Sumer 2Pub Date : 2023-08-15DOI: 10.21931/rb/css/2023.08.02.3
Haneen Adnan Abd, Essam Fadel Al- Jumaili
{"title":"Transcription Factor 7- Like -2 (TCF7L2) rs7903146 (C/T) polymorphism in\u0000Iraqi patients with Type 2 Diabetes Mellitus","authors":"Haneen Adnan Abd, Essam Fadel Al- Jumaili","doi":"10.21931/rb/css/2023.08.02.3","DOIUrl":"https://doi.org/10.21931/rb/css/2023.08.02.3","url":null,"abstract":"Type 2 diabetes (T2D) is a metabolic disorder that develops as different cell\u0000groups resist insulin action on peripheral tissues. Eventually, the pancreas cannot\u0000produce sufficient insulin to overcome this resistance, resulting in insulin deficiency. The transcription factor 7-like-2 gene (TCF7L2) rs7903146 (C/T) polymorphism is one of the most susceptible genes to T2DM discovered to date, with\u0000the contribution to the disease through the Wnt/β-catenin signaling pathway affecting pancreatic islet development. To investigate and analyze the correlation\u0000of TCF7L2 gene polymorphisms and their association with type 2 diabetes for\u0000Iraqi patients. This study included 80 blood samples equally divided into two\u0000groups: patients with T2DM and normal healthy controls. All Genotypes of\u0000rs7903146 (C/T) SNP in theTCF7L2 gene were evaluated by real-time polymerase chain reaction via TaqMan allelic discrimination. Analysis of the distribution\u0000of the TCF7L2 rs7903146 genotype and allele revealed that the TT genotype was\u0000more frequent in the T2DM group (32.5%) than in healthy controls (12.5%) (OR\u0000= 5.9, 95% confidence interval (CI = 1.6–20.6, p = 0.05). The T allele was more\u0000frequent in diabetic patients (52.5%) than healthy control (25%), and it was associated with high risk of diabetes (odd ratio = 3.3, 95% CI= 1.6- 6.4), P=0.0005.\u0000Conclusion: The T allele of rs7903146 polymorphism of TCF7L2 confers susceptibility to the development of T2DM in the Iraqi population.\u0000Keywords: Type 2 diabetes mellitus · Transcription factor 7-like-2 ·rs7903146\u0000polymorphism","PeriodicalId":201642,"journal":{"name":"Sumer 2","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116839063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}