Pharmazie最新文献_第3页

Application of green synthesized silver nanoparticles in Burn therapy: a review. 绿色合成银纳米粒子在烧伤治疗中的应用：综述。

IF 1.6 4区医学

Pharmazie Pub Date : 2024-05-15 DOI: 10.1691/ph.2024.3045

A A Mohammed, A A Alqahtani, M M Ahmed

{"title":"Application of green synthesized silver nanoparticles in Burn therapy: a review.","authors":"A A Mohammed, A A Alqahtani, M M Ahmed","doi":"10.1691/ph.2024.3045","DOIUrl":"https://doi.org/10.1691/ph.2024.3045","url":null,"abstract":"Silver nanoparticles (AgNPs), owing to their unusual characteristics, have been used in various pharmaceutical, cosmetic, and healthcare products. AgNPs, with their exceptional biological potential, exhibit antibacterial, antifungal, antiviral, anti-inflammatory, anticancer, and wound healing properties and have been extensively used in burn therapy. Several studies have established the use of silver nanoparticles in the treatment of burn injuries, resulting in reduced inflammation, quick tissue regeneration, and the remarkable creation of collagen fibers. Conventional physical and chemical techniques have synthesized AgNPs, but they appear to be highly costly and hazardous. Recently, there has been considerable interest in the synthesis of AgNPs using the green chemistry approach because of its tremendous benefits, including being non-toxic, low energy consumption, pollution-free, economical, environmentally friendly, and more sustainable. This review emphasizes the green synthesis of AgNPs using bacteria, fungi, plants, and other microorganisms and the current research related to the application of green synthesized AgNPs in burn therapy, including the biological aspects of AgNPs, their mode of action, and any possible detrimental effects.","PeriodicalId":20145,"journal":{"name":"Pharmazie","volume":"79 3","pages":"42-48"},"PeriodicalIF":1.6,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic activity of liposomal Thymus capitatus essential oil on HT-29 human colorectal cancer cell line. 脂质体百里香精油对 HT-29 人类结直肠癌细胞系的细胞毒活性

IF 1.6 4区医学

Pharmazie Pub Date : 2024-05-15 DOI: 10.1691/ph.2024.3037

T Kryeziu, U Bağci, A Loshaj-Shala, A Oral, G J Stefkov, A Zimmer, M Basholli-Salihu

{"title":"Cytotoxic activity of liposomal Thymus capitatus essential oil on HT-29 human colorectal cancer cell line.","authors":"T Kryeziu, U Bağci, A Loshaj-Shala, A Oral, G J Stefkov, A Zimmer, M Basholli-Salihu","doi":"10.1691/ph.2024.3037","DOIUrl":"https://doi.org/10.1691/ph.2024.3037","url":null,"abstract":"Multidrug resistance, severe side effects, and high cancer treatment costs are still well-known issues and remain an open challenge. These factors reduce the therapy's efficiency and safety, seriously affecting human health. Developing therapeutic approaches based on plant extracts, especially based on essential oils with cytotoxic and antioxidant properties, could be of efficacious strategies. This work incorporated Thymus capitatus essential oil (TEO) in liposomes. Thymus capitatus is a plant native to the northern region of Albania and found specifically in the Mediterranean region. TEO has several biological activities and cytotoxic properties. Due to its volatility, poor solubility, and chemical instability, however, its applicability is restricted. Incorporation into liposomes enables its effective use because the exposure time to the active compounds can be extended, increasing its efficacy against colorectal cancer cell lines, as highlighted in in vitro studies. TEO demonstrated detectable cytotoxic action against HT-29 colorectal cancer cells, and this action could be enhanced by applying various formulations of TEO-loaded liposomes to this cell line. Among the tested nanosystems, TEO-Phospholipon 90H liposomes showed more significant cytotoxic effects than TEO-Lipoid S100 liposomes and TEO-Phospholipon 85G liposomes. TEO-Phospholipon 90 H liposomes also maintained its physicochemical stability for six months at 25 °C. This research suggests that TEO, particularly when encapsulated in TEO-Phospholipon 90 H liposomes, may offer a promising therapeutic approach. However, these findings are based on in vitro studies and further in vivo research is needed to validate the efficacy and safety of this approach in clinical settings.","PeriodicalId":20145,"journal":{"name":"Pharmazie","volume":"79 3","pages":"49-56"},"PeriodicalIF":1.6,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurite outgrowth promotion in PC12 cells by 24(R)-ethyllophenol from Morus alba. 桑叶中的 24(R)-ethyllophenol 对 PC12 细胞神经元生长的促进作用

IF 1.5 4区医学

Pharmazie Pub Date : 2024-05-15 DOI: 10.1691/ph.2024.3656

S Honma, K Handa, R Mitsumata, D Shimada, S Takei, G Tanaka, K Watanabe, M Yoshida

引用次数: 0

Direct comparison of anti-inflammatory effects of 14-, 15-, and 16-membered macrolide antibiotics in experimental inflammation model induced by carrageenan in rats. 直接比较 14、15 和 16 元大环内酯类抗生素在卡拉胶诱导的大鼠实验性炎症模型中的抗炎作用。

IF 1.6 4区医学

Pharmazie Pub Date : 2024-05-15 DOI: 10.1691/ph.2024.3667

K Taguchi, V T G Chuang, H Ogino, R Hara, O Iketani, Y Enoki, J Kizu, S Hori, K Matsumoto

{"title":"Direct comparison of anti-inflammatory effects of 14-, 15-, and 16-membered macrolide antibiotics in experimental inflammation model induced by carrageenan in rats.","authors":"K Taguchi, V T G Chuang, H Ogino, R Hara, O Iketani, Y Enoki, J Kizu, S Hori, K Matsumoto","doi":"10.1691/ph.2024.3667","DOIUrl":"https://doi.org/10.1691/ph.2024.3667","url":null,"abstract":"Some macrolide antibiotics, which share a basic lactone ring structure, also exhibit anti-inflammatory actions in addition to their antibacterial activities. However, no study has directly compared anti-inflammatory effects on acute inflammation among macrolide antibiotics with the distinct size of the lactone ring. In this study, we evaluated and compared the anti-inflammatory activities of four 14-membered macrolides (erythromycin, clarithromycin, roxithromycin, oleandomycin), one 15-membered macrolide (azithromycin), and three 16-membered macrolides (midecamycin, josamycin, leucomycin) using a rat carrageenan-induced footpad edema model. All macrolide antibiotics were intraperitoneally administered to rats one hour before the induction of inflammatory edema with 1% λ -carrageenan. The anti-inflammatory effects on acute inflammation were evaluated by changing the edema volume. All 14-membered and 15-membered macrolide antibiotics significantly suppressed the development of edema. Conversely, none of the 16-membered macrolide antibiotics inhibited the growth of edema. In conclusion, compared to 16-membered macrolide antibiotics, 14-membered and 15-membered macrolide antibiotics have stronger anti-inflammatory effects. Further research should be done to determine why different lactone ring sizes should have distinct anti-inflammatory effects.","PeriodicalId":20145,"journal":{"name":"Pharmazie","volume":"79 3","pages":"64-66"},"PeriodicalIF":1.6,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of care transfer model led by the hospital clinical pharmacist on reduction of hospital readmissions in the elderly. 由医院临床药剂师主导的护理转移模式对减少老年人再住院率的影响。

IF 1.5 4区医学

Pharmazie Pub Date : 2024-05-15 DOI: 10.1691/ph.2024.3666

I Marinović, V Baćićrca, S Marušić, I Grgurević, M Brkić, N Jambrek, J Mesarić, I Samardžić

{"title":"Effect of care transfer model led by the hospital clinical pharmacist on reduction of hospital readmissions in the elderly.","authors":"I Marinović, V Baćićrca, S Marušić, I Grgurević, M Brkić, N Jambrek, J Mesarić, I Samardžić","doi":"10.1691/ph.2024.3666","DOIUrl":"10.1691/ph.2024.3666","url":null,"abstract":"Transfer of care is a critical point for patient safety and requires an optimal care transfer model in order to ensure safe pharmacotherapy transfer. Polypharmacy among elderly is associated with adverse health consequences such as hospital readmissions. Hospital readmissions represent priorities in health care research and are one of the measures for assessing patient safety. Medication-related problems among elderly are associated with polypharmacy. The aim of the study was to show the impact of a developed model of care transfer led by a hospital clinical pharmacist on the number of hospital readmissions in the 12-months period in the elderly. A randomized controlled study of patients aged 65 or more was conducted at Dubrava University Hospital, Community Health Centre Zagreb - East and community pharmacies in the City of Zagreb and Zagreb County, Croatia. An intervention group received specially designed care transfer led by the hospital clinical pharmacist. Model included high-intensity pharmacotherapy interventions delivered at admission, during hospital stay and discharge, transition to primary care and post-discharge and cooperation between all healthcare professionals. In all, 182 patients in the intervention and 171 in the control group were analysed. The total number of hospital readmissions and emergency readmissions, within one year from the hospital discharge, was lower in the intervention group than in the control group (41.7% vs. 58.3%, p=0.005; 40.8% vs. 59.2%, p=0.008). The model of the health care transfer applied in this research thus significantly reduced hospital readmissions in the 1-year period in elderly patients. Therefore, the hospital clinical pharmacists should design and coordinate the transfer between hospital and primary care.","PeriodicalId":20145,"journal":{"name":"Pharmazie","volume":"79 3","pages":"91-96"},"PeriodicalIF":1.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An anti-inflammatory active ingredients in Poriae cutis: Screening based on network pharmacology. 茯苓中的抗炎活性成分：基于网络药理学的筛选

IF 1.6 4区医学

Pharmazie Pub Date : 2024-05-15 DOI: 10.1691/ph.2024.3647

Runze Jin, Zitong Zhao, Qing Zhang, Y U Sun, Wei Wang, Daiyin Peng, Sihui Nian, Lingyun Zhou

引用次数: 0

Quality evaluation of highly purified human menopausal gonadotropin preparations by means of gel electrophoresis and mass spectrometry. 通过凝胶电泳和质谱法对高度纯化的人类绝经期促性腺激素制剂进行质量评估。

IF 1.5 4区医学

Pharmazie Pub Date : 2024-05-15 DOI: 10.1691/ph.2024.4003

L Muqaku, V Dorrer, M Noe, C R Noe, D Nebija

{"title":"Quality evaluation of highly purified human menopausal gonadotropin preparations by means of gel electrophoresis and mass spectrometry.","authors":"L Muqaku, V Dorrer, M Noe, C R Noe, D Nebija","doi":"10.1691/ph.2024.4003","DOIUrl":"10.1691/ph.2024.4003","url":null,"abstract":"Human gonadotropins are glycoprotein hormones with a highly complex structure, which demands the application of sophisticated analytical methodologies to assess their quality. The principal objective of this study was a comparative evaluation of gel electrophoretic techniques and mass spectrometry-based methods for the quality study of the two urinary-derived, highly purified, human menopausal gonadotropin preparations, Menopur 75/75 I. U. and Meriofert 75 I. U. Molecular mass (Mr), isoelectric point (pI), and isoform pattern of studied compounds were estimated via SDS-PAGE and 2D gel electrophoresis, whereas matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used for the downstream characterization of peptides obtained after in-gel tryptic digestion of selected protein spots. Additionally, for the estimation of the glycosylation pattern of these biologics, the enzymatic release of oligosaccharides was performed, and the isoform pattern was studied. Gel electrophoresis showed a typical electrophoretic behaviour for protein biotherapeutics medicines consisting of extremely complex spot patterns migrating at different masses and pIs. MS analysis proved to be a powerful tool for the identification and detailed characterization of the gonadotropins and the relevant peptides were identified with high sequence coverages. The results of this study are not only useful for the quality assessment of this class of complex biopharmaceuticals but may also serve as a supporting platform for further development of biopharmaceuticals based on modulation of the glycosylation pattern to enhance efficacy or reduce side effects.","PeriodicalId":20145,"journal":{"name":"Pharmazie","volume":"79 3","pages":"57-63"},"PeriodicalIF":1.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatase and rutile titanium oxide nanoparticles induce acute kidney injury by coadministration with paraquat, cisplatin or 5-aminosalicylic acid. 与百草枯、顺铂或 5-氨基水杨酸同时服用，钝钛和金红石氧化钛纳米颗粒会诱发急性肾损伤。

IF 1.6 4区医学

Pharmazie Pub Date : 2024-02-29 DOI: 10.1691/ph.2024.3655

H Kamiyama, C Nonaka, H Saitoh, M Ohno, Y Shimizu, K Isoda

{"title":"Anatase and rutile titanium oxide nanoparticles induce acute kidney injury by coadministration with paraquat, cisplatin or 5-aminosalicylic acid.","authors":"H Kamiyama, C Nonaka, H Saitoh, M Ohno, Y Shimizu, K Isoda","doi":"10.1691/ph.2024.3655","DOIUrl":"10.1691/ph.2024.3655","url":null,"abstract":"Nanoparticles are used in a variety of fields; for example, titanium oxide nanoparticles are used in paints, food additives, cosmetics, and sunscreen materials. Although the use of titanium oxide nanoparticles is regulated, their safety has not been established. Furthermore, the interaction between titanium oxide nanoparticles and various chemical substances and pharmaceuticals is unknown. We co-administered rutile-type titanium oxide nanoparticles (nTR) or anatase-type titanium oxide nanoparticles (nTA) to mice together with paraquat (PQ), cisplatin (CDDP), or anti-5-aminosalicylic acid (5-ASA), and investigated the extent, if any, of liver and kidney injury. As a result, when nTA and nTR were administered alone, no increases were observed in aspartate aminotransferase (AST) and alanine aminotransferase (ALT), which are indicators of liver damage, or urea nitrogen (BUN), which is an indicator of kidney damage. Next, nTA and nTR were co-administered with PQ, CDDP or 5-ASA. Although no increase in ALT or AST was observed, BUN levels increased significantly and acute kidney injury was induced. The findings suggested that titanium oxide nanoparticles induce acute kidney injury through their interaction with chemicals and drugs.","PeriodicalId":20145,"journal":{"name":"Pharmazie","volume":"79 1","pages":"2-5"},"PeriodicalIF":1.6,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Physalis peruviana L. (leaf crude extracts) on blood glucose and functional biomarkers in streptozotocin-nicotinamide-induced diabetic rats. Physalis peruviana L.（叶粗提取物）对链脲佐菌素-烟酰胺诱导的糖尿病大鼠血糖和功能性生物标志物的影响。

IF 1.6 4区医学

Pharmazie Pub Date : 2024-02-29 DOI: 10.1691/ph.2024.3640

F M Kasali, J N Kadima, J B Safari, A G Agaba, J Tusiimire, B A Witika

{"title":"Effects of Physalis peruviana L. (leaf crude extracts) on blood glucose and functional biomarkers in streptozotocin-nicotinamide-induced diabetic rats.","authors":"F M Kasali, J N Kadima, J B Safari, A G Agaba, J Tusiimire, B A Witika","doi":"10.1691/ph.2024.3640","DOIUrl":"10.1691/ph.2024.3640","url":null,"abstract":"Promoting antidiabetic phytomedicines necessitates evidence-based preclinical investigations, particularly in animal models. The present study investigated the validity of using the streptozotocin-nicotinamide-induced type 2 diabetic (STZ/NA-induced T2DM) model to evaluate the effects of Physalis peruviana leaf crude extracts on controlling blood glucose levels and regulating physiological biomarkers in rats. Aqueous and methanol extracts dissolved in carboxymethylcellulose 1% (100, 200, mg/kg/day) were administered orally to STZ/NA-induced T2DM rats alongside glibenclamide (5 mg/kg) as the standard drug for four weeks. Blood samples were collected in fasting rats on days 1, 7, 14, 21, and 28 to measure glucose concentration, lipoprotein-cholesterol, and common serum biomarkers. Nutrition characteristics were also monitored, as well as the pancreas histology. Administration of STZ/NA in Wistar rats induced the T2DM significantly lower than did STZ alone (glycaemia 200 vs 400 mg/dL). The significant effects observed with plant extracts compared to untreated diabetic rats were blood glucose reduction (28-52 %), HDL-C increase, LDL-C decrease, ALAT increase, WBC increase, body weight gain (24%), and pancreas protection. The findings confirm the antidiabetic effect of P. peruviana in T2DM animal model.","PeriodicalId":20145,"journal":{"name":"Pharmazie","volume":"79 1","pages":"6-10"},"PeriodicalIF":1.6,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A clinical-pharmaceutical medication reconciliation with patient interview for a medication review to identify drug-related problems in elective patients during hospital admission. 在入院期间对择期住院病人进行用药检查时，采用临床-药物用药核对和病人访谈的方法，以发现与用药相关的问题。

IF 1.6 4区医学

Pharmazie Pub Date : 2024-02-29 DOI: 10.1691/ph.2024.3660

E-M Schmidt, M Oetting, A Spiegel, O Zube, T Bertsche

{"title":"A clinical-pharmaceutical medication reconciliation with patient interview for a medication review to identify drug-related problems in elective patients during hospital admission.","authors":"E-M Schmidt, M Oetting, A Spiegel, O Zube, T Bertsche","doi":"10.1691/ph.2024.3660","DOIUrl":"10.1691/ph.2024.3660","url":null,"abstract":"Background and aim: Drug-related problems (DRPs), e.g.drug-drug interactions (DDI), can lead to adversedrug reactions (ADRs) and thus complications during hospitalization. For this reason, such DRP, DDI and ADR should be identified and characterized as early as possible during hospital admission. We aimed to perform a clinical-pharmaceutical medication reconciliation in which patient-related information was collected and compared to drug-related information in a medication review. Investigations: During a 24-week-period, we consecutively invited patients electively admitted to Urology, Otolaryngology, Oral and Maxillofacial Surgery, General and Visceral Surgery, and Oncology Departments of a 300-bed hospital. A clinical pharmacist performed a patient interview asking for medication, ADR, and adherence. The medication reconciliation considered packages for a brown-bag analysis, medication lists, and data from the clinical information-system (CIS). In a medication review, we matched patient-related information to drug-related information from the drug label, guidelines, drug-databases and websites to identify DRPs. Results: In the study, 356 patients (median age: 58 years) taking 1,712 drugs participated. Of all patients, 7.3% reported ADR and 10.7% missing adherence. 5.3% brought packages that enabled a brown-bag analysis and 21.1% a medication list. In 76.7% of patients, information from CIS was incomplete or not up-to-date. Among the most frequently identified DRPs were \"Medication without diagnosis\" (31.2%) and \"Inappropriate timing of administration\" (11.5%). The proportion of patients affected by severe DDI ranged from 0.8%-16.6%, depending on the drug information source. Conclusions: Incomplete patient data, frequently identified DRPs and inconsistent drug-based information make pharmaceutical involvement in medication reconciliation on admission a necessity.","PeriodicalId":20145,"journal":{"name":"Pharmazie","volume":"79 1","pages":"35-40"},"PeriodicalIF":1.6,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0