub Date : 2015-01-01 DOI: 10.4103/2347-5617.179349

Y. Alahmadawy, R. Eltanamly, M. Khattab, Mosatafa Hamed Nabih

引用次数: 0

360° laser retinopexy in preventing retinal re-detachment after 23-gauge vitrectomy for primary repair of retinal detachment 360°激光视网膜固定术预防23号玻璃体切除术后视网膜再脱离

Egyptian Retina Journal Pub Date : 2015-01-01 DOI: 10.4103/2347-5617.179339

O. Barrada, M. Nabih, Ayman M Khattabm, Ashraf A Nosseir

{"title":"360° laser retinopexy in preventing retinal re-detachment after 23-gauge vitrectomy for primary repair of retinal detachment","authors":"O. Barrada, M. Nabih, Ayman M Khattabm, Ashraf A Nosseir","doi":"10.4103/2347-5617.179339","DOIUrl":"https://doi.org/10.4103/2347-5617.179339","url":null,"abstract":"Aims: To evaluate the role of intraoperative 360° laser retinopexy in the prevention of retinal re-detachment in cases of primary rhegmatogenous retinal detachment (RRD). Settings and Design: Prospective randomized controlled trial, 80 eyes of 80 patients with primary RRD. Subjects and Methods: Totally, 80 eyes of 80 patients with primary RRD will be divided into two groups. In Group (A), laser will be applied to all existing breaks as well as 360° laser retinopexy anterior to the equator will be performed while Group (B) laser will be applied only to the retinal breaks and will not receive the 360° laser treatment. Follow-up was for 3 months after clearance of the tamponading agent. Statistical Analysis Used: Backward logistic multi-regression analysis identified significant independent predictors of re-detachment (P < 0.01, Hosmer-Lemeshow, χ2: 7.593, P = 0.474). Results: Backward logistic multi-regression analysis identified significant independent predictors of re-detachment (P < 0.01, Hosmer-Lemeshow, χ2: 7.593, P = 0.474): Duration of detachment and preoperative visual acuity. Specifically, for every day more of duration of detachment, the odds of re-detachment increased by a factor of 1.007 (P < 0.01). Likewise, for every day more of duration of detachment, the odds of re-detachment was increased by a factor of 8.840 if a preoperative visual acuity of hand motion with bad projection (HMBP) or worse was present (P = 0.05). Conclusions: We concluded that prophylactic intraoperative 360° laser retinopexy did not have a statistically significant role in the prevention of retinal re-detachment after primary retinal repair. The statistically significant preoperative risk factors that have a poor prognostic effect on surgical outcomes are preoperative visual acuity of ≤ HMBP or worse and a longer duration of the retinal detachment.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115089095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Endogenous endophthalmitis following prolong use of methotrexate 长期使用甲氨蝶呤引起内源性眼内炎

Egyptian Retina Journal Pub Date : 2015-01-01 DOI: 10.4103/2347-5617.179350

Vishal Katiyar, Ankur Yadav, Prateep Phadikar, S. Gupta

{"title":"Endogenous endophthalmitis following prolong use of methotrexate","authors":"Vishal Katiyar, Ankur Yadav, Prateep Phadikar, S. Gupta","doi":"10.4103/2347-5617.179350","DOIUrl":"https://doi.org/10.4103/2347-5617.179350","url":null,"abstract":"A 46 yr old male presented to us with a 2 day history of pain, redness and discharge in left eye. The patient was on oral Methotrexate (12.5 mg) weekly with folic acid supplement for the last 1 year for recurrent Uveitis (LE). There was a history of three previous episodes of acute anterior uveitis in left eye 2 years back for which he was prescribed oral steroids. The uveitis attack use to flare up on tapering the steroids. In the hope to reduce the recurrences and to prevent long-term complications, the patient was shifted to oral methotrexate (12.5 mg) weekly with folic acid supplementation. On the basis of clinical examination and B- scan a presumptive diagnosis of endogenous endophthalmitis was made. Vitreous tap revealed a straw colored sample and the culture subsequently grew methicillin sensitive Staphylococcus epidermidis. Intravitreal injection of (Piperacillin+Tazobactum) 225 microgram in 0.1 ml was administered. In addition, intravenous (piperacillin+tazobactum) 4.5 gram BD was given for 3 days. Post intra vitreal injection the symtoms and signs resolved remarkably. Methotrexate has not been previously implicated with endogenous endophthalmitis. Besides, Endogenous endophthalmitis is an ongoing diagnostic and therapeutic dilemma for ophthalmologists as it is relatively rare and often presents like uveitis. It requires a high index of suspicion for prompt diagnosis and treatment. The treatment of EE is still controversial due to a lack of clinical trials. Future large group studies need to be done for validation of the above therapeutic regime.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129612880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of matrix metalloproteinases in retinal pigment epithelial cell-induced gel contraction and collapse 基质金属蛋白酶在视网膜色素上皮细胞诱导的凝胶收缩和塌陷中的作用

Egyptian Retina Journal Pub Date : 2015-01-01 DOI: 10.4103/2347-5617.179345

U. Shalaby, A. Saeed, M. Farid

{"title":"The role of matrix metalloproteinases in retinal pigment epithelial cell-induced gel contraction and collapse","authors":"U. Shalaby, A. Saeed, M. Farid","doi":"10.4103/2347-5617.179345","DOIUrl":"https://doi.org/10.4103/2347-5617.179345","url":null,"abstract":"Purpose: To determine the role of matrix metalloproteinases (MMP)-1, -2, and -9 in directing the behavior of human retinal pigment epithelial (HRPE) cells during contraction of three-dimensional collagen gels. Materials and Methods: The effect of HRPE cells on collagen gel invasion and contraction were quantified by using phase contrast microscopy. Immunohistochemistry of the gel using monoclonal antibodies against MMP-1, -2, and -9 was performed. The effects of MMP inhibitor, Batimastat (BB-94) on cultured HRPE cells, and gel contraction were observed. Results: HRPE cells mostly proliferated as sheets of cells on the surface of the collagen gel and only minimally invaded the gel. However, some HRPE cells were seen to invade the gel as single cells detaching from the surface sheets. Surface-located sheets of cells exerted a dose-dependent contraction on the gel and generally failed to express MMPs. Single cells invading the gel expressed MMP-2 and -9. No expression of MMP-1 was observed by HRPE cells. BB-94, at a dose of 500 nM and 5 μM, reduced the amount of gel contraction. Conclusions: These data indicate that MMPs are selectively involved in HRPE invasion and collagen gel contraction. Both these processes may be implicated in the pathogenesis of similar conditions in vivo in which contraction of collagen gel is a feature, for example, proliferative vitreoretinopathy.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124859611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Optical coherence tomogram and demographic profile in central retinal artery occlusion: A South Indian study 视网膜中央动脉闭塞的光学相干断层扫描和人口统计学特征:一项南印度研究

Egyptian Retina Journal Pub Date : 2015-01-01 DOI: 10.4103/2347-5617.179340

Y. Shilpa, B. Kalpana, Mohammed Sadiqulla

{"title":"Optical coherence tomogram and demographic profile in central retinal artery occlusion: A South Indian study","authors":"Y. Shilpa, B. Kalpana, Mohammed Sadiqulla","doi":"10.4103/2347-5617.179340","DOIUrl":"https://doi.org/10.4103/2347-5617.179340","url":null,"abstract":"Aim: To describe the demographic profile and optical coherence tomography (OCT) findings in patients with central retinal artery occlusion (CRAO). Materials and Methods: Thirty-eight patients with CRAO who presented to Vitreo Retina Department at Minto Ophthalmic Hospital between January 2009 and December 2013 were studied. All the patients underwent detailed ophthalmic examination including OCT and routine laboratory investigations. All patients were subjected to cardiac evaluation. Results: In our study, 27 (71%) were males and 11 (29%) were females. The average age of our patients was 44.8 years (range 25-65 years). Seven patients had diabetes, and six had hypertension. Seven (18%) patients had CRAO with sparing of the cilioretinal artery. History of smoking was present in 15 (56%) of males with an average duration of 16.9 years. OCT showed average central macular thickness of 288.2 mm in acute stage and 163.75 mm in chronic stage. Conclusion: CRAO had varying etiologies but had similar clinical findings and OCT features. In our study, smoking was found to be the most common association in males. CRAO was also seen in younger age groups too. In all cases, OCT in acute stage shows increased reflectivity of inner retina and a hyporeflective band and in chronic stage thinning of sensory retinal layer. OCT findings were similar irrespective of the etiology.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116973899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Unilateral acute angle-closure glaucoma as an unusual presentation of Vogt–Koyanagi–Harada disease: A diagnostic challenge 单侧急性闭角型青光眼作为Vogt-Koyanagi-Harada病的一种不寻常的表现:一个诊断挑战

Egyptian Retina Journal Pub Date : 2014-09-01 DOI: 10.4103/2347-5617.164630

M. Shousha, R. Amin

引用次数: 1

An interesting case of "bear track dystrophy" 一个有趣的“熊径营养不良”案例

Egyptian Retina Journal Pub Date : 2014-09-01 DOI: 10.4103/2347-5617.164632

Avinash Mishra, S. Aggarwal, Sonal S Shah, Puja Negi

引用次数: 1

Relation of ocular fundus changes with blood pressure and proteinuria in pregnancy induced hypertension 妊高征患者眼底变化与血压、蛋白尿的关系

Egyptian Retina Journal Pub Date : 2014-09-01 DOI: 10.4103/2347-5617.164631

A. Bhandari, S. Bangal, D. Padghan, P. Gogri

{"title":"Relation of ocular fundus changes with blood pressure and proteinuria in pregnancy induced hypertension","authors":"A. Bhandari, S. Bangal, D. Padghan, P. Gogri","doi":"10.4103/2347-5617.164631","DOIUrl":"https://doi.org/10.4103/2347-5617.164631","url":null,"abstract":"Context: Pregnancy induced hypertension (PIH) is defined as hypertensive disorder of pregnancy, which occurs in the absence of other causes of elevated blood pressure (BP) and is associated with pedal edema, proteinuria or both. Aims: To evaluate the ocular fundus changes and its relation with the severity of proteinuria and BP in PIH patients. Settings and Design: Hospital based prospective observational study. Subjects and Methods: Study conducted over a period of 2 years. A total 100 patients of pregnancy having preeclampsia and eclampsia were included. Statistical Analysis Used: Chi-square test. Results: Of 100 cases 32 (32%) had mild preeclampsia while 50 (50%) had severe preeclampsia. Eighteen (18%) patients had eclampsia. All cases had proteinuria of varying degree ranging from 1+ to 4+. Forty-four cases (44%) had retinal changes. Cases with severe proteinuria and higher BP had more severe grades of retinopathy. Conclusions: Examination of fundus by ophthalmoscope is simple, noninvasive, safe, and reliable procedure, which can be done in out-patient department or at bedside. It should be done routinely in all patients of PIH. It is the BP, systolic and diastolic to which the severity of the retinal changes was found to be directly proportional. Higher grades of proteinuria were associated with higher grades of retinal changes.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125181164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Unusual occurrence of central serous retinopathy after head injury 颅脑损伤后中枢性浆液性视网膜病变的罕见发生

Egyptian Retina Journal Pub Date : 2014-09-01 DOI: 10.4103/2347-5617.164635

S. Deshpande, M. Deshpande, Neha Dhiware

引用次数: 1

Trabeculectomy with augmented adjunctive mitomycin-C and bevacizumab for persistent silicone oil induced glaucoma 增强辅助丝裂霉素c和贝伐单抗治疗持续性硅油性青光眼的小梁切除术

Egyptian Retina Journal Pub Date : 2014-09-01 DOI: 10.4103/2347-5617.164634

A. Saeed, U. Shalaby, M. Farid

{"title":"Trabeculectomy with augmented adjunctive mitomycin-C and bevacizumab for persistent silicone oil induced glaucoma","authors":"A. Saeed, U. Shalaby, M. Farid","doi":"10.4103/2347-5617.164634","DOIUrl":"https://doi.org/10.4103/2347-5617.164634","url":null,"abstract":"Purpose: Was to provide a solution to the problem of persistent silicone oil induced glaucoma (SOIG), which represents a common type of intractable glaucoma that usually adds to the hazards of complicated vitreoretinal surgeries. The trial aimed to evaluate the efficacy and safety of an augmented adjunctive approach of various lines combined with surgical glaucoma treatment. Patients and Methods: Twenty-four eyes of 24 patients presented with SOIG were included in this interventional case series clinical trial. All eyes underwent trabeculectomy with intraoperative mitomycin-C (MMC) application plus bevacizumab injection (1.25 mg) together with early postoperative topical MMC drops (0.03 mg/ml). The main outcome results included the cumulative probability of surgical success, intraocular pressure (IOP) values, number of anti-glaucoma drugs needed, corrected distance visual acuity, any reported complication or additional intervention. Results: This combined approach achieved a cumulative probability of success of 0.765 at the end of the 24 months study period and was in a range of 0.883 at 2 weeks and 0.647 at 6 months. Complete success was achieved in a range of 82.4% at 2 weeks and 35.3% at 18 and 24 months. There were always highly statistically significant decreases in the mean IOP values and numbers of the given IOP-lowering drugs at all postoperative time points (P was always <0.001). All complications were controlled with no major drawbacks. No significant adverse effects were caused by this combined approach. Conclusion: The combined approach could present an efficient, safe, familiar, and applicable treatment strategy for the treatment of persistent SOIG. It can provide a favorable long-term outcome representing a simple solution to the problem of persistent SOIG, which represents a challenging type of refractory glaucoma.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128513148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0