Joseph A Ward, Thomas Calderbank, Chee Chee Tang, Naveen V Goddard, Fiona A MacNeill, Marios K Tasoulis, Aadil A Khan
{"title":"Estimating the Prevalence of Breast Implant-Associated Anaplastic Large-Cell Lymphoma: A Systematic Review.","authors":"Joseph A Ward, Thomas Calderbank, Chee Chee Tang, Naveen V Goddard, Fiona A MacNeill, Marios K Tasoulis, Aadil A Khan","doi":"10.1097/PRS.0000000000011768","DOIUrl":"10.1097/PRS.0000000000011768","url":null,"abstract":"<p><strong>Background: </strong>Assessment of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) prevalence is challenged by a lack of population-level data for the prevalence of breast implants in the wider population. Absence of such data obscures the true prevalence of BIA-ALCL and hinders informed consent consultations. The authors performed a systematic review to synthesize data from published studies reporting BIA-ALCL cases in defined patient populations to better inform the evidence base.</p><p><strong>Methods: </strong>PubMed and Embase were searched to obtain studies reporting the prevalence of BIA-ALCL in defined patient cohorts with breast implants where case prevalence was calculable. Study characteristics, the number of BIA-ALCL cases, and total sample size were extracted and used to calculate the prevalence of BIA-ALCL per 100,000 implanted patients.</p><p><strong>Results: </strong>Of 1477 publications identified by the search, 38 studies incorporating 28 cohort and 6 registry studies satisfied the inclusion criteria, encompassing a total population sample of 17,038,371 patients and 1170 BIA-ALCL cases. The prevalence of BIA-ALCL was found to be 30.54 per 100,000 implanted patients with textured implants (1 case per 3274 implanted patients) and 6.70 per 100,000 implanted patients with implants of any type (1 case per 14,925 implanted patients).</p><p><strong>Conclusions: </strong>By synthesizing the published literature, this work provides a determination of BIA-ALCL prevalence using study- and population-level data where the prevalence of breast implants is known. The accurate determination of BIA-ALCL prevalence is of fundamental importance for patients undergoing implant-related surgery to enable the provision of valid informed consent.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"660e-669e"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ofir Ron, Idan Farber, Meir Retchkiman, Dor Halpern, Alexander Cohen, Sam Cohen, Yaron Shoham, Yuval Krieger, Eldad Silberstein
{"title":"Aplasia Cutis: From Diagnosis to Management- Two Decades of Clinical Insights.","authors":"Ofir Ron, Idan Farber, Meir Retchkiman, Dor Halpern, Alexander Cohen, Sam Cohen, Yaron Shoham, Yuval Krieger, Eldad Silberstein","doi":"10.1097/PRS.0000000000012138","DOIUrl":"https://doi.org/10.1097/PRS.0000000000012138","url":null,"abstract":"<p><strong>Background: </strong>Aplasia Cutis Congenita (ACC) causes local skin absence, usually on the scalp, with a potential underlying skin layer involvement. It carries severe risks, including hemorrhage and a 20-55% mortality rate. Despite various classification systems, a validated treatment algorithm is lacking. This study validates a novel classification-guided treatment approach for ACC that has been used over the past two decades.</p><p><strong>Methods: </strong>A retrospective analysis of ACC cases at Soroka University Medical Center (2000-2024) was conducted. Patients were classified based on defect size, tissue involvement, and vascular exposure. Characteristics, treatment, outcomes, and mortality rates before and after implementing our classification-guided approach were investigated.</p><p><strong>Results: </strong>77 ACC cases were evaluated over 24 years. The scalp was affected in 96.1% of cases, with defect size ranging between 0.25 and 150 cm2. Surgical intervention was performed in 18.2% of cases. Limb anomalies were present in 20.8% of cases, with prevalence increasing with an increase of defect severity (P = 0.001). Adam-Oliver syndrome was diagnosed in 10.4% of patients. The mortality rate decreased from 37.5% (3/8) pre-2008 to 0% (0/22) post-2008 in the high-risk group (P = 0.017). All deaths occurred in Type III patients due to massive hemorrhage following delayed surgical intervention. Integra® dermal regeneration template was used successfully as an effective single-stage treatment for some extensive defects.</p><p><strong>Conclusions: </strong>Our classification-guided treatment approach has improved ACC outcomes in high-risk cases. Immediate surgical intervention for severe cases has significantly reduced mortality.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harrison D Davis, Daniel Mazzaferro, Theodore E Habarth-Morales, Charles A Messa, Ankoor A Talwar, Abhishek A Desai, Phoebe B McAuliffe, Robyn B Broach, Joseph M Serletti, Ivona Percec
{"title":"A Large Prospective Volumetric and Patient-Reported Outcome Analysis Of Hyaluronic Acid Fillers to the Face.","authors":"Harrison D Davis, Daniel Mazzaferro, Theodore E Habarth-Morales, Charles A Messa, Ankoor A Talwar, Abhishek A Desai, Phoebe B McAuliffe, Robyn B Broach, Joseph M Serletti, Ivona Percec","doi":"10.1097/PRS.0000000000012135","DOIUrl":"https://doi.org/10.1097/PRS.0000000000012135","url":null,"abstract":"<p><strong>Background: </strong>Hyaluronic acid (HA) facial fillers are a non-surgical treatment for age-related changes. Literature on long-term volumetric results and patient-reported outcomes (PROs) is limited. This prospective study aims to precisely define and measure objective tissue metrics and PROs of HA fillers in different facial regions over 12 weeks.</p><p><strong>Methods: </strong>Females aged 40 to 65 received injections in facial regions using HA fillers: Restylane-L® in nasolabial folds and marionette lines, Restylane-L Lyft® in the malars, and Restylane Silk® in the lip border. Patients completed FACE-Q® questionnaires, were photographed with 3D Vectra® M3 Imaging Software pre-injection, immediately post-injection, and at 2-, 4-, and 12-weeks post-injection. Volumes were analyzed from eight regions: left, right malars and extended midface (MEM), upper perioral (UP), lower perioral and jawline (LPJ), and lips. Tissue displacement factor (TDF) and effective volume (EV) were calculated. Statistical analyses included Mann Whitney U tests and risk-adjusted linear regression.</p><p><strong>Results: </strong>101 women participated. Restylane-L Lyft® had the highest TDF, 1.25, followed by Restylane-L®, 1.14, and Restylane Silk®, 0.56. EV for Restylane-L Lyft® was highest, 89.8%, followed by Restylane-L®, 89.7%, and Restylane Silk®, 70%. Volume maintenance was 65.5% (whole face), 79.2% (MEM), 62.7% (UP), and 37.2% (lips) over 12 weeks. PROs demonstrated improvements in facial appearance, treated regions, psychological and social function.</p><p><strong>Conclusions: </strong>We define the novel tissue metrics, TDF and EV, relative to HA treatments, with greatest volume maintenance in the midface and greatest loss around the mimetic areas throughout 12 weeks. Significantly improved PROs were observed for patients undergoing large volume HA filler injections.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oguzhan Karasu, M Suhan Ayhan, Muzaffer Duran, Elif Ayca Sahin, Naim Deniz Ayaz, A Meltem Yalinay
{"title":"A Novel Approach for Preventing Biofilm Formation on Various Breast Implant Surfaces: Bacteriophage Therapy.","authors":"Oguzhan Karasu, M Suhan Ayhan, Muzaffer Duran, Elif Ayca Sahin, Naim Deniz Ayaz, A Meltem Yalinay","doi":"10.1097/PRS.0000000000012132","DOIUrl":"https://doi.org/10.1097/PRS.0000000000012132","url":null,"abstract":"<p><strong>Background: </strong>Capsular contracture is a common complication in breast implant surgery, with subclinical bacterial inflammation being a significant factor. Traditional methods to prevent capsular contracture include antibiotic irrigation and systemic antibiotics. However, the rise of antibiotic-resistant bacteria has driven the need for alternative treatments. Bacteriophages, capable of lysing bacteria and preventing biofilm formation, are emerging as a potential alternative. This study aims to compare the efficacy of local bacteriophage therapy and local antibiotic treatment in preventing biofilm formation on breast implants.</p><p><strong>Material and methods: </strong>Fifty-four Wistar Albino rats were divided into three groups: control, antibiotic, and bacteriophage, each with three subgroups for different time points (6 hours, 24 hours, and 30 days). Three types of implant surfaces (smooth, textured, and polyurethane) were incubated with a biofilm-producing strain of Staphylococcus epidermidis before implantation. The implant surfaces in the experimental groups were treated with either antibiotic or bacteriophage solutions before implantation. Samples were collected at 6 hours, 24 hours, and 30 days post-implantation for colony counting and mRNA analysis of the sesI gene.</p><p><strong>Results: </strong>Both bacteriophage and antibiotic treatments significantly reduced colony counts, and mRNA expression compared to the control group at all time points (p<0.05). No significant difference was found between the antibiotic and bacteriophage groups. Textured and polyurethane implants showed lower bacterial loads in the experimental groups compared to smooth implants.</p><p><strong>Conclusion: </strong>This study highlights bacteriophages as a promising alternative to antibiotics for preventing biofilm formation on breast implants, representing a pioneering effort in demonstrating their potential.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Confronting Racial Disparities in Breast Reconstruction: A Former Medical Student's Journey Through Breast Cancer and Advocacy for Equity in Healthcare.","authors":"Tokoya Williams","doi":"10.1097/PRS.0000000000012130","DOIUrl":"https://doi.org/10.1097/PRS.0000000000012130","url":null,"abstract":"","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina M Yver, Elizabeth R McGonagle, Tessa A Hadlock
{"title":"Muscle Foreshortening after Free Gracilis Transfer for Smile: Where? When? Why?","authors":"Christina M Yver, Elizabeth R McGonagle, Tessa A Hadlock","doi":"10.1097/PRS.0000000000011713","DOIUrl":"10.1097/PRS.0000000000011713","url":null,"abstract":"<p><strong>Background: </strong>Gracilis free muscle transfer (GFMT) remains the standard for smile restoration in patients with longstanding facial palsy. Resting oral commissure lateralization (ROCL) following GFMT is aesthetically unappealing and can cause functional problems including dysarthria and oral incompetence. The risk factors for ROCL following GFMT are poorly understood.</p><p><strong>Methods: </strong>Of all patients who underwent GFMT for smile restoration from 2003 to 2021, patients with subsequent ROCL were identified from a facial nerve database using predetermined search criteria. Medical records were reviewed to identify potential risk factors for muscle foreshortening.</p><p><strong>Results: </strong>Of 412 patients who underwent successful GFMT since 2003, 41 patients (10%) subsequently developed ROCL. ROCL rates varied significantly based on gracilis innervation source, with ipsilateral cranial nerve VII innervation and dual innervation (crossfacial nerve graft plus ipsilateral-to-masseter nerve) demonstrating the highest foreshortening rates (27.3% and 15.4%, respectively), compared with the lowest rates of foreshortening when the gracilis muscle was innervated by the crossfacial nerve graft alone (3.2%) ( P = 0.005). Patients with a history of irradiation to the surgical field were significantly more likely to develop ROCL (22%) compared with those without a history of irradiation (8.6%) ( P < 0.001). Furthermore, the rate of ROCL was significantly higher among patients who underwent concurrent stabilization of the nasolabial fold using a wide band of fascia lata (20.8%), compared with those who did not (6.6%) ( P < 0.001).</p><p><strong>Conclusion: </strong>The authors report potential risk factors for ROCL following GFMT for smile restoration, including innervation source, radiation history, and concurrent fascia lata static suspension.</p><p><strong>Clinical question/level of evidence: </strong>Therapeutic, III.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"794e-800e"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gordon C Wong, Sandra V Kotsis, H Myra Kim, Kevin C Chung
{"title":"Noninferiority Study Design: Application to Clinical Trials.","authors":"Gordon C Wong, Sandra V Kotsis, H Myra Kim, Kevin C Chung","doi":"10.1097/PRS.0000000000011633","DOIUrl":"10.1097/PRS.0000000000011633","url":null,"abstract":"<p><strong>Summary: </strong>The noninferiority trial, a distinct category within randomized controlled trials, is garnering increased attention in medical research. Its unique and evolving role comes to the forefront in scenarios where new treatments, despite not surpassing the efficacy of an existing standard, bring additional benefits such as reduced side effects, enhanced compliance, or cost savings. As the field of surgery witnesses a growing number of published noninferiority trials, it becomes imperative for surgeons to grasp the intricacies of this trial type to accurately decipher and interpret their outcomes.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"834e-840e"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bashar A Hassan, Adam D Sylvester, Daniel J Wescott, Deborah L Cunningham, Adekunle Elegbede, Paul N Manson, Michael P Grant
{"title":"An Introduction to the Orbital Buttresses.","authors":"Bashar A Hassan, Adam D Sylvester, Daniel J Wescott, Deborah L Cunningham, Adekunle Elegbede, Paul N Manson, Michael P Grant","doi":"10.1097/PRS.0000000000011603","DOIUrl":"10.1097/PRS.0000000000011603","url":null,"abstract":"<p><strong>Summary: </strong>Facial buttresses are supportive bony structures of the facial skeleton that form a thick, strong, and protective framework for the face. Surgical fixation may be required to restore morphology and function when damage to these buttresses occurs. The authors sought to determine whether, similar to buttresses of the facial skeleton, buttresses of the internal orbit exist. They analyzed 10 human cadaver skulls imaged by microcomputed tomography. Image processing, and thickness and heat mapping, were performed using Avizo and ImageJ software. After identifying the orbital buttresses, the authors reviewed computed tomography scans of patients who had orbital fractures over a 3-year period to determine the frequency of fracture of the orbital buttresses. The authors identified 5 buttresses of the internal orbit: superomedial fronto-ethmoidal strut with the deep orbital buttress, inferomedial strut with the posterior ledge, inferior orbital fissure, sphenoid-frontal superolateral strut, and the sphenoid lip. The mean (SD) threshold orbital buttress thickness was 1.36 (0.25) mm. A total of 1186 orbits of 593 individuals were analyzed for orbital buttress involvement. Orbital buttresses were spared in 770 (65%) orbits. The inferomedial strut with the posterior ledge was the most commonly fractured buttress in 14.4% of orbits ( n = 171), followed by the sphenoid strut and lip (66 [5.6%]). To the authors' knowledge, this is the first description of the buttresses of the internal orbit. Orbital reconstruction for fracture repair or oncologic purposes requires the support of orbital buttresses. Understanding the anatomy of orbital buttresses is crucial for successful surgical planning, proper implant positioning, and restoration of function and appearance.</p>","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":" ","pages":"780e-783e"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discussion: A Comparison of Textured versus Smooth-Surfaced Implants in Subfascial Breast Augmentation.","authors":"Amir H Dorafshar, Laura R Brown","doi":"10.1097/PRS.0000000000011799","DOIUrl":"10.1097/PRS.0000000000011799","url":null,"abstract":"","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":"155 4","pages":"646-647"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reputation Management.","authors":"Anne V Seyferth, Kevin C Chung","doi":"10.1097/PRS.0000000000011851","DOIUrl":"10.1097/PRS.0000000000011851","url":null,"abstract":"","PeriodicalId":20128,"journal":{"name":"Plastic and reconstructive surgery","volume":"155 4","pages":"589-593"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}