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Radiologist Assistant: Improving Patient Care While Providing Workforce Solutions in Saudi Arabia 放射科医生助理:在沙特阿拉伯提供劳动力解决方案的同时改善患者护理
IF 0.5
Pharmacophore Pub Date : 2023-01-01 DOI: 10.51847/qwhtebcfzi
Y. Hadi, Abdulrahman Ibrahim Abu Aqil, Q. Alshammari
{"title":"Radiologist Assistant: Improving Patient Care While Providing Workforce Solutions in Saudi Arabia","authors":"Y. Hadi, Abdulrahman Ibrahim Abu Aqil, Q. Alshammari","doi":"10.51847/qwhtebcfzi","DOIUrl":"https://doi.org/10.51847/qwhtebcfzi","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70832077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of the Role of Cognitive-Behavioral Therapy on Anxiety Disorders of Children and Adolescents 认知行为疗法在儿童青少年焦虑症治疗中的作用综述
Pharmacophore Pub Date : 2023-01-01 DOI: 10.51847/lkulo5pb1t
Nicolae Dumitru Nicoară, Paula Marian, Alin Ovidiu Petriș, Cristian Delcea, Felicia Manole
{"title":"A Review of the Role of Cognitive-Behavioral Therapy on Anxiety Disorders of Children and Adolescents","authors":"Nicolae Dumitru Nicoară, Paula Marian, Alin Ovidiu Petriș, Cristian Delcea, Felicia Manole","doi":"10.51847/lkulo5pb1t","DOIUrl":"https://doi.org/10.51847/lkulo5pb1t","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135181738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Exceptionally Long Survival with Lorlatinib in a Patient with Alk-Rearranged Lung 氯拉替尼治疗alk重排肺患者的超长生存期
Pharmacophore Pub Date : 2023-01-01 DOI: 10.51847/n1yjzejnbd
Katarzyna Szklener, Karolina Nieoczym, Katarzyna Niedziela, Łukasz Światłowski, Sławomir Mańdziuk
{"title":"Exceptionally Long Survival with Lorlatinib in a Patient with Alk-Rearranged Lung","authors":"Katarzyna Szklener, Karolina Nieoczym, Katarzyna Niedziela, Łukasz Światłowski, Sławomir Mańdziuk","doi":"10.51847/n1yjzejnbd","DOIUrl":"https://doi.org/10.51847/n1yjzejnbd","url":null,"abstract":"Genetic abnormalities in the anaplastic lymphoma (ALK) kinase gene are present in 3-5% of Non-squamous Cell Lung Cancer (NSCLC) cases. ALK gene rearrangement plays a crucial role in determining the sensitivity of neoplastic cells to small molecule ALK tyrosine kinase inhibitors. However, some patients may develop resistance to ALK inhibitors over time, leading to disease progression. In such cases, it is important to perform genetic testing to identify any emerging mutations that may be responsible for resistance and to select the appropriate subsequent treatment. We provide a case of a 56-year-old patient with advanced NSCLC. The patient achieved an overall progression-free survival of 71 months, which highlights the potential benefits of using a sequence of ALK inhibitors in treating advanced ALK-rearranged lung adenocarcinoma. Overall, this case study highlights the importance of genetic profiling and personalized treatment in managing advanced NSCLC, and it offers hope for improved outcomes in patients","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135002033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interdisciplinary Perspective of Laghumalini Vasant an Ayurvedic Formulation Towards Therapeutic Potential in Antenatal Care Laghumalini Vasant和阿育吠陀配方对产前护理治疗潜力的跨学科视角
IF 0.5
Pharmacophore Pub Date : 2023-01-01 DOI: 10.51847/5fppjrfii5
A. Wanjari, B. Rathi, Dinesh Santoshrao Wanjari, Rohit Ajit Gokarn
{"title":"Interdisciplinary Perspective of Laghumalini Vasant an Ayurvedic Formulation Towards Therapeutic Potential in Antenatal Care","authors":"A. Wanjari, B. Rathi, Dinesh Santoshrao Wanjari, Rohit Ajit Gokarn","doi":"10.51847/5fppjrfii5","DOIUrl":"https://doi.org/10.51847/5fppjrfii5","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, Attitudes, and Practices Associated with Vitamin D Misuse among General Population during COVID-19 COVID-19期间普通人群中与维生素D滥用相关的知识、态度和做法
IF 0.5
Pharmacophore Pub Date : 2023-01-01 DOI: 10.51847/cmnejaqtlr
M. M. A. El-Mawgod, A. Agarwal, Bishri Fawzan Almesned, M. M. Alruwaili, Shuruq Alshammari, Rehab Madallah Sulaiman Almatrafi
{"title":"Knowledge, Attitudes, and Practices Associated with Vitamin D Misuse among General Population during COVID-19","authors":"M. M. A. El-Mawgod, A. Agarwal, Bishri Fawzan Almesned, M. M. Alruwaili, Shuruq Alshammari, Rehab Madallah Sulaiman Almatrafi","doi":"10.51847/cmnejaqtlr","DOIUrl":"https://doi.org/10.51847/cmnejaqtlr","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70817521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI Assessment of Rotator Cuff Tear in Patients with Shoulder Pain 肩痛患者肩袖撕裂的MRI评估
IF 0.5
Pharmacophore Pub Date : 2023-01-01 DOI: 10.51847/q4teobtciz
Q. Alshammari, Awatif Radhy Alshammari, Amjad R. Alyahyawi, Alaa Sharef Alhmshe, Alanoud Saad Alshammari, Mai Fhaid Alshammari, S. Cg, M. Alshammari, M. A. Alghamdi, Asma Saud Alanazi
{"title":"MRI Assessment of Rotator Cuff Tear in Patients with Shoulder Pain","authors":"Q. Alshammari, Awatif Radhy Alshammari, Amjad R. Alyahyawi, Alaa Sharef Alhmshe, Alanoud Saad Alshammari, Mai Fhaid Alshammari, S. Cg, M. Alshammari, M. A. Alghamdi, Asma Saud Alanazi","doi":"10.51847/q4teobtciz","DOIUrl":"https://doi.org/10.51847/q4teobtciz","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"9 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70830803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of Amikacin in Eye Media Using Various Drugs 不同药物对阿米卡星在眼介质中的药动学影响
IF 0.5
Pharmacophore Pub Date : 2023-01-01 DOI: 10.51847/qzs08gqjvc
Markha Khozh-Akhmedovna Bersanova, Lina Magomedovna Batkhieva, Tamar Elbrusovna Baramiya, Daniela Georgievna Birkaya, Elena Vladimirovna Belokobylskaya, Zulmira Temirsoltanovna Saidova
{"title":"Pharmacokinetics of Amikacin in Eye Media Using Various Drugs","authors":"Markha Khozh-Akhmedovna Bersanova, Lina Magomedovna Batkhieva, Tamar Elbrusovna Baramiya, Daniela Georgievna Birkaya, Elena Vladimirovna Belokobylskaya, Zulmira Temirsoltanovna Saidova","doi":"10.51847/qzs08gqjvc","DOIUrl":"https://doi.org/10.51847/qzs08gqjvc","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"8 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70832090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenolic Composition, Anti-Biofilm, Anti-Quorum Sensing, Antioxidant and Enzyme Inhibitory Activities of Pteleopsis Suberosa (Combretaceae) Leaves 蕨叶的酚类成分、抗生物膜、抗群体感应、抗氧化和酶抑制活性
IF 0.5
Pharmacophore Pub Date : 2023-01-01 DOI: 10.51847/uflidelfqf
Alain Yaya Koudoro, A. N. Tamfu, Aristide Munvera, Selcuk Kucukaydin, Pascal Agbangnan Dossa Cokou, F. Avlessi, Dominique Sohounhloue Codjo Koko, O. Ceylan
{"title":"Phenolic Composition, Anti-Biofilm, Anti-Quorum Sensing, Antioxidant and Enzyme Inhibitory Activities of Pteleopsis Suberosa (Combretaceae) Leaves","authors":"Alain Yaya Koudoro, A. N. Tamfu, Aristide Munvera, Selcuk Kucukaydin, Pascal Agbangnan Dossa Cokou, F. Avlessi, Dominique Sohounhloue Codjo Koko, O. Ceylan","doi":"10.51847/uflidelfqf","DOIUrl":"https://doi.org/10.51847/uflidelfqf","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70835929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of Blockchain Technologies into Healthcare Delivery 将区块链技术集成到医疗保健服务中
IF 0.5
Pharmacophore Pub Date : 2023-01-01 DOI: 10.51847/2lqydxj3ir
Kanagala Anusha, Gorantla Anil Kumar, Nadella Kishore, Majji Tarun
{"title":"Integration of Blockchain Technologies into Healthcare Delivery","authors":"Kanagala Anusha, Gorantla Anil Kumar, Nadella Kishore, Majji Tarun","doi":"10.51847/2lqydxj3ir","DOIUrl":"https://doi.org/10.51847/2lqydxj3ir","url":null,"abstract":"","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70810929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual Screening for SARS-COV-2 Entry Inhibitors by Dual Targeting of TMPRSS2 and CTSL 基于TMPRSS2和CTSL双重靶向的SARS-COV-2进入抑制剂虚拟筛选
IF 0.5
Pharmacophore Pub Date : 2023-01-01 DOI: 10.51847/6imwqjwvpa
Ian Lemuel Sigue Virtucio, J. Punzalan, J. Billones
{"title":"Virtual Screening for SARS-COV-2 Entry Inhibitors by Dual Targeting of TMPRSS2 and CTSL","authors":"Ian Lemuel Sigue Virtucio, J. Punzalan, J. Billones","doi":"10.51847/6imwqjwvpa","DOIUrl":"https://doi.org/10.51847/6imwqjwvpa","url":null,"abstract":"The COVID-19 pandemic remains to be a global public health crisis due to the emergence of new variants of concern and the scarcity of drug treatments. The cell entry of SARS-CoV-2 requires activation of its spike protein by host proteases TMPRSS2 and CTSL, which triggers membrane fusion and facilitates the endocytic uptake mechanism, respectively. This study employed a structure-based virtual screening technique to identify drugs and natural products that simultaneously target TMPRSS2 and CTSL. Two pharmacophore models were generated from the binding sites of the proteins in complex with their co-crystallized ligands. Both structure-based pharmacophores were used to screen a ligand library composed of 41,775 compounds (10,849 drugs from the ChEMBL database and 30,926 natural products from the NPASS database). A total of 115 compounds (54 drugs and 61 natural products) that fit both TMPRSS2 and CTSL pharmacophore models were identified. The common hits were docked into both proteases to obtain a short list of compounds. Molecular docking filtered 17 compounds (5 drugs and 12 natural products) that have higher binding energy values than the co-crystallized ligands and known inhibitors of both proteins. The top hits were then subjected to ADMET, drug-likeness, and synthetic accessibility filters. Based on docking scores, pharmacokinetics, and drug-likeness, Silibinin was the most promising repurposed drug candidate as a treatment for SARS-CoV-2 infection via dual inhibition of TMPRSS2 and CTSL. Among the natural products, barettin was the best candidate for further development as a novel dual TMPRSS2 and CTSL inhibitor.","PeriodicalId":20012,"journal":{"name":"Pharmacophore","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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