Egyptian Retina Journal最新文献_第5页

Evaluation of erythropoietin level in vitreous and serum with detection of erythropoietin gene polymorphism in Egyptian patients with proliferative diabetic retinopathy 埃及增殖性糖尿病视网膜病变患者玻璃体及血清促红细胞生成素水平及促红细胞生成素基因多态性检测

Egyptian Retina Journal Pub Date : 2017-05-01 DOI: 10.4103/erj.erj_16_17

T. Moustafa, M. Aly, Zakia Abu-Zahab, R. Shahien

{"title":"Evaluation of erythropoietin level in vitreous and serum with detection of erythropoietin gene polymorphism in Egyptian patients with proliferative diabetic retinopathy","authors":"T. Moustafa, M. Aly, Zakia Abu-Zahab, R. Shahien","doi":"10.4103/erj.erj_16_17","DOIUrl":"https://doi.org/10.4103/erj.erj_16_17","url":null,"abstract":"Purpose: To measure erythropoietin (EPO) level in vitreous and serum of patients with proliferative diabetic retinopathy (PDR) and to detect EPO single nucleotide polymorphism (SNP) genotyping expression in them. Materials and Methods: Concentrations of EPO in vitreous and serum of twenty diabetic patients with PDR undergoing vitrectomy (PDR group) were measured by chemiluminescent immunoassay and compared with those in nondiabetic (ND) patients undergoing vitrectomy for recent retinal detachment (ND group). Genotyping of EPO gene SNP (rs551238) was performed using real-time polymerase chain reaction technique. Results: There were a significant increase in serum EPO level in PDR group than in ND group and a highly significant increase in vitreous EPO level in PDR group than in ND group. Within the PDR group, vitreous EPO level was significantly higher than its serum level; there was up to 6-fold increase in the EPO vitreous level than its serum level. EPO gene SNP rs551238 was significantly associated with PDR in Egyptian patients. Conclusion: The results of the current study suggest the involvement of EPO in the pathogenesis of PDR. Hence, augmenting vascular endothelial growth factor inhibition with the use of EPO inhibitors may provide a better outcome in PDR treatment. The detection of EPO gene SNP rs551238 in Egyptian patients with PDR may help in the identification of the genetic predisposition to diabetic retinopathy in Egyptians and so may help in prevention and early detection of susceptible candidates to PDR.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124026370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intravitreal versus posterior subtenon injection of triamcinolone acetonide in treatment of diabetic macular edema 玻璃体内注射曲安奈德治疗糖尿病性黄斑水肿对比研究

Egyptian Retina Journal Pub Date : 2017-05-01 DOI: 10.4103/erj.erj_4_17

S. Elfassi, D. Hassanein, Ramy Riad, Hany S. Hamza

{"title":"Intravitreal versus posterior subtenon injection of triamcinolone acetonide in treatment of diabetic macular edema","authors":"S. Elfassi, D. Hassanein, Ramy Riad, Hany S. Hamza","doi":"10.4103/erj.erj_4_17","DOIUrl":"https://doi.org/10.4103/erj.erj_4_17","url":null,"abstract":"Purpose: The aim of the study was to compare the efficacy and safety of intravitreal triamcinolone acetonide (IVTA) versus posterior subtenon injection of triamcinolone acetonide (PSBTA) for diabetic macular edema (DME). Materials and Methods: The study design was a prospective, interventional, randomized controlled study. Participants: The study participants were 26 patients (Thirty eyes) with DME and central subfield thickness (CST) >250 μm. Intervention: Eyes were randomly assigned to two equal groups; Group A received a single 4 mg IVTA and Group B received a 40 mg PSBTA. Four patients had bilateral DME; they received IVTA in one eye and PSBTA in another eye. Main Outcome Measures: Changes in visual acuity (VA) and CST obtained using optical coherence tomography were measured during a 3-month follow-up. Potential treatment complications were monitored including change in intraocular pressure (IOP). Results: The mean preoperative CST was 393.7 ± 93.0 μm and 351.5 ± 56.4 μm in Group A and B, respectively. Both groups showed comparable significant improvement in CST and VA at 1 and 3 months postinjection compared to preoperative values. The mean CST in Group A was 282.2 ± 65.0 μm compared to 284.0 ± 59.0 μm in Group B at 1 month (P = 0.910) and 276.3 μm ± 71.1 compared to 260.2 μm ± 63.3 at 3 months (P = 0.519). The mean VA in LogMAR in both groups at 3 months was 0.47 ± 0.23 and 0.32 ± 0.29, respectively (P = 0.142), compared to preoperative VA of 0.80 ± 0.19 and 0.68 ± 0.23, respectively. The preoperative IOP was 13.80 ± 2.07 in the IVTA group and 13.07 ± 1.83 in the PSBTA group. IOP showed significantly higher elevation in the IVTA group at 1 and 3 months (19.4 mmHg ± 1.35 and 19.0 mmHg ± 1.36) compared to the PSBTA (16.5 mmHg ± 1.40 and 16.2 mmHg ± 1.50) (P = 0.000). No eyes had IOPs >21 mmHg. Conclusions: Posterior subtenon injection of TA is a safe and valid alternative to the intravitreal injection for the treatment of DME having a comparable effect on VA and CST, yet a lower risk of IOP elevation.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"11 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114035786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A study on evaluation of bevacizumab in the management of diabetic retinopathy 贝伐单抗在糖尿病视网膜病变治疗中的评价研究

Egyptian Retina Journal Pub Date : 2017-05-01 DOI: 10.4103/erj.erj_6_17

M. Sadiq, A. Zaki, B. Rao, P. Vaasanthi, K. Thriveni, P. Prasad, J. Rudra, Faisal Imran

{"title":"A study on evaluation of bevacizumab in the management of diabetic retinopathy","authors":"M. Sadiq, A. Zaki, B. Rao, P. Vaasanthi, K. Thriveni, P. Prasad, J. Rudra, Faisal Imran","doi":"10.4103/erj.erj_6_17","DOIUrl":"https://doi.org/10.4103/erj.erj_6_17","url":null,"abstract":"Aims: The study stands to evaluate the usage of bevacizumab against diabetic retinal neovascularisation. Materials and Methods: The outcome measures of study include the determination of visual acuity and retinal cum macular thickness after bevacizumab administration. Twenty diabetic retinopathy patients were screened for bevacizumab administration and given either one or two doses of bevacizumab. Patient's visual acuity and optical tomography's results were analyzed to determine the vision, retinal, and macular thickness. Statistical Analysis Used: The numeric results were passed through analysis of variance, employing “Student's t-test” as posttest for statistically determining the numeric outcomes. Results: Within 1 month of bevacizumab administration visual acuity (distant vision, near vision, and pinhole vision) was improved to logarithm of the minimum angle of resolution (MAR) 0.63 ± 0.07 from 0.87 ± 0.12 of distant vision. Pinhole vision was improved to log MAR 0.37 ± 0.06 from 0.478 ± 0.07 and near vision was improve to log MAR 0.477 ± 0.071 from 0.528 ± 0.069, and retinal thickness was decreased to 336 ± 17.35 μm from 429 ± 30.20 μm. Mean macular thickness was improved to 363.75 ± 24.54 μm from 452.37 ± 30.99 μm. Conclusion: Hence, the off-label use of bevacizumab for the said treatment may be proven beneficial.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"299 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122825239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pars plana vitrectomy for dislocated crystalline/artificial intraocular lens: Factors predicting the visual outcome 晶状体/人工晶状体脱位玻璃体切除术:预测视力结果的因素

Egyptian Retina Journal Pub Date : 2017-05-01 DOI: 10.4103/erj.erj_16_16

Siddhartha Bose, S. Gupta, P. Kishore, Siddharth Agrawal, Vishal Katiyar, Pramod Kumar

{"title":"Pars plana vitrectomy for dislocated crystalline/artificial intraocular lens: Factors predicting the visual outcome","authors":"Siddhartha Bose, S. Gupta, P. Kishore, Siddharth Agrawal, Vishal Katiyar, Pramod Kumar","doi":"10.4103/erj.erj_16_16","DOIUrl":"https://doi.org/10.4103/erj.erj_16_16","url":null,"abstract":"Aims: This study aims to study the factors predicting the visual outcome of pars plana vitrectomy (PPV) done for dislocated crystalline or artificial intraocular lens (IOL). Settings and Design: This was a retrospective observational study. Subjects and Methods: The records of patients who underwent PPV with lens retrieval and IOL exchange or repositioning for traumatic or iatrogenic dislocation of crystalline or artificial IOL were reviewed. Pre- and post-operative visual acuity and complications were recorded. Six-month patient follow-up data were reviewed. Statistical Analysis Used: Chi-square test. Results: Final best-corrected visual acuity (BCVA) 6/60 or better was found in the majority of patients who underwent PPV within 1 year of dislocation, but for patients who were delayed for over a year, the final BCVA was <6/60 (P = 0.001). Significant correlations were found between delayed PPV and postoperative retinal detachment (RD) (P = 0.001); between PPV for dislocated nuclear fragment(s) due to complicated cataract surgery and preoperative uveitis (P = 0.007) as well as postoperative cystoid macular edema (CME) (P = 0.001); between preoperative corneal edema and postoperative corneal decompensation (P = 0.03). Finally, the final BCVA <6/60 had significant correlations with preoperative corneal edema (P = 0.001) and uveitis (P = 0.039) and with postoperative corneal decompensation (P = 0.013), CME (P = 0.001), and RD (P = 0.001). Conclusions: In cases of dislocated lens, factors such as delayed intervention, dislocated nuclear fragment(s), preoperative uveitis, and corneal edema were related to increased postoperative sight-threatening complications resulting in poorer visual outcome.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"267 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122468893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of fundus autofluorescence patterns in early dry age-related macular degeneration with best-corrected visual acuity 早期干性年龄相关性黄斑变性眼底自身荧光模式与最佳矫正视力的相关性

Egyptian Retina Journal Pub Date : 2017-05-01 DOI: 10.4103/erj.erj_7_17

A. Shaarawy, A. Bessa, MohamedA Lolah, A. Ragab

{"title":"Correlation of fundus autofluorescence patterns in early dry age-related macular degeneration with best-corrected visual acuity","authors":"A. Shaarawy, A. Bessa, MohamedA Lolah, A. Ragab","doi":"10.4103/erj.erj_7_17","DOIUrl":"https://doi.org/10.4103/erj.erj_7_17","url":null,"abstract":"Background: Correlation of abnormal fundus autofluorescence (FAF) patterns with best-corrected visual acuity (BCVA).Aim: This study aims to evaluate FAF patterns in eyes with early dry age-related macular degeneration (AMD) and correlate these patterns with logarithm of minimum angle of resolution (logMAR) BCVA. Settings and Design: Institutional, descriptive prospective cohort study. Subjects and Methods: One hundred fifty-nine eyes of 103 patients with early dry AMD were recruited. FAF imaging was done for all patients with the aid of confocal scanning laser ophthalmoscopy (cSLO). BCVA was recorded for all patients using logMAR BCVA. Statistical Analysis Used: Data were fed to the computer and analyzed using IBM SPSS software package Version 20.0 (Armonk, NY, USA: IBM Corp). Kruskal–Wallis test for abnormally quantitative variables, to compare between more than two studied groups and post hoc (Dunn's multiple comparisons test) for pairwise comparisons. The significance of the obtained results was judged at the 5% level. Results: Seven FAF patterns have been identified (normal, minimal change, focal increased, linear, patchy, reticular, and speckled pattern). The mean logMAR BCVA among eyes with different FAF patterns was significantly variable. Eyes with patchy FAF pattern had the best mean BCVA (0.15 ± 0.0), while eyes with linear FAF pattern had the worst mean BCVA (0.52). Conclusions: The mean logMAR BCVA was statistically significant variable among different FAF patterns in eyes with early AMD suggesting a possible link between each FAF pattern and the visual prognosis. This finding can aid in determining the visual potential of eyes with early AMD according to FAF pattern in large samples studies.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116506999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intravitreal bevacizumab alone or combined with macular laser for treatment of diabetic macular edema 贝伐单抗玻璃体内单独或联合黄斑激光治疗糖尿病黄斑水肿

Egyptian Retina Journal Pub Date : 2017-05-01 DOI: 10.4103/erj.erj_8_17

U. Shalaby, T. Soliman, Ayser El-Hameed Fayed

{"title":"Intravitreal bevacizumab alone or combined with macular laser for treatment of diabetic macular edema","authors":"U. Shalaby, T. Soliman, Ayser El-Hameed Fayed","doi":"10.4103/erj.erj_8_17","DOIUrl":"https://doi.org/10.4103/erj.erj_8_17","url":null,"abstract":"Purpose: We aimed to evaluate the best-corrected visual acuity (BCVA) and assess improvement of central macular thickness (CMT) in patients with diffuse diabetic macular edema (DDME) after an intravitreal injection of bevacizumab (Avastin®) alone, or followed by modified grid macular laser photocoagulation. Subjects and Methods: This was a randomized prospective interventional study that included 78 eyes of 40 patients with DDME, divided into two groups of interventions: Group A received bevacizumab (Avastin®) injections monthly for 3 months then pro re nata, and Group B received bevacizumab as Group A but followed by grid macular laser photocoagulation 2 weeks after the first injection. Patients were observed monthly for a 12-month period and their BCVA, intraocular pressure, and CMT were recorded. Results: Compared with the baseline, there was a significant decrease of CMT in both groups of patients (−138.3 ± 40.15 vs. −156.5 ± 33.47, respectively). The improvement in ME was more in the combined group than the Avastin® group (P < 0.0001). After 12-month follow-up, the mean average change in visual acuity letter score was significantly improved in both groups (P < 0.018 and < 0.002, respectively). Conclusion: Combined Avastin® and modified grid macular photocoagulation led to more stable improvement in the treatment of eyes with DDME.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128802269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Management of globe perforation: From laser to silicon oil 全球射孔管理:从激光到硅油

Egyptian Retina Journal Pub Date : 2017-05-01 DOI: 10.4103/erj.erj_10_17

B. Khan, V. Anand, M. Kashyap

{"title":"Management of globe perforation: From laser to silicon oil","authors":"B. Khan, V. Anand, M. Kashyap","doi":"10.4103/erj.erj_10_17","DOIUrl":"https://doi.org/10.4103/erj.erj_10_17","url":null,"abstract":"Purpose: To analyze clinical manifestations, management, and visual outcome in cases with globe perforation due to variable etiologies. Material and Methods: Fifty cases (35 males and 15 females) were included in the study. Out of the fifty cases, 5 cases had perforation after giving posterior subtenon's injection, 2 cases had after injecting subconjunctival gentamycin and dexamethasone, 35 cases after peribulbar anesthesia, 4 cases while taking suture during retinal detachment (RD) surgery, and 4 while making scleral tunnel in RD surgeries. A total of 41 patients underwent vitrectomy, from which 37 patients had vitrectomy with fluid–gas exchange and endolaser and 4 patients had vitrectomy with scleral buckle and silicon oil. Five patients underwent indirect argon laser photocoagulation to seal the retinal break, and in 4 cases, scleral buckle were placed and cryotherapy was done. Results: The final visual acuity after a mean follow-up of 6 months was better than 20/30–20/40 in 28 patients, between 20/40 and 20/60 in 5 patients, and 20/120–20/200 in 17 patients. Conclusion: If diagnosed early and treated adequately, a majority of patients with globe perforation could be saved with a good visual outcome.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117133246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Retinitis pigmentosa and congenital ocular toxoplasmosis: a rare coexistent case presentation 视网膜色素变性与先天性眼弓形虫病:罕见共存病例

Egyptian Retina Journal Pub Date : 2017-01-01 DOI: 10.4103/erj.erj_19_16

S. Bose, Vishal Katiyar, S. Gupta

引用次数: 1

Densiron-68 in the treatment of retinal detachment associated with inferior proliferative vitreoretinopathy or caused by lower or posterior breaks Densiron-68治疗视网膜脱离合并下增生性玻璃体视网膜病变或由下或后断裂引起的视网膜脱离

Egyptian Retina Journal Pub Date : 2017-01-01 DOI: 10.4103/erj.erj_18_16

Ayman A. Alkawas, Elsadek Maaly, Basem M. Ibrahim, M. Al-Humiari

{"title":"Densiron-68 in the treatment of retinal detachment associated with inferior proliferative vitreoretinopathy or caused by lower or posterior breaks","authors":"Ayman A. Alkawas, Elsadek Maaly, Basem M. Ibrahim, M. Al-Humiari","doi":"10.4103/erj.erj_18_16","DOIUrl":"https://doi.org/10.4103/erj.erj_18_16","url":null,"abstract":"Aim: The aim of this study is to demonstrate the efficacy and complications of heavy silicone oil (Densiron-68®) in the treatment of retinal detachment (RD) with inferior, posterior breaks, or associated with proliferative vitreoretinopathy (PVR). Materials and Methods: A prospective interventional noncomparative case series study of 25 eyes of 25 patients. Inclusion criteria were patients having RD arising from PVR, posterior breaks or inferior retinal breaks between 4 and 8 o'clock hours. Primary vitrectomy followed by Densiron-68 injection was performed for each patient. The study protocol involved at least 8 visits: 1st day, 1, 2, 3 weeks 1, 2, 3, and 6 months. Densiron-68 removal was performed after 2–3 months. The assessment of retinal attachment, visual acuity (VA), and complications were recorded. Results: Final anatomical success was 84% (21 of 25) cases which increased to 92% with second intervention. Mean final VA improved from mean logarithm of minimum angle of resolution of 1.89± (0.66) preoperatively to 1.094± (0.29) postoperatively. The most common complications were cataract in 60% of phakic eyes, and early emulsification in 32%. Conclusion: Densiron-68 could be used to support the lower retina in cases with RD associated with PVR, inferior, or posterior breaks. It gives a better tamponade to the inferior retina in the in the supine or upright positioning of the patient with high anatomical success rate.","PeriodicalId":201997,"journal":{"name":"Egyptian Retina Journal","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122945139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Near-infrared imaging of the choroid in the evaluation of neurofibromatosis 脉络膜近红外成像对神经纤维瘤病的评价

Egyptian Retina Journal Pub Date : 2017-01-01 DOI: 10.4103/2347-5617.204834

T. Lekha, Uddaraju Venkata Sai Shanthi, J. Janaki

引用次数: 0